High serum levels of soluble CD40-L in patients with undifferentiated nasopharyngeal carcinoma: pathogenic and clinical relevance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-12

AUTHORS

Laura Caggiari, Massimo Guidoboni, Emanuela Vaccher, Luigi Barzan, Giovanni Franchin, Annunziata Gloghini, Debora Martorelli, Paola Zancai, Maria Teresa Bortolin, Mario Mazzucato, Diego Serraino, Antonino Carbone, Paolo De Paoli, Riccardo Dolcetti

ABSTRACT

BACKGROUND: Engagement of CD40 promotes survival of undifferentiated nasopharyngeal carcinoma (UNPC) cells and similar effects are induced by the EBV oncoprotein LMP-1 that is expressed in a fraction of cases. Considering that CD40 may be activated also by the soluble isoform of CD40L (sCD40L), we investigated the serum levels of sCD40L in a series of 61 UNPC patients from Italy, a non-endemic area for this disease. RESULTS: At diagnosis, serum samples of UNPC patients contained significantly higher levels of sCD40L than age-matched healthy controls (p < 0.001). High levels of sCD40L (i.e., >18 ng/ml) were more frequently found in patients <40 years of age (p = 0.03) and with distant metastases at presentation (p = 0.03). Serum levels of sCD40L were inversely associated with the expression of the EBV oncoprotein LMP-1 (p = 0.03), which mimics a constitutively activated CD40. The amount of sCD40L decreased in a fraction of patients treated with local radiotherapy alone. Moreover, CD40L+ lymphoid cells admixed to neoplastic UNPC cells were detected in cases with high serum levels of sCD40L, suggesting that sCD40L is probably produced within the tumor mass. CONCLUSION: sCD40L may contribute to CD40 activation in UNPC cells, particularly of LMP-1-negative cases, further supporting the crucial role of CD40 signalling in the pathogenesis of UNPC. sCD40L levels may be useful to identify UNPC patients with occult distant metastases at presentation. More... »

PAGES

5

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1750-9378-2-5

DOI

http://dx.doi.org/10.1186/1750-9378-2-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012991254

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17331231


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Dept. of Pre-Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caggiari", 
        "givenName": "Laura", 
        "id": "sg:person.0753207414.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753207414.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dept. of Pre-Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guidoboni", 
        "givenName": "Massimo", 
        "id": "sg:person.0603211266.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603211266.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dept. of Medical Oncology, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vaccher", 
        "givenName": "Emanuela", 
        "id": "sg:person.0615230720.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615230720.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Head and Neck Department, Azienda Ospedaliera, Pordenone, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barzan", 
        "givenName": "Luigi", 
        "id": "sg:person.01074222612.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074222612.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dept. of Radiotherapy, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franchin", 
        "givenName": "Giovanni", 
        "id": "sg:person.01210122332.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210122332.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dept. of Pathology, Diagnostic Immunohistochemistry and Molecular Pathology Unit, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gloghini", 
        "givenName": "Annunziata", 
        "id": "sg:person.01366355245.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366355245.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dept. of Pre-Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martorelli", 
        "givenName": "Debora", 
        "id": "sg:person.0721015071.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721015071.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dept. of Pre-Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zancai", 
        "givenName": "Paola", 
        "id": "sg:person.01203750411.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203750411.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Microbiology Unit, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bortolin", 
        "givenName": "Maria Teresa", 
        "id": "sg:person.01105510710.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105510710.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Blood Bank, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mazzucato", 
        "givenName": "Mario", 
        "id": "sg:person.01173533766.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173533766.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dept. of Pre-Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Serraino", 
        "givenName": "Diego", 
        "id": "sg:person.01026414135.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026414135.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Dept. of Pathology, Istituto Nazionale Tumori, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carbone", 
        "givenName": "Antonino", 
        "id": "sg:person.015771501257.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015771501257.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Microbiology Unit, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Paoli", 
        "givenName": "Paolo", 
        "id": "sg:person.01075120733.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075120733.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dept. of Pre-Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy", 
            "Immunovirology and Biotherapy Unit, Centro di Riferimento Oncologico, National Cancer Institute, Via Franco Gallini 2, 33081, Aviano (PN), Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dolcetti", 
        "givenName": "Riccardo", 
        "id": "sg:person.01271561571.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271561571.82"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19971114)73:4<562::aid-ijc18>3.0.co;2-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002928727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19830715)52:2<362::aid-cncr2820520230>3.0.co;2-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003747716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2005.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007595699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2005.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007595699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1368-8375(01)00034-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008985844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19991115)86:10<1912::aid-cncr6>3.0.co;2-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009560890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4613-1747-0_10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009741716", 
          "https://doi.org/10.1007/978-1-4613-1747-0_10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.11.5965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016536860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-230x(03)87296-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016861144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-230x(03)87296-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016861144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19870301)59:5<945::aid-cncr2820590516>3.0.co;2-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020928406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2273.1989.tb00337.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022096098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0898-6568(02)00083-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023228174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0898-6568(02)00083-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023228174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/scbi.2001.0410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026522683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830250639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026933911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1529-0131(199905)42:5<871::aid-anr5>3.0.co;2-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027671320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1044579x0200086x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029015588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1044579x0200086x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029015588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-5699(98)01340-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030160678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65269-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033667072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.2001.5256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035074309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.critrevonc.2003.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035439023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/344777a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035874104", 
          "https://doi.org/10.1038/344777a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80408-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036329573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-0348-03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040565107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1044579x02000883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041079992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1044579x02000883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041079992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.1998.00522.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041501246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.1998.00522.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041501246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01200735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043673330", 
          "https://doi.org/10.1007/bf01200735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01200735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043673330", 
          "https://doi.org/10.1007/bf01200735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000215781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046160152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047482756", 
          "https://doi.org/10.1038/35393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047482756", 
          "https://doi.org/10.1038/35393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.16.1.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047761374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(97)00104-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048699902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cdli.8.6.1104-1109.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050169626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2007-1002578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057477199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.286.5438.300", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062566886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/32.2.6198355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064094424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/32.2.6198355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064094424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.18.4.669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071511616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.23.6.1697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071515213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.29.3.595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071516127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074253948", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlb.67.1.2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074581398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074651028", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074718595", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074968482", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075099834", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-002-0333-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075220398", 
          "https://doi.org/10.1007/s00262-002-0333-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075489813", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076803581", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077003916", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078401977", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080835239", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081805285", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082419535", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082419542", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082882746", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.4.1310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083246618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083310007", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-12", 
    "datePublishedReg": "2007-12-01", 
    "description": "BACKGROUND: Engagement of CD40 promotes survival of undifferentiated nasopharyngeal carcinoma (UNPC) cells and similar effects are induced by the EBV oncoprotein LMP-1 that is expressed in a fraction of cases. Considering that CD40 may be activated also by the soluble isoform of CD40L (sCD40L), we investigated the serum levels of sCD40L in a series of 61 UNPC patients from Italy, a non-endemic area for this disease.\nRESULTS: At diagnosis, serum samples of UNPC patients contained significantly higher levels of sCD40L than age-matched healthy controls (p < 0.001). High levels of sCD40L (i.e., >18 ng/ml) were more frequently found in patients <40 years of age (p = 0.03) and with distant metastases at presentation (p = 0.03). Serum levels of sCD40L were inversely associated with the expression of the EBV oncoprotein LMP-1 (p = 0.03), which mimics a constitutively activated CD40. The amount of sCD40L decreased in a fraction of patients treated with local radiotherapy alone. Moreover, CD40L+ lymphoid cells admixed to neoplastic UNPC cells were detected in cases with high serum levels of sCD40L, suggesting that sCD40L is probably produced within the tumor mass.\nCONCLUSION: sCD40L may contribute to CD40 activation in UNPC cells, particularly of LMP-1-negative cases, further supporting the crucial role of CD40 signalling in the pathogenesis of UNPC. sCD40L levels may be useful to identify UNPC patients with occult distant metastases at presentation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1750-9378-2-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1037008", 
        "issn": [
          "1750-9378"
        ], 
        "name": "Infectious Agents and Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "name": "High serum levels of soluble CD40-L in patients with undifferentiated nasopharyngeal carcinoma: pathogenic and clinical relevance", 
    "pagination": "5", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3de3d3b1baf2b60f89641517dc7a64e5fbb7c2a1d481b56a1917491f2803f1a7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17331231"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101276559"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1750-9378-2-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012991254"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1750-9378-2-5", 
      "https://app.dimensions.ai/details/publication/pub.1012991254"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000536.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1750-9378-2-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1750-9378-2-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1750-9378-2-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1750-9378-2-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1750-9378-2-5'


 

This table displays all metadata directly associated to this object as RDF triples.

338 TRIPLES      21 PREDICATES      83 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1750-9378-2-5 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N3a7226dcd16b46f4bb7bc1856a7f5754
4 schema:citation sg:pub.10.1007/978-1-4613-1747-0_10
5 sg:pub.10.1007/bf01200735
6 sg:pub.10.1007/s00262-002-0333-z
7 sg:pub.10.1038/344777a0
8 sg:pub.10.1038/35393
9 https://app.dimensions.ai/details/publication/pub.1074253948
10 https://app.dimensions.ai/details/publication/pub.1074651028
11 https://app.dimensions.ai/details/publication/pub.1074718595
12 https://app.dimensions.ai/details/publication/pub.1074968482
13 https://app.dimensions.ai/details/publication/pub.1075099834
14 https://app.dimensions.ai/details/publication/pub.1075489813
15 https://app.dimensions.ai/details/publication/pub.1076803581
16 https://app.dimensions.ai/details/publication/pub.1077003916
17 https://app.dimensions.ai/details/publication/pub.1078401977
18 https://app.dimensions.ai/details/publication/pub.1080835239
19 https://app.dimensions.ai/details/publication/pub.1081805285
20 https://app.dimensions.ai/details/publication/pub.1082419535
21 https://app.dimensions.ai/details/publication/pub.1082419542
22 https://app.dimensions.ai/details/publication/pub.1082882746
23 https://app.dimensions.ai/details/publication/pub.1083310007
24 https://doi.org/10.1002/(sici)1097-0142(19991115)86:10<1912::aid-cncr6>3.0.co;2-s
25 https://doi.org/10.1002/(sici)1097-0215(19971114)73:4<562::aid-ijc18>3.0.co;2-b
26 https://doi.org/10.1002/1097-0142(19830715)52:2<362::aid-cncr2820520230>3.0.co;2-v
27 https://doi.org/10.1002/1097-0142(19870301)59:5<945::aid-cncr2820590516>3.0.co;2-b
28 https://doi.org/10.1002/1529-0131(199905)42:5<871::aid-anr5>3.0.co;2-j
29 https://doi.org/10.1002/eji.1830250639
30 https://doi.org/10.1002/jlb.67.1.2
31 https://doi.org/10.1006/excr.2001.5256
32 https://doi.org/10.1006/scbi.2001.0410
33 https://doi.org/10.1016/j.canlet.2005.03.015
34 https://doi.org/10.1016/j.critrevonc.2003.10.008
35 https://doi.org/10.1016/s0002-9440(10)65269-8
36 https://doi.org/10.1016/s0065-230x(03)87296-2
37 https://doi.org/10.1016/s0167-5699(98)01340-1
38 https://doi.org/10.1016/s0360-3016(97)00104-1
39 https://doi.org/10.1016/s0898-6568(02)00083-9
40 https://doi.org/10.1016/s1044579x0200086x
41 https://doi.org/10.1016/s1044579x02000883
42 https://doi.org/10.1016/s1074-7613(00)80408-2
43 https://doi.org/10.1016/s1368-8375(01)00034-3
44 https://doi.org/10.1046/j.1365-2141.1998.00522.x
45 https://doi.org/10.1055/s-2007-1002578
46 https://doi.org/10.1074/jbc.271.11.5965
47 https://doi.org/10.1111/j.1365-2273.1989.tb00337.x
48 https://doi.org/10.1126/science.286.5438.300
49 https://doi.org/10.1128/cdli.8.6.1104-1109.2001
50 https://doi.org/10.1146/annurev.immunol.16.1.111
51 https://doi.org/10.1158/1078-0432.ccr-0348-03
52 https://doi.org/10.1159/000215781
53 https://doi.org/10.1177/32.2.6198355
54 https://doi.org/10.1200/jco.1998.16.4.1310
55 https://doi.org/10.3892/ijo.18.4.669
56 https://doi.org/10.3892/ijo.23.6.1697
57 https://doi.org/10.3892/ijo.29.3.595
58 schema:datePublished 2007-12
59 schema:datePublishedReg 2007-12-01
60 schema:description BACKGROUND: Engagement of CD40 promotes survival of undifferentiated nasopharyngeal carcinoma (UNPC) cells and similar effects are induced by the EBV oncoprotein LMP-1 that is expressed in a fraction of cases. Considering that CD40 may be activated also by the soluble isoform of CD40L (sCD40L), we investigated the serum levels of sCD40L in a series of 61 UNPC patients from Italy, a non-endemic area for this disease. RESULTS: At diagnosis, serum samples of UNPC patients contained significantly higher levels of sCD40L than age-matched healthy controls (p < 0.001). High levels of sCD40L (i.e., >18 ng/ml) were more frequently found in patients <40 years of age (p = 0.03) and with distant metastases at presentation (p = 0.03). Serum levels of sCD40L were inversely associated with the expression of the EBV oncoprotein LMP-1 (p = 0.03), which mimics a constitutively activated CD40. The amount of sCD40L decreased in a fraction of patients treated with local radiotherapy alone. Moreover, CD40L+ lymphoid cells admixed to neoplastic UNPC cells were detected in cases with high serum levels of sCD40L, suggesting that sCD40L is probably produced within the tumor mass. CONCLUSION: sCD40L may contribute to CD40 activation in UNPC cells, particularly of LMP-1-negative cases, further supporting the crucial role of CD40 signalling in the pathogenesis of UNPC. sCD40L levels may be useful to identify UNPC patients with occult distant metastases at presentation.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N36abbe2934404ff9b17960320cc3c6c7
65 N95ab06178e8b48728dec210cbfd30fb4
66 sg:journal.1037008
67 schema:name High serum levels of soluble CD40-L in patients with undifferentiated nasopharyngeal carcinoma: pathogenic and clinical relevance
68 schema:pagination 5
69 schema:productId N28f6352c63904ec99f72bc1fdf03e050
70 N99ba6ed77b9f4b57b3753ba6eab5d55d
71 Nd05db0ef1555402aa2e77f3b757bdde7
72 Nf1def1a59ef74167a8927df52c51237f
73 Nfd3d67f3984544a4a60ab46f90a820e6
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012991254
75 https://doi.org/10.1186/1750-9378-2-5
76 schema:sdDatePublished 2019-04-11T00:21
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nbf7c884ad2a044e993f8cd2c62294220
79 schema:url http://link.springer.com/10.1186%2F1750-9378-2-5
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N01359021464d4e1cb944ea4fcf499f60 rdf:first sg:person.0603211266.70
84 rdf:rest Nce62fa7ac19e4c728581ecb096d98e28
85 N03ef6afe6730423fb7f58c3b414fa09a rdf:first sg:person.01210122332.09
86 rdf:rest Ne6976636b74b41ca9fc3103925ed1137
87 N1005c107adf64106892ccb153040fb0e schema:name Dept. of Pre-Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy
88 rdf:type schema:Organization
89 N185dd274225f4e7fbe98c1f2eaac5289 schema:name Dept. of Pre-Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy
90 Immunovirology and Biotherapy Unit, Centro di Riferimento Oncologico, National Cancer Institute, Via Franco Gallini 2, 33081, Aviano (PN), Italy
91 rdf:type schema:Organization
92 N1da38428386f4407a13a1a5c32b48209 rdf:first sg:person.01173533766.41
93 rdf:rest N5ea26143eb4d42fca82e3b9050708c7f
94 N28f6352c63904ec99f72bc1fdf03e050 schema:name readcube_id
95 schema:value 3de3d3b1baf2b60f89641517dc7a64e5fbb7c2a1d481b56a1917491f2803f1a7
96 rdf:type schema:PropertyValue
97 N2b2bdaebf7734a4d850bfdbd26e7cef9 schema:name Dept. of Radiotherapy, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy
98 rdf:type schema:Organization
99 N2ccf7591b207423eb0a33ef5abc7965d rdf:first sg:person.01271561571.82
100 rdf:rest rdf:nil
101 N36abbe2934404ff9b17960320cc3c6c7 schema:volumeNumber 2
102 rdf:type schema:PublicationVolume
103 N3a7226dcd16b46f4bb7bc1856a7f5754 rdf:first sg:person.0753207414.27
104 rdf:rest N01359021464d4e1cb944ea4fcf499f60
105 N53b4c779b8f04f6cb64c353c07e90bba schema:name Head and Neck Department, Azienda Ospedaliera, Pordenone, Italy
106 rdf:type schema:Organization
107 N5808f22a50d2449389c0914214f9f025 rdf:first sg:person.01074222612.10
108 rdf:rest N03ef6afe6730423fb7f58c3b414fa09a
109 N5ea26143eb4d42fca82e3b9050708c7f rdf:first sg:person.01026414135.91
110 rdf:rest N6fb2ca1663df465bb5310377f1cf4130
111 N618a5f7562cd4aac912f9ae680601810 rdf:first sg:person.01203750411.43
112 rdf:rest Naddd75d486b54b438197208881f65d01
113 N6968180e415742cb8a597e4913b187c8 schema:name Dept. of Pathology, Diagnostic Immunohistochemistry and Molecular Pathology Unit, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy
114 rdf:type schema:Organization
115 N6fb2ca1663df465bb5310377f1cf4130 rdf:first sg:person.015771501257.75
116 rdf:rest N73463c6d244d4de0a55a2a446a38d3b0
117 N73463c6d244d4de0a55a2a446a38d3b0 rdf:first sg:person.01075120733.33
118 rdf:rest N2ccf7591b207423eb0a33ef5abc7965d
119 N8abc90060c9e41c1a267744354a9884f schema:name Dept. of Pre-Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy
120 rdf:type schema:Organization
121 N95ab06178e8b48728dec210cbfd30fb4 schema:issueNumber 1
122 rdf:type schema:PublicationIssue
123 N99ba6ed77b9f4b57b3753ba6eab5d55d schema:name dimensions_id
124 schema:value pub.1012991254
125 rdf:type schema:PropertyValue
126 Nad064eee640e45318e0b72d52fdf1aba schema:name Dept. of Pre-Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy
127 rdf:type schema:Organization
128 Naddd75d486b54b438197208881f65d01 rdf:first sg:person.01105510710.66
129 rdf:rest N1da38428386f4407a13a1a5c32b48209
130 Nb61fd3f2ae144b31bda6c0dd466fb407 schema:name Dept. of Medical Oncology, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy
131 rdf:type schema:Organization
132 Nbf7c884ad2a044e993f8cd2c62294220 schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 Nce62fa7ac19e4c728581ecb096d98e28 rdf:first sg:person.0615230720.01
135 rdf:rest N5808f22a50d2449389c0914214f9f025
136 Ncfb821f5a4674c5ba6cf7424d128e97e rdf:first sg:person.0721015071.14
137 rdf:rest N618a5f7562cd4aac912f9ae680601810
138 Nd05db0ef1555402aa2e77f3b757bdde7 schema:name pubmed_id
139 schema:value 17331231
140 rdf:type schema:PropertyValue
141 Nd92fb807361d42e6a8c507b9225a2b52 schema:name Microbiology Unit, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy
142 rdf:type schema:Organization
143 Ndabc59ba0410435c9ddcc2406e3c634d schema:name Dept. of Pre-Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy
144 rdf:type schema:Organization
145 Ne1b7cbbfe6c345738db72f4b124f57cf schema:name Microbiology Unit, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy
146 rdf:type schema:Organization
147 Ne6976636b74b41ca9fc3103925ed1137 rdf:first sg:person.01366355245.45
148 rdf:rest Ncfb821f5a4674c5ba6cf7424d128e97e
149 Nf1def1a59ef74167a8927df52c51237f schema:name nlm_unique_id
150 schema:value 101276559
151 rdf:type schema:PropertyValue
152 Nfd3d67f3984544a4a60ab46f90a820e6 schema:name doi
153 schema:value 10.1186/1750-9378-2-5
154 rdf:type schema:PropertyValue
155 Nfe1eba6868324469a9c998eddd88915d schema:name Blood Bank, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy
156 rdf:type schema:Organization
157 Nff6b9c269d8c4dd4947e476fb4223229 schema:name Dept. of Pre-Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS - National Cancer Institute, Aviano (PN), Italy
158 rdf:type schema:Organization
159 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
160 schema:name Medical and Health Sciences
161 rdf:type schema:DefinedTerm
162 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
163 schema:name Oncology and Carcinogenesis
164 rdf:type schema:DefinedTerm
165 sg:journal.1037008 schema:issn 1750-9378
166 schema:name Infectious Agents and Cancer
167 rdf:type schema:Periodical
168 sg:person.01026414135.91 schema:affiliation Nad064eee640e45318e0b72d52fdf1aba
169 schema:familyName Serraino
170 schema:givenName Diego
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026414135.91
172 rdf:type schema:Person
173 sg:person.01074222612.10 schema:affiliation N53b4c779b8f04f6cb64c353c07e90bba
174 schema:familyName Barzan
175 schema:givenName Luigi
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074222612.10
177 rdf:type schema:Person
178 sg:person.01075120733.33 schema:affiliation Nd92fb807361d42e6a8c507b9225a2b52
179 schema:familyName De Paoli
180 schema:givenName Paolo
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075120733.33
182 rdf:type schema:Person
183 sg:person.01105510710.66 schema:affiliation Ne1b7cbbfe6c345738db72f4b124f57cf
184 schema:familyName Bortolin
185 schema:givenName Maria Teresa
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105510710.66
187 rdf:type schema:Person
188 sg:person.01173533766.41 schema:affiliation Nfe1eba6868324469a9c998eddd88915d
189 schema:familyName Mazzucato
190 schema:givenName Mario
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173533766.41
192 rdf:type schema:Person
193 sg:person.01203750411.43 schema:affiliation N1005c107adf64106892ccb153040fb0e
194 schema:familyName Zancai
195 schema:givenName Paola
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203750411.43
197 rdf:type schema:Person
198 sg:person.01210122332.09 schema:affiliation N2b2bdaebf7734a4d850bfdbd26e7cef9
199 schema:familyName Franchin
200 schema:givenName Giovanni
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210122332.09
202 rdf:type schema:Person
203 sg:person.01271561571.82 schema:affiliation N185dd274225f4e7fbe98c1f2eaac5289
204 schema:familyName Dolcetti
205 schema:givenName Riccardo
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271561571.82
207 rdf:type schema:Person
208 sg:person.01366355245.45 schema:affiliation N6968180e415742cb8a597e4913b187c8
209 schema:familyName Gloghini
210 schema:givenName Annunziata
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366355245.45
212 rdf:type schema:Person
213 sg:person.015771501257.75 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
214 schema:familyName Carbone
215 schema:givenName Antonino
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015771501257.75
217 rdf:type schema:Person
218 sg:person.0603211266.70 schema:affiliation Nff6b9c269d8c4dd4947e476fb4223229
219 schema:familyName Guidoboni
220 schema:givenName Massimo
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603211266.70
222 rdf:type schema:Person
223 sg:person.0615230720.01 schema:affiliation Nb61fd3f2ae144b31bda6c0dd466fb407
224 schema:familyName Vaccher
225 schema:givenName Emanuela
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615230720.01
227 rdf:type schema:Person
228 sg:person.0721015071.14 schema:affiliation Ndabc59ba0410435c9ddcc2406e3c634d
229 schema:familyName Martorelli
230 schema:givenName Debora
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721015071.14
232 rdf:type schema:Person
233 sg:person.0753207414.27 schema:affiliation N8abc90060c9e41c1a267744354a9884f
234 schema:familyName Caggiari
235 schema:givenName Laura
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753207414.27
237 rdf:type schema:Person
238 sg:pub.10.1007/978-1-4613-1747-0_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009741716
239 https://doi.org/10.1007/978-1-4613-1747-0_10
240 rdf:type schema:CreativeWork
241 sg:pub.10.1007/bf01200735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043673330
242 https://doi.org/10.1007/bf01200735
243 rdf:type schema:CreativeWork
244 sg:pub.10.1007/s00262-002-0333-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1075220398
245 https://doi.org/10.1007/s00262-002-0333-z
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/344777a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035874104
248 https://doi.org/10.1038/344777a0
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/35393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047482756
251 https://doi.org/10.1038/35393
252 rdf:type schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1074253948 schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1074651028 schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1074718595 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1074968482 schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1075099834 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1075489813 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1076803581 schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1077003916 schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1078401977 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1080835239 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1081805285 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1082419535 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1082419542 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1082882746 schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1083310007 schema:CreativeWork
268 https://doi.org/10.1002/(sici)1097-0142(19991115)86:10<1912::aid-cncr6>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1009560890
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1002/(sici)1097-0215(19971114)73:4<562::aid-ijc18>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1002928727
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1002/1097-0142(19830715)52:2<362::aid-cncr2820520230>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1003747716
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1002/1097-0142(19870301)59:5<945::aid-cncr2820590516>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1020928406
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1002/1529-0131(199905)42:5<871::aid-anr5>3.0.co;2-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1027671320
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1002/eji.1830250639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026933911
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1002/jlb.67.1.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074581398
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1006/excr.2001.5256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035074309
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1006/scbi.2001.0410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026522683
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.canlet.2005.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007595699
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.critrevonc.2003.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035439023
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/s0002-9440(10)65269-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033667072
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/s0065-230x(03)87296-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016861144
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/s0167-5699(98)01340-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030160678
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/s0360-3016(97)00104-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048699902
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/s0898-6568(02)00083-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023228174
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/s1044579x0200086x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029015588
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/s1044579x02000883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041079992
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/s1074-7613(00)80408-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036329573
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/s1368-8375(01)00034-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008985844
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1046/j.1365-2141.1998.00522.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041501246
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1055/s-2007-1002578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057477199
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1074/jbc.271.11.5965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016536860
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1111/j.1365-2273.1989.tb00337.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022096098
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1126/science.286.5438.300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062566886
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1128/cdli.8.6.1104-1109.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050169626
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1146/annurev.immunol.16.1.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047761374
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1158/1078-0432.ccr-0348-03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040565107
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1159/000215781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046160152
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1177/32.2.6198355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064094424
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1200/jco.1998.16.4.1310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083246618
329 rdf:type schema:CreativeWork
330 https://doi.org/10.3892/ijo.18.4.669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071511616
331 rdf:type schema:CreativeWork
332 https://doi.org/10.3892/ijo.23.6.1697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071515213
333 rdf:type schema:CreativeWork
334 https://doi.org/10.3892/ijo.29.3.595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071516127
335 rdf:type schema:CreativeWork
336 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
337 schema:name Dept. of Pathology, Istituto Nazionale Tumori, Milan, Italy
338 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...