Acute hepatocellular and cholestatic injury during therapy with hydrochlorothiazide - clinicohistopathologic findings: a case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Fabrizio Taglietti, Franca Del Nonno, Andrea Baiocchini, Laura Falasca, Stefano Pieri, Alessandro Capone, Elisabetta Grilli, Pierangelo Chinello, Nicola Petrosillo

ABSTRACT

INTRODUCTION: Hydrochlorothiazide and thiazide-like diuretics are considered first-line drugs for initial therapy in uncomplicated arterial hypertension. Acute cholecystitis is a well-known complication during treatment with thiazide, and these drugs are also reported to be followed by pronounced insulin resistance. CASE PRESENTATION: We describe a case of acute cholestatic hepatitis in a 68-year-old Caucasian man who was receiving olmesartan and hydrochlorothiazide for arterial hypertension. From the clinical and histologic findings, we diagnosed him as having hepatocellular-cholestatic injury and a disorder of glucose metabolism in the liver. To the best of our knowledge, no histopathologic description of hydrochlorothiazide hepatotoxicity has previously been documented in the literature. CONCLUSION: In the differential diagnosis of cholestatic hepatitis, clinicians should be aware of the possibility of liver damage in patients receiving hydrochlorothiazide therapy. More... »

PAGES

332

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1752-1947-4-332

DOI

http://dx.doi.org/10.1186/1752-1947-4-332

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014022095

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20964809


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