Developmental patterning of glutamatergic synapses onto retinal ganglion cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-03-26

AUTHORS

Josh L Morgan, Timm Schubert, Rachel OL Wong

ABSTRACT

BackgroundNeurons receive excitatory synaptic inputs that are distributed across their dendritic arbors at densities and with spatial patterns that influence their output. How specific synaptic distributions are attained during development is not well understood. The distribution of glutamatergic inputs across the dendritic arbors of mammalian retinal ganglion cells (RGCs) has long been correlated to the spatial receptive field profiles of these neurons. Thus, determining how glutamatergic inputs are patterned onto RGC dendritic arbors during development could provide insight into the cellular mechanisms that shape their functional receptive fields.ResultsWe transfected developing and mature mouse RGCs with plasmids encoding fluorescent proteins that label their dendrites and glutamatergic postsynaptic sites. We found that as dendritic density (dendritic length per unit area of dendritic field) decreases with maturation, the density of synapses along the dendrites increases. These changes appear coordinated such that RGCs attain the mature average density of postsynaptic sites per unit area (areal density) by the time synaptic function emerges. Furthermore, stereotypic centro-peripheral gradients in the areal density of synapses across the arbor of RGCs are established at an early developmental stage.ConclusionThe spatial pattern of glutamatergic inputs onto RGCs arises early in synaptogenesis despite ensuing reorganization of dendritic structure. We raise the possibility that these early patterns of synaptic distributions may arise from constraints placed on the number of contacts presynaptic neurons are able to make with the RGCs. More... »

PAGES

8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1749-8104-3-8

DOI

http://dx.doi.org/10.1186/1749-8104-3-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039473723

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18366789


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dendrites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disks Large Homolog 4 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Excitatory Postsynaptic Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutamic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guanylate Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Luminescent Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patch-Clamp Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retina", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinal Ganglion Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synapses", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synaptic Transmission", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biological Structure, University of Washington, 98195, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Biological Structure, University of Washington, 98195, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morgan", 
        "givenName": "Josh L", 
        "id": "sg:person.010770132347.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010770132347.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Structure, University of Washington, 98195, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Biological Structure, University of Washington, 98195, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schubert", 
        "givenName": "Timm", 
        "id": "sg:person.01347737611.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347737611.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Structure, University of Washington, 98195, Seattle, WA, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Biological Structure, University of Washington, 98195, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wong", 
        "givenName": "Rachel OL", 
        "id": "sg:person.012033226162.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012033226162.55"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/364144a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017721976", 
          "https://doi.org/10.1038/364144a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021111716", 
          "https://doi.org/10.1038/nn1191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/85987", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020081163", 
          "https://doi.org/10.1038/85987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/12175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013676929", 
          "https://doi.org/10.1038/12175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/371070a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038200756", 
          "https://doi.org/10.1038/371070a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037622183", 
          "https://doi.org/10.1038/nn717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000050176", 
          "https://doi.org/10.1038/nn1615"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-03-26", 
    "datePublishedReg": "2008-03-26", 
    "description": "BackgroundNeurons receive excitatory synaptic inputs that are distributed across their dendritic arbors at densities and with spatial patterns that influence their output. How specific synaptic distributions are attained during development is not well understood. The distribution of glutamatergic inputs across the dendritic arbors of mammalian retinal ganglion cells (RGCs) has long been correlated to the spatial receptive field profiles of these neurons. Thus, determining how glutamatergic inputs are patterned onto RGC dendritic arbors during development could provide insight into the cellular mechanisms that shape their functional receptive fields.ResultsWe transfected developing and mature mouse RGCs with plasmids encoding fluorescent proteins that label their dendrites and glutamatergic postsynaptic sites. We found that as dendritic density (dendritic length per unit area of dendritic field) decreases with maturation, the density of synapses along the dendrites increases. These changes appear coordinated such that RGCs attain the mature average density of postsynaptic sites per unit area (areal density) by the time synaptic function emerges. Furthermore, stereotypic centro-peripheral gradients in the areal density of synapses across the arbor of RGCs are established at an early developmental stage.ConclusionThe spatial pattern of glutamatergic inputs onto RGCs arises early in synaptogenesis despite ensuing reorganization of dendritic structure. We raise the possibility that these early patterns of synaptic distributions may arise from constraints placed on the number of contacts presynaptic neurons are able to make with the RGCs.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1749-8104-3-8", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1037699", 
        "issn": [
          "1749-8104"
        ], 
        "name": "Neural Development", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "keywords": [
      "retinal ganglion cells", 
      "glutamatergic inputs", 
      "dendritic arbors", 
      "ganglion cells", 
      "synaptic distribution", 
      "postsynaptic sites", 
      "mammalian retinal ganglion cells", 
      "mouse retinal ganglion cells", 
      "RGC dendritic arbors", 
      "glutamatergic postsynaptic sites", 
      "centro-peripheral gradient", 
      "density of synapses", 
      "spatial receptive field profiles", 
      "excitatory synaptic inputs", 
      "functional receptive fields", 
      "dendritic density", 
      "glutamatergic synapses", 
      "synaptic inputs", 
      "presynaptic neurons", 
      "synaptic function", 
      "cellular mechanisms", 
      "synapses", 
      "arbors", 
      "receptive field profiles", 
      "receptive fields", 
      "neurons", 
      "early patterns", 
      "early developmental stages", 
      "cells", 
      "synaptogenesis", 
      "ResultsWe", 
      "dendrites", 
      "maturation", 
      "developmental stages", 
      "patterns", 
      "fluorescent protein", 
      "development", 
      "protein", 
      "sites", 
      "increase", 
      "plasmid", 
      "profile", 
      "changes", 
      "mechanism", 
      "stage", 
      "function", 
      "reorganization", 
      "number", 
      "developmental patterning", 
      "area", 
      "possibility", 
      "distribution", 
      "insights", 
      "dendritic structure", 
      "density", 
      "dendrite increases", 
      "input", 
      "output", 
      "patterning", 
      "spatial patterns", 
      "gradient", 
      "average density", 
      "unit area", 
      "field", 
      "structure", 
      "areal density", 
      "constraints", 
      "field profile"
    ], 
    "name": "Developmental patterning of glutamatergic synapses onto retinal ganglion cells", 
    "pagination": "8", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039473723"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1749-8104-3-8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18366789"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1749-8104-3-8", 
      "https://app.dimensions.ai/details/publication/pub.1039473723"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_466.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1749-8104-3-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1749-8104-3-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1749-8104-3-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1749-8104-3-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1749-8104-3-8'


 

This table displays all metadata directly associated to this object as RDF triples.

243 TRIPLES      22 PREDICATES      119 URIs      104 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1749-8104-3-8 schema:about N0fd038948851482a8fc97db206334c25
2 N197449d0edd84625b240e302c46854ae
3 N2393e0595e7d4623a4f90796cb3c6f08
4 N28212d8272f94ebeb028dbbec257d15c
5 N2b22270dfcb847d7af03c63a9db52fc5
6 N2bd2b50b005e4f5ca6452cd2280e5f74
7 N418a2605ccd4419195ab049f364578d9
8 N502cd298886248008472afb439d9d214
9 N65a49769db314d0a8b1a46bb10f2dc6c
10 N7ccea6989de34fb0bd7ccdbe38cac031
11 N7d0bcb8996004f6d8a17fd300c2bab72
12 N8271ff21af4040e7ac64692685eca439
13 N8a24ccef91d5470684f2fe71b01eadb6
14 Na6c8d9202fed48abb52afeff39b90243
15 Nb30eeab5cf414027911e646de610f34a
16 Nbc2f0944a841418dacd5f160a0cb7561
17 Nf35f2fe527e54ce58c547005bd13e4c8
18 Nf77c4c2b33aa4f688c421011af8141f4
19 anzsrc-for:11
20 anzsrc-for:1109
21 schema:author N81ecef1baa73464a8f16fdf6f4c0a926
22 schema:citation sg:pub.10.1038/12175
23 sg:pub.10.1038/364144a0
24 sg:pub.10.1038/371070a0
25 sg:pub.10.1038/85987
26 sg:pub.10.1038/nn1191
27 sg:pub.10.1038/nn1615
28 sg:pub.10.1038/nn717
29 schema:datePublished 2008-03-26
30 schema:datePublishedReg 2008-03-26
31 schema:description BackgroundNeurons receive excitatory synaptic inputs that are distributed across their dendritic arbors at densities and with spatial patterns that influence their output. How specific synaptic distributions are attained during development is not well understood. The distribution of glutamatergic inputs across the dendritic arbors of mammalian retinal ganglion cells (RGCs) has long been correlated to the spatial receptive field profiles of these neurons. Thus, determining how glutamatergic inputs are patterned onto RGC dendritic arbors during development could provide insight into the cellular mechanisms that shape their functional receptive fields.ResultsWe transfected developing and mature mouse RGCs with plasmids encoding fluorescent proteins that label their dendrites and glutamatergic postsynaptic sites. We found that as dendritic density (dendritic length per unit area of dendritic field) decreases with maturation, the density of synapses along the dendrites increases. These changes appear coordinated such that RGCs attain the mature average density of postsynaptic sites per unit area (areal density) by the time synaptic function emerges. Furthermore, stereotypic centro-peripheral gradients in the areal density of synapses across the arbor of RGCs are established at an early developmental stage.ConclusionThe spatial pattern of glutamatergic inputs onto RGCs arises early in synaptogenesis despite ensuing reorganization of dendritic structure. We raise the possibility that these early patterns of synaptic distributions may arise from constraints placed on the number of contacts presynaptic neurons are able to make with the RGCs.
32 schema:genre article
33 schema:inLanguage en
34 schema:isAccessibleForFree true
35 schema:isPartOf Ne61c71b2da9a4550b3299bdb51d99c4f
36 Nf5e1b5b2d664445db99166b1f9bc34b7
37 sg:journal.1037699
38 schema:keywords RGC dendritic arbors
39 ResultsWe
40 arbors
41 area
42 areal density
43 average density
44 cells
45 cellular mechanisms
46 centro-peripheral gradient
47 changes
48 constraints
49 dendrite increases
50 dendrites
51 dendritic arbors
52 dendritic density
53 dendritic structure
54 density
55 density of synapses
56 development
57 developmental patterning
58 developmental stages
59 distribution
60 early developmental stages
61 early patterns
62 excitatory synaptic inputs
63 field
64 field profile
65 fluorescent protein
66 function
67 functional receptive fields
68 ganglion cells
69 glutamatergic inputs
70 glutamatergic postsynaptic sites
71 glutamatergic synapses
72 gradient
73 increase
74 input
75 insights
76 mammalian retinal ganglion cells
77 maturation
78 mechanism
79 mouse retinal ganglion cells
80 neurons
81 number
82 output
83 patterning
84 patterns
85 plasmid
86 possibility
87 postsynaptic sites
88 presynaptic neurons
89 profile
90 protein
91 receptive field profiles
92 receptive fields
93 reorganization
94 retinal ganglion cells
95 sites
96 spatial patterns
97 spatial receptive field profiles
98 stage
99 structure
100 synapses
101 synaptic distribution
102 synaptic function
103 synaptic inputs
104 synaptogenesis
105 unit area
106 schema:name Developmental patterning of glutamatergic synapses onto retinal ganglion cells
107 schema:pagination 8
108 schema:productId N682c170064e249eeaded1e93c865fb5d
109 Nba38dee3adb6499eb7a5ff133839b554
110 Nc40fbfd2d1c3409ea9861dbada283b99
111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039473723
112 https://doi.org/10.1186/1749-8104-3-8
113 schema:sdDatePublished 2022-06-01T22:06
114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
115 schema:sdPublisher N08ba6e02e9aa43ebb90c845a4cfef2d8
116 schema:url https://doi.org/10.1186/1749-8104-3-8
117 sgo:license sg:explorer/license/
118 sgo:sdDataset articles
119 rdf:type schema:ScholarlyArticle
120 N08ba6e02e9aa43ebb90c845a4cfef2d8 schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 N0fd038948851482a8fc97db206334c25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Synaptic Transmission
124 rdf:type schema:DefinedTerm
125 N197449d0edd84625b240e302c46854ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Dendrites
127 rdf:type schema:DefinedTerm
128 N2393e0595e7d4623a4f90796cb3c6f08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Retina
130 rdf:type schema:DefinedTerm
131 N28212d8272f94ebeb028dbbec257d15c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Disks Large Homolog 4 Protein
133 rdf:type schema:DefinedTerm
134 N2b22270dfcb847d7af03c63a9db52fc5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Animals
136 rdf:type schema:DefinedTerm
137 N2bd2b50b005e4f5ca6452cd2280e5f74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Luminescent Proteins
139 rdf:type schema:DefinedTerm
140 N418a2605ccd4419195ab049f364578d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Glutamic Acid
142 rdf:type schema:DefinedTerm
143 N502cd298886248008472afb439d9d214 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Guanylate Kinases
145 rdf:type schema:DefinedTerm
146 N65a49769db314d0a8b1a46bb10f2dc6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Patch-Clamp Techniques
148 rdf:type schema:DefinedTerm
149 N682c170064e249eeaded1e93c865fb5d schema:name dimensions_id
150 schema:value pub.1039473723
151 rdf:type schema:PropertyValue
152 N7ccea6989de34fb0bd7ccdbe38cac031 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Transfection
154 rdf:type schema:DefinedTerm
155 N7d0bcb8996004f6d8a17fd300c2bab72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Membrane Proteins
157 rdf:type schema:DefinedTerm
158 N81ecef1baa73464a8f16fdf6f4c0a926 rdf:first sg:person.010770132347.65
159 rdf:rest N8c78734441ea4cd988e129fa2f5b5952
160 N8271ff21af4040e7ac64692685eca439 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Retinal Ganglion Cells
162 rdf:type schema:DefinedTerm
163 N8a24ccef91d5470684f2fe71b01eadb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Mice
165 rdf:type schema:DefinedTerm
166 N8c78734441ea4cd988e129fa2f5b5952 rdf:first sg:person.01347737611.30
167 rdf:rest Nf2105696e93f4a319fa8ebcb71f1dea2
168 Na6c8d9202fed48abb52afeff39b90243 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Biomarkers
170 rdf:type schema:DefinedTerm
171 Nb30eeab5cf414027911e646de610f34a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Synapses
173 rdf:type schema:DefinedTerm
174 Nba38dee3adb6499eb7a5ff133839b554 schema:name pubmed_id
175 schema:value 18366789
176 rdf:type schema:PropertyValue
177 Nbc2f0944a841418dacd5f160a0cb7561 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Mice, Inbred C57BL
179 rdf:type schema:DefinedTerm
180 Nc40fbfd2d1c3409ea9861dbada283b99 schema:name doi
181 schema:value 10.1186/1749-8104-3-8
182 rdf:type schema:PropertyValue
183 Ne61c71b2da9a4550b3299bdb51d99c4f schema:volumeNumber 3
184 rdf:type schema:PublicationVolume
185 Nf2105696e93f4a319fa8ebcb71f1dea2 rdf:first sg:person.012033226162.55
186 rdf:rest rdf:nil
187 Nf35f2fe527e54ce58c547005bd13e4c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Intracellular Signaling Peptides and Proteins
189 rdf:type schema:DefinedTerm
190 Nf5e1b5b2d664445db99166b1f9bc34b7 schema:issueNumber 1
191 rdf:type schema:PublicationIssue
192 Nf77c4c2b33aa4f688c421011af8141f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Excitatory Postsynaptic Potentials
194 rdf:type schema:DefinedTerm
195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
196 schema:name Medical and Health Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
199 schema:name Neurosciences
200 rdf:type schema:DefinedTerm
201 sg:journal.1037699 schema:issn 1749-8104
202 schema:name Neural Development
203 schema:publisher Springer Nature
204 rdf:type schema:Periodical
205 sg:person.010770132347.65 schema:affiliation grid-institutes:grid.34477.33
206 schema:familyName Morgan
207 schema:givenName Josh L
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010770132347.65
209 rdf:type schema:Person
210 sg:person.012033226162.55 schema:affiliation grid-institutes:grid.34477.33
211 schema:familyName Wong
212 schema:givenName Rachel OL
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012033226162.55
214 rdf:type schema:Person
215 sg:person.01347737611.30 schema:affiliation grid-institutes:grid.34477.33
216 schema:familyName Schubert
217 schema:givenName Timm
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347737611.30
219 rdf:type schema:Person
220 sg:pub.10.1038/12175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013676929
221 https://doi.org/10.1038/12175
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/364144a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017721976
224 https://doi.org/10.1038/364144a0
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/371070a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038200756
227 https://doi.org/10.1038/371070a0
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/85987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020081163
230 https://doi.org/10.1038/85987
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/nn1191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021111716
233 https://doi.org/10.1038/nn1191
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/nn1615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000050176
236 https://doi.org/10.1038/nn1615
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/nn717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037622183
239 https://doi.org/10.1038/nn717
240 rdf:type schema:CreativeWork
241 grid-institutes:grid.34477.33 schema:alternateName Department of Biological Structure, University of Washington, 98195, Seattle, WA, USA
242 schema:name Department of Biological Structure, University of Washington, 98195, Seattle, WA, USA
243 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...