Flare hypercalcemia after letrozole in a patient with liver metastasis from breast cancer: a case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-10-04

AUTHORS

Katsumasa Kuroi, Toshinari Yamashita, Tomoyuki Aruga, Kazumi Horiguchi, Dai Kitagawa, Susumu Sekine, Hiromi Tokita, Yuka Hirashima

ABSTRACT

INTRODUCTION: Tamoxifen may occasionally precipitate serious and potentially life-threatening hypercalcemia. However, to date, this has not been documented with aromatase inhibitors. CASE PRESENTATION: A 65-year-old Japanese woman with liver metastasis from breast cancer was admitted to our hospital with vomiting, anorexia, fatigue, arthralgia, muscle pain and dehydration. She had started a course of letrozole five weeks earlier. Our patient's calcium level was 11.6 mg/dL. She was rehydrated and elcatonin was administered. Our patient's parathyroid hormone and parathyroid hormone-related protein levels were not increased and a bone scintigram revealed no evidence of skeletal metastasis. After our patient's serum calcium level returned to within the normal range, letrozole was restarted at one-half of the previous dose (1.25 mg). There were no episodes of hypercalcemia. However, 84 days after restarting letrozole, our patient again complained of arthralgia and treatment was changed to toremifene. During these periods, repeated ultrasonograms revealed no progression of liver metastasis. CONCLUSION: To the best of our knowledge, this is the first case report of flare hypercalcemia after treatment with letrozole in a patient with metastatic breast cancer. More... »

PAGES

495-495

References to SciGraph publications

  • 1994-10. Hypercalcemia in patients with breast cancer: a survival study in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2006-05. Tamoxifen flare hypercalcemia: an additional support for gallium nitrate usage in JOURNAL OF BONE AND MINERAL METABOLISM
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1752-1947-5-495

    DOI

    http://dx.doi.org/10.1186/1752-1947-5-495

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21970715


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