Metastatic gallbladder adenocarcinoma with signet-ring cells: A case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-09-14

AUTHORS

Fernando Bazan, Juan Sanchez, Guadalupe Aguilar, Aleksandar Radosevic, Marcos Busto, Flavio Zuccarino, Lara Pijuan, Noelia Risueño

ABSTRACT

INTRODUCTION: Signet-ring cell carcinoma is a rare and aggressive variant of mucinous adenocarcinoma. Only a few cases of gallbladder adenocarcinoma with signet-ring cells have been reported and because of this there is a lack of knowledge about the behavior and biology of this pathology. CASE PRESENTATION: We present the case of a 63-year-old Arab man with gallbladder signet-ring cell adenocarcinoma. He had an elective cholecystectomy and refused chemotherapy. Two months later, a small hepatic metastatic nodule was found, and nine months later he presented with multiple metastases in the liver, lymphatic nodes, both pleuras, peritoneum and subcutaneous tissue. CONCLUSION: The proliferation of signet-ring cells in a gallbladder adenocarcinoma worsens the prognosis of an already adverse neoplasm. New lines of treatment in chemotherapy, such as cisplatin, or new biological therapy, such as monoclonal antibody c-myc oncogene, should be encouraged to improve the survival and life quality of these oncologic patients. More... »

PAGES

458-458

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1752-1947-5-458

DOI

http://dx.doi.org/10.1186/1752-1947-5-458

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033415800

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21917161


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