Modeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Pernille Yde, Benedicte Mengel, Mogens H Jensen, Sandeep Krishna, Ala Trusina

ABSTRACT

BACKGROUND: Waves propagating in "excitable media" is a reliable way to transmit signals in space. A fascinating example where living cells comprise such a medium is Dictyostelium D. which propagates waves of chemoattractant to attract distant cells. While neutrophils chemotax in a similar fashion as Dictyostelium D., it is unclear if chemoattractant waves exist in mammalian tissues and what mechanisms could propagate them. RESULTS: We propose that chemoattractant cytokine waves may naturally develop as a result of NF-κB response. Using a heuristic mathematical model of NF-κB-like circuits coupled in space we show that the known characteristics of NF-κB response favor cytokine waves. CONCLUSIONS: While the propagating wave of cytokines is generally beneficial for inflammation resolution, our model predicts that there exist special conditions that can cause chronic inflammation and re-occurrence of acute inflammatory response. More... »

PAGES

115

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1752-0509-5-115

DOI

http://dx.doi.org/10.1186/1752-0509-5-115

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023471183

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21771307


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57 schema:description BACKGROUND: Waves propagating in "excitable media" is a reliable way to transmit signals in space. A fascinating example where living cells comprise such a medium is Dictyostelium D. which propagates waves of chemoattractant to attract distant cells. While neutrophils chemotax in a similar fashion as Dictyostelium D., it is unclear if chemoattractant waves exist in mammalian tissues and what mechanisms could propagate them. RESULTS: We propose that chemoattractant cytokine waves may naturally develop as a result of NF-κB response. Using a heuristic mathematical model of NF-κB-like circuits coupled in space we show that the known characteristics of NF-κB response favor cytokine waves. CONCLUSIONS: While the propagating wave of cytokines is generally beneficial for inflammation resolution, our model predicts that there exist special conditions that can cause chronic inflammation and re-occurrence of acute inflammatory response.
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