Gene-environment interactions and obesity: recent developments and future directions View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Tao Huang, Frank B Hu

ABSTRACT

Obesity, a major public health concern, is a multifactorial disease caused by both environmental and genetic factors. Although recent genome-wide association studies have identified many loci related to obesity or body mass index, the identified variants explain only a small proportion of the heritability of obesity. Better understanding of the interplay between genetic and environmental factors is the basis for developing effective personalized obesity prevention and management strategies. This article reviews recent advances in identifying gene-environment interactions related to obesity and describes epidemiological designs and newly developed statistical approaches to characterizing and discovering gene-environment interactions on obesity risk. More... »

PAGES

s2

References to SciGraph publications

  • 2010-01. Gene and pathway-based second-wave analysis of genome-wide association studies in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2010-04. Gene–environment-wide association studies: emerging approaches in NATURE REVIEWS GENETICS
  • 2006-10. Genes, environment and the value of prospective cohort studies in NATURE REVIEWS GENETICS
  • 2010-09. Genome-wide gene and pathway analysis in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2006-12. Genotype-by-nutrient interactions assessed in European obese women in EUROPEAN JOURNAL OF NUTRITION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1755-8794-8-s1-s2

    DOI

    http://dx.doi.org/10.1186/1755-8794-8-s1-s2

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25951849


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