Chemical consequences of cutaneous photoageing View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Sarah A Thurstan, Neil K Gibbs, Abigail K Langton, Christopher EM Griffiths, Rachel EB Watson, Michael J Sherratt

ABSTRACT

Human skin, in common with other organs, ages as a consequence of the passage of time, but in areas exposed to solar ultraviolet radiation, the effects of this intrinsic ageing process are exacerbated. In particular, both the severity and speed of onset of age-related changes, such as wrinkle formation and loss of elasticity, are enhanced in photoaged (also termed extrinsically aged) as compared with aged, photoprotected, skin. The anatomy of skin is characterised by two major layers: an outer, avascular, yet highly cellular and dynamic epidermis and an underlying vascularised, comparatively static and cell-poor, dermis. The structural consequences of photoageing are mainly evident in the extracellular matrix-rich but cell-poor dermis where key extracellular matrix proteins are particularly susceptible to photodamage. Most investigations to date have concentrated on the cell as both a target for and mediator of, ultraviolet radiation-induced photoageing. As the main effectors of dermal remodelling produced by cells (extracellular proteases) generally have low substrate specificity, we recently suggested that the differential susceptibility of key extracellular matrix proteins to the processes of photoageing may be due to direct, as opposed to cell-mediated, photodamage.In this review, we discuss the experimental evidence for ultraviolet radiation (and related reactive oxygen species)-mediated differential degradation of normally long lived dermal proteins including the fibrillar collagens, elastic fibre components, glycoproteins and proteoglycans. Whilst these components exhibit highly diverse primary and hence macro- and supra-molecular structures, we present evidence that amino acid composition alone may be a useful predictor of age-related protein degradation in both photoexposed and, as a consequence of differential oxidation sensitivity, photoprotected, tissues. More... »

PAGES

34

References to SciGraph publications

  • 2005. Collagen Suprastructures in COLLAGEN
  • 1952-06. Factors Which Influence the Water Content of the Stratum Corneum1 in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2003-09. Proteins of the Extracellular Matrix Are Sensitizers of Photo-oxidative Stress in Human Skin Cells in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1989-09. Age-Related Mechanical Properties of Human Skin: An In Vivo Study in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2009-12. Tissue elasticity and the ageing elastic fibre in GEROSCIENCE
  • 2011-01. Urocanic Acid in the Skin: A Mixed Blessing? in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1989-07. Anchoring Fibrils and Type VII collagen are Absent From Skin in Severe Recessive Dystrophic Epidermolysis Bullosa in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1996-01. Molecular basis of sun-induced premature skin ageing and retinoid antagonism in NATURE
  • 1980-12. Mechanical properties and Young's modulus of human skin in vivo in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 1979-07. Structural Changes in Aging Human Skin in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2002-04. Photoaging is Associated with Protein Oxidation in Human Skin In Vivo in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1990-03. Fibrillin Immunoreactive Fibers Constitute a Unique Network in the Human Dermis: Immunohistochemical Comparison of the Distributions of Fibrillin, Vitronectin, Amyloid P Component, and Orcein Stainable Structures in Normal Skin and Elastosis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1995-12. Low Doses of Repetitive Ultraviolet A Induce Morphologic Changes in Human Skin in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1999-10. Accumulation of Matrilysin (MMP-7) and Macrophage Metalloelastase (MMP-12) in Actinic Damage in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2001-05. A Short-Term Screening Protocol, Using Fibrillin-1 as a Reporter Molecule, for Photoaging Repair Agents in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1976-03. OXYTALAN, ELAUNIN, AND ELASTIC FIBERS IN THE HUMAN SKIN in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1982-05. Studies in Cutaneous Aging: I. The Elastic Fiber Network in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2003-11. Regulation of matrix metalloproteinases: An overview in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1752-153x-6-34

    DOI

    http://dx.doi.org/10.1186/1752-153x-6-34

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019637745

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22534143


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Manchester", 
              "id": "https://www.grid.ac/institutes/grid.5379.8", 
              "name": [
                "Inflammation Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thurstan", 
            "givenName": "Sarah A", 
            "id": "sg:person.01036424635.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036424635.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Manchester", 
              "id": "https://www.grid.ac/institutes/grid.5379.8", 
              "name": [
                "Inflammation Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gibbs", 
            "givenName": "Neil K", 
            "id": "sg:person.0604563143.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604563143.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Manchester", 
              "id": "https://www.grid.ac/institutes/grid.5379.8", 
              "name": [
                "Inflammation Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Langton", 
            "givenName": "Abigail K", 
            "id": "sg:person.01264736667.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264736667.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Manchester", 
              "id": "https://www.grid.ac/institutes/grid.5379.8", 
              "name": [
                "Inflammation Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Griffiths", 
            "givenName": "Christopher EM", 
            "id": "sg:person.07704176017.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07704176017.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Manchester", 
              "id": "https://www.grid.ac/institutes/grid.5379.8", 
              "name": [
                "Inflammation Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watson", 
            "givenName": "Rachel EB", 
            "id": "sg:person.016651732002.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016651732002.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Manchester", 
              "id": "https://www.grid.ac/institutes/grid.5379.8", 
              "name": [
                "Developmental Biomedicine Research Groups, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sherratt", 
            "givenName": "Michael J", 
            "id": "sg:person.01320347756.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320347756.05"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1146/annurev.cb.04.110188.001305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000077747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-4827(61)90192-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001311041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c1pp05164d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003606022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1034/j.1600-0781.2003.00004.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003763083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rstb.2001.1022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006677370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12532761", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006685011", 
              "https://doi.org/10.1111/1523-1747.ep12532761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/379335a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007036344", 
              "https://doi.org/10.1038/379335a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1747.2001.01322.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008651004", 
              "https://doi.org/10.1046/j.1523-1747.2001.01322.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/10715760600911303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009995022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rstb.2007.2134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010143563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2010.276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012000285", 
              "https://doi.org/10.1038/jid.2010.276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0190-9622(08)80964-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012877725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1747.2002.01708.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016087589", 
              "https://doi.org/10.1046/j.1523-1747.2002.01708.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11357-009-9103-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016602286", 
              "https://doi.org/10.1007/s11357-009-9103-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11357-009-9103-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016602286", 
              "https://doi.org/10.1007/s11357-009-9103-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.maturitas.2011.04.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017772961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.136.3.729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018942226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019199651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019199651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1432-1033.1995.0001f.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019328472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12481882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020158299", 
              "https://doi.org/10.1111/1523-1747.ep12481882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m002346200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020753788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12325517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021420471", 
              "https://doi.org/10.1111/1523-1747.ep12325517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0923-1811(94)90017-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023691362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0923-1811(94)90017-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023691362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1034/j.1600-0625.2002.110502.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024143648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1747.2003.12414.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024318079", 
              "https://doi.org/10.1046/j.1523-1747.2003.12414.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1523-1747.2003.12414.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024318079"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0047-6374(01)00424-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024920958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/03008207409152242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025969603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12277331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026176657", 
              "https://doi.org/10.1111/1523-1747.ep12277331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b507492d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026347166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b507492d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026347166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1026028303196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026351662", 
              "https://doi.org/10.1023/a:1026028303196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/molbev/msn142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026421903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci115204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027262920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1751-1097.1998.tb02480.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027953684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-4362.1994.tb01540.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028500107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0909-725x.2006.00135.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030859605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0909-725x.2006.00135.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030859605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3500381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031001497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3500381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031001497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2133.1975.tb05113.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033703040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1122446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033927661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1751-1097.2007.00275.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034122914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ar.1092380202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034522272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0909-752x.2006.00146.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036608518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0625.2008.00786.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039542095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.124.5.817", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039775714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1432-1033.1982.tb05868.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040318611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00406415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040547445", 
              "https://doi.org/10.1007/bf00406415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00406415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040547445", 
              "https://doi.org/10.1007/bf00406415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1751-1097.1991.tb02071.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040881331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12874430", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040948638", 
              "https://doi.org/10.1111/1523-1747.ep12874430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b307576c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041982685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000212969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042166380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0047-6374(01)00225-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042448185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0141-8130(99)00047-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042901530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000051543", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043649010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12280259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045042851", 
              "https://doi.org/10.1111/1523-1747.ep12280259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jphotobiol.2006.05.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045055539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.1952.52", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045785725", 
              "https://doi.org/10.1038/jid.1952.52"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1034/j.1600-0781.2001.170302.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046287621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2133.2005.06716.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046440917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2133.2005.06716.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046440917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m006700200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047251272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/b978-0-12-363710-9.50009-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047611744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0190-9622(89)70276-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047912977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/bc.2002.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048086430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1747.1999.00731.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048620080", 
              "https://doi.org/10.1046/j.1523-1747.1999.00731.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12507866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048689378", 
              "https://doi.org/10.1111/1523-1747.ep12507866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2133.2007.08108.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049670595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jps.20815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049918323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj0970139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050149961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj0970139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050149961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1468-2494.2010.00574.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050423377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1468-2494.2010.00574.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050423377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2133.1968.tb12322.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051961251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/0264-6021:3500381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056714942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1088/0031-9155/42/5/004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059023169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.8.11.8595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072300031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075075782", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fasebj.5.13.1916105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077838273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083284285", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-202x(89)90058-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083416482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/b103823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085722916", 
              "https://doi.org/10.1007/b103823"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-12", 
        "datePublishedReg": "2012-12-01", 
        "description": " Human skin, in common with other organs, ages as a consequence of the passage of time, but in areas exposed to solar ultraviolet radiation, the effects of this intrinsic ageing process are exacerbated. In particular, both the severity and speed of onset of age-related changes, such as wrinkle formation and loss of elasticity, are enhanced in photoaged (also termed extrinsically aged) as compared with aged, photoprotected, skin. The anatomy of skin is characterised by two major layers: an outer, avascular, yet highly cellular and dynamic epidermis and an underlying vascularised, comparatively static and cell-poor, dermis. The structural consequences of photoageing are mainly evident in the extracellular matrix-rich but cell-poor dermis where key extracellular matrix proteins are particularly susceptible to photodamage. Most investigations to date have concentrated on the cell as both a target for and mediator of, ultraviolet radiation-induced photoageing. As the main effectors of dermal remodelling produced by cells (extracellular proteases) generally have low substrate specificity, we recently suggested that the differential susceptibility of key extracellular matrix proteins to the processes of photoageing may be due to direct, as opposed to cell-mediated, photodamage.In this review, we discuss the experimental evidence for ultraviolet radiation (and related reactive oxygen species)-mediated differential degradation of normally long lived dermal proteins including the fibrillar collagens, elastic fibre components, glycoproteins and proteoglycans. Whilst these components exhibit highly diverse primary and hence macro- and supra-molecular structures, we present evidence that amino acid composition alone may be a useful predictor of age-related protein degradation in both photoexposed and, as a consequence of differential oxidation sensitivity, photoprotected, tissues.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1752-153x-6-34", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1039133", 
            "issn": [
              "1864-6158", 
              "2191-2858"
            ], 
            "name": "Chemistry Central Journal", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "6"
          }
        ], 
        "name": "Chemical consequences of cutaneous photoageing", 
        "pagination": "34", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "5d905b8f809dd46c1e9d4245b5ff05451cbae8dcc305a40475c9f8fe24d01832"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22534143"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101314213"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1752-153x-6-34"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1019637745"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1752-153x-6-34", 
          "https://app.dimensions.ai/details/publication/pub.1019637745"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T23:24", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000512.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F1752-153X-6-34"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1752-153x-6-34'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1752-153x-6-34'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1752-153x-6-34'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1752-153x-6-34'


     

    This table displays all metadata directly associated to this object as RDF triples.

    349 TRIPLES      21 PREDICATES      105 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1752-153x-6-34 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N02b4b33156b54746bcbbc52a5fd15de3
    4 schema:citation sg:pub.10.1007/b103823
    5 sg:pub.10.1007/bf00406415
    6 sg:pub.10.1007/s11357-009-9103-6
    7 sg:pub.10.1023/a:1026028303196
    8 sg:pub.10.1038/379335a0
    9 sg:pub.10.1038/jid.1952.52
    10 sg:pub.10.1038/jid.2010.276
    11 sg:pub.10.1046/j.1523-1747.1999.00731.x
    12 sg:pub.10.1046/j.1523-1747.2001.01322.x
    13 sg:pub.10.1046/j.1523-1747.2002.01708.x
    14 sg:pub.10.1046/j.1523-1747.2003.12414.x
    15 sg:pub.10.1111/1523-1747.ep12277331
    16 sg:pub.10.1111/1523-1747.ep12280259
    17 sg:pub.10.1111/1523-1747.ep12325517
    18 sg:pub.10.1111/1523-1747.ep12481882
    19 sg:pub.10.1111/1523-1747.ep12507866
    20 sg:pub.10.1111/1523-1747.ep12532761
    21 sg:pub.10.1111/1523-1747.ep12874430
    22 https://app.dimensions.ai/details/publication/pub.1075075782
    23 https://app.dimensions.ai/details/publication/pub.1083284285
    24 https://doi.org/10.1002/ar.1092380202
    25 https://doi.org/10.1002/jps.20815
    26 https://doi.org/10.1002/path.2730
    27 https://doi.org/10.1016/0014-4827(61)90192-6
    28 https://doi.org/10.1016/0022-202x(89)90058-4
    29 https://doi.org/10.1016/0923-1811(94)90017-5
    30 https://doi.org/10.1016/b978-0-12-363710-9.50009-5
    31 https://doi.org/10.1016/j.jphotobiol.2006.05.005
    32 https://doi.org/10.1016/j.maturitas.2011.04.011
    33 https://doi.org/10.1016/s0047-6374(01)00225-1
    34 https://doi.org/10.1016/s0047-6374(01)00424-9
    35 https://doi.org/10.1016/s0141-8130(99)00047-1
    36 https://doi.org/10.1016/s0190-9622(08)80964-4
    37 https://doi.org/10.1016/s0190-9622(89)70276-0
    38 https://doi.org/10.1034/j.1600-0625.2002.110502.x
    39 https://doi.org/10.1034/j.1600-0781.2001.170302.x
    40 https://doi.org/10.1034/j.1600-0781.2003.00004.x
    41 https://doi.org/10.1039/b307576c
    42 https://doi.org/10.1039/b507492d
    43 https://doi.org/10.1039/c1pp05164d
    44 https://doi.org/10.1042/0264-6021:3500381
    45 https://doi.org/10.1042/bj0970139
    46 https://doi.org/10.1042/bj3500381
    47 https://doi.org/10.1046/j.1523-1747.2003.12414.x
    48 https://doi.org/10.1074/jbc.m002346200
    49 https://doi.org/10.1074/jbc.m006700200
    50 https://doi.org/10.1080/10715760600911303
    51 https://doi.org/10.1083/jcb.124.5.817
    52 https://doi.org/10.1083/jcb.136.3.729
    53 https://doi.org/10.1088/0031-9155/42/5/004
    54 https://doi.org/10.1093/molbev/msn142
    55 https://doi.org/10.1096/fasebj.5.13.1916105
    56 https://doi.org/10.1098/rstb.2001.1022
    57 https://doi.org/10.1098/rstb.2007.2134
    58 https://doi.org/10.1111/j.0909-725x.2006.00135.x
    59 https://doi.org/10.1111/j.0909-752x.2006.00146.x
    60 https://doi.org/10.1111/j.1365-2133.1968.tb12322.x
    61 https://doi.org/10.1111/j.1365-2133.1975.tb05113.x
    62 https://doi.org/10.1111/j.1365-2133.2005.06716.x
    63 https://doi.org/10.1111/j.1365-2133.2007.08108.x
    64 https://doi.org/10.1111/j.1365-4362.1994.tb01540.x
    65 https://doi.org/10.1111/j.1432-1033.1982.tb05868.x
    66 https://doi.org/10.1111/j.1432-1033.1995.0001f.x
    67 https://doi.org/10.1111/j.1468-2494.2010.00574.x
    68 https://doi.org/10.1111/j.1600-0625.2008.00786.x
    69 https://doi.org/10.1111/j.1751-1097.1991.tb02071.x
    70 https://doi.org/10.1111/j.1751-1097.1998.tb02480.x
    71 https://doi.org/10.1111/j.1751-1097.2007.00275.x
    72 https://doi.org/10.1126/science.1122446
    73 https://doi.org/10.1146/annurev.cb.04.110188.001305
    74 https://doi.org/10.1159/000051543
    75 https://doi.org/10.1159/000212969
    76 https://doi.org/10.1172/jci115204
    77 https://doi.org/10.1515/bc.2002.020
    78 https://doi.org/10.3109/03008207409152242
    79 https://doi.org/10.4161/cc.8.11.8595
    80 schema:datePublished 2012-12
    81 schema:datePublishedReg 2012-12-01
    82 schema:description Human skin, in common with other organs, ages as a consequence of the passage of time, but in areas exposed to solar ultraviolet radiation, the effects of this intrinsic ageing process are exacerbated. In particular, both the severity and speed of onset of age-related changes, such as wrinkle formation and loss of elasticity, are enhanced in photoaged (also termed extrinsically aged) as compared with aged, photoprotected, skin. The anatomy of skin is characterised by two major layers: an outer, avascular, yet highly cellular and dynamic epidermis and an underlying vascularised, comparatively static and cell-poor, dermis. The structural consequences of photoageing are mainly evident in the extracellular matrix-rich but cell-poor dermis where key extracellular matrix proteins are particularly susceptible to photodamage. Most investigations to date have concentrated on the cell as both a target for and mediator of, ultraviolet radiation-induced photoageing. As the main effectors of dermal remodelling produced by cells (extracellular proteases) generally have low substrate specificity, we recently suggested that the differential susceptibility of key extracellular matrix proteins to the processes of photoageing may be due to direct, as opposed to cell-mediated, photodamage.In this review, we discuss the experimental evidence for ultraviolet radiation (and related reactive oxygen species)-mediated differential degradation of normally long lived dermal proteins including the fibrillar collagens, elastic fibre components, glycoproteins and proteoglycans. Whilst these components exhibit highly diverse primary and hence macro- and supra-molecular structures, we present evidence that amino acid composition alone may be a useful predictor of age-related protein degradation in both photoexposed and, as a consequence of differential oxidation sensitivity, photoprotected, tissues.
    83 schema:genre research_article
    84 schema:inLanguage en
    85 schema:isAccessibleForFree true
    86 schema:isPartOf N6b1c3bece7f54a30b7e4a6572978a215
    87 Nf1a840a34e53481db063160535595bc1
    88 sg:journal.1039133
    89 schema:name Chemical consequences of cutaneous photoageing
    90 schema:pagination 34
    91 schema:productId N40d58daeb86f40adbeb304ec67ffa023
    92 Na44f44378ab946c6beacd0419969c539
    93 Nadcdc7bde4e346ef862e93f07732b3fd
    94 Nefc9301a79f740749b42cdcc9fa30b27
    95 Nf10772a3a7644c718d1fabc725c7899f
    96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019637745
    97 https://doi.org/10.1186/1752-153x-6-34
    98 schema:sdDatePublished 2019-04-10T23:24
    99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    100 schema:sdPublisher N9d8997d41d734b28b70d9d40e0f473f9
    101 schema:url http://link.springer.com/10.1186%2F1752-153X-6-34
    102 sgo:license sg:explorer/license/
    103 sgo:sdDataset articles
    104 rdf:type schema:ScholarlyArticle
    105 N02b4b33156b54746bcbbc52a5fd15de3 rdf:first sg:person.01036424635.84
    106 rdf:rest Nc38394aeff0345808954bbce23fab4ee
    107 N3ee1ca2568014a0a98bae042873433c3 rdf:first sg:person.016651732002.57
    108 rdf:rest N8322a27a55864714932c1b12be25b5f3
    109 N40d58daeb86f40adbeb304ec67ffa023 schema:name doi
    110 schema:value 10.1186/1752-153x-6-34
    111 rdf:type schema:PropertyValue
    112 N4acdee89817445549dd45168f726393c rdf:first sg:person.01264736667.47
    113 rdf:rest Nec90b2ab8aad4accb0d7be5245330884
    114 N6b1c3bece7f54a30b7e4a6572978a215 schema:volumeNumber 6
    115 rdf:type schema:PublicationVolume
    116 N8322a27a55864714932c1b12be25b5f3 rdf:first sg:person.01320347756.05
    117 rdf:rest rdf:nil
    118 N9d8997d41d734b28b70d9d40e0f473f9 schema:name Springer Nature - SN SciGraph project
    119 rdf:type schema:Organization
    120 Na44f44378ab946c6beacd0419969c539 schema:name nlm_unique_id
    121 schema:value 101314213
    122 rdf:type schema:PropertyValue
    123 Nadcdc7bde4e346ef862e93f07732b3fd schema:name dimensions_id
    124 schema:value pub.1019637745
    125 rdf:type schema:PropertyValue
    126 Nc38394aeff0345808954bbce23fab4ee rdf:first sg:person.0604563143.16
    127 rdf:rest N4acdee89817445549dd45168f726393c
    128 Nec90b2ab8aad4accb0d7be5245330884 rdf:first sg:person.07704176017.63
    129 rdf:rest N3ee1ca2568014a0a98bae042873433c3
    130 Nefc9301a79f740749b42cdcc9fa30b27 schema:name readcube_id
    131 schema:value 5d905b8f809dd46c1e9d4245b5ff05451cbae8dcc305a40475c9f8fe24d01832
    132 rdf:type schema:PropertyValue
    133 Nf10772a3a7644c718d1fabc725c7899f schema:name pubmed_id
    134 schema:value 22534143
    135 rdf:type schema:PropertyValue
    136 Nf1a840a34e53481db063160535595bc1 schema:issueNumber 1
    137 rdf:type schema:PublicationIssue
    138 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    139 schema:name Biological Sciences
    140 rdf:type schema:DefinedTerm
    141 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    142 schema:name Biochemistry and Cell Biology
    143 rdf:type schema:DefinedTerm
    144 sg:journal.1039133 schema:issn 1864-6158
    145 2191-2858
    146 schema:name Chemistry Central Journal
    147 rdf:type schema:Periodical
    148 sg:person.01036424635.84 schema:affiliation https://www.grid.ac/institutes/grid.5379.8
    149 schema:familyName Thurstan
    150 schema:givenName Sarah A
    151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036424635.84
    152 rdf:type schema:Person
    153 sg:person.01264736667.47 schema:affiliation https://www.grid.ac/institutes/grid.5379.8
    154 schema:familyName Langton
    155 schema:givenName Abigail K
    156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264736667.47
    157 rdf:type schema:Person
    158 sg:person.01320347756.05 schema:affiliation https://www.grid.ac/institutes/grid.5379.8
    159 schema:familyName Sherratt
    160 schema:givenName Michael J
    161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320347756.05
    162 rdf:type schema:Person
    163 sg:person.016651732002.57 schema:affiliation https://www.grid.ac/institutes/grid.5379.8
    164 schema:familyName Watson
    165 schema:givenName Rachel EB
    166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016651732002.57
    167 rdf:type schema:Person
    168 sg:person.0604563143.16 schema:affiliation https://www.grid.ac/institutes/grid.5379.8
    169 schema:familyName Gibbs
    170 schema:givenName Neil K
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604563143.16
    172 rdf:type schema:Person
    173 sg:person.07704176017.63 schema:affiliation https://www.grid.ac/institutes/grid.5379.8
    174 schema:familyName Griffiths
    175 schema:givenName Christopher EM
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07704176017.63
    177 rdf:type schema:Person
    178 sg:pub.10.1007/b103823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085722916
    179 https://doi.org/10.1007/b103823
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1007/bf00406415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040547445
    182 https://doi.org/10.1007/bf00406415
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1007/s11357-009-9103-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016602286
    185 https://doi.org/10.1007/s11357-009-9103-6
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1023/a:1026028303196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026351662
    188 https://doi.org/10.1023/a:1026028303196
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/379335a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007036344
    191 https://doi.org/10.1038/379335a0
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/jid.1952.52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045785725
    194 https://doi.org/10.1038/jid.1952.52
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/jid.2010.276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012000285
    197 https://doi.org/10.1038/jid.2010.276
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1046/j.1523-1747.1999.00731.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048620080
    200 https://doi.org/10.1046/j.1523-1747.1999.00731.x
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1046/j.1523-1747.2001.01322.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008651004
    203 https://doi.org/10.1046/j.1523-1747.2001.01322.x
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1046/j.1523-1747.2002.01708.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016087589
    206 https://doi.org/10.1046/j.1523-1747.2002.01708.x
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1046/j.1523-1747.2003.12414.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024318079
    209 https://doi.org/10.1046/j.1523-1747.2003.12414.x
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1111/1523-1747.ep12277331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026176657
    212 https://doi.org/10.1111/1523-1747.ep12277331
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1111/1523-1747.ep12280259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045042851
    215 https://doi.org/10.1111/1523-1747.ep12280259
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1111/1523-1747.ep12325517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021420471
    218 https://doi.org/10.1111/1523-1747.ep12325517
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1111/1523-1747.ep12481882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020158299
    221 https://doi.org/10.1111/1523-1747.ep12481882
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1111/1523-1747.ep12507866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048689378
    224 https://doi.org/10.1111/1523-1747.ep12507866
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1111/1523-1747.ep12532761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006685011
    227 https://doi.org/10.1111/1523-1747.ep12532761
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1111/1523-1747.ep12874430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040948638
    230 https://doi.org/10.1111/1523-1747.ep12874430
    231 rdf:type schema:CreativeWork
    232 https://app.dimensions.ai/details/publication/pub.1075075782 schema:CreativeWork
    233 https://app.dimensions.ai/details/publication/pub.1083284285 schema:CreativeWork
    234 https://doi.org/10.1002/ar.1092380202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034522272
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1002/jps.20815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049918323
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1002/path.2730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019199651
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1016/0014-4827(61)90192-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001311041
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1016/0022-202x(89)90058-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083416482
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1016/0923-1811(94)90017-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023691362
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/b978-0-12-363710-9.50009-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047611744
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.jphotobiol.2006.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045055539
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.maturitas.2011.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017772961
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/s0047-6374(01)00225-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042448185
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/s0047-6374(01)00424-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024920958
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/s0141-8130(99)00047-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042901530
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/s0190-9622(08)80964-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012877725
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/s0190-9622(89)70276-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047912977
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1034/j.1600-0625.2002.110502.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024143648
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1034/j.1600-0781.2001.170302.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046287621
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1034/j.1600-0781.2003.00004.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003763083
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1039/b307576c schema:sameAs https://app.dimensions.ai/details/publication/pub.1041982685
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1039/b507492d schema:sameAs https://app.dimensions.ai/details/publication/pub.1026347166
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1039/c1pp05164d schema:sameAs https://app.dimensions.ai/details/publication/pub.1003606022
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1042/0264-6021:3500381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056714942
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1042/bj0970139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050149961
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1042/bj3500381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031001497
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1046/j.1523-1747.2003.12414.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024318079
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1074/jbc.m002346200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020753788
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1074/jbc.m006700200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047251272
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1080/10715760600911303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009995022
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1083/jcb.124.5.817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039775714
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1083/jcb.136.3.729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018942226
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1088/0031-9155/42/5/004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059023169
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1093/molbev/msn142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026421903
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1096/fasebj.5.13.1916105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077838273
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1098/rstb.2001.1022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006677370
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1098/rstb.2007.2134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010143563
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1111/j.0909-725x.2006.00135.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030859605
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1111/j.0909-752x.2006.00146.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036608518
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1111/j.1365-2133.1968.tb12322.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051961251
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1111/j.1365-2133.1975.tb05113.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033703040
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1111/j.1365-2133.2005.06716.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046440917
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1111/j.1365-2133.2007.08108.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049670595
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1111/j.1365-4362.1994.tb01540.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028500107
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1111/j.1432-1033.1982.tb05868.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040318611
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1111/j.1432-1033.1995.0001f.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019328472
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1111/j.1468-2494.2010.00574.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050423377
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1111/j.1600-0625.2008.00786.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039542095
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1111/j.1751-1097.1991.tb02071.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040881331
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1111/j.1751-1097.1998.tb02480.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027953684
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1111/j.1751-1097.2007.00275.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034122914
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1126/science.1122446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033927661
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1146/annurev.cb.04.110188.001305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000077747
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1159/000051543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043649010
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1159/000212969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042166380
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1172/jci115204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027262920
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1515/bc.2002.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048086430
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.3109/03008207409152242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025969603
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.4161/cc.8.11.8595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300031
    345 rdf:type schema:CreativeWork
    346 https://www.grid.ac/institutes/grid.5379.8 schema:alternateName University of Manchester
    347 schema:name Developmental Biomedicine Research Groups, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    348 Inflammation Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    349 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...