Simple isatin derivatives as free radical scavengers: Synthesis, biological evaluation and structure-activity relationship View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Gang Chen, Ye Wang, Xiaojiang Hao, Shuzhen Mu, Qianyun Sun

ABSTRACT

To develop more potent small molecules with enhanced free radical scavenger properties, a series of N-substituted isatin derivatives was synthesized, and the cytoprotective effect on the apoptosis of PC12 cells induced by H2O2 was screened. All these compounds were found to be active, and N-ethyl isatin was found with the most potent activity of 69.7% protective effect on PC12 cells. Structure-activity relationship analyses showed the bioactivity of N-alkyl isatins decline as the increasing of the chain of the alkyl group, furthermore odd-even effect was found in the activity, which is interesting for further investigation. More... »

PAGES

37

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1752-153x-5-37

DOI

http://dx.doi.org/10.1186/1752-153x-5-37

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041155589

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21722377


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