Postembryonic neuronal addition in Zebrafish dorsal root ganglia is regulated by Notch signaling View Full Text


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Article Info

DATE

2012-06-27

AUTHORS

Hillary Faye McGraw, Corey D Snelson, Andrew Prendergast, Arminda Suli, David W Raible

ABSTRACT

BackgroundThe sensory neurons and glia of the dorsal root ganglia (DRG) arise from neural crest cells in the developing vertebrate embryo. In mouse and chick, DRG formation is completed during embryogenesis. In contrast, zebrafish continue to add neurons and glia to the DRG into adulthood, long after neural crest migration is complete. The molecular and cellular regulation of late DRG growth in the zebrafish remains to be characterized.ResultsIn the present study, we use transgenic zebrafish lines to examine neuronal addition during postembryonic DRG growth. Neuronal addition is continuous over the period of larval development. Fate-mapping experiments support the hypothesis that new neurons are added from a population of resident, neural crest-derived progenitor cells. Conditional inhibition of Notch signaling was used to assess the role of this signaling pathway in neuronal addition. An increase in the number of DRG neurons is seen when Notch signaling is inhibited during both early and late larval development.ConclusionsPostembryonic growth of the zebrafish DRG comes about, in part, by addition of new neurons from a resident progenitor population, a process regulated by Notch signaling. More... »

PAGES

23

References to SciGraph publications

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  • 2007-08-26. Differential Notch signalling distinguishes neural stem cells from intermediate progenitors in NATURE
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  • 2006-02. Notch signalling in vertebrate neural development in NATURE REVIEWS NEUROSCIENCE
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  • 2009-03-11. Transient and Stable Transgenesis Using Tol2 Transposon Vectors in ZEBRAFISH
  • 1984. The Development of the Rat Spinal Cord in NONE
  • 2003-05-06. Neomycin-Induced Hair Cell Death and Rapid Regeneration in the Lateral Line of Zebrafish (Danio rerio) in JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
  • 1997-11. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation in CHROMOSOMA
  • 2007-09-02. Nociceptive sensory neurons derive from contralaterally migrating, fate-restricted neural crest cells in NATURE NEUROSCIENCE
  • 2006. Specification of Sensory Neuron Cell Fate from the Neural Crest in NEURAL CREST INDUCTION AND DIFFERENTIATION
  • 2007-10-26. The neuropathic pain triad: neurons, immune cells and glia in NATURE NEUROSCIENCE
  • 2007-02. Specification and connectivity of neuronal subtypes in the sensory lineage in NATURE REVIEWS NEUROSCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1749-8104-7-23

    DOI

    http://dx.doi.org/10.1186/1749-8104-7-23

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031092645

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22738203


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