Histopathological diagnosis of myocarditis in a dengue outbreak in Sri Lanka, 2009 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-07-29

AUTHORS

Kosala GAD Weerakoon, Senanayake AM Kularatne, Deepthika H Edussuriya, Sarachchandra KA Kodikara, Laxman PG Gunatilake, Vasanti G Pinto, Ashoka B Seneviratne, Sunethra Gunasena

ABSTRACT

BACKGROUND: In 2009, an outbreak of dengue caused high fatality in Sri Lanka. We conducted 5 autopsies of clinically suspected myocarditis cases at the General Hospital, Peradeniya to describe the histopathology of the heart and other organs. METHODS: The diagnosis of dengue was confirmed with specific IgM and IgG ELISA, HAI and RT-PCR techniques. The histology was done in tissue sections stained with hematoxylin and eosin. RESULTS: Of the 319 cases of dengue fever, 166(52%) had severe infection. Of them, 149 patients (90%) had secondary dengue infection and in 5 patients, DEN-1 was identified as the causative serotype. The clinical diagnosis of myocarditis was considered in 45(27%) patients. The autopsies were done in 5 patients who succumbed to shock (3 females and 2 males) aged 13- 31 years. All had pleural effusions, ascites, bleeding patches in tissue planes and histological evidence of myocarditis. The main histological findings of the heart were interstitial oedema with inflammatory cell infiltration and necrosis of myocardial fibers. One patient had pericarditis. The concurrent pulmonary abnormalities were septal congestion, pulmonary haemorrhage and diffuse alveolar damage; one case showed massive necrosis of liver. CONCLUSIONS: The histology supports occurrence of myocarditis in dengue infection. More... »

PAGES

268-268

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1756-0500-4-268

DOI

http://dx.doi.org/10.1186/1756-0500-4-268

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029336064

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21798066


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