Feasibility of combination allogeneic stem cell therapy for spinal cord injury: a case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010

AUTHORS

Thomas E Ichim, Fabio Solano, Fabian Lara, Eugenia Paris, Federico Ugalde, Jorge Rodriguez, Boris Minev, Vladimir Bogin, Famela Ramos, Erik J Woods, Michael P Murphy, Amit N Patel, Robert J Harman, Neil H Riordan

ABSTRACT

Cellular therapy for spinal cord injury (SCI) is overviewed focusing on bone marrow mononuclear cells, olfactory ensheathing cells, and mesenchymal stem cells. A case is made for the possibility of combining cell types, as well as for allogeneic use. We report the case of 29 year old male who suffered a crush fracture of the L1 vertebral body, lacking lower sensorimotor function, being a score A on the ASIA scale. Stem cell therapy comprised of intrathecal administration of allogeneic umbilical cord blood ex-vivo expanded CD34 and umbilical cord matrix MSC was performed 5 months, 8 months, and 14 months after injury. Cell administration was well tolerated with no adverse effects observed. Neuropathic pain subsided from intermittent 10/10 to once a week 3/10 VAS. Recovery of muscle, bowel and sexual function was noted, along with a decrease in ASIA score to "D". This case supports further investigation into allogeneic-based stem cell therapies for SCI. More... »

PAGES

1-10

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1755-7682-3-30

    DOI

    http://dx.doi.org/10.1186/1755-7682-3-30

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028246650

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21070647


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