Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Massimo Sartelli, Fausto Catena, Luca Ansaloni, Federico Coccolini, Davide Corbella, Ernest E Moore, Mark Malangoni, George Velmahos, Raul Coimbra, Kaoru Koike, Ari Leppaniemi, Walter Biffl, Zsolt Balogh, Cino Bendinelli, Sanjay Gupta, Yoram Kluger, Ferdinando Agresta, Salomone Di Saverio, Gregorio Tugnoli, Elio Jovine, Carlos A Ordonez, James F Whelan, Gustavo P Fraga, Carlos Augusto Gomes, Gerson Alves Pereira, Kuo-Ching Yuan, Miklosh Bala, Miroslav P Peev, Offir Ben-Ishay, Yunfeng Cui, Sanjay Marwah, Sanoop Zachariah, Imtiaz Wani, Muthukumaran Rangarajan, Boris Sakakushev, Victor Kong, Adamu Ahmed, Ashraf Abbas, Ricardo Alessandro Teixeira Gonsaga, Gianluca Guercioni, Nereo Vettoretto, Elia Poiasina, Rafael Díaz-Nieto, Damien Massalou, Matej Skrovina, Ihor Gerych, Goran Augustin, Jakub Kenig, Vladimir Khokha, Cristian Tranà, Kenneth Yuh Yen Kok, Alain Chichom Mefire, Jae Gil Lee, Suk-Kyung Hong, Helmut Alfredo Segovia Lohse, Wagih Ghnnam, Alfredo Verni, Varut Lohsiriwat, Boonying Siribumrungwong, Tamer El Zalabany, Alberto Tavares, Gianluca Baiocchi, Koray Das, Julien Jarry, Maurice Zida, Norio Sato, Kiyoshi Murata, Tomohisa Shoko, Takayuki Irahara, Ahmed O Hamedelneel, Noel Naidoo, Abdul Rashid Kayode Adesunkanmi, Yoshiro Kobe, Wataru Ishii, Kazuyuki Oka, Yoshimitsu Izawa, Hytham Hamid, Iqbal Khan, AK Attri, Rajeev Sharma, Juan Sanjuan, Marisol Badiel, Rita Barnabé

ABSTRACT

The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs). 1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41%) were women and 1,121 (59%) were men. Among these patients, 1,645 (86.7%) were affected by community-acquired IAIs while the remaining 253 (13.3%) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7%) of the enrolled patients. 827 patients (43.6%) were affected by generalized peritonitis while 1071 (56.4%) suffered from localized peritonitis or abscesses. The overall mortality rate was 10.5% (199/1898). According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001). More... »

PAGES

37

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1749-7922-9-37

    DOI

    http://dx.doi.org/10.1186/1749-7922-9-37

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000113338

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24883079


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