Gene expression profiling of oxidative stress response of C. elegans aging defective AMPK mutants using massively parallel transcriptome sequencing View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Heesun Shin, Hyojin Lee, Anthony P Fejes, David L Baillie, Hyeon-Sook Koo, Steven JM Jones

ABSTRACT

BACKGROUND: A strong association between stress resistance and longevity in multicellular organisms has been established as many mutations that extend lifespan also show increased resistance to stress. AAK-2, the C. elegans homolog of an alpha subunit of AMP-activated protein kinase (AMPK) is an intracellular fuel sensor that regulates cellular energy homeostasis and functions in stress resistance and lifespan extension. FINDINGS: Here, we investigated global transcriptional responses of aak-2 mutants to oxidative stress and in turn identified potential downstream targets of AAK-2 involved in stress resistance in C. elegans. We employed massively parallel Illumina sequencing technology and performed comprehensive comparative transcriptome analysis. Specifically, we compared the transcriptomes of aak-2 and wild type animals under normal conditions and conditions of induced oxidative stress. This research has presented a snapshot of genome-wide transcriptional activities that take place in C. elegans in response to oxidative stress both in the presence and absence of AAK-2. CONCLUSIONS: The analysis presented in this study has enabled us to identify potential genes involved in stress resistance that may be either directly or indirectly under the control of AAK-2. Furthermore, we have extended our current knowledge of general defense responses of C. elegans against oxidative stress supporting the function for AAK-2 in inhibition of biosynthetic processes, especially lipid synthesis, under oxidative stress and transcriptional regulation of genes involved in reproductive processes. More... »

PAGES

34

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1756-0500-4-34

DOI

http://dx.doi.org/10.1186/1756-0500-4-34

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021823502

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21303547


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Genome Sciences Centre, BC Cancer Agency, Suite 100 570 West 7th Avenue, V5Z 4S6, Vancouver, British Columbia, Canada", 
            "Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada, V5A 1S6"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shin", 
        "givenName": "Heesun", 
        "id": "sg:person.01034505366.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034505366.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, 120-749, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hyojin", 
        "id": "sg:person.01335600553.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335600553.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Genome Sciences Centre, BC Cancer Agency, Suite 100 570 West 7th Avenue, V5Z 4S6, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fejes", 
        "givenName": "Anthony P", 
        "id": "sg:person.0672053321.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672053321.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada, V5A 1S6"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baillie", 
        "givenName": "David L", 
        "id": "sg:person.01315322630.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315322630.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, 120-749, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koo", 
        "givenName": "Hyeon-Sook", 
        "id": "sg:person.01323526507.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323526507.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Genome Sciences Centre, BC Cancer Agency, Suite 100 570 West 7th Avenue, V5Z 4S6, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Steven JM", 
        "id": "sg:person.011076371162.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011076371162.80"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1101/gad.1061103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000773339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2007.08.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000866349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.5.2.363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001099969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0609590104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002174097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05828", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003303566", 
          "https://doi.org/10.1038/nature05828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tem.2008.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004103841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(88)90214-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004394740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(01)00453-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006833987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0891-5849(99)00242-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009022035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/366461a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011026745", 
          "https://doi.org/10.1038/366461a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1474-9726.2007.00302.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014146964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506234102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019199853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506234102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019199853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0531-5565(01)00144-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019442581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1087782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019529411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1474-9728.2003.00043.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019691092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020263570", 
          "https://doi.org/10.1038/nature07536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/260523a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020973869", 
          "https://doi.org/10.1038/260523a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021086830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bth088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022171874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1028303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022651934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2006.01.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023296032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-483x(01)00531-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023856010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.3935405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024679422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.134.3.699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024679517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exger.2006.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026313848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.05.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027622072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2001.5627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029218867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.12.6.1725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030898238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(03)00560-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031618751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.02232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032320999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbalip.2008.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033209945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2004.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033736922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(88)90215-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034850071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.088112.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036573222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038335617", 
          "https://doi.org/10.1038/nbt848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038335617", 
          "https://doi.org/10.1038/nbt848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.3274805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038477351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m709115200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039013664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1998.9109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039428286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.2000.5210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041680159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.079558.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045837493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1255404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046190922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1474-9726.2006.00205.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046868783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1474-9726.2006.00205.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046868783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.02070-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048686824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049923916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050814907", 
          "https://doi.org/10.1038/nature01789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050814907", 
          "https://doi.org/10.1038/nature01789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2007-8-9-r194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051368798", 
          "https://doi.org/10.1186/gb-2007-8-9-r194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00393a034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055173607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1057586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062444351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1120781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062453240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1162011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062458525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2007-0877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14622416.5.4.433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067587781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1895/wormbook.1.76.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068724240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074678191", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075238006", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1992.tb05478.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076153959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.7.10.986", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083159139"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-12", 
    "datePublishedReg": "2011-12-01", 
    "description": "BACKGROUND: A strong association between stress resistance and longevity in multicellular organisms has been established as many mutations that extend lifespan also show increased resistance to stress. AAK-2, the C. elegans homolog of an alpha subunit of AMP-activated protein kinase (AMPK) is an intracellular fuel sensor that regulates cellular energy homeostasis and functions in stress resistance and lifespan extension.\nFINDINGS: Here, we investigated global transcriptional responses of aak-2 mutants to oxidative stress and in turn identified potential downstream targets of AAK-2 involved in stress resistance in C. elegans. We employed massively parallel Illumina sequencing technology and performed comprehensive comparative transcriptome analysis. Specifically, we compared the transcriptomes of aak-2 and wild type animals under normal conditions and conditions of induced oxidative stress. This research has presented a snapshot of genome-wide transcriptional activities that take place in C. elegans in response to oxidative stress both in the presence and absence of AAK-2.\nCONCLUSIONS: The analysis presented in this study has enabled us to identify potential genes involved in stress resistance that may be either directly or indirectly under the control of AAK-2. Furthermore, we have extended our current knowledge of general defense responses of C. elegans against oxidative stress supporting the function for AAK-2 in inhibition of biosynthetic processes, especially lipid synthesis, under oxidative stress and transcriptional regulation of genes involved in reproductive processes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1756-0500-4-34", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1039457", 
        "issn": [
          "1756-0500"
        ], 
        "name": "BMC Research Notes", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Gene expression profiling of oxidative stress response of C. elegans aging defective AMPK mutants using massively parallel transcriptome sequencing", 
    "pagination": "34", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "67f992c8e93e3754a1e4bfe0d4fb2d8ccda1baa8a39fb86593cc19175f3a6520"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21303547"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101462768"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1756-0500-4-34"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021823502"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1756-0500-4-34", 
      "https://app.dimensions.ai/details/publication/pub.1021823502"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1756-0500-4-34"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1756-0500-4-34'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1756-0500-4-34'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1756-0500-4-34'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1756-0500-4-34'


 

This table displays all metadata directly associated to this object as RDF triples.

286 TRIPLES      21 PREDICATES      86 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1756-0500-4-34 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author Ne6edfc9a9ffc44a6a10db88f5e614295
4 schema:citation sg:pub.10.1038/260523a0
5 sg:pub.10.1038/366461a0
6 sg:pub.10.1038/nature01789
7 sg:pub.10.1038/nature05828
8 sg:pub.10.1038/nature07536
9 sg:pub.10.1038/nbt848
10 sg:pub.10.1186/gb-2007-8-9-r194
11 https://app.dimensions.ai/details/publication/pub.1074678191
12 https://app.dimensions.ai/details/publication/pub.1075238006
13 https://doi.org/10.1002/j.1460-2075.1992.tb05478.x
14 https://doi.org/10.1006/bbrc.2001.5627
15 https://doi.org/10.1006/dbio.1998.9109
16 https://doi.org/10.1006/jmbi.2000.5210
17 https://doi.org/10.1016/0092-8674(88)90214-0
18 https://doi.org/10.1016/0092-8674(88)90215-2
19 https://doi.org/10.1016/j.bbalip.2008.12.013
20 https://doi.org/10.1016/j.cell.2008.05.044
21 https://doi.org/10.1016/j.cellsig.2006.01.021
22 https://doi.org/10.1016/j.cmet.2004.12.003
23 https://doi.org/10.1016/j.cub.2007.08.047
24 https://doi.org/10.1016/j.exger.2006.02.008
25 https://doi.org/10.1016/j.tem.2008.11.002
26 https://doi.org/10.1016/s0014-5793(03)00560-x
27 https://doi.org/10.1016/s0300-483x(01)00531-5
28 https://doi.org/10.1016/s0531-5565(01)00144-9
29 https://doi.org/10.1016/s0891-5849(99)00242-7
30 https://doi.org/10.1016/s0960-9822(01)00453-5
31 https://doi.org/10.1021/bi00393a034
32 https://doi.org/10.1046/j.1474-9728.2003.00043.x
33 https://doi.org/10.1073/pnas.0506234102
34 https://doi.org/10.1073/pnas.0609590104
35 https://doi.org/10.1074/jbc.m709115200
36 https://doi.org/10.1083/jcb.134.3.699
37 https://doi.org/10.1091/mbc.12.6.1725
38 https://doi.org/10.1093/bioinformatics/bth088
39 https://doi.org/10.1101/gad.1028303
40 https://doi.org/10.1101/gad.1061103
41 https://doi.org/10.1101/gad.1255404
42 https://doi.org/10.1101/gr.079558.108
43 https://doi.org/10.1101/gr.088112.108
44 https://doi.org/10.1101/gr.3274805
45 https://doi.org/10.1101/gr.3935405
46 https://doi.org/10.1101/gr.7.10.986
47 https://doi.org/10.1111/j.1474-9726.2006.00205.x
48 https://doi.org/10.1111/j.1474-9726.2007.00302.x
49 https://doi.org/10.1126/science.1057586
50 https://doi.org/10.1126/science.1087782
51 https://doi.org/10.1126/science.1120781
52 https://doi.org/10.1126/science.1162011
53 https://doi.org/10.1128/mcb.02070-06
54 https://doi.org/10.1128/mcb.5.2.363
55 https://doi.org/10.1210/en.2007-0877
56 https://doi.org/10.1242/dev.02232
57 https://doi.org/10.1242/jcs.01540
58 https://doi.org/10.1371/journal.pgen.1000503
59 https://doi.org/10.1517/14622416.5.4.433
60 https://doi.org/10.1895/wormbook.1.76.1
61 schema:datePublished 2011-12
62 schema:datePublishedReg 2011-12-01
63 schema:description BACKGROUND: A strong association between stress resistance and longevity in multicellular organisms has been established as many mutations that extend lifespan also show increased resistance to stress. AAK-2, the C. elegans homolog of an alpha subunit of AMP-activated protein kinase (AMPK) is an intracellular fuel sensor that regulates cellular energy homeostasis and functions in stress resistance and lifespan extension. FINDINGS: Here, we investigated global transcriptional responses of aak-2 mutants to oxidative stress and in turn identified potential downstream targets of AAK-2 involved in stress resistance in C. elegans. We employed massively parallel Illumina sequencing technology and performed comprehensive comparative transcriptome analysis. Specifically, we compared the transcriptomes of aak-2 and wild type animals under normal conditions and conditions of induced oxidative stress. This research has presented a snapshot of genome-wide transcriptional activities that take place in C. elegans in response to oxidative stress both in the presence and absence of AAK-2. CONCLUSIONS: The analysis presented in this study has enabled us to identify potential genes involved in stress resistance that may be either directly or indirectly under the control of AAK-2. Furthermore, we have extended our current knowledge of general defense responses of C. elegans against oxidative stress supporting the function for AAK-2 in inhibition of biosynthetic processes, especially lipid synthesis, under oxidative stress and transcriptional regulation of genes involved in reproductive processes.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf Nd34961fd94294a07a33c19f7fd56da2c
68 Nf4fb1a6a62bc46b89b233f6855009712
69 sg:journal.1039457
70 schema:name Gene expression profiling of oxidative stress response of C. elegans aging defective AMPK mutants using massively parallel transcriptome sequencing
71 schema:pagination 34
72 schema:productId N823e73b22c1e41869ee9207d1ef08ab7
73 N88c06cde71d6411fa6bc7fdcf6187269
74 Nab2c2fa995ae4cbdbc6cfa36e3130259
75 Nb3dffced1f1d454b92b70ea30a1cfe62
76 Nd9166d54cff5416b8d067398035b7a60
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021823502
78 https://doi.org/10.1186/1756-0500-4-34
79 schema:sdDatePublished 2019-04-10T20:47
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N97cd52c4d01a4243824d3933574ded37
82 schema:url http://link.springer.com/10.1186%2F1756-0500-4-34
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N1ac169eed5cb423d8eddc2afbff91f2c rdf:first sg:person.01315322630.05
87 rdf:rest N977d8cde7f634900a1d53af1549aa46c
88 N823e73b22c1e41869ee9207d1ef08ab7 schema:name dimensions_id
89 schema:value pub.1021823502
90 rdf:type schema:PropertyValue
91 N88c06cde71d6411fa6bc7fdcf6187269 schema:name readcube_id
92 schema:value 67f992c8e93e3754a1e4bfe0d4fb2d8ccda1baa8a39fb86593cc19175f3a6520
93 rdf:type schema:PropertyValue
94 N977d8cde7f634900a1d53af1549aa46c rdf:first sg:person.01323526507.04
95 rdf:rest Nf0675aae4e8f46dca816dfd01664d47b
96 N97cd52c4d01a4243824d3933574ded37 schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 Nab2c2fa995ae4cbdbc6cfa36e3130259 schema:name doi
99 schema:value 10.1186/1756-0500-4-34
100 rdf:type schema:PropertyValue
101 Nb3dffced1f1d454b92b70ea30a1cfe62 schema:name nlm_unique_id
102 schema:value 101462768
103 rdf:type schema:PropertyValue
104 Nbf1fe14bb4a94e3492eb64e6c920b662 rdf:first sg:person.0672053321.72
105 rdf:rest N1ac169eed5cb423d8eddc2afbff91f2c
106 Nd34961fd94294a07a33c19f7fd56da2c schema:volumeNumber 4
107 rdf:type schema:PublicationVolume
108 Nd9166d54cff5416b8d067398035b7a60 schema:name pubmed_id
109 schema:value 21303547
110 rdf:type schema:PropertyValue
111 Nd9c8149c26b040e499a1833b792f588c rdf:first sg:person.01335600553.29
112 rdf:rest Nbf1fe14bb4a94e3492eb64e6c920b662
113 Ne6edfc9a9ffc44a6a10db88f5e614295 rdf:first sg:person.01034505366.45
114 rdf:rest Nd9c8149c26b040e499a1833b792f588c
115 Nf0675aae4e8f46dca816dfd01664d47b rdf:first sg:person.011076371162.80
116 rdf:rest rdf:nil
117 Nf4fb1a6a62bc46b89b233f6855009712 schema:issueNumber 1
118 rdf:type schema:PublicationIssue
119 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
120 schema:name Biological Sciences
121 rdf:type schema:DefinedTerm
122 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
123 schema:name Genetics
124 rdf:type schema:DefinedTerm
125 sg:journal.1039457 schema:issn 1756-0500
126 schema:name BMC Research Notes
127 rdf:type schema:Periodical
128 sg:person.01034505366.45 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
129 schema:familyName Shin
130 schema:givenName Heesun
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034505366.45
132 rdf:type schema:Person
133 sg:person.011076371162.80 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
134 schema:familyName Jones
135 schema:givenName Steven JM
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011076371162.80
137 rdf:type schema:Person
138 sg:person.01315322630.05 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
139 schema:familyName Baillie
140 schema:givenName David L
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315322630.05
142 rdf:type schema:Person
143 sg:person.01323526507.04 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
144 schema:familyName Koo
145 schema:givenName Hyeon-Sook
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323526507.04
147 rdf:type schema:Person
148 sg:person.01335600553.29 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
149 schema:familyName Lee
150 schema:givenName Hyojin
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335600553.29
152 rdf:type schema:Person
153 sg:person.0672053321.72 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
154 schema:familyName Fejes
155 schema:givenName Anthony P
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672053321.72
157 rdf:type schema:Person
158 sg:pub.10.1038/260523a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020973869
159 https://doi.org/10.1038/260523a0
160 rdf:type schema:CreativeWork
161 sg:pub.10.1038/366461a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011026745
162 https://doi.org/10.1038/366461a0
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/nature01789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050814907
165 https://doi.org/10.1038/nature01789
166 rdf:type schema:CreativeWork
167 sg:pub.10.1038/nature05828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003303566
168 https://doi.org/10.1038/nature05828
169 rdf:type schema:CreativeWork
170 sg:pub.10.1038/nature07536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020263570
171 https://doi.org/10.1038/nature07536
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/nbt848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038335617
174 https://doi.org/10.1038/nbt848
175 rdf:type schema:CreativeWork
176 sg:pub.10.1186/gb-2007-8-9-r194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051368798
177 https://doi.org/10.1186/gb-2007-8-9-r194
178 rdf:type schema:CreativeWork
179 https://app.dimensions.ai/details/publication/pub.1074678191 schema:CreativeWork
180 https://app.dimensions.ai/details/publication/pub.1075238006 schema:CreativeWork
181 https://doi.org/10.1002/j.1460-2075.1992.tb05478.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1076153959
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1006/bbrc.2001.5627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029218867
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1006/dbio.1998.9109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039428286
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1006/jmbi.2000.5210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041680159
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/0092-8674(88)90214-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004394740
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/0092-8674(88)90215-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034850071
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.bbalip.2008.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033209945
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.cell.2008.05.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027622072
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.cellsig.2006.01.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023296032
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.cmet.2004.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033736922
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.cub.2007.08.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000866349
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.exger.2006.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026313848
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.tem.2008.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004103841
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/s0014-5793(03)00560-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031618751
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/s0300-483x(01)00531-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023856010
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/s0531-5565(01)00144-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019442581
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/s0891-5849(99)00242-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009022035
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s0960-9822(01)00453-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006833987
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1021/bi00393a034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055173607
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1046/j.1474-9728.2003.00043.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019691092
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1073/pnas.0506234102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019199853
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1073/pnas.0609590104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002174097
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1074/jbc.m709115200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039013664
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1083/jcb.134.3.699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024679517
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1091/mbc.12.6.1725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030898238
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1093/bioinformatics/bth088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022171874
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1101/gad.1028303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022651934
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1101/gad.1061103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000773339
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1101/gad.1255404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046190922
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1101/gr.079558.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045837493
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1101/gr.088112.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036573222
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1101/gr.3274805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038477351
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1101/gr.3935405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024679422
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1101/gr.7.10.986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083159139
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1111/j.1474-9726.2006.00205.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046868783
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1111/j.1474-9726.2007.00302.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014146964
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1126/science.1057586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062444351
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1126/science.1087782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019529411
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1126/science.1120781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062453240
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1126/science.1162011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062458525
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1128/mcb.02070-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048686824
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1128/mcb.5.2.363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001099969
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1210/en.2007-0877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248844
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1242/dev.02232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032320999
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1242/jcs.01540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049923916
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1371/journal.pgen.1000503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021086830
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1517/14622416.5.4.433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067587781
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1895/wormbook.1.76.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068724240
276 rdf:type schema:CreativeWork
277 https://www.grid.ac/institutes/grid.15444.30 schema:alternateName Yonsei University
278 schema:name Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, 120-749, Seoul, Republic of Korea
279 rdf:type schema:Organization
280 https://www.grid.ac/institutes/grid.248762.d schema:alternateName BC Cancer Agency
281 schema:name Genome Sciences Centre, BC Cancer Agency, Suite 100 570 West 7th Avenue, V5Z 4S6, Vancouver, British Columbia, Canada
282 rdf:type schema:Organization
283 https://www.grid.ac/institutes/grid.61971.38 schema:alternateName Simon Fraser University
284 schema:name Genome Sciences Centre, BC Cancer Agency, Suite 100 570 West 7th Avenue, V5Z 4S6, Vancouver, British Columbia, Canada
285 Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada, V5A 1S6
286 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...