Ontology type: schema:ScholarlyArticle Open Access: True
2011-12
AUTHORSJong Sun Park, Jae-Joon Yim, Won Jun Kang, June-Key Chung, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Young-Soo Shim, Sang-Min Lee
ABSTRACTBACKGROUND: Carcinoma of unknown primary tumors (CUP) is present in 0.5%-9% of all patients with malignant neoplasms; only 20%-27% of primary sites are identified before the patients die. Currently, 18F-fluorodeoxy-glucose positron-emission tomography (18F-FDG PET) or PET combined with computed tomography (PET/CT) is widely used for the diagnosis of CUP. However, the diagnostic yield of the primary site varies. The aim of this study was to determine whether PET or PET/CT has additional advantages over the conventional diagnostic workup in detecting the primary origin of CUP. FINDINGS: Twenty patients with unknown primary tumors that underwent PET or PET/CT were included in this study. For all patients, the conventional diagnostic workup was unsuccessful in detecting the primary sites. Among 20 patients, 11 had PET scans. The remaining nine patients had PET/CT. In all 20 patients, neither the PET nor PET/CT identified the primary site of the tumor, including six cases with cervical lymph node metastases. The PET and PET/CT revealed sites of FDG uptake other than those associated with known metastases in seven patients, but these findings did not influence patient management or therapy. Two patients had unnecessary invasive diagnostic procedures due to false positive results on the PET or PET/CT. CONCLUSIONS: Although it is inconclusive because of small sample size of the study, the additional value of PET or PET/CT for the detection of primary sites in patients with CUP might be less than expected; especially in patients that have already had extensive conventional diagnostic workups. Further study is needed to confirm this finding. More... »
PAGES56
http://scigraph.springernature.com/pub.10.1186/1756-0500-4-56
DOIhttp://dx.doi.org/10.1186/1756-0500-4-56
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1041518447
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/21385465
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"name": [
"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Korea"
],
"type": "Organization"
},
"familyName": "Park",
"givenName": "Jong Sun",
"id": "sg:person.0726712374.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726712374.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Yim",
"givenName": "Jae-Joon",
"id": "sg:person.01162551442.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162551442.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Kang",
"givenName": "Won Jun",
"id": "sg:person.01077644577.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077644577.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Chung",
"givenName": "June-Key",
"id": "sg:person.0751347234.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751347234.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Yoo",
"givenName": "Chul-Gyu",
"id": "sg:person.01355161055.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355161055.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Young Whan",
"id": "sg:person.01210676453.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210676453.82"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Han",
"givenName": "Sung Koo",
"id": "sg:person.01237102766.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237102766.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Shim",
"givenName": "Young-Soo",
"id": "sg:person.0623605475.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623605475.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University",
"id": "https://www.grid.ac/institutes/grid.31501.36",
"name": [
"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Sang-Min",
"id": "sg:person.01315300754.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315300754.59"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s00330-008-1194-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000522982",
"https://doi.org/10.1007/s00330-008-1194-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00330-008-1194-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000522982",
"https://doi.org/10.1007/s00330-008-1194-4"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1368-8375(98)00129-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001460745"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archinte.1988.00380090101024",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004490715"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00259-009-1295-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013991088",
"https://doi.org/10.1007/s00259-009-1295-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00259-009-1295-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013991088",
"https://doi.org/10.1007/s00259-009-1295-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00259-009-1295-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013991088",
"https://doi.org/10.1007/s00259-009-1295-6"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1148/radiology.210.1.r99ja48177",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017042432"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0306-9877(02)00221-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021599352"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(99)00077-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023000432"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00259-002-0819-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030924555",
"https://doi.org/10.1007/s00259-002-0819-0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.20687",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031685270"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.22410",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031973513"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3348/kjr.2006.7.1.57",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033019274"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3348/kjr.2006.7.1.57",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033019274"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s004050100408",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039124167",
"https://doi.org/10.1007/s004050100408"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1148/radiol.2341031554",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040334036"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00006231-200310000-00008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041335821"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00006231-200310000-00008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041335821"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00259-004-1734-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045689393",
"https://doi.org/10.1007/s00259-004-1734-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00259-004-1734-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045689393",
"https://doi.org/10.1007/s00259-004-1734-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmra050276",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050685987"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archinte.148.9.2035",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1054112195"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074639415",
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00405-002-0470-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1075085711",
"https://doi.org/10.1007/s00405-002-0470-1"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077207593",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/oxfordjournals.annonc.a058007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077829892"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1995.13.8.2094",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082444258"
],
"type": "CreativeWork"
}
],
"datePublished": "2011-12",
"datePublishedReg": "2011-12-01",
"description": "BACKGROUND: Carcinoma of unknown primary tumors (CUP) is present in 0.5%-9% of all patients with malignant neoplasms; only 20%-27% of primary sites are identified before the patients die. Currently, 18F-fluorodeoxy-glucose positron-emission tomography (18F-FDG PET) or PET combined with computed tomography (PET/CT) is widely used for the diagnosis of CUP. However, the diagnostic yield of the primary site varies. The aim of this study was to determine whether PET or PET/CT has additional advantages over the conventional diagnostic workup in detecting the primary origin of CUP.\nFINDINGS: Twenty patients with unknown primary tumors that underwent PET or PET/CT were included in this study. For all patients, the conventional diagnostic workup was unsuccessful in detecting the primary sites. Among 20 patients, 11 had PET scans. The remaining nine patients had PET/CT. In all 20 patients, neither the PET nor PET/CT identified the primary site of the tumor, including six cases with cervical lymph node metastases. The PET and PET/CT revealed sites of FDG uptake other than those associated with known metastases in seven patients, but these findings did not influence patient management or therapy. Two patients had unnecessary invasive diagnostic procedures due to false positive results on the PET or PET/CT.\nCONCLUSIONS: Although it is inconclusive because of small sample size of the study, the additional value of PET or PET/CT for the detection of primary sites in patients with CUP might be less than expected; especially in patients that have already had extensive conventional diagnostic workups. Further study is needed to confirm this finding.",
"genre": "research_article",
"id": "sg:pub.10.1186/1756-0500-4-56",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1039457",
"issn": [
"1756-0500"
],
"name": "BMC Research Notes",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "4"
}
],
"name": "Detection of primary sites in unknown primary tumors using FDG-PET or FDG-PET/CT",
"pagination": "56",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"c5c7fb3161e2ce1ceb9da4db91c7e5d336cf7c96f7dca86cb1dd15a61b42ae9c"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"21385465"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101462768"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/1756-0500-4-56"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1041518447"
]
}
],
"sameAs": [
"https://doi.org/10.1186/1756-0500-4-56",
"https://app.dimensions.ai/details/publication/pub.1041518447"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T15:52",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000515.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1186%2F1756-0500-4-56"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1756-0500-4-56'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1756-0500-4-56'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1756-0500-4-56'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1756-0500-4-56'
This table displays all metadata directly associated to this object as RDF triples.
197 TRIPLES
21 PREDICATES
51 URIs
21 LITERALS
9 BLANK NODES