Tularemia in Alaska, 1938 - 2010 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-11-18

AUTHORS

Cristina M Hansen, Amy J Vogler, Paul Keim, David M Wagner, Karsten Hueffer

ABSTRACT

Tularemia is a serious, potentially life threatening zoonotic disease. The causative agent, Francisella tularensis, is ubiquitous in the Northern hemisphere, including Alaska, where it was first isolated from a rabbit tick (Haemophysalis leporis-palustris) in 1938. Since then, F. tularensis has been isolated from wildlife and humans throughout the state. Serologic surveys have found measurable antibodies with prevalence ranging from < 1% to 50% and 4% to 18% for selected populations of wildlife species and humans, respectively. We reviewed and summarized known literature on tularemia surveillance in Alaska and summarized the epidemiological information on human cases reported to public health officials. Additionally, available F. tularensis isolates from Alaska were analyzed using canonical SNPs and a multi-locus variable-number tandem repeats (VNTR) analysis (MLVA) system. The results show that both F. t. tularensis and F. t. holarctica are present in Alaska and that subtype A.I, the most virulent type, is responsible for most recently reported human clinical cases in the state. More... »

PAGES

61-61

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1751-0147-53-61

DOI

http://dx.doi.org/10.1186/1751-0147-53-61

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047031633

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22099502


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