Vancomycin-induced Henoch-Schönlein purpura: a case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-04-10

AUTHORS

Stanislas Bataille, Aurélie Daumas, Anne-Marie Tasei, Noémie Jourde-Chiche, Bertrand Dussol, Stéphane Burtey, Solène Taugourdeau, Yvon Berland, Laurent Chiche

ABSTRACT

INTRODUCTION: Henoch-Schönlein purpura is a small-vessel systemic vasculitis. Although its exact pathophysiology remains unknown, Henoch-Schönlein purpura has been reported in association with various medical conditions including hypersensitivity. We report the case of a patient with vancomycin-induced Henoch-Schönlein purpura. CASE PRESENTATION: A 42-year-old Caucasian man who had previously undergone a heart transplant was diagnosed as having an intra-abdominal abscess after he underwent a Hartmann procedure. At 15 days after initiation of antibiotic therapy including vancomycin, he developed a purpuric rash of the lower limbs, arthralgia, and macroscopic hematuria. At that time, our patient was already on hemodialysis for end-stage renal disease. Henoch-Schönlein purpura was diagnosed. After a second 15-day course of vancomycin, a second flare of Henoch-Schönlein purpura occurred. Skin biopsies showed leucocytoclastic vasculitis with IgA deposits and eosinophils in the peri-capillary inflammatory infiltrate, suggesting an allergic mechanism. After vancomycin was stopped, we did not observe any further flares. Only five cases of isolated cutaneous vasculitis, one case of lupus-like syndrome and one case of Henoch-Schönlein purpura after vancomycin treatment have been described to date in the literature. CONCLUSIONS: Clinicians should be aware that systemic vasculitis can be induced by some treatments. Vancomycin is a widely prescribed antibiotic. Occurrence of rare but serious Henoch-Schönlein purpura associated with vancomycin requires its prompt discontinuation. More... »

PAGES

106-106

References to SciGraph publications

  • 2001-10-05. Henoch-Schönlein purpura nephritis: an update in EUROPEAN JOURNAL OF PEDIATRICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1752-1947-6-106

    DOI

    http://dx.doi.org/10.1186/1752-1947-6-106

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029362437

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22490390


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