Effect of an herbal extract Number Ten (NT) on body weight in rats View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-09-14

AUTHORS

David A York, Sonyja Thomas, Frank L Greenway, Zhijun Liu, Jennifer C Rood

ABSTRACT

BackgroundChinese herbal extract Number Ten (NT) is a dietary herbal formulation prepared from rhubarb, ginger, astragalus, red sage and tumeric. This study tested the effectiveness of NT in reducing body weight gain in rats.MethodsSixty female Wistar rats were fed a high fat diet and acclimated to gavage feeding. The rats were divided into five treatment groups: (1) Control (n = 15); (2) NT-H (n = 15), 1.5 g/day; (3) NT-L (n = 10), 0.75 g/day; (4) Pr-fed (n = 10), pair fed to NT-H; (5) d-FF (n = 10), d-fenfluramine 2 mg/kg. Ten rats per group were sacrificed on day 56. Weight, food intake, clinical chemistry and body composition were evaluated. Five animals in the control and 1.5 g/day NT groups were left untreated during a two week recovery period.ResultsThe 0.75 g/day NT, 1.5 g/day NT, d-fenfluramine and pair fed groups gained 24.6%, 33.3%, 12.3% and 33.3% less than the control respectively (P < 0.0006). Leptin decreased 27.5% to 46.2% in the treatment groups vs. control (P < 0.009). Parametrial fat decreased 14.1% to 55.5% in the NT and pair fed groups vs. control (P < 0.006). The NT groups had soft stools, loss of hair around the mouth and coloration to the urine and stool without evidence of blood or bilirubin (attributed to chromogens in NT). There were no differences between groups in the clinical chemistry.ConclusionThis study demonstrated the efficacy of NT in reducing weight gain in rodents. More... »

PAGES

10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1749-8546-2-10

DOI

http://dx.doi.org/10.1186/1749-8546-2-10

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031775843

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17868447


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