Leser-Trélat syndrome in patients affected by six multiple metachronous primitive cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Giovanni Ponti, Gabriele Luppi, Lorena Losi, Alberto Giannetti, Stefania Seidenari

ABSTRACT

Leser-Trélat syndrome is characterized by the eruptive appearance of multiple seborrheic keratoses in association with underlying malignant disease. Usually, the sign of Leser-Trélat is associated with adenocarcinoma, most frequently of the colon, breast, or stomach, but also of the lung, kidney, liver, and pancreas. Herein, we present a case that we believe is the first report of the sign of Leser-Trélat in association with occult gastric adenocarcinoma and the anamnestic oncologic history of five other multiple primitive cancers. Epidermal growth factor receptor (EGFR) immunohistochemical expression analysis of multiple seborrheic keratoses revealed an intense membranous staining in the basal keratinocytes and in all the upper epidermal layers. Patients with the sign of Leser-Trélat should undergo a diagnostic screening programme for malignant disease along with patients with known Leser-Trélat syndrome who present with a recent acute and florid eruption of their seborrheic keratoses. We propose the importance of combining the molecular features of multiple seborrheic keratoses with EGFR immunohistochemistry analyses to determine the likelihood of Leser-Trélat syndrome and the consequent high risk of underlying multiple visceral malignancies. More... »

PAGES

2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1756-8722-3-2

DOI

http://dx.doi.org/10.1186/1756-8722-3-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050231153

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20064244


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