Abnormalities in brain structure and behavior in GSK-3alpha mutant mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-11-19

AUTHORS

Oksana Kaidanovich-Beilin, Tatiana V Lipina, Keizo Takao, Matthijs van Eede, Satoko Hattori, Christine Laliberté, Mustafa Khan, Kenichi Okamoto, John W Chambers, Paul J Fletcher, Katrina MacAulay, Bradley W Doble, Mark Henkelman, Tsuyoshi Miyakawa, John Roder, James R Woodgett

ABSTRACT

BackgroundGlycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded by two genes that generate two related proteins: GSK-3α and GSK-3β. Mice lacking a functional GSK-3α gene were engineered in our laboratory; they are viable and display insulin sensitivity. In this study, we have characterized brain functions of GSK-3α KO mice by using a well-established battery of behavioral tests together with neurochemical and neuroanatomical analysis.ResultsSimilar to the previously described behaviours of GSK-3β+/-mice, GSK-3α mutants display decreased exploratory activity, decreased immobility time and reduced aggressive behavior. However, genetic inactivation of the GSK-3α gene was associated with: decreased locomotion and impaired motor coordination, increased grooming activity, loss of social motivation and novelty; enhanced sensorimotor gating and impaired associated memory and coordination. GSK-3α KO mice exhibited a deficit in fear conditioning, however memory formation as assessed by a passive avoidance test was normal, suggesting that the animals are sensitized for active avoidance of a highly aversive stimulus in the fear-conditioning paradigm. Changes in cerebellar structure and function were observed in mutant mice along with a significant decrease of the number and size of Purkinje cells.ConclusionTaken together, these data support a role for the GSK-3α gene in CNS functioning and possible involvement in the development of psychiatric disorders. More... »

PAGES

35

References to SciGraph publications

  • 2007-02-23. Antagonism between Notch and bone morphogenetic protein receptor signaling regulates neurogenesis in the cerebellar rhombic lip in NEURAL DEVELOPMENT
  • 2008-09-10. Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders in MOLECULAR BRAIN
  • 1998-01. Selective dopamine D4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition in PSYCHOPHARMACOLOGY
  • 2009-10-04. GSK-3 is a master regulator of neural progenitor homeostasis in NATURE NEUROSCIENCE
  • 1995-04. Noradrenaline is essential for mouse fetal development in NATURE
  • 2003-02. Wnts and TGFβ in synaptogenesis: old friends signalling at new places in NATURE REVIEWS NEUROSCIENCE
  • 1993-01. A synaptic model of memory: long-term potentiation in the hippocampus in NATURE
  • 1990-08. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development in NATURE
  • 2007-09. On the mechanism of cerebellar contributions to cognition in THE CEREBELLUM
  • 2004-01-25. Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia in NATURE GENETICS
  • 1986-06. Effects of lithium and rubidium on shock-induced changes in open-field activity in PSYCHOPHARMACOLOGY
  • 2001-05. Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice in PSYCHOPHARMACOLOGY
  • 2002-07-13. Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration in ACTA NEUROPATHOLOGICA
  • 1981-12. Clinical and neuropathological aspects of long-term damage to the central nervous system after lithium medication in EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
  • 1985-03. The tail suspension test: A new method for screening antidepressants in mice in PSYCHOPHARMACOLOGY
  • 2005-04-13. Glycogen Synthase Kinase-3: a Putative Molecular Target for Lithium Mimetic Drugs in NEUROPSYCHOPHARMACOLOGY
  • 2009-07-07. A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases in MOLECULAR BRAIN
  • 2005-03-10. Modulators of the glycine site on NMDA receptors, d-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia in PSYCHOPHARMACOLOGY
  • 1983-12. Lithium effects on active and passive avoidance behavior in the rat in PSYCHOPHARMACOLOGY
  • 1997-10. Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice in NATURE
  • 1997-10. Neuronal position in the developing brain is regulated by mouse disabled-1 in NATURE
  • 2000-07. Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation in NATURE
  • 1997-07. Inbred strain differences in prepulse inhibition of the mouse startle response in PSYCHOPHARMACOLOGY
  • 1977-04. Depression: a new animal model sensitive to antidepressant treatments in NATURE
  • 2004-03-24. In Vivo Regulation of Glycogen Synthase Kinase-3β (GSK3β) by Serotonergic Activity in Mouse Brain in NEUROPSYCHOPHARMACOLOGY
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    http://scigraph.springernature.com/pub.10.1186/1756-6606-2-35

    DOI

    http://dx.doi.org/10.1186/1756-6606-2-35

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002054835

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19925672


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