Ontology type: schema:ScholarlyArticle Open Access: True
2011-12
AUTHORSPablo Granero Castro, Alberto Miyar de León, Jose Granero Trancón, Paloma Álvarez Martínez, Jose A Álvarez Pérez, Jose C Fernández Fernández, Carmen M García Bernardo, Luis Barneo Serra, Juan J González González
ABSTRACTINTRODUCTION: Glucagonoma syndrome is a rare paraneoplastic phenomenon, with an estimated incidence of one in 20 million, characterized by necrolytic migratory erythema, hyperglucagonemia, diabetes mellitus, anemia, weight loss, glossitis, cheilitis, steatorrhea, diarrhea, venous thrombosis and neuropsychiatric disturbances in the setting of a glucagon-producing alpha-cell tumor of the pancreas. Necrolytic migratory erythema is the presenting manifestation in the majority of cases, so its early suspicion and correct diagnosis is a key factor in the management of the patient. CASE PRESENTATION: We present the case of a 70-year-old Caucasian woman with glucagonoma syndrome due to an alpha-cell tumor located in the tail of the pancreas, successfully treated with surgical resection. CONCLUSION: Clinicians should be aware of the unusual initial manifestations of glucagonoma. Early diagnosis allows complete surgical resection of the neoplasm and provides the only chance of a cure. More... »
PAGES402
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DOIhttp://dx.doi.org/10.1186/1752-1947-5-402
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