Mapping of the chromosomal amplification 1p21-22 in bladder cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Mauro Scaravilli, Paola Asero, Teuvo LJ Tammela, Tapio Visakorpi, Outi R Saramäki

ABSTRACT

BACKGROUND: The aim of the study was to characterize a recurrent amplification at chromosomal region 1p21-22 in bladder cancer. METHODS: ArrayCGH (aCGH) was performed to identify DNA copy number variations in 7 clinical samples and 6 bladder cancer cell lines. FISH was used to map the amplicon at 1p21-22 in the cell lines. Gene expression microarrays and qRT-PCR were used to study the expression of putative target genes in the region. RESULTS: aCGH identified an amplification at 1p21-22 in 10/13 (77%) samples. The minimal region of the amplification was mapped to a region of about 1 Mb in size, containing a total of 11 known genes. The highest amplification was found in SCaBER squamous cell carcinoma cell line. Four genes, TMED5, DR1, RPL5 and EVI5, showed significant overexpression in the SCaBER cell line compared to all the other samples tested. Oncomine database analysis revealed upregulation of DR1 in superficial and infiltrating bladder cancer samples, compared to normal bladder. CONCLUSIONS: In conclusions, we have identified and mapped chromosomal amplification at 1p21-22 in bladder cancer as well as studied the expression of the genes in the region. DR1 was found to be significantly overexpressed in the SCaBER, which is a model of squamous cell carcinoma. However, the overexpression was found also in a published clinical sample cohort of superficial and infiltrating bladder cancers. Further studies with more clinical material are needed to investigate the role of the amplification at 1p21-22. More... »

PAGES

547

References to SciGraph publications

  • 2002-04. Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer in ONCOGENE
  • 1998-10. High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays in NATURE GENETICS
  • 2004-01. DBCCR1 mediates death in cultured bladder tumor cells in ONCOGENE
  • 1991-04. Amplification and over-expression of c-erbB-2 in transitional cell carcinoma of the urinary bladder in BRITISH JOURNAL OF CANCER
  • 2001-12. Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas in NATURE GENETICS
  • 2005-08. FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma in ONCOGENE
  • 1999-05. Somatic mutation of PTEN in bladder carcinoma in BRITISH JOURNAL OF CANCER
  • 2009-04. Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma in NATURE GENETICS
  • 1999-04. Mutation of the 9q34 gene TSC1 in sporadic bladder cancer in ONCOGENE
  • 2001-12. Destabilization of chromosome 9 in transitional cell carcinoma of the urinary bladder in BRITISH JOURNAL OF CANCER
  • 2004-03. High-resolution analysis of genomic copy number alterations in bladder cancer by microarray-based comparative genomic hybridization in ONCOGENE
  • 2004-07. E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer in ONCOGENE
  • 2004-02. Amplification and overexpression of E2F3 in human bladder cancer in ONCOGENE
  • 2007-07. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1756-0500-7-547

    DOI

    http://dx.doi.org/10.1186/1756-0500-7-547

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051157362

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25135188


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