Metamorphosis of an identified serotonergic neuron in the Drosophila olfactory system View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-10-24

AUTHORS

Bidisha Roy, Ajeet P Singh, Chetak Shetty, Varun Chaudhary, Annemarie North, Matthias Landgraf, K VijayRaghavan, Veronica Rodrigues

ABSTRACT

BACKGROUND: Odors are detected by sensory neurons that carry information to the olfactory lobe where they connect to projection neurons and local interneurons in glomeruli: anatomically well-characterized structures that collect, integrate and relay information to higher centers. Recent studies have revealed that the sensitivity of such networks can be modulated by wide-field feedback neurons. The connectivity and function of such feedback neurons are themselves subject to alteration by external cues, such as hormones, stress, or experience. Very little is known about how this class of central neurons changes its anatomical properties to perform functions in altered developmental contexts. A mechanistic understanding of how central neurons change their anatomy to meet new functional requirements will benefit greatly from the establishment of a model preparation where cellular and molecular changes can be examined in an identified central neuron. RESULTS: In this study, we examine a wide-field serotonergic neuron in the Drosophila olfactory pathway and map the dramatic changes that it undergoes from larva to adult. We show that expression of a dominant-negative form of the ecdysterone receptor prevents remodeling. We further use different transgenic constructs to silence neuronal activity and report defects in the morphology of the adult-specific dendritic trees. The branching of the presynaptic axonal arbors is regulated by mechanisms that affect axon growth and retrograde transport. The neuron develops its normal morphology in the absence of sensory input to the antennal lobe, or of the mushroom bodies. However, ablation of its presumptive postsynaptic partners, the projection neurons and/or local interneurons, affects the growth and branching of terminal arbors. CONCLUSION: Our studies establish a cellular system for studying remodeling of a central neuromodulatory feedback neuron and also identify key elements in this process. Understanding the morphogenesis of such neurons, which have been shown in other systems to modulate the sensitivity and directionality of response to odors, links anatomy to the development of olfactory behavior. More... »

PAGES

20-20

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1749-8104-2-20

DOI

http://dx.doi.org/10.1186/1749-8104-2-20

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030076565

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17958902


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49 adult-specific dendritic trees
50 adults
51 alterations
52 anatomical properties
53 anatomy
54 antennal lobe
55 arbors
56 axon growth
57 axonal arbors
58 behavior
59 body
60 branching
61 cellular systems
62 center
63 central neuromodulatory feedback neuron
64 central neurons
65 changes
66 class
67 connectivity
68 constructs
69 context
70 cues
71 defects
72 dendritic tree
73 development
74 developmental context
75 different transgenic constructs
76 directionality
77 directionality of response
78 dominant negative form
79 dramatic changes
80 ecdysterone receptor prevents
81 elements
82 establishment
83 experience
84 expression
85 external cues
86 feedback neurons
87 form
88 function
89 functional requirements
90 glomeruli
91 growth
92 higher centers
93 hormone
94 information
95 input
96 interneurons
97 key elements
98 larvae
99 link
100 lobe
101 local interneurons
102 mechanism
103 mechanistic understanding
104 metamorphosis
105 model preparation
106 molecular changes
107 morphogenesis
108 morphology
109 mushroom bodies
110 network
111 neuromodulatory feedback neuron
112 neuronal activity
113 neurons
114 new functional requirements
115 normal morphology
116 odor
117 olfactory behavior
118 olfactory lobe
119 olfactory pathway
120 olfactory system
121 partners
122 pathway
123 postsynaptic partners
124 preparation
125 presumptive postsynaptic partners
126 presynaptic axonal arbors
127 prevents
128 process
129 projection neurons
130 properties
131 receptor prevents
132 remodeling
133 report defects
134 requirements
135 response
136 retrograde transport
137 sensitivity
138 sensory input
139 sensory neurons
140 serotonergic neurons
141 stress
142 structure
143 study
144 such feedback neurons
145 such networks
146 such neurons
147 system
148 terminal arbors
149 transgenic constructs
150 transport
151 trees
152 understanding
153 wide-field feedback neurons
154 wide-field serotonergic neuron
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