Population dynamics and host reactions in young foxes following experimental infection with the minute intestinal fluke, Haplorchis pumilio View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Sofie Nissen, Stig Milan Thamsborg, Per Walther Kania, Páll S Leifsson, Anders Dalsgaard, Maria Vang Johansen

ABSTRACT

BACKGROUND: Infections with fish-borne zoonotic trematodes (FZT) including the minute intestinal fluke, Haplorchis pumilio, are highly prevalent in Southeast Asia. However, little is known about the infection dynamics and clinical symptoms in the final hosts which include a range of animal species and man. We aimed to generate such information using an experimental model with H. pumilio in foxes. METHOD: Eight commercially bred foxes were each orally infected with 2000 H. pumilio metacercariae. Another three foxes served as uninfected controls. Faecal examination for eggs was performed twice weekly. The body weight was measured, standard haematological and biochemical analysis were performed regularly. All foxes were euthanized at day 56 post infection (p.i.). Adult worms were quantified and location in the small intestine noted. RESULTS: Anorexia was observed in all infected foxes starting day 12 p.i. and lasting for approximately a week. A weight loss was noticed in the infected group in weeks 3-6 p.i. Five of eight infected foxes excreted H. pumilio eggs day 9 p.i. onwards, the remaining three started on day 13 p.i. Mean (± SD) faecal egg counts showed an initial peak at day 16-20 with a maximum of 1443 ± 1176 eggs per gram of faeces (epg), where after a stable egg output around 4-500 epg was seen. Worm burdens ranged between 116-2070 adult flukes with a mean (± SD) worm recovery of 948 ± 666. The majority of worms were found in the lower part of the jejunum. Total white blood cell and lymphocyte counts were significant lower in the infected group from first week p.i. onwards and throughout the study period. A significantly lower level of eosinophils was found in week 2 p.i. and transient anaemia was seen in week 2 and 4 p.i. CONCLUSION: This study showed a short prepatency period, an initial peak in egg excretion, establishment of infection in all animals with predilection site in the lower jejunum and a marked but transient clinical effect of the infection. The findings on egg output and prepatency should be taken into consideration when control programs targeting dogs and other reservoir hosts are to be established. More... »

PAGES

4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1756-3305-6-4

DOI

http://dx.doi.org/10.1186/1756-3305-6-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002042020

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23289937


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anorexia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feces", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fertility", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fish Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Foxes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Goldfish", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterophyidae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Host-Parasite Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestine, Small", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metacercariae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parasite Egg Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Population Dynamics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trematode Infections", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Groennegaardsvej 15, C DK-1870, Frederiksberg, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nissen", 
        "givenName": "Sofie", 
        "id": "sg:person.01263377120.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263377120.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Groennegaardsvej 15, C DK-1870, Frederiksberg, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thamsborg", 
        "givenName": "Stig Milan", 
        "id": "sg:person.01057116550.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057116550.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Groennegaardsvej 15, C DK-1870, Frederiksberg, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kania", 
        "givenName": "Per Walther", 
        "id": "sg:person.0722334620.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722334620.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Groennegaardsvej 15, C DK-1870, Frederiksberg, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leifsson", 
        "givenName": "P\u00e1ll S", 
        "id": "sg:person.01160173311.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160173311.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Groennegaardsvej 15, C DK-1870, Frederiksberg, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dalsgaard", 
        "givenName": "Anders", 
        "id": "sg:person.0602327062.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602327062.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Groennegaardsvej 15, C DK-1870, Frederiksberg, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johansen", 
        "givenName": "Maria Vang", 
        "id": "sg:person.0662521445.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662521445.03"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ijpara.2005.07.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001954191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpara.2005.07.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001954191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2009.07.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003669316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00365540510034473", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005144447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1645/ge-1785.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007769617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vetpar.2008.10.088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018048918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpg.2007.12.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018580946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exppara.2008.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018979232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.parint.2011.06.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021898863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2003.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029580741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2003.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029580741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/vbz.2009.0134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031256831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2761.1982.tb00478.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031965645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2761.1982.tb00478.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031965645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0000742", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033021156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.aquaculture.2010.02.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034258391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vetpar.2006.02.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036345871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid1504.081147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037327191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00436-002-0701-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039580705", 
          "https://doi.org/10.1007/s00436-002-0701-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vetpar.2012.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040011686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-308x(09)69003-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042546800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2006.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044555124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid1312.070554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045579889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00436-002-0719-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050836371", 
          "https://doi.org/10.1007/s00436-002-0719-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trstmh.2008.10.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054751834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3347/kjp.1981.19.2.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071149209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3347/kjp.1983.21.1.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071149253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3347/kjp.2009.47.3.315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071150317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3347/kjp.2009.47.3.315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071150317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3347/kjp.2009.47.s.s69", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071150348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3347/kjp.2009.47.s.s69", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071150348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3347/kjp.2010.48.3.225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071150389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3347/kjp.2010.48.3.225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071150389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078180204", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082157082", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082488182", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "BACKGROUND: Infections with fish-borne zoonotic trematodes (FZT) including the minute intestinal fluke, Haplorchis pumilio, are highly prevalent in Southeast Asia. However, little is known about the infection dynamics and clinical symptoms in the final hosts which include a range of animal species and man. We aimed to generate such information using an experimental model with H. pumilio in foxes.\nMETHOD: Eight commercially bred foxes were each orally infected with 2000 H. pumilio metacercariae. Another three foxes served as uninfected controls. Faecal examination for eggs was performed twice weekly. The body weight was measured, standard haematological and biochemical analysis were performed regularly. All foxes were euthanized at day 56 post infection (p.i.). Adult worms were quantified and location in the small intestine noted.\nRESULTS: Anorexia was observed in all infected foxes starting day 12 p.i. and lasting for approximately a week. A weight loss was noticed in the infected group in weeks 3-6 p.i. Five of eight infected foxes excreted H. pumilio eggs day 9 p.i. onwards, the remaining three started on day 13 p.i. Mean (\u00b1 SD) faecal egg counts showed an initial peak at day 16-20 with a maximum of 1443 \u00b1 1176 eggs per gram of faeces (epg), where after a stable egg output around 4-500 epg was seen. Worm burdens ranged between 116-2070 adult flukes with a mean (\u00b1 SD) worm recovery of 948 \u00b1 666. The majority of worms were found in the lower part of the jejunum. Total white blood cell and lymphocyte counts were significant lower in the infected group from first week p.i. onwards and throughout the study period. A significantly lower level of eosinophils was found in week 2 p.i. and transient anaemia was seen in week 2 and 4 p.i.\nCONCLUSION: This study showed a short prepatency period, an initial peak in egg excretion, establishment of infection in all animals with predilection site in the lower jejunum and a marked but transient clinical effect of the infection. The findings on egg output and prepatency should be taken into consideration when control programs targeting dogs and other reservoir hosts are to be established.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1756-3305-6-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1039458", 
        "issn": [
          "1756-3305"
        ], 
        "name": "Filaria Journal", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Population dynamics and host reactions in young foxes following experimental infection with the minute intestinal fluke, Haplorchis pumilio", 
    "pagination": "4", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "09b99283cbde2073691bed6dd437d2c0601831ee7591ef6d2eab0bed5bb70e75"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23289937"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101462774"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1756-3305-6-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002042020"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1756-3305-6-4", 
      "https://app.dimensions.ai/details/publication/pub.1002042020"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000509.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1756-3305-6-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1756-3305-6-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1756-3305-6-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1756-3305-6-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1756-3305-6-4'


 

This table displays all metadata directly associated to this object as RDF triples.

268 TRIPLES      21 PREDICATES      78 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1756-3305-6-4 schema:about N1ba9eb5f57b740c68e64fd38fd423192
2 N235895fd79314f4ebb87762ef020f5a9
3 N289e3e4b7f214a229d28366d9166066e
4 N346b97e211754402ad74f6702428690c
5 N4eceac734f6f44829738a7cb5a0a0a1a
6 N51643fadc68c4aca80892ab7e72ba28b
7 N765a24a2ee02446cb61d5db59073efd6
8 N881d31b46b8b40f290c6b329716e91b6
9 N90ef5bd87d104d8ba84842de133ea7c6
10 N917df26bf4fb424ba1982cc6bd8fcee4
11 N9add3f74ce15402199748ebf74c234ef
12 Nb4575b165b4f43eb9f3ea1858af1f79a
13 Nb6a7188609ad47979e5c8010ef487f80
14 Nbec9e823ec3043e7bd07b6052de08462
15 Nccad1df00204443ca87dfeeabbce059d
16 Ncf552ce1df1b42af80ccccc7dbcb95ff
17 Nd14a2880f84b4f65b275cd4ed1b7170f
18 Nd3d1ba5e719e4504834fae0492cd6829
19 Nf55d2c93c0ab48d5b2e323f5282f7fce
20 anzsrc-for:11
21 anzsrc-for:1108
22 schema:author N92481207086049c799f7db900f72422d
23 schema:citation sg:pub.10.1007/s00436-002-0701-9
24 sg:pub.10.1007/s00436-002-0719-z
25 https://app.dimensions.ai/details/publication/pub.1078180204
26 https://app.dimensions.ai/details/publication/pub.1082157082
27 https://app.dimensions.ai/details/publication/pub.1082488182
28 https://doi.org/10.1016/j.actatropica.2003.05.001
29 https://doi.org/10.1016/j.actatropica.2006.10.010
30 https://doi.org/10.1016/j.actatropica.2009.07.027
31 https://doi.org/10.1016/j.aquaculture.2010.02.002
32 https://doi.org/10.1016/j.bpg.2007.12.004
33 https://doi.org/10.1016/j.exppara.2008.07.002
34 https://doi.org/10.1016/j.ijpara.2005.07.013
35 https://doi.org/10.1016/j.parint.2011.06.007
36 https://doi.org/10.1016/j.trstmh.2008.10.011
37 https://doi.org/10.1016/j.vetpar.2006.02.015
38 https://doi.org/10.1016/j.vetpar.2008.10.088
39 https://doi.org/10.1016/j.vetpar.2012.08.004
40 https://doi.org/10.1016/s0065-308x(09)69003-5
41 https://doi.org/10.1080/00365540510034473
42 https://doi.org/10.1089/vbz.2009.0134
43 https://doi.org/10.1111/j.1365-2761.1982.tb00478.x
44 https://doi.org/10.1371/journal.pntd.0000742
45 https://doi.org/10.1645/ge-1785.1
46 https://doi.org/10.3201/eid1312.070554
47 https://doi.org/10.3201/eid1504.081147
48 https://doi.org/10.3347/kjp.1981.19.2.109
49 https://doi.org/10.3347/kjp.1983.21.1.58
50 https://doi.org/10.3347/kjp.2009.47.3.315
51 https://doi.org/10.3347/kjp.2009.47.s.s69
52 https://doi.org/10.3347/kjp.2010.48.3.225
53 schema:datePublished 2013-12
54 schema:datePublishedReg 2013-12-01
55 schema:description BACKGROUND: Infections with fish-borne zoonotic trematodes (FZT) including the minute intestinal fluke, Haplorchis pumilio, are highly prevalent in Southeast Asia. However, little is known about the infection dynamics and clinical symptoms in the final hosts which include a range of animal species and man. We aimed to generate such information using an experimental model with H. pumilio in foxes. METHOD: Eight commercially bred foxes were each orally infected with 2000 H. pumilio metacercariae. Another three foxes served as uninfected controls. Faecal examination for eggs was performed twice weekly. The body weight was measured, standard haematological and biochemical analysis were performed regularly. All foxes were euthanized at day 56 post infection (p.i.). Adult worms were quantified and location in the small intestine noted. RESULTS: Anorexia was observed in all infected foxes starting day 12 p.i. and lasting for approximately a week. A weight loss was noticed in the infected group in weeks 3-6 p.i. Five of eight infected foxes excreted H. pumilio eggs day 9 p.i. onwards, the remaining three started on day 13 p.i. Mean (± SD) faecal egg counts showed an initial peak at day 16-20 with a maximum of 1443 ± 1176 eggs per gram of faeces (epg), where after a stable egg output around 4-500 epg was seen. Worm burdens ranged between 116-2070 adult flukes with a mean (± SD) worm recovery of 948 ± 666. The majority of worms were found in the lower part of the jejunum. Total white blood cell and lymphocyte counts were significant lower in the infected group from first week p.i. onwards and throughout the study period. A significantly lower level of eosinophils was found in week 2 p.i. and transient anaemia was seen in week 2 and 4 p.i. CONCLUSION: This study showed a short prepatency period, an initial peak in egg excretion, establishment of infection in all animals with predilection site in the lower jejunum and a marked but transient clinical effect of the infection. The findings on egg output and prepatency should be taken into consideration when control programs targeting dogs and other reservoir hosts are to be established.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf N04373e52adea4e9180bb3e9b48d290a9
60 N9c829d7c6ebb4b3594bb53ace90e44b7
61 sg:journal.1039458
62 schema:name Population dynamics and host reactions in young foxes following experimental infection with the minute intestinal fluke, Haplorchis pumilio
63 schema:pagination 4
64 schema:productId N024560ce637647149c7a7b220474057f
65 N139add8f6ef8465caa5dd1198036b235
66 N2f0dfedea7364d85882f3f53adef733d
67 N6beca46afe384a69bcc709cdc987f0e3
68 Na22653724ebb4414baef095b7404d5db
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002042020
70 https://doi.org/10.1186/1756-3305-6-4
71 schema:sdDatePublished 2019-04-10T19:08
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N8b5b15397447424e89160e293a3400b8
74 schema:url http://link.springer.com/10.1186%2F1756-3305-6-4
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N024560ce637647149c7a7b220474057f schema:name doi
79 schema:value 10.1186/1756-3305-6-4
80 rdf:type schema:PropertyValue
81 N04373e52adea4e9180bb3e9b48d290a9 schema:issueNumber 1
82 rdf:type schema:PublicationIssue
83 N096fe217616b48b6931605bbd8b7b2a5 rdf:first sg:person.01160173311.12
84 rdf:rest Na331e5e619d0453bbe20a58a24a3339a
85 N139add8f6ef8465caa5dd1198036b235 schema:name readcube_id
86 schema:value 09b99283cbde2073691bed6dd437d2c0601831ee7591ef6d2eab0bed5bb70e75
87 rdf:type schema:PropertyValue
88 N1ba9eb5f57b740c68e64fd38fd423192 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Feces
90 rdf:type schema:DefinedTerm
91 N235895fd79314f4ebb87762ef020f5a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Trematode Infections
93 rdf:type schema:DefinedTerm
94 N23dfd0b6b15542a6b8b52fd69db7ebd1 rdf:first sg:person.0722334620.71
95 rdf:rest N096fe217616b48b6931605bbd8b7b2a5
96 N289e3e4b7f214a229d28366d9166066e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Lymphocyte Count
98 rdf:type schema:DefinedTerm
99 N2f0dfedea7364d85882f3f53adef733d schema:name nlm_unique_id
100 schema:value 101462774
101 rdf:type schema:PropertyValue
102 N346b97e211754402ad74f6702428690c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Metacercariae
104 rdf:type schema:DefinedTerm
105 N4eceac734f6f44829738a7cb5a0a0a1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Goldfish
107 rdf:type schema:DefinedTerm
108 N51643fadc68c4aca80892ab7e72ba28b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Anorexia
110 rdf:type schema:DefinedTerm
111 N6beca46afe384a69bcc709cdc987f0e3 schema:name pubmed_id
112 schema:value 23289937
113 rdf:type schema:PropertyValue
114 N6ecb17b906354666a9dfaccb875872f3 rdf:first sg:person.0662521445.03
115 rdf:rest rdf:nil
116 N765a24a2ee02446cb61d5db59073efd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Body Weight
118 rdf:type schema:DefinedTerm
119 N7c517eaf1a5548228cddd79f87a69a45 rdf:first sg:person.01057116550.51
120 rdf:rest N23dfd0b6b15542a6b8b52fd69db7ebd1
121 N881d31b46b8b40f290c6b329716e91b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Female
123 rdf:type schema:DefinedTerm
124 N8b5b15397447424e89160e293a3400b8 schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N90ef5bd87d104d8ba84842de133ea7c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Animals
128 rdf:type schema:DefinedTerm
129 N917df26bf4fb424ba1982cc6bd8fcee4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Population Dynamics
131 rdf:type schema:DefinedTerm
132 N92481207086049c799f7db900f72422d rdf:first sg:person.01263377120.05
133 rdf:rest N7c517eaf1a5548228cddd79f87a69a45
134 N9add3f74ce15402199748ebf74c234ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Heterophyidae
136 rdf:type schema:DefinedTerm
137 N9c829d7c6ebb4b3594bb53ace90e44b7 schema:volumeNumber 6
138 rdf:type schema:PublicationVolume
139 Na22653724ebb4414baef095b7404d5db schema:name dimensions_id
140 schema:value pub.1002042020
141 rdf:type schema:PropertyValue
142 Na331e5e619d0453bbe20a58a24a3339a rdf:first sg:person.0602327062.28
143 rdf:rest N6ecb17b906354666a9dfaccb875872f3
144 Nb4575b165b4f43eb9f3ea1858af1f79a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Anemia
146 rdf:type schema:DefinedTerm
147 Nb6a7188609ad47979e5c8010ef487f80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Fertility
149 rdf:type schema:DefinedTerm
150 Nbec9e823ec3043e7bd07b6052de08462 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Foxes
152 rdf:type schema:DefinedTerm
153 Nccad1df00204443ca87dfeeabbce059d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Host-Parasite Interactions
155 rdf:type schema:DefinedTerm
156 Ncf552ce1df1b42af80ccccc7dbcb95ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Intestine, Small
158 rdf:type schema:DefinedTerm
159 Nd14a2880f84b4f65b275cd4ed1b7170f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Parasite Egg Count
161 rdf:type schema:DefinedTerm
162 Nd3d1ba5e719e4504834fae0492cd6829 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Time Factors
164 rdf:type schema:DefinedTerm
165 Nf55d2c93c0ab48d5b2e323f5282f7fce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Fish Diseases
167 rdf:type schema:DefinedTerm
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
172 schema:name Medical Microbiology
173 rdf:type schema:DefinedTerm
174 sg:journal.1039458 schema:issn 1756-3305
175 schema:name Filaria Journal
176 rdf:type schema:Periodical
177 sg:person.01057116550.51 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
178 schema:familyName Thamsborg
179 schema:givenName Stig Milan
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057116550.51
181 rdf:type schema:Person
182 sg:person.01160173311.12 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
183 schema:familyName Leifsson
184 schema:givenName Páll S
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160173311.12
186 rdf:type schema:Person
187 sg:person.01263377120.05 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
188 schema:familyName Nissen
189 schema:givenName Sofie
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263377120.05
191 rdf:type schema:Person
192 sg:person.0602327062.28 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
193 schema:familyName Dalsgaard
194 schema:givenName Anders
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602327062.28
196 rdf:type schema:Person
197 sg:person.0662521445.03 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
198 schema:familyName Johansen
199 schema:givenName Maria Vang
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662521445.03
201 rdf:type schema:Person
202 sg:person.0722334620.71 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
203 schema:familyName Kania
204 schema:givenName Per Walther
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722334620.71
206 rdf:type schema:Person
207 sg:pub.10.1007/s00436-002-0701-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039580705
208 https://doi.org/10.1007/s00436-002-0701-9
209 rdf:type schema:CreativeWork
210 sg:pub.10.1007/s00436-002-0719-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1050836371
211 https://doi.org/10.1007/s00436-002-0719-z
212 rdf:type schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1078180204 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1082157082 schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1082488182 schema:CreativeWork
216 https://doi.org/10.1016/j.actatropica.2003.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029580741
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.actatropica.2006.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044555124
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.actatropica.2009.07.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003669316
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.aquaculture.2010.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034258391
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.bpg.2007.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018580946
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.exppara.2008.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018979232
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.ijpara.2005.07.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001954191
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.parint.2011.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021898863
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.trstmh.2008.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054751834
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.vetpar.2006.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036345871
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.vetpar.2008.10.088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018048918
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.vetpar.2012.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040011686
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0065-308x(09)69003-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042546800
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1080/00365540510034473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005144447
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1089/vbz.2009.0134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031256831
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1111/j.1365-2761.1982.tb00478.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031965645
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1371/journal.pntd.0000742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033021156
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1645/ge-1785.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007769617
251 rdf:type schema:CreativeWork
252 https://doi.org/10.3201/eid1312.070554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045579889
253 rdf:type schema:CreativeWork
254 https://doi.org/10.3201/eid1504.081147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037327191
255 rdf:type schema:CreativeWork
256 https://doi.org/10.3347/kjp.1981.19.2.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071149209
257 rdf:type schema:CreativeWork
258 https://doi.org/10.3347/kjp.1983.21.1.58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071149253
259 rdf:type schema:CreativeWork
260 https://doi.org/10.3347/kjp.2009.47.3.315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071150317
261 rdf:type schema:CreativeWork
262 https://doi.org/10.3347/kjp.2009.47.s.s69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071150348
263 rdf:type schema:CreativeWork
264 https://doi.org/10.3347/kjp.2010.48.3.225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071150389
265 rdf:type schema:CreativeWork
266 https://www.grid.ac/institutes/grid.5254.6 schema:alternateName University of Copenhagen
267 schema:name Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Groennegaardsvej 15, C DK-1870, Frederiksberg, Denmark
268 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...