High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-12

AUTHORS

Yuker Wang, Victoria EH Carlton, George Karlin-Neumann, Ronald Sapolsky, Li Zhang, Martin Moorhead, Zhigang C Wang, Andrea L Richardson, Robert Warren, Axel Walther, Melissa Bondy, Aysegul Sahin, Ralf Krahe, Musaffe Tuna, Patricia A Thompson, Paul T Spellman, Joe W Gray, Gordon B Mills, Malek Faham

ABSTRACT

BACKGROUND: A major challenge facing DNA copy number (CN) studies of tumors is that most banked samples with extensive clinical follow-up information are Formalin-Fixed Paraffin Embedded (FFPE). DNA from FFPE samples generally underperforms or suffers high failure rates compared to fresh frozen samples because of DNA degradation and cross-linking during FFPE fixation and processing. As FFPE protocols may vary widely between labs and samples may be stored for decades at room temperature, an ideal FFPE CN technology should work on diverse sample sets. Molecular Inversion Probe (MIP) technology has been applied successfully to obtain high quality CN and genotype data from cell line and frozen tumor DNA. Since the MIP probes require only a small (approximately 40 bp) target binding site, we reasoned they may be well suited to assess degraded FFPE DNA. We assessed CN with a MIP panel of 50,000 markers in 93 FFPE tumor samples from 7 diverse collections. For 38 FFPE samples from three collections we were also able to asses CN in matched fresh frozen tumor tissue. RESULTS: Using an input of 37 ng genomic DNA, we generated high quality CN data with MIP technology in 88% of FFPE samples from seven diverse collections. When matched fresh frozen tissue was available, the performance of FFPE DNA was comparable to that of DNA obtained from matched frozen tumor (genotype concordance averaged 99.9%), with only a modest loss in performance in FFPE. CONCLUSION: MIP technology can be used to generate high quality CN and genotype data in FFPE as well as fresh frozen samples. More... »

PAGES

8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1755-8794-2-8

DOI

http://dx.doi.org/10.1186/1755-8794-2-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046400945

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19228381


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Affymetrix (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417703.6", 
          "name": [
            "Affymetrix Inc., Santa Clara, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yuker", 
        "id": "sg:person.012263040417.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012263040417.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affymetrix (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417703.6", 
          "name": [
            "Affymetrix Inc., Santa Clara, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carlton", 
        "givenName": "Victoria EH", 
        "id": "sg:person.013606272467.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013606272467.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affymetrix (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417703.6", 
          "name": [
            "Affymetrix Inc., Santa Clara, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karlin-Neumann", 
        "givenName": "George", 
        "id": "sg:person.0600176140.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600176140.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affymetrix (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417703.6", 
          "name": [
            "Affymetrix Inc., Santa Clara, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sapolsky", 
        "givenName": "Ronald", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Li", 
        "id": "sg:person.014341675760.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014341675760.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affymetrix (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417703.6", 
          "name": [
            "Affymetrix Inc., Santa Clara, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moorhead", 
        "givenName": "Martin", 
        "id": "sg:person.01023105217.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023105217.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "DF, BWH Cancer Center, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Zhigang C", 
        "id": "sg:person.01136755451.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136755451.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "DF, BWH Cancer Center, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Richardson", 
        "givenName": "Andrea L", 
        "id": "sg:person.01325463611.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325463611.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California San Francisco, San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Warren", 
        "givenName": "Robert", 
        "id": "sg:person.01146353045.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146353045.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Cancer Research UK, London Research Institute, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walther", 
        "givenName": "Axel", 
        "id": "sg:person.01164134332.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164134332.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bondy", 
        "givenName": "Melissa", 
        "id": "sg:person.01003156731.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003156731.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sahin", 
        "givenName": "Aysegul", 
        "id": "sg:person.015041554177.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015041554177.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krahe", 
        "givenName": "Ralf", 
        "id": "sg:person.01175176567.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175176567.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tuna", 
        "givenName": "Musaffe", 
        "id": "sg:person.01257173775.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257173775.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Arizona Cancer Center, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "Patricia A", 
        "id": "sg:person.013276037727.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013276037727.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lawrence Berkeley National Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.184769.5", 
          "name": [
            "Lawrence Berkeley National Laboratory, Berkeley, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spellman", 
        "givenName": "Paul T", 
        "id": "sg:person.01064253031.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064253031.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lawrence Berkeley National Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.184769.5", 
          "name": [
            "Lawrence Berkeley National Laboratory, Berkeley, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gray", 
        "givenName": "Joe W", 
        "id": "sg:person.014525340267.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014525340267.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mills", 
        "givenName": "Gordon B", 
        "id": "sg:person.012742742357.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012742742357.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affymetrix (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417703.6", 
          "name": [
            "Affymetrix Inc., Santa Clara, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Faham", 
        "givenName": "Malek", 
        "id": "sg:person.01230770417.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230770417.44"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-1418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000890486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-3-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003588930", 
          "https://doi.org/10.1186/1476-4598-3-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djm252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003595118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pdm.0b013e31815aca30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003937996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pdm.0b013e31815aca30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003937996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pdm.0b013e31815aca30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003937996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cancergencyto.2007.06.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008562219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008728252", 
          "https://doi.org/10.1038/nbt821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008728252", 
          "https://doi.org/10.1038/nbt821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-3597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009297447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-0595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012195931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2006.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014507074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0000537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014829007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-2486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017385868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/448959a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023941035", 
          "https://doi.org/10.1038/448959a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64472-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024741346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0804385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025462530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.20599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027832755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/humu.20220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029650988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/humu.20220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029650988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.3185605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029969824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2007-8-11-r246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032008562", 
          "https://doi.org/10.1186/gb-2007-8-11-r246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.5686107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032239741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032791095", 
          "https://doi.org/10.1038/ng1220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032791095", 
          "https://doi.org/10.1038/ng1220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000104453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033107342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0001093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033426824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cll.2004.05.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034207410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0004.2007.00882.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039812544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2008-9-5-r86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044050585", 
          "https://doi.org/10.1186/gb-2008-9-5-r86"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gni177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044827446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-0812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048650781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/mp.56.3.184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062819779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/mp.56.3.184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062819779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076997945", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-12", 
    "datePublishedReg": "2009-12-01", 
    "description": "BACKGROUND: A major challenge facing DNA copy number (CN) studies of tumors is that most banked samples with extensive clinical follow-up information are Formalin-Fixed Paraffin Embedded (FFPE). DNA from FFPE samples generally underperforms or suffers high failure rates compared to fresh frozen samples because of DNA degradation and cross-linking during FFPE fixation and processing. As FFPE protocols may vary widely between labs and samples may be stored for decades at room temperature, an ideal FFPE CN technology should work on diverse sample sets. Molecular Inversion Probe (MIP) technology has been applied successfully to obtain high quality CN and genotype data from cell line and frozen tumor DNA. Since the MIP probes require only a small (approximately 40 bp) target binding site, we reasoned they may be well suited to assess degraded FFPE DNA. We assessed CN with a MIP panel of 50,000 markers in 93 FFPE tumor samples from 7 diverse collections. For 38 FFPE samples from three collections we were also able to asses CN in matched fresh frozen tumor tissue.\nRESULTS: Using an input of 37 ng genomic DNA, we generated high quality CN data with MIP technology in 88% of FFPE samples from seven diverse collections. When matched fresh frozen tissue was available, the performance of FFPE DNA was comparable to that of DNA obtained from matched frozen tumor (genotype concordance averaged 99.9%), with only a modest loss in performance in FFPE.\nCONCLUSION: MIP technology can be used to generate high quality CN and genotype data in FFPE as well as fresh frozen samples.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1755-8794-2-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438870", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440196", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2696316", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2696323", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2699025", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440150", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435487", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440138", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438826", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2475326", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435643", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440216", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1039191", 
        "issn": [
          "1755-8794"
        ], 
        "name": "BMC Medical Genomics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "name": "High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays", 
    "pagination": "8", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "dd088b778041f1d3cad100bc69f38109ef507e8bc0f5fdc969cada0306eac222"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19228381"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101319628"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1755-8794-2-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046400945"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1755-8794-2-8", 
      "https://app.dimensions.ai/details/publication/pub.1046400945"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000515.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1755-8794-2-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1755-8794-2-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1755-8794-2-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1755-8794-2-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1755-8794-2-8'


 

This table displays all metadata directly associated to this object as RDF triples.

328 TRIPLES      21 PREDICATES      58 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1755-8794-2-8 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N6f600905388148ffa34d151c0375e63c
4 schema:citation sg:pub.10.1038/448959a
5 sg:pub.10.1038/nbt821
6 sg:pub.10.1038/ng1220
7 sg:pub.10.1186/1476-4598-3-6
8 sg:pub.10.1186/gb-2007-8-11-r246
9 sg:pub.10.1186/gb-2008-9-5-r86
10 https://app.dimensions.ai/details/publication/pub.1076997945
11 https://doi.org/10.1002/gcc.20599
12 https://doi.org/10.1002/humu.20220
13 https://doi.org/10.1016/j.cancergencyto.2007.06.017
14 https://doi.org/10.1016/j.cll.2004.05.013
15 https://doi.org/10.1016/j.surg.2006.08.018
16 https://doi.org/10.1016/s0002-9440(10)64472-0
17 https://doi.org/10.1056/nejmoa0804385
18 https://doi.org/10.1093/jnci/djm252
19 https://doi.org/10.1093/nar/gni177
20 https://doi.org/10.1097/pdm.0b013e31815aca30
21 https://doi.org/10.1101/gr.3185605
22 https://doi.org/10.1101/gr.5686107
23 https://doi.org/10.1111/j.1399-0004.2007.00882.x
24 https://doi.org/10.1136/mp.56.3.184
25 https://doi.org/10.1158/0008-5472.can-05-2486
26 https://doi.org/10.1158/0008-5472.can-06-0595
27 https://doi.org/10.1158/0008-5472.can-06-3597
28 https://doi.org/10.1158/0008-5472.can-08-0812
29 https://doi.org/10.1158/1078-0432.ccr-04-1418
30 https://doi.org/10.1159/000104453
31 https://doi.org/10.1371/journal.pone.0000537
32 https://doi.org/10.1371/journal.pone.0001093
33 schema:datePublished 2009-12
34 schema:datePublishedReg 2009-12-01
35 schema:description BACKGROUND: A major challenge facing DNA copy number (CN) studies of tumors is that most banked samples with extensive clinical follow-up information are Formalin-Fixed Paraffin Embedded (FFPE). DNA from FFPE samples generally underperforms or suffers high failure rates compared to fresh frozen samples because of DNA degradation and cross-linking during FFPE fixation and processing. As FFPE protocols may vary widely between labs and samples may be stored for decades at room temperature, an ideal FFPE CN technology should work on diverse sample sets. Molecular Inversion Probe (MIP) technology has been applied successfully to obtain high quality CN and genotype data from cell line and frozen tumor DNA. Since the MIP probes require only a small (approximately 40 bp) target binding site, we reasoned they may be well suited to assess degraded FFPE DNA. We assessed CN with a MIP panel of 50,000 markers in 93 FFPE tumor samples from 7 diverse collections. For 38 FFPE samples from three collections we were also able to asses CN in matched fresh frozen tumor tissue. RESULTS: Using an input of 37 ng genomic DNA, we generated high quality CN data with MIP technology in 88% of FFPE samples from seven diverse collections. When matched fresh frozen tissue was available, the performance of FFPE DNA was comparable to that of DNA obtained from matched frozen tumor (genotype concordance averaged 99.9%), with only a modest loss in performance in FFPE. CONCLUSION: MIP technology can be used to generate high quality CN and genotype data in FFPE as well as fresh frozen samples.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree true
39 schema:isPartOf N35895864d1ca46c790de1bdfd1dd66a3
40 Nd173c60046c34d6ea01e1cd0fbea7914
41 sg:journal.1039191
42 schema:name High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays
43 schema:pagination 8
44 schema:productId N2f4f64f8482c4b1b826465c5a608ef2e
45 N450be9547642434c8844232239bc0878
46 Nd145a2b0ef3148838661dc8c628a1dc7
47 Nefe49c6eeb2845f399736a9f52739250
48 Nfa22123515b14d55ab12a8c720d5938a
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046400945
50 https://doi.org/10.1186/1755-8794-2-8
51 schema:sdDatePublished 2019-04-10T21:38
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher N753d1c0fdc2240d28bbfd5f3294881dc
54 schema:url http://link.springer.com/10.1186%2F1755-8794-2-8
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N0286a0a27dd94fd597ee9e27a510fdc0 rdf:first sg:person.012742742357.13
59 rdf:rest N1e67075ca9d14c2a9e82dbdfa277f54a
60 N065e21d38fb24ca4baf5f301b7204a54 rdf:first sg:person.01164134332.79
61 rdf:rest N324728406dbf4ad695274432b03482c2
62 N0b79aad39333418fb179bf0b2ee49174 rdf:first sg:person.015041554177.45
63 rdf:rest Nb8b42cc9bcd749ee9450c18724e89d2b
64 N198cf4929b1a420494eab057eee176e0 rdf:first N9ed15abfb4a44d45ace22925547a5752
65 rdf:rest N8db8e3d374b14ad8aa8753a46a64a428
66 N1e67075ca9d14c2a9e82dbdfa277f54a rdf:first sg:person.01230770417.44
67 rdf:rest rdf:nil
68 N208f13ea2e664360b85e53d6adf86429 rdf:first sg:person.013276037727.20
69 rdf:rest N27133770eeef4619b93be02516501ffd
70 N2279ea624a034e98a9240ec28ff69af8 rdf:first sg:person.0600176140.86
71 rdf:rest N198cf4929b1a420494eab057eee176e0
72 N27133770eeef4619b93be02516501ffd rdf:first sg:person.01064253031.26
73 rdf:rest N6a80cdbd0e594606a1e688a24e073466
74 N2f4f64f8482c4b1b826465c5a608ef2e schema:name doi
75 schema:value 10.1186/1755-8794-2-8
76 rdf:type schema:PropertyValue
77 N324728406dbf4ad695274432b03482c2 rdf:first sg:person.01003156731.73
78 rdf:rest N0b79aad39333418fb179bf0b2ee49174
79 N35895864d1ca46c790de1bdfd1dd66a3 schema:volumeNumber 2
80 rdf:type schema:PublicationVolume
81 N450be9547642434c8844232239bc0878 schema:name dimensions_id
82 schema:value pub.1046400945
83 rdf:type schema:PropertyValue
84 N5a6404326f4646fc91fb79f484794750 rdf:first sg:person.01257173775.60
85 rdf:rest N208f13ea2e664360b85e53d6adf86429
86 N6a80cdbd0e594606a1e688a24e073466 rdf:first sg:person.014525340267.00
87 rdf:rest N0286a0a27dd94fd597ee9e27a510fdc0
88 N6f600905388148ffa34d151c0375e63c rdf:first sg:person.012263040417.40
89 rdf:rest Nc2bab086c96a4934b354e0b22ded8e2c
90 N753d1c0fdc2240d28bbfd5f3294881dc schema:name Springer Nature - SN SciGraph project
91 rdf:type schema:Organization
92 N8db8e3d374b14ad8aa8753a46a64a428 rdf:first sg:person.014341675760.67
93 rdf:rest Nb20ecbb1c3ca4e34941dce6f7a67759e
94 N9951f11a62834fd2afe652a57188a969 rdf:first sg:person.01136755451.95
95 rdf:rest Ncb5f2ae37db44995be7e2e4bb3fc12c9
96 N9ed15abfb4a44d45ace22925547a5752 schema:affiliation https://www.grid.ac/institutes/grid.417703.6
97 schema:familyName Sapolsky
98 schema:givenName Ronald
99 rdf:type schema:Person
100 Na93ed713a1824324bcdbd1824fd905c6 schema:name DF, BWH Cancer Center, Boston, MA, USA
101 rdf:type schema:Organization
102 Nb20ecbb1c3ca4e34941dce6f7a67759e rdf:first sg:person.01023105217.94
103 rdf:rest N9951f11a62834fd2afe652a57188a969
104 Nb8b42cc9bcd749ee9450c18724e89d2b rdf:first sg:person.01175176567.24
105 rdf:rest N5a6404326f4646fc91fb79f484794750
106 Nbe16fd596d614ad79790a358c68189ca rdf:first sg:person.01146353045.32
107 rdf:rest N065e21d38fb24ca4baf5f301b7204a54
108 Nc2bab086c96a4934b354e0b22ded8e2c rdf:first sg:person.013606272467.29
109 rdf:rest N2279ea624a034e98a9240ec28ff69af8
110 Ncb5f2ae37db44995be7e2e4bb3fc12c9 rdf:first sg:person.01325463611.20
111 rdf:rest Nbe16fd596d614ad79790a358c68189ca
112 Nd145a2b0ef3148838661dc8c628a1dc7 schema:name readcube_id
113 schema:value dd088b778041f1d3cad100bc69f38109ef507e8bc0f5fdc969cada0306eac222
114 rdf:type schema:PropertyValue
115 Nd173c60046c34d6ea01e1cd0fbea7914 schema:issueNumber 1
116 rdf:type schema:PublicationIssue
117 Neac779a4f0464852827673996f165aac schema:name DF, BWH Cancer Center, Boston, MA, USA
118 rdf:type schema:Organization
119 Nefe49c6eeb2845f399736a9f52739250 schema:name nlm_unique_id
120 schema:value 101319628
121 rdf:type schema:PropertyValue
122 Nfa22123515b14d55ab12a8c720d5938a schema:name pubmed_id
123 schema:value 19228381
124 rdf:type schema:PropertyValue
125 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
126 schema:name Biological Sciences
127 rdf:type schema:DefinedTerm
128 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
129 schema:name Biochemistry and Cell Biology
130 rdf:type schema:DefinedTerm
131 sg:grant.2435487 http://pending.schema.org/fundedItem sg:pub.10.1186/1755-8794-2-8
132 rdf:type schema:MonetaryGrant
133 sg:grant.2435643 http://pending.schema.org/fundedItem sg:pub.10.1186/1755-8794-2-8
134 rdf:type schema:MonetaryGrant
135 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1186/1755-8794-2-8
136 rdf:type schema:MonetaryGrant
137 sg:grant.2438870 http://pending.schema.org/fundedItem sg:pub.10.1186/1755-8794-2-8
138 rdf:type schema:MonetaryGrant
139 sg:grant.2440138 http://pending.schema.org/fundedItem sg:pub.10.1186/1755-8794-2-8
140 rdf:type schema:MonetaryGrant
141 sg:grant.2440150 http://pending.schema.org/fundedItem sg:pub.10.1186/1755-8794-2-8
142 rdf:type schema:MonetaryGrant
143 sg:grant.2440196 http://pending.schema.org/fundedItem sg:pub.10.1186/1755-8794-2-8
144 rdf:type schema:MonetaryGrant
145 sg:grant.2440216 http://pending.schema.org/fundedItem sg:pub.10.1186/1755-8794-2-8
146 rdf:type schema:MonetaryGrant
147 sg:grant.2475326 http://pending.schema.org/fundedItem sg:pub.10.1186/1755-8794-2-8
148 rdf:type schema:MonetaryGrant
149 sg:grant.2696316 http://pending.schema.org/fundedItem sg:pub.10.1186/1755-8794-2-8
150 rdf:type schema:MonetaryGrant
151 sg:grant.2696323 http://pending.schema.org/fundedItem sg:pub.10.1186/1755-8794-2-8
152 rdf:type schema:MonetaryGrant
153 sg:grant.2699025 http://pending.schema.org/fundedItem sg:pub.10.1186/1755-8794-2-8
154 rdf:type schema:MonetaryGrant
155 sg:journal.1039191 schema:issn 1755-8794
156 schema:name BMC Medical Genomics
157 rdf:type schema:Periodical
158 sg:person.01003156731.73 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
159 schema:familyName Bondy
160 schema:givenName Melissa
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003156731.73
162 rdf:type schema:Person
163 sg:person.01023105217.94 schema:affiliation https://www.grid.ac/institutes/grid.417703.6
164 schema:familyName Moorhead
165 schema:givenName Martin
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023105217.94
167 rdf:type schema:Person
168 sg:person.01064253031.26 schema:affiliation https://www.grid.ac/institutes/grid.184769.5
169 schema:familyName Spellman
170 schema:givenName Paul T
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064253031.26
172 rdf:type schema:Person
173 sg:person.01136755451.95 schema:affiliation Neac779a4f0464852827673996f165aac
174 schema:familyName Wang
175 schema:givenName Zhigang C
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136755451.95
177 rdf:type schema:Person
178 sg:person.01146353045.32 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
179 schema:familyName Warren
180 schema:givenName Robert
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146353045.32
182 rdf:type schema:Person
183 sg:person.01164134332.79 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
184 schema:familyName Walther
185 schema:givenName Axel
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164134332.79
187 rdf:type schema:Person
188 sg:person.01175176567.24 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
189 schema:familyName Krahe
190 schema:givenName Ralf
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175176567.24
192 rdf:type schema:Person
193 sg:person.012263040417.40 schema:affiliation https://www.grid.ac/institutes/grid.417703.6
194 schema:familyName Wang
195 schema:givenName Yuker
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012263040417.40
197 rdf:type schema:Person
198 sg:person.01230770417.44 schema:affiliation https://www.grid.ac/institutes/grid.417703.6
199 schema:familyName Faham
200 schema:givenName Malek
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230770417.44
202 rdf:type schema:Person
203 sg:person.01257173775.60 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
204 schema:familyName Tuna
205 schema:givenName Musaffe
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257173775.60
207 rdf:type schema:Person
208 sg:person.012742742357.13 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
209 schema:familyName Mills
210 schema:givenName Gordon B
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012742742357.13
212 rdf:type schema:Person
213 sg:person.01325463611.20 schema:affiliation Na93ed713a1824324bcdbd1824fd905c6
214 schema:familyName Richardson
215 schema:givenName Andrea L
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325463611.20
217 rdf:type schema:Person
218 sg:person.013276037727.20 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
219 schema:familyName Thompson
220 schema:givenName Patricia A
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013276037727.20
222 rdf:type schema:Person
223 sg:person.013606272467.29 schema:affiliation https://www.grid.ac/institutes/grid.417703.6
224 schema:familyName Carlton
225 schema:givenName Victoria EH
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013606272467.29
227 rdf:type schema:Person
228 sg:person.014341675760.67 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
229 schema:familyName Zhang
230 schema:givenName Li
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014341675760.67
232 rdf:type schema:Person
233 sg:person.014525340267.00 schema:affiliation https://www.grid.ac/institutes/grid.184769.5
234 schema:familyName Gray
235 schema:givenName Joe W
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014525340267.00
237 rdf:type schema:Person
238 sg:person.015041554177.45 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
239 schema:familyName Sahin
240 schema:givenName Aysegul
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015041554177.45
242 rdf:type schema:Person
243 sg:person.0600176140.86 schema:affiliation https://www.grid.ac/institutes/grid.417703.6
244 schema:familyName Karlin-Neumann
245 schema:givenName George
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600176140.86
247 rdf:type schema:Person
248 sg:pub.10.1038/448959a schema:sameAs https://app.dimensions.ai/details/publication/pub.1023941035
249 https://doi.org/10.1038/448959a
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nbt821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008728252
252 https://doi.org/10.1038/nbt821
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/ng1220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032791095
255 https://doi.org/10.1038/ng1220
256 rdf:type schema:CreativeWork
257 sg:pub.10.1186/1476-4598-3-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003588930
258 https://doi.org/10.1186/1476-4598-3-6
259 rdf:type schema:CreativeWork
260 sg:pub.10.1186/gb-2007-8-11-r246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032008562
261 https://doi.org/10.1186/gb-2007-8-11-r246
262 rdf:type schema:CreativeWork
263 sg:pub.10.1186/gb-2008-9-5-r86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044050585
264 https://doi.org/10.1186/gb-2008-9-5-r86
265 rdf:type schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1076997945 schema:CreativeWork
267 https://doi.org/10.1002/gcc.20599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027832755
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/humu.20220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029650988
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.cancergencyto.2007.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008562219
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.cll.2004.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034207410
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.surg.2006.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014507074
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0002-9440(10)64472-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024741346
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1056/nejmoa0804385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025462530
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1093/jnci/djm252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003595118
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1093/nar/gni177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044827446
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1097/pdm.0b013e31815aca30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003937996
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1101/gr.3185605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029969824
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1101/gr.5686107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032239741
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1111/j.1399-0004.2007.00882.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039812544
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1136/mp.56.3.184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062819779
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1158/0008-5472.can-05-2486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017385868
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1158/0008-5472.can-06-0595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012195931
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1158/0008-5472.can-06-3597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009297447
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1158/0008-5472.can-08-0812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048650781
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1158/1078-0432.ccr-04-1418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000890486
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1159/000104453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033107342
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1371/journal.pone.0000537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014829007
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1371/journal.pone.0001093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033426824
310 rdf:type schema:CreativeWork
311 https://www.grid.ac/institutes/grid.134563.6 schema:alternateName University of Arizona
312 schema:name Arizona Cancer Center, Tucson, AZ, USA
313 rdf:type schema:Organization
314 https://www.grid.ac/institutes/grid.184769.5 schema:alternateName Lawrence Berkeley National Laboratory
315 schema:name Lawrence Berkeley National Laboratory, Berkeley, CA, USA
316 rdf:type schema:Organization
317 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
318 schema:name MD Anderson Cancer Center, Houston, TX, USA
319 rdf:type schema:Organization
320 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
321 schema:name University of California San Francisco, San Francisco, CA, USA
322 rdf:type schema:Organization
323 https://www.grid.ac/institutes/grid.417703.6 schema:alternateName Affymetrix (United States)
324 schema:name Affymetrix Inc., Santa Clara, CA, USA
325 rdf:type schema:Organization
326 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
327 schema:name Cancer Research UK, London Research Institute, London, UK
328 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...