Spatial and temporal genetic heterogeneity of epidermal growth factor receptor gene status in a patient with non-small cell lung cancer: ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Makoto Ogata, Toshiki Shimizu, Takashi Yokoi, Shosaku Nomura

ABSTRACT

INTRODUCTION: To date, an epidermal growth factor receptor-activating mutation is recognized as a genetic hallmark that predicts a good response to treatment with epidermal growth factor receptor tyrosine kinase inhibitor. However, there has been less long-term observation of the mutational status within the same patient. To the best of our knowledge, this is the first case report which illustrates the instability of the genetic status of pulmonary adenocarcinoma cells. CASE PRESENTATION: A 64-year-old Japanese woman with advanced lung adenocarcinoma had been undergoing various anticancer treatments, including epidermal growth factor receptor tyrosine kinase inhibitor, for seven years. She had been receiving locoregional treatment in addition to systemic treatment. She maintained a good performance status until seven years after the initial diagnosis, although she had local and distant recurrences. We analyzed the genetic status of the epidermal growth factor receptor gene in a series of specimens obtained from various tumor-containing lesions throughout the therapeutic period. The results of the genetic analyses clearly showed that the spatial and temporal genetic heterogeneity of the epidermal growth factor receptor gene status originated from an identical tumor ancestor. CONCLUSIONS: An alternative paradigm to determine a therapeutic strategy for a patient with lung cancer should be considered given the genetic heterogeneity and instability of tumor cells. More... »

PAGES

553

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1752-1947-5-553

DOI

http://dx.doi.org/10.1186/1752-1947-5-553

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023819517

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22108465


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, 570-8506, Moriguchi City, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ogata", 
        "givenName": "Makoto", 
        "id": "sg:person.0733255273.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733255273.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, 570-8506, Moriguchi City, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimizu", 
        "givenName": "Toshiki", 
        "id": "sg:person.01304212154.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304212154.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, 570-8506, Moriguchi City, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yokoi", 
        "givenName": "Takashi", 
        "id": "sg:person.01004070343.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004070343.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, 570-8506, Moriguchi City, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nomura", 
        "givenName": "Shosaku", 
        "id": "sg:person.0637542245.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637542245.62"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.clon.2007.04.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001756938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2008.00782.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002240511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdn679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005869097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.03.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006708194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.03.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006708194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cancergencyto.2009.06.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011191542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jto.0b013e3181a94af4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011894909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2005.08.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022189736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2005.08.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022189736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jto.0b013e3181e8b3c5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022640134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024864586", 
          "https://doi.org/10.1038/sj.bjc.6604629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-0331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028389586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa040938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042907590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.23868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050180321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.10.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-1705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077108278"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-12", 
    "datePublishedReg": "2011-12-01", 
    "description": "INTRODUCTION: To date, an epidermal growth factor receptor-activating mutation is recognized as a genetic hallmark that predicts a good response to treatment with epidermal growth factor receptor tyrosine kinase inhibitor. However, there has been less long-term observation of the mutational status within the same patient. To the best of our knowledge, this is the first case report which illustrates the instability of the genetic status of pulmonary adenocarcinoma cells.\nCASE PRESENTATION: A 64-year-old Japanese woman with advanced lung adenocarcinoma had been undergoing various anticancer treatments, including epidermal growth factor receptor tyrosine kinase inhibitor, for seven years. She had been receiving locoregional treatment in addition to systemic treatment. She maintained a good performance status until seven years after the initial diagnosis, although she had local and distant recurrences. We analyzed the genetic status of the epidermal growth factor receptor gene in a series of specimens obtained from various tumor-containing lesions throughout the therapeutic period. The results of the genetic analyses clearly showed that the spatial and temporal genetic heterogeneity of the epidermal growth factor receptor gene status originated from an identical tumor ancestor.\nCONCLUSIONS: An alternative paradigm to determine a therapeutic strategy for a patient with lung cancer should be considered given the genetic heterogeneity and instability of tumor cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1752-1947-5-553", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1038062", 
        "issn": [
          "1752-1947"
        ], 
        "name": "Journal of Medical Case Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "Spatial and temporal genetic heterogeneity of epidermal growth factor receptor gene status in a patient with non-small cell lung cancer: a case report", 
    "pagination": "553", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "717aeee9350419dbe26dcea70b0099e22608a75469fe1d28dde1a945c14bfe36"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22108465"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101293382"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1752-1947-5-553"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1023819517"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1752-1947-5-553", 
      "https://app.dimensions.ai/details/publication/pub.1023819517"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1752-1947-5-553"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1752-1947-5-553'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1752-1947-5-553'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1752-1947-5-553'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1752-1947-5-553'


 

This table displays all metadata directly associated to this object as RDF triples.

132 TRIPLES      21 PREDICATES      43 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1752-1947-5-553 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N30d60d6e24064f60b516f11044d60a87
4 schema:citation sg:pub.10.1038/sj.bjc.6604629
5 https://doi.org/10.1002/ijc.23868
6 https://doi.org/10.1016/j.cancergencyto.2009.06.025
7 https://doi.org/10.1016/j.canlet.2005.08.029
8 https://doi.org/10.1016/j.cell.2005.03.032
9 https://doi.org/10.1016/j.clon.2007.04.006
10 https://doi.org/10.1056/nejmoa040938
11 https://doi.org/10.1093/annonc/mdn679
12 https://doi.org/10.1097/jto.0b013e3181a94af4
13 https://doi.org/10.1097/jto.0b013e3181e8b3c5
14 https://doi.org/10.1111/j.1349-7006.2008.00782.x
15 https://doi.org/10.1158/0008-5472.can-05-0331
16 https://doi.org/10.1158/0008-5472.can-05-1705
17 https://doi.org/10.1200/jco.2003.10.038
18 schema:datePublished 2011-12
19 schema:datePublishedReg 2011-12-01
20 schema:description INTRODUCTION: To date, an epidermal growth factor receptor-activating mutation is recognized as a genetic hallmark that predicts a good response to treatment with epidermal growth factor receptor tyrosine kinase inhibitor. However, there has been less long-term observation of the mutational status within the same patient. To the best of our knowledge, this is the first case report which illustrates the instability of the genetic status of pulmonary adenocarcinoma cells. CASE PRESENTATION: A 64-year-old Japanese woman with advanced lung adenocarcinoma had been undergoing various anticancer treatments, including epidermal growth factor receptor tyrosine kinase inhibitor, for seven years. She had been receiving locoregional treatment in addition to systemic treatment. She maintained a good performance status until seven years after the initial diagnosis, although she had local and distant recurrences. We analyzed the genetic status of the epidermal growth factor receptor gene in a series of specimens obtained from various tumor-containing lesions throughout the therapeutic period. The results of the genetic analyses clearly showed that the spatial and temporal genetic heterogeneity of the epidermal growth factor receptor gene status originated from an identical tumor ancestor. CONCLUSIONS: An alternative paradigm to determine a therapeutic strategy for a patient with lung cancer should be considered given the genetic heterogeneity and instability of tumor cells.
21 schema:genre research_article
22 schema:inLanguage en
23 schema:isAccessibleForFree true
24 schema:isPartOf N32106040d24042d2b2084c348cde536b
25 Ndd063f488e03456f8e06d7c0319e7c4a
26 sg:journal.1038062
27 schema:name Spatial and temporal genetic heterogeneity of epidermal growth factor receptor gene status in a patient with non-small cell lung cancer: a case report
28 schema:pagination 553
29 schema:productId N1f2fd1fe2d5945d3b551317156d92c2b
30 N54173aa00b194bce90a75a003a8c6776
31 N8a322f956a104bb4919bbbdf7c380f63
32 Nd23de758cd784c5f9db6b4b8cbdf8d01
33 Nd80fbe69b8bb4e43846c5b8667135179
34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023819517
35 https://doi.org/10.1186/1752-1947-5-553
36 schema:sdDatePublished 2019-04-10T16:42
37 schema:sdLicense https://scigraph.springernature.com/explorer/license/
38 schema:sdPublisher N21a371da9b8e45c99168d68445ca3f5d
39 schema:url http://link.springer.com/10.1186%2F1752-1947-5-553
40 sgo:license sg:explorer/license/
41 sgo:sdDataset articles
42 rdf:type schema:ScholarlyArticle
43 N1f2fd1fe2d5945d3b551317156d92c2b schema:name dimensions_id
44 schema:value pub.1023819517
45 rdf:type schema:PropertyValue
46 N21a371da9b8e45c99168d68445ca3f5d schema:name Springer Nature - SN SciGraph project
47 rdf:type schema:Organization
48 N30d60d6e24064f60b516f11044d60a87 rdf:first sg:person.0733255273.39
49 rdf:rest Ncbbd6431bddd42b79c20306095d99628
50 N32106040d24042d2b2084c348cde536b schema:volumeNumber 5
51 rdf:type schema:PublicationVolume
52 N54173aa00b194bce90a75a003a8c6776 schema:name nlm_unique_id
53 schema:value 101293382
54 rdf:type schema:PropertyValue
55 N8a322f956a104bb4919bbbdf7c380f63 schema:name doi
56 schema:value 10.1186/1752-1947-5-553
57 rdf:type schema:PropertyValue
58 Nc0e67ae1460d46bd95565a7300679435 rdf:first sg:person.0637542245.62
59 rdf:rest rdf:nil
60 Nc5c5e9e6148e47c59684f5a5567282b2 rdf:first sg:person.01004070343.25
61 rdf:rest Nc0e67ae1460d46bd95565a7300679435
62 Ncbbd6431bddd42b79c20306095d99628 rdf:first sg:person.01304212154.76
63 rdf:rest Nc5c5e9e6148e47c59684f5a5567282b2
64 Nd23de758cd784c5f9db6b4b8cbdf8d01 schema:name readcube_id
65 schema:value 717aeee9350419dbe26dcea70b0099e22608a75469fe1d28dde1a945c14bfe36
66 rdf:type schema:PropertyValue
67 Nd80fbe69b8bb4e43846c5b8667135179 schema:name pubmed_id
68 schema:value 22108465
69 rdf:type schema:PropertyValue
70 Ndd063f488e03456f8e06d7c0319e7c4a schema:issueNumber 1
71 rdf:type schema:PublicationIssue
72 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
73 schema:name Medical and Health Sciences
74 rdf:type schema:DefinedTerm
75 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
76 schema:name Oncology and Carcinogenesis
77 rdf:type schema:DefinedTerm
78 sg:journal.1038062 schema:issn 1752-1947
79 schema:name Journal of Medical Case Reports
80 rdf:type schema:Periodical
81 sg:person.01004070343.25 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
82 schema:familyName Yokoi
83 schema:givenName Takashi
84 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004070343.25
85 rdf:type schema:Person
86 sg:person.01304212154.76 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
87 schema:familyName Shimizu
88 schema:givenName Toshiki
89 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304212154.76
90 rdf:type schema:Person
91 sg:person.0637542245.62 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
92 schema:familyName Nomura
93 schema:givenName Shosaku
94 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637542245.62
95 rdf:type schema:Person
96 sg:person.0733255273.39 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
97 schema:familyName Ogata
98 schema:givenName Makoto
99 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733255273.39
100 rdf:type schema:Person
101 sg:pub.10.1038/sj.bjc.6604629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024864586
102 https://doi.org/10.1038/sj.bjc.6604629
103 rdf:type schema:CreativeWork
104 https://doi.org/10.1002/ijc.23868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050180321
105 rdf:type schema:CreativeWork
106 https://doi.org/10.1016/j.cancergencyto.2009.06.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011191542
107 rdf:type schema:CreativeWork
108 https://doi.org/10.1016/j.canlet.2005.08.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022189736
109 rdf:type schema:CreativeWork
110 https://doi.org/10.1016/j.cell.2005.03.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006708194
111 rdf:type schema:CreativeWork
112 https://doi.org/10.1016/j.clon.2007.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001756938
113 rdf:type schema:CreativeWork
114 https://doi.org/10.1056/nejmoa040938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042907590
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1093/annonc/mdn679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005869097
117 rdf:type schema:CreativeWork
118 https://doi.org/10.1097/jto.0b013e3181a94af4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011894909
119 rdf:type schema:CreativeWork
120 https://doi.org/10.1097/jto.0b013e3181e8b3c5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022640134
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1111/j.1349-7006.2008.00782.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002240511
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1158/0008-5472.can-05-0331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028389586
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1158/0008-5472.can-05-1705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077108278
127 rdf:type schema:CreativeWork
128 https://doi.org/10.1200/jco.2003.10.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203891
129 rdf:type schema:CreativeWork
130 https://www.grid.ac/institutes/grid.410783.9 schema:alternateName Kansai Medical University
131 schema:name First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, 570-8506, Moriguchi City, Osaka, Japan
132 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...