Hepatitis E virus in Norway rats (Rattus norvegicus) captured around a pig farm View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01-05

AUTHORS

Yuta Kanai, Satoshi Miyasaka, Sachiko Uyama, Sachiyo Kawami, Yuko Kato-Mori, Muneo Tsujikawa, Mikihiro Yunoki, Shoko Nishiyama, Kazuyoshi Ikuta, Katsuro Hagiwara

ABSTRACT

BackgroundHepatitis E virus (HEV) transmitted via the oral route through the consumption of contaminated water or uncooked or undercooked contaminated meat has been implicated in major outbreaks. Rats may play a critical role in HEV outbreaks, considering their negative effects on environmental hygiene and food sanitation. Although the serological evidence of HEV infection in wild rodents has been reported worldwide, the infectivity and propagation of HEV in wild rats remain unknown. To investigate if rats are a possible carrier of HEV, we studied wild Norway rats (Rattus norvegicus) that were caught near a pig farm, where HEV was prevalent among the pigs.MethodsWe examined 56 Norway rats for HEV. RNA from internal organs was examined for RT-PCR and positive samples were sequenced. Positive tissue samples were incubated with A549 cell line to isolate HEV. Anti-HEV antibodies were detected by ELISA.ResultsSixteen rats were seropositive, and the HEV RNA was detected in 10 of the 56 rats. Sequencing of the partial ORF1 gene from 7 samples resulted in partially sequenced HEV, belonging to genotype 3, which was genetically identical to the HEV prevalent in the swine from the source farm. The infectious HEVs were isolated from the Norway rats by using the human A549 cell line.ConclusionsThere was a relatively high prevalence (17.9%) of the HEV genome in wild Norway rats. The virus was mainly detected in the liver and spleen. The results indicate that these animals might be possible carrier of swine HEV in endemic regions. The HEV contamination risk due to rats needs to be examined in human habitats. More... »

PAGES

4

References to SciGraph publications

  • 2009-06-13. Experimental infection of Balb/c nude mice with Hepatitis E virus in BMC INFECTIOUS DISEASES
  • 1993. Molecular organization and replication of hepatitis E virus (HEV) in UNCONVENTIONAL AGENTS AND UNCLASSIFIED VIRUSES
  • 1993. Molecular characterization of hepatitis C and E viruses in UNCONVENTIONAL AGENTS AND UNCLASSIFIED VIRUSES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1756-0500-5-4

    DOI

    http://dx.doi.org/10.1186/1756-0500-5-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052185009

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22217009


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