Immunization with HIV protease peptides linked to syngeneic erythrocytes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-12

AUTHORS

Andreas Boberg, Sabrina Dominici, Andreas Brave, Kristian Hallermalm, Jorma Hinkula, Mauro Magnani, Britta Wahren

ABSTRACT

New potent vaccine adjuvants are desirable for increasing the efficacy of novel vaccine modalities such as DNA and peptides. We therefore tested if syngeneic erythrocytes could serve as delivery vectors for selected HIV peptides and compared the potency of these constructs to immunization with peptides in phosphate buffered saline or in incomplete Freunds adjuvant. Immunization of mice with peptides in a low dose (5 ng) coupled to erythrocytes induced a weak immune response in mice. These peptides alone (5 microg) gave no immune responses, while formulating the peptides (50 microg) in IFA induced strong homologous immunity as well as prominent cross reactivity to a related mutant epitope. Thus, vaccine delivery using syngeneic erythrocytes, although attractive for clinical use, might be of limited value due to the low amount of antigen that can be loaded per erythrocyte. More... »

PAGES

9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1750-9378-2-9

DOI

http://dx.doi.org/10.1186/1750-9378-2-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017934536

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17442099


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141 https://www.grid.ac/institutes/grid.419734.c schema:alternateName Public Health Agency of Sweden
142 schema:name Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
143 Swedish Institute for Infectious Disease Control, Stockholm, Sweden
144 rdf:type schema:Organization
145 https://www.grid.ac/institutes/grid.5640.7 schema:alternateName Linköping University
146 schema:name Department for Molecular Virology, IMK, Faculty of Health Science, Linköping University, Linköping, Sweden
147 rdf:type schema:Organization
 




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