Lower ratio of high-molecular-weight adiponectin level to total may be associated with coronary high-risk plaque View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Masao Moroi, Shamima Akter, Ryo Nakazato, Taeko Kunimasa, Hirofumi Masai, Tatsuhiko Furuhashi, Hiroshi Fukuda, Eiichi Koda, Kaoru Sugi, Subrina Jesmin

ABSTRACT

BACKGROUND: Although high-molecular-weight (HMW) adiponectin is believed to protect against atherosclerosis, the association between HMW adiponectin and the composition of coronary plaques is unknown. We evaluated whether the HMW to total adiponectin ratio was associated with the presence of coronary plaque and its composition using multi-slice computed tomography coronary angiography (MSCTCA). METHODS: Serum total and HMW adiponectin levels were measured in 53 consecutive patients (age, 71) with >50% coronary artery stenosis detected by MSCTCA. A low-attenuation coronary plaque was defined as a plaque with a mean CT density <50 Hounsfield units. Multivariate logistic regression analyses were performed to evaluate the predictors of the presence of low-attenuation coronary plaques, which is thought to be high risk, on CT. RESULTS: Decreased serum levels of total as well as HMW adiponectin were significantly associated with the presence of at least one calcified or non-calcified coronary artery plaque (total adiponectin level: odds ratio 0.76, 95% CI 0.58-0.99, P = 0.048; HMW adiponectin level: odds ratio 0.65, 95% CI 0.42-0.99, P = 0.047). A low ratio of HMW to total adiponectin was significantly associated with the presence of low-attenuation coronary plaques (4.55, 1.94-21.90, P = 0.049). However, neither the total adiponectin nor the HMW adiponectin level was associated with the presence of low-attenuation coronary plaques. CONCLUSION: Lower total or HMW adiponectin levels are associated with the presence of calcified and non-calcified coronary plaques, whereas a lower ratio of HMW to total adiponectin associated with the presence of low-attenuation coronary plaques (thought to be high risk). Measurement of total and HMW adiponectin levels and the HMW to total adiponectin ratio may be useful for risk stratification of coronary artery plaques. More... »

PAGES

83

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1756-0500-6-83

DOI

http://dx.doi.org/10.1186/1756-0500-6-83

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008227826

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23497474


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