Brain function assessment in different conscious states View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-06

AUTHORS

Murat Ozgoren, Onur Bayazit, Sibel Kocaaslan, Necati Gokmen, Adile Oniz

ABSTRACT

BACKGROUND: The study of brain functioning is a major challenge in neuroscience fields as human brain has a dynamic and ever changing information processing. Case is worsened with conditions where brain undergoes major changes in so-called different conscious states. Even though the exact definition of consciousness is a hard one, there are certain conditions where the descriptions have reached a consensus. The sleep and the anesthesia are different conditions which are separable from each other and also from wakefulness. The aim of our group has been to tackle the issue of brain functioning with setting up similar research conditions for these three conscious states. METHODS: In order to achieve this goal we have designed an auditory stimulation battery with changing conditions to be recorded during a 40 channel EEG polygraph (Nuamps) session. The stimuli (modified mismatch, auditory evoked etc.) have been administered both in the operation room and the sleep lab via Embedded Interactive Stimulus Unit which was developed in our lab. The overall study has provided some results for three domains of consciousness. In order to be able to monitor the changes we have incorporated Bispectral Index Monitoring to both sleep and anesthesia conditions. RESULTS: The first stage results have provided a basic understanding in these altered states such that auditory stimuli have been successfully processed in both light and deep sleep stages. The anesthesia provides a sudden change in brain responsiveness; therefore a dosage dependent anesthetic administration has proved to be useful. The auditory processing was exemplified targeting N1 wave, with a thorough analysis from spectrogram to sLORETA. The frequency components were observed to be shifting throughout the stages. The propofol administration and the deeper sleep stages both resulted in the decreasing of N1 component. The sLORETA revealed similar activity at BA7 in sleep (BIS 70) and target propofol concentration of 1.2 microg/mL. CONCLUSIONS: The current study utilized similar stimulation and recording system and incorporated BIS dependent values to validate a common approach to sleep and anesthesia. Accordingly the brain has a complex behavior pattern, dynamically changing its responsiveness in accordance with stimulations and states. More... »

PAGES

s6

References to SciGraph publications

  • 2006-09. Increased local and decreased remote functional connectivity at EEG alpha and beta frequency bands in opioid-dependent patients in PSYCHOPHARMACOLOGY
  • 2008-10. Analysis of non-REM sleep staging with electroencephalography bispectral index in SLEEP AND BIOLOGICAL RHYTHMS
  • 2003-08. Discovering the Capacity of Human Memory in BRAIN AND MIND
  • 2006. Narcolepsy-Cataplexy in ENCYCLOPEDIC REFERENCE OF GENOMICS AND PROTEOMICS IN MOLECULAR MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1753-4631-4-s1-s6

    DOI

    http://dx.doi.org/10.1186/1753-4631-4-s1-s6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041323754

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20522267


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1701", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Psychology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/17", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Psychology and Cognitive Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Dokuz Eyl\u00fcl University", 
              "id": "https://www.grid.ac/institutes/grid.21200.31", 
              "name": [
                "Department of Biophysics, Faculty of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ozgoren", 
            "givenName": "Murat", 
            "id": "sg:person.01124136171.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124136171.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dokuz Eyl\u00fcl University", 
              "id": "https://www.grid.ac/institutes/grid.21200.31", 
              "name": [
                "Department of Biophysics, Faculty of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bayazit", 
            "givenName": "Onur", 
            "id": "sg:person.01240364571.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240364571.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dokuz Eyl\u00fcl University", 
              "id": "https://www.grid.ac/institutes/grid.21200.31", 
              "name": [
                "Department of Biophysics, Faculty of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kocaaslan", 
            "givenName": "Sibel", 
            "id": "sg:person.01031434617.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031434617.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dokuz Eyl\u00fcl University", 
              "id": "https://www.grid.ac/institutes/grid.21200.31", 
              "name": [
                "Department. of Anesthesiology, Faculty of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gokmen", 
            "givenName": "Necati", 
            "id": "sg:person.01161653715.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161653715.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dokuz Eyl\u00fcl University", 
              "id": "https://www.grid.ac/institutes/grid.21200.31", 
              "name": [
                "Department of Biophysics, Faculty of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oniz", 
            "givenName": "Adile", 
            "id": "sg:person.01145663217.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145663217.63"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1006/nimg.1998.0414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000177942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00003446-199502000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000615935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00003446-199502000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000615935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00003446-199502000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000615935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.compbiomed.2009.07.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002492763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2869.1997.00033.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002998325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2869.1997.00033.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002998325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1388-2457(01)00650-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005035094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000542-200511000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007265059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000542-200511000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007265059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000542-200511000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007265059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000542-200511000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007265059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijpsycho.2008.05.407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007307788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-0102(03)00007-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009070015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-0102(03)00007-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009070015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1440-1819.2001.00810.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009693173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awl004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010492289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1874440001004010121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010512895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1025405628479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010860598", 
              "https://doi.org/10.1023/a:1025405628479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainres.2004.01.084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011180390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0306-4522(01)00028-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011355400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ana.0b013e3181990d00", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013563226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ana.0b013e3181990d00", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013563226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ana.0b013e3181990d00", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013563226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ana.0b013e3181990d00", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013563226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.compbiomed.2009.11.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013813735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijpsycho.2005.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014678045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bja/89.3.382", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017669370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1479-8425.2008.00372.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020246025", 
              "https://doi.org/10.1111/j.1479-8425.2008.00372.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1479-8425.2008.00372.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020246025", 
              "https://doi.org/10.1111/j.1479-8425.2008.00372.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00213-006-0474-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020246538", 
              "https://doi.org/10.1007/s00213-006-0474-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0531-5131(01)00687-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022511450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1388-2457(02)00304-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024672564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1388-2457(02)00304-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024672564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/bmt.2010.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024756749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainresrev.2006.06.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025412737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.smrv.2004.01.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025855303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/aln.0b013e31819dad6f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032874664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/aln.0b013e31819dad6f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032874664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/aln.0b013e31819dad6f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032874664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bja/aeh022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033231504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2007.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033706213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-8760(84)90014-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034118282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clinph.2006.09.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036159388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0166-2236(00)01714-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036718555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s1062798705000700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039164325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1087-0792(99)90012-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040104595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bpa.2005.07.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040663863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropsychologia.2008.10.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041057906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004691-199503000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044445961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004691-199503000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044445961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.concog.2008.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045103981"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/3-540-29623-9_5845", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045486934", 
              "https://doi.org/10.1007/3-540-29623-9_5845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0140525x00078407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046258130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0140525x00078407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046258130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.292.6531.1291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047353938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0079-6123(05)50015-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050082609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0079-6123(05)50015-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050082609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainres.2007.10.106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053398232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0269881108089810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054041019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0269881108089810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054041019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8235588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062653722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075233746", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077501535", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079774800", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/iembs.2006.259909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1096109382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/iembs.2006.259909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1096109382"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2010-06", 
        "datePublishedReg": "2010-06-01", 
        "description": "BACKGROUND: The study of brain functioning is a major challenge in neuroscience fields as human brain has a dynamic and ever changing information processing. Case is worsened with conditions where brain undergoes major changes in so-called different conscious states. Even though the exact definition of consciousness is a hard one, there are certain conditions where the descriptions have reached a consensus. The sleep and the anesthesia are different conditions which are separable from each other and also from wakefulness. The aim of our group has been to tackle the issue of brain functioning with setting up similar research conditions for these three conscious states.\nMETHODS: In order to achieve this goal we have designed an auditory stimulation battery with changing conditions to be recorded during a 40 channel EEG polygraph (Nuamps) session. The stimuli (modified mismatch, auditory evoked etc.) have been administered both in the operation room and the sleep lab via Embedded Interactive Stimulus Unit which was developed in our lab. The overall study has provided some results for three domains of consciousness. In order to be able to monitor the changes we have incorporated Bispectral Index Monitoring to both sleep and anesthesia conditions.\nRESULTS: The first stage results have provided a basic understanding in these altered states such that auditory stimuli have been successfully processed in both light and deep sleep stages. The anesthesia provides a sudden change in brain responsiveness; therefore a dosage dependent anesthetic administration has proved to be useful. The auditory processing was exemplified targeting N1 wave, with a thorough analysis from spectrogram to sLORETA. The frequency components were observed to be shifting throughout the stages. The propofol administration and the deeper sleep stages both resulted in the decreasing of N1 component. The sLORETA revealed similar activity at BA7 in sleep (BIS 70) and target propofol concentration of 1.2 microg/mL.\nCONCLUSIONS: The current study utilized similar stimulation and recording system and incorporated BIS dependent values to validate a common approach to sleep and anesthesia. Accordingly the brain has a complex behavior pattern, dynamically changing its responsiveness in accordance with stimulations and states.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1753-4631-4-s1-s6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1295581", 
            "issn": [
              "2195-0008"
            ], 
            "name": "EPJ Nonlinear Biomedical Physics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "Suppl 1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "4"
          }
        ], 
        "name": "Brain function assessment in different conscious states", 
        "pagination": "s6", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "c4dab0e763ddc57fc04ec2cefa82725899d29ef816642158570f9c71179e7642"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "20522267"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101303143"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1753-4631-4-s1-s6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1041323754"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1753-4631-4-s1-s6", 
          "https://app.dimensions.ai/details/publication/pub.1041323754"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T21:44", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000551.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F1753-4631-4-S1-S6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1753-4631-4-s1-s6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1753-4631-4-s1-s6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1753-4631-4-s1-s6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1753-4631-4-s1-s6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    242 TRIPLES      21 PREDICATES      77 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1753-4631-4-s1-s6 schema:about anzsrc-for:17
    2 anzsrc-for:1701
    3 schema:author N5c83b1f4d4d4450881365d57e6aabeab
    4 schema:citation sg:pub.10.1007/3-540-29623-9_5845
    5 sg:pub.10.1007/s00213-006-0474-4
    6 sg:pub.10.1023/a:1025405628479
    7 sg:pub.10.1111/j.1479-8425.2008.00372.x
    8 https://app.dimensions.ai/details/publication/pub.1075233746
    9 https://app.dimensions.ai/details/publication/pub.1077501535
    10 https://app.dimensions.ai/details/publication/pub.1079774800
    11 https://doi.org/10.1006/nimg.1998.0414
    12 https://doi.org/10.1016/0167-8760(84)90014-x
    13 https://doi.org/10.1016/j.bpa.2005.07.012
    14 https://doi.org/10.1016/j.brainres.2004.01.084
    15 https://doi.org/10.1016/j.brainres.2007.10.106
    16 https://doi.org/10.1016/j.brainresrev.2006.06.003
    17 https://doi.org/10.1016/j.clinph.2006.09.001
    18 https://doi.org/10.1016/j.compbiomed.2009.07.001
    19 https://doi.org/10.1016/j.compbiomed.2009.11.005
    20 https://doi.org/10.1016/j.concog.2008.10.005
    21 https://doi.org/10.1016/j.ijpsycho.2005.12.008
    22 https://doi.org/10.1016/j.ijpsycho.2008.05.407
    23 https://doi.org/10.1016/j.neuropsychologia.2008.10.002
    24 https://doi.org/10.1016/j.smrv.2004.01.003
    25 https://doi.org/10.1016/j.tins.2007.02.001
    26 https://doi.org/10.1016/s0079-6123(05)50015-3
    27 https://doi.org/10.1016/s0166-2236(00)01714-8
    28 https://doi.org/10.1016/s0168-0102(03)00007-5
    29 https://doi.org/10.1016/s0306-4522(01)00028-8
    30 https://doi.org/10.1016/s0531-5131(01)00687-2
    31 https://doi.org/10.1016/s1087-0792(99)90012-6
    32 https://doi.org/10.1016/s1388-2457(01)00650-2
    33 https://doi.org/10.1016/s1388-2457(02)00304-8
    34 https://doi.org/10.1017/s0140525x00078407
    35 https://doi.org/10.1017/s1062798705000700
    36 https://doi.org/10.1046/j.1365-2869.1997.00033.x
    37 https://doi.org/10.1046/j.1440-1819.2001.00810.x
    38 https://doi.org/10.1093/bja/89.3.382
    39 https://doi.org/10.1093/bja/aeh022
    40 https://doi.org/10.1093/brain/awl004
    41 https://doi.org/10.1097/00000542-200511000-00006
    42 https://doi.org/10.1097/00003446-199502000-00002
    43 https://doi.org/10.1097/00004691-199503000-00006
    44 https://doi.org/10.1097/aln.0b013e31819dad6f
    45 https://doi.org/10.1097/ana.0b013e3181990d00
    46 https://doi.org/10.1109/iembs.2006.259909
    47 https://doi.org/10.1126/science.8235588
    48 https://doi.org/10.1136/bmj.292.6531.1291
    49 https://doi.org/10.1177/0269881108089810
    50 https://doi.org/10.1515/bmt.2010.009
    51 https://doi.org/10.2174/1874440001004010121
    52 schema:datePublished 2010-06
    53 schema:datePublishedReg 2010-06-01
    54 schema:description BACKGROUND: The study of brain functioning is a major challenge in neuroscience fields as human brain has a dynamic and ever changing information processing. Case is worsened with conditions where brain undergoes major changes in so-called different conscious states. Even though the exact definition of consciousness is a hard one, there are certain conditions where the descriptions have reached a consensus. The sleep and the anesthesia are different conditions which are separable from each other and also from wakefulness. The aim of our group has been to tackle the issue of brain functioning with setting up similar research conditions for these three conscious states. METHODS: In order to achieve this goal we have designed an auditory stimulation battery with changing conditions to be recorded during a 40 channel EEG polygraph (Nuamps) session. The stimuli (modified mismatch, auditory evoked etc.) have been administered both in the operation room and the sleep lab via Embedded Interactive Stimulus Unit which was developed in our lab. The overall study has provided some results for three domains of consciousness. In order to be able to monitor the changes we have incorporated Bispectral Index Monitoring to both sleep and anesthesia conditions. RESULTS: The first stage results have provided a basic understanding in these altered states such that auditory stimuli have been successfully processed in both light and deep sleep stages. The anesthesia provides a sudden change in brain responsiveness; therefore a dosage dependent anesthetic administration has proved to be useful. The auditory processing was exemplified targeting N1 wave, with a thorough analysis from spectrogram to sLORETA. The frequency components were observed to be shifting throughout the stages. The propofol administration and the deeper sleep stages both resulted in the decreasing of N1 component. The sLORETA revealed similar activity at BA7 in sleep (BIS 70) and target propofol concentration of 1.2 microg/mL. CONCLUSIONS: The current study utilized similar stimulation and recording system and incorporated BIS dependent values to validate a common approach to sleep and anesthesia. Accordingly the brain has a complex behavior pattern, dynamically changing its responsiveness in accordance with stimulations and states.
    55 schema:genre research_article
    56 schema:inLanguage en
    57 schema:isAccessibleForFree true
    58 schema:isPartOf N9e0c3c7cefb34c45bee2726e7391aa9c
    59 Nd773c6072cb348d2a2656ca3413c2697
    60 sg:journal.1295581
    61 schema:name Brain function assessment in different conscious states
    62 schema:pagination s6
    63 schema:productId N419e7d1dbaa348b89b55bb8388ce6244
    64 N4b3d7b6dd7df47c49b5fd888cc8044e0
    65 N967eb7a1b1ad4b00a3d230dfbddb4586
    66 Nd76b2defe9884ebba7223031585f990e
    67 Ne1e1a9dffa9c4224ae565f07027cda63
    68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041323754
    69 https://doi.org/10.1186/1753-4631-4-s1-s6
    70 schema:sdDatePublished 2019-04-10T21:44
    71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    72 schema:sdPublisher Nc106f141743c47fa87615dd9582712b0
    73 schema:url http://link.springer.com/10.1186%2F1753-4631-4-S1-S6
    74 sgo:license sg:explorer/license/
    75 sgo:sdDataset articles
    76 rdf:type schema:ScholarlyArticle
    77 N2b1ae1e6fe664cbcb52bfa49b9f7c846 rdf:first sg:person.01031434617.11
    78 rdf:rest N6ce607eb5d344e34b632ff7663311c4f
    79 N419e7d1dbaa348b89b55bb8388ce6244 schema:name readcube_id
    80 schema:value c4dab0e763ddc57fc04ec2cefa82725899d29ef816642158570f9c71179e7642
    81 rdf:type schema:PropertyValue
    82 N4b3d7b6dd7df47c49b5fd888cc8044e0 schema:name dimensions_id
    83 schema:value pub.1041323754
    84 rdf:type schema:PropertyValue
    85 N5c83b1f4d4d4450881365d57e6aabeab rdf:first sg:person.01124136171.22
    86 rdf:rest Nec40f12ae63a407da6d6458f1e00048d
    87 N6ce607eb5d344e34b632ff7663311c4f rdf:first sg:person.01161653715.58
    88 rdf:rest Ncb575df42a8c4559b38d45b615a68c71
    89 N967eb7a1b1ad4b00a3d230dfbddb4586 schema:name pubmed_id
    90 schema:value 20522267
    91 rdf:type schema:PropertyValue
    92 N9e0c3c7cefb34c45bee2726e7391aa9c schema:issueNumber Suppl 1
    93 rdf:type schema:PublicationIssue
    94 Nc106f141743c47fa87615dd9582712b0 schema:name Springer Nature - SN SciGraph project
    95 rdf:type schema:Organization
    96 Ncb575df42a8c4559b38d45b615a68c71 rdf:first sg:person.01145663217.63
    97 rdf:rest rdf:nil
    98 Nd76b2defe9884ebba7223031585f990e schema:name nlm_unique_id
    99 schema:value 101303143
    100 rdf:type schema:PropertyValue
    101 Nd773c6072cb348d2a2656ca3413c2697 schema:volumeNumber 4
    102 rdf:type schema:PublicationVolume
    103 Ne1e1a9dffa9c4224ae565f07027cda63 schema:name doi
    104 schema:value 10.1186/1753-4631-4-s1-s6
    105 rdf:type schema:PropertyValue
    106 Nec40f12ae63a407da6d6458f1e00048d rdf:first sg:person.01240364571.92
    107 rdf:rest N2b1ae1e6fe664cbcb52bfa49b9f7c846
    108 anzsrc-for:17 schema:inDefinedTermSet anzsrc-for:
    109 schema:name Psychology and Cognitive Sciences
    110 rdf:type schema:DefinedTerm
    111 anzsrc-for:1701 schema:inDefinedTermSet anzsrc-for:
    112 schema:name Psychology
    113 rdf:type schema:DefinedTerm
    114 sg:journal.1295581 schema:issn 2195-0008
    115 schema:name EPJ Nonlinear Biomedical Physics
    116 rdf:type schema:Periodical
    117 sg:person.01031434617.11 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
    118 schema:familyName Kocaaslan
    119 schema:givenName Sibel
    120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031434617.11
    121 rdf:type schema:Person
    122 sg:person.01124136171.22 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
    123 schema:familyName Ozgoren
    124 schema:givenName Murat
    125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124136171.22
    126 rdf:type schema:Person
    127 sg:person.01145663217.63 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
    128 schema:familyName Oniz
    129 schema:givenName Adile
    130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145663217.63
    131 rdf:type schema:Person
    132 sg:person.01161653715.58 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
    133 schema:familyName Gokmen
    134 schema:givenName Necati
    135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161653715.58
    136 rdf:type schema:Person
    137 sg:person.01240364571.92 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
    138 schema:familyName Bayazit
    139 schema:givenName Onur
    140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240364571.92
    141 rdf:type schema:Person
    142 sg:pub.10.1007/3-540-29623-9_5845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045486934
    143 https://doi.org/10.1007/3-540-29623-9_5845
    144 rdf:type schema:CreativeWork
    145 sg:pub.10.1007/s00213-006-0474-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020246538
    146 https://doi.org/10.1007/s00213-006-0474-4
    147 rdf:type schema:CreativeWork
    148 sg:pub.10.1023/a:1025405628479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010860598
    149 https://doi.org/10.1023/a:1025405628479
    150 rdf:type schema:CreativeWork
    151 sg:pub.10.1111/j.1479-8425.2008.00372.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020246025
    152 https://doi.org/10.1111/j.1479-8425.2008.00372.x
    153 rdf:type schema:CreativeWork
    154 https://app.dimensions.ai/details/publication/pub.1075233746 schema:CreativeWork
    155 https://app.dimensions.ai/details/publication/pub.1077501535 schema:CreativeWork
    156 https://app.dimensions.ai/details/publication/pub.1079774800 schema:CreativeWork
    157 https://doi.org/10.1006/nimg.1998.0414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000177942
    158 rdf:type schema:CreativeWork
    159 https://doi.org/10.1016/0167-8760(84)90014-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034118282
    160 rdf:type schema:CreativeWork
    161 https://doi.org/10.1016/j.bpa.2005.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040663863
    162 rdf:type schema:CreativeWork
    163 https://doi.org/10.1016/j.brainres.2004.01.084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011180390
    164 rdf:type schema:CreativeWork
    165 https://doi.org/10.1016/j.brainres.2007.10.106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053398232
    166 rdf:type schema:CreativeWork
    167 https://doi.org/10.1016/j.brainresrev.2006.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025412737
    168 rdf:type schema:CreativeWork
    169 https://doi.org/10.1016/j.clinph.2006.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036159388
    170 rdf:type schema:CreativeWork
    171 https://doi.org/10.1016/j.compbiomed.2009.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002492763
    172 rdf:type schema:CreativeWork
    173 https://doi.org/10.1016/j.compbiomed.2009.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013813735
    174 rdf:type schema:CreativeWork
    175 https://doi.org/10.1016/j.concog.2008.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045103981
    176 rdf:type schema:CreativeWork
    177 https://doi.org/10.1016/j.ijpsycho.2005.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014678045
    178 rdf:type schema:CreativeWork
    179 https://doi.org/10.1016/j.ijpsycho.2008.05.407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007307788
    180 rdf:type schema:CreativeWork
    181 https://doi.org/10.1016/j.neuropsychologia.2008.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041057906
    182 rdf:type schema:CreativeWork
    183 https://doi.org/10.1016/j.smrv.2004.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025855303
    184 rdf:type schema:CreativeWork
    185 https://doi.org/10.1016/j.tins.2007.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033706213
    186 rdf:type schema:CreativeWork
    187 https://doi.org/10.1016/s0079-6123(05)50015-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050082609
    188 rdf:type schema:CreativeWork
    189 https://doi.org/10.1016/s0166-2236(00)01714-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036718555
    190 rdf:type schema:CreativeWork
    191 https://doi.org/10.1016/s0168-0102(03)00007-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009070015
    192 rdf:type schema:CreativeWork
    193 https://doi.org/10.1016/s0306-4522(01)00028-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011355400
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1016/s0531-5131(01)00687-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022511450
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1016/s1087-0792(99)90012-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040104595
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1016/s1388-2457(01)00650-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005035094
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1016/s1388-2457(02)00304-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024672564
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1017/s0140525x00078407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046258130
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1017/s1062798705000700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039164325
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1046/j.1365-2869.1997.00033.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002998325
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1046/j.1440-1819.2001.00810.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009693173
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1093/bja/89.3.382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017669370
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1093/bja/aeh022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033231504
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1093/brain/awl004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010492289
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1097/00000542-200511000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007265059
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1097/00003446-199502000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000615935
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1097/00004691-199503000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044445961
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1097/aln.0b013e31819dad6f schema:sameAs https://app.dimensions.ai/details/publication/pub.1032874664
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1097/ana.0b013e3181990d00 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013563226
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1109/iembs.2006.259909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1096109382
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1126/science.8235588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653722
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1136/bmj.292.6531.1291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047353938
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1177/0269881108089810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054041019
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1515/bmt.2010.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024756749
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.2174/1874440001004010121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010512895
    238 rdf:type schema:CreativeWork
    239 https://www.grid.ac/institutes/grid.21200.31 schema:alternateName Dokuz Eylül University
    240 schema:name Department of Biophysics, Faculty of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey
    241 Department. of Anesthesiology, Faculty of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey
    242 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...