High-dose stereotactic body radiotherapy correlates increased local control and overall survival in patients with inoperable hepatocellular carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Won Il Jang, Mi-Sook Kim, Sun Hyun Bae, Chul Koo Cho, Hyung Jun Yoo, Young Seok Seo, Jin-Kyu Kang, So Young Kim, Dong Han Lee, Chul Ju Han, Jin Kim, Su Cheol Park, Sang Bum Kim, Eung-Ho Cho, Young Han Kim

ABSTRACT

BACKGROUND: Recent studies using stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC) have reported high tumor response and local control. However, the optimal SBRT dose remains unknown, and it is still not clear whether a dose response relationship for local control (LC) and overall survival (OS) exist or not. We performed this study to determine whether a dose response relationship for LC and OS is observed in SBRT for inoperable HCC. METHODS: Between 2003 and 2011, 108 patients with HCC were treated with SBRT. All patients were unsuitable for surgery or local ablation and had incomplete response to transarterial chemoembolization. Eighty-two patients with a longest tumor diameter (LD) less than or equal to 7.0 cm who were treated with 3-fraction SBRT and were analyzed. This cohort comprised 74 Child-Turcotte-Pugh (CTP) class A patients and 8 CTP class B7 patients. The median LD was 3.0 cm (range, 1.0-7.0 cm), and the median dose was 51 Gy (range, 33-60 Gy). RESULTS: LC and OS rates at 2 years after SBRT were 87% and 63%, respectively, with a median follow-up duration of 30 months for all patients. The 2-year LC/OS rates for patients treated with doses of > 54, 45-54, and < 45 Gy were 100/71, 78/64, and 64%/30%, respectively (p = .009/p < .001). Multivariate analysis revealed that the SBRT dose (p = .005) and Barcelona Clinic Liver Cancer stage (p = .015) were significant prognostic factors for OS. Correlation analysis revealed a positive linear relationship between the SBRT dose and LC (p = .006, R = .899)/OS (p = .002, R = .940) at 2 years. Based on the tumor-control probability model, a dose of 54.8 Gy provides 2-year LC with a 90% probability. Five patients experienced grade 3 or higher gastrointestinal toxicity, and 6 had deteriorating of CTP score by greater than or equal to 2 within 3 months of SBRT. CONCLUSIONS: This study demonstrated a dose response relationship for LC and OS with SBRT for HCC. Higher LC rates resulting from an increased dose may translate into survival benefits for patients with HCC. More... »

PAGES

250

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1748-717x-8-250

DOI

http://dx.doi.org/10.1186/1748-717x-8-250

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039364339

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24160944


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Hepatocellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemoembolization, Therapeutic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Radiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Statistical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multivariate Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Probability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiosurgery", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, X-Ray Computed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Korea Institute of Radiological and Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415464.6", 
          "name": [
            "Department of Radiation Oncology, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jang", 
        "givenName": "Won Il", 
        "id": "sg:person.01306764130.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306764130.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Institute of Radiological and Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415464.6", 
          "name": [
            "Department of Radiation Oncology, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Mi-Sook", 
        "id": "sg:person.016544247014.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016544247014.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Radiation Oncology, Kyung Hee University Gangdong Hospital, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bae", 
        "givenName": "Sun Hyun", 
        "id": "sg:person.01335707537.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335707537.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Institute of Radiological and Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415464.6", 
          "name": [
            "Department of Radiation Oncology, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Chul Koo", 
        "id": "sg:person.0660416637.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660416637.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Institute of Radiological and Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415464.6", 
          "name": [
            "Department of Radiation Oncology, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoo", 
        "givenName": "Hyung Jun", 
        "id": "sg:person.016440253400.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016440253400.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Institute of Radiological and Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415464.6", 
          "name": [
            "Department of Radiation Oncology, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seo", 
        "givenName": "Young Seok", 
        "id": "sg:person.01213325326.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213325326.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Institute of Radiological and Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415464.6", 
          "name": [
            "Department of Radiation Oncology, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kang", 
        "givenName": "Jin-Kyu", 
        "id": "sg:person.01323455574.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323455574.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Institute of Radiological and Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415464.6", 
          "name": [
            "Division of Heavy Ion Clinical Research, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "So Young", 
        "id": "sg:person.01160354500.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160354500.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Institute of Radiological and Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415464.6", 
          "name": [
            "Cyberknife Center, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Dong Han", 
        "id": "sg:person.01225322237.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225322237.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Institute of Radiological and Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415464.6", 
          "name": [
            "Department of Internal Medicine, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Chul Ju", 
        "id": "sg:person.0623004755.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623004755.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Institute of Radiological and Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415464.6", 
          "name": [
            "Department of Internal Medicine, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jin", 
        "id": "sg:person.01304163056.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304163056.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Institute of Radiological and Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415464.6", 
          "name": [
            "Department of Internal Medicine, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Su Cheol", 
        "id": "sg:person.0653764505.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653764505.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Institute of Radiological and Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415464.6", 
          "name": [
            "Department of Surgery, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Sang Bum", 
        "id": "sg:person.0671120155.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671120155.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Institute of Radiological and Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415464.6", 
          "name": [
            "Department of Surgery, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Eung-Ho", 
        "id": "sg:person.01014561065.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014561065.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Institute of Radiological and Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415464.6", 
          "name": [
            "Department of Radiology, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Young Han", 
        "id": "sg:person.01042760437.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042760437.25"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s1470-2045(08)70284-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002260226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-230x-9-31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002692483", 
          "https://doi.org/10.1186/1471-230x-9-31"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(02)03929-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002997071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(02)03929-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002997071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2012.05.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003169563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2005.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003211599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2010.261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003265331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009055747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00384-013-1717-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010012627", 
          "https://doi.org/10.1007/s00384-013-1717-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.21593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010503228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.21593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010503228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/27.4.251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011833416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.44.1659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012458621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(94)00471-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012681231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjsurg.2007.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014113215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3857/roj.2012.30.4.189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014397694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2009.06.092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015294133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.14.3529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015883962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.19.6329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017605315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.27533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018094042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/02841869509127197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023036250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(85)90341-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025409329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.2371032102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027343849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.2003.50047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030703205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1118/1.2968096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031120022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0030-1247132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031319462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(94)00418-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033032320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2012.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036521547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1746.2009.06125.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036799048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.2000.20456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038888047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2009.09.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039743176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(02)02864-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041823191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2011.425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046919308", 
          "https://doi.org/10.1038/ajg.2011.425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/153303461000900506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049376611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/153303461000900506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049376611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2004.08.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050410884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2011.04.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050600815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(02)02846-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052821361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2011.11.058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053309927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.11.2210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074645669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076364874", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "BACKGROUND: Recent studies using stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC) have reported high tumor response and local control. However, the optimal SBRT dose remains unknown, and it is still not clear whether a dose response relationship for local control (LC) and overall survival (OS) exist or not. We performed this study to determine whether a dose response relationship for LC and OS is observed in SBRT for inoperable HCC.\nMETHODS: Between 2003 and 2011, 108 patients with HCC were treated with SBRT. All patients were unsuitable for surgery or local ablation and had incomplete response to transarterial chemoembolization. Eighty-two patients with a longest tumor diameter (LD) less than or equal to 7.0 cm who were treated with 3-fraction SBRT and were analyzed. This cohort comprised 74 Child-Turcotte-Pugh (CTP) class A patients and 8 CTP class B7 patients. The median LD was 3.0 cm (range, 1.0-7.0 cm), and the median dose was 51 Gy (range, 33-60 Gy).\nRESULTS: LC and OS rates at 2 years after SBRT were 87% and 63%, respectively, with a median follow-up duration of 30 months for all patients. The 2-year LC/OS rates for patients treated with doses of > 54, 45-54, and < 45 Gy were 100/71, 78/64, and 64%/30%, respectively (p = .009/p < .001). Multivariate analysis revealed that the SBRT dose (p = .005) and Barcelona Clinic Liver Cancer stage (p = .015) were significant prognostic factors for OS. Correlation analysis revealed a positive linear relationship between the SBRT dose and LC (p = .006, R = .899)/OS (p = .002, R = .940) at 2 years. Based on the tumor-control probability model, a dose of 54.8 Gy provides 2-year LC with a 90% probability. Five patients experienced grade 3 or higher gastrointestinal toxicity, and 6 had deteriorating of CTP score by greater than or equal to 2 within 3 months of SBRT.\nCONCLUSIONS: This study demonstrated a dose response relationship for LC and OS with SBRT for HCC. Higher LC rates resulting from an increased dose may translate into survival benefits for patients with HCC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1748-717x-8-250", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1036451", 
        "issn": [
          "1748-717X"
        ], 
        "name": "Radiation Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "High-dose stereotactic body radiotherapy correlates increased local control and overall survival in patients with inoperable hepatocellular carcinoma", 
    "pagination": "250", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bb82fa9432afdb2e31fdd36b4fd7ee5a1dc4786c80b4d12a3d61125182b400a4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24160944"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101265111"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1748-717x-8-250"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039364339"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1748-717x-8-250", 
      "https://app.dimensions.ai/details/publication/pub.1039364339"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000537.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1748-717X-8-250"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1748-717x-8-250'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1748-717x-8-250'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1748-717x-8-250'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1748-717x-8-250'


 

This table displays all metadata directly associated to this object as RDF triples.

369 TRIPLES      21 PREDICATES      87 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1748-717x-8-250 schema:about N016fa2f4a5044f92818cc84f324a90cc
2 N0472caeba398487e9a42f2c7d98f3cce
3 N05d283d7e2a7444693cef0fd65af540e
4 N0652d57fb93549338baa9e4802224ff2
5 N0a2713a380d64357a95300da85a36809
6 N1072d29ee62e466d8de0ad6217efb6d1
7 N35c5767046bb41f7939d84a94a1a2d84
8 N4ba79427a1a443588d6219da5f0b0a33
9 N520c1a33cfe5480bbe3f9748e14d2e7c
10 N65e9eecacb5749e6a54a401044bbff3f
11 N8025de36853d4447af64b37dcf1b7a94
12 N8923d41a5bd14d7f89460f32e6f2cb89
13 N9ccc197f001c4d7e8a995c1cf0f4f4d1
14 Nab4ce3066e484a1189ab8c6be0ec9c82
15 Nb3b389c4f567434191dda47e3f5aede9
16 Nc9d3f3dff2244de68b2b1b0af436a451
17 Ne1ff614e10a7427eb10be25ad2471ec0
18 Ne8af07aa0709417585abc28783ee1c19
19 Nefe6e1ffcfe8462b800e15a91cb446ba
20 Nfc7d9f20b3a6454797544ff107b05770
21 anzsrc-for:11
22 anzsrc-for:1112
23 schema:author Nd6084cd75565417f82cf369ae1a50421
24 schema:citation sg:pub.10.1007/s00384-013-1717-6
25 sg:pub.10.1038/ajg.2011.425
26 sg:pub.10.1186/1471-230x-9-31
27 https://app.dimensions.ai/details/publication/pub.1076364874
28 https://doi.org/10.1001/jama.2010.261
29 https://doi.org/10.1002/cncr.27533
30 https://doi.org/10.1002/jso.21593
31 https://doi.org/10.1016/0360-3016(85)90341-4
32 https://doi.org/10.1016/0360-3016(94)00418-k
33 https://doi.org/10.1016/0360-3016(94)00471-4
34 https://doi.org/10.1016/j.amjsurg.2007.10.010
35 https://doi.org/10.1016/j.ijrobp.2004.08.028
36 https://doi.org/10.1016/j.ijrobp.2009.06.092
37 https://doi.org/10.1016/j.ijrobp.2009.09.042
38 https://doi.org/10.1016/j.ijrobp.2011.04.011
39 https://doi.org/10.1016/j.ijrobp.2011.11.058
40 https://doi.org/10.1016/j.ijrobp.2012.06.005
41 https://doi.org/10.1016/j.jhep.2012.05.007
42 https://doi.org/10.1016/s0360-3016(02)02846-8
43 https://doi.org/10.1016/s0360-3016(02)02864-x
44 https://doi.org/10.1016/s0360-3016(02)03929-9
45 https://doi.org/10.1016/s1470-2045(08)70284-5
46 https://doi.org/10.1053/j.gastro.2005.04.009
47 https://doi.org/10.1053/jhep.2000.20456
48 https://doi.org/10.1053/jhep.2003.50047
49 https://doi.org/10.1055/s-0030-1247132
50 https://doi.org/10.1093/jjco/27.4.251
51 https://doi.org/10.1111/j.1440-1746.2009.06125.x
52 https://doi.org/10.1118/1.2968096
53 https://doi.org/10.1148/radiol.2371032102
54 https://doi.org/10.1177/153303461000900506
55 https://doi.org/10.1200/jco.2000.18.11.2210
56 https://doi.org/10.1200/jco.2007.14.3529
57 https://doi.org/10.1200/jco.2008.19.6329
58 https://doi.org/10.1200/jco.2012.44.1659
59 https://doi.org/10.3109/02841869509127197
60 https://doi.org/10.3322/caac.20107
61 https://doi.org/10.3857/roj.2012.30.4.189
62 schema:datePublished 2013-12
63 schema:datePublishedReg 2013-12-01
64 schema:description BACKGROUND: Recent studies using stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC) have reported high tumor response and local control. However, the optimal SBRT dose remains unknown, and it is still not clear whether a dose response relationship for local control (LC) and overall survival (OS) exist or not. We performed this study to determine whether a dose response relationship for LC and OS is observed in SBRT for inoperable HCC. METHODS: Between 2003 and 2011, 108 patients with HCC were treated with SBRT. All patients were unsuitable for surgery or local ablation and had incomplete response to transarterial chemoembolization. Eighty-two patients with a longest tumor diameter (LD) less than or equal to 7.0 cm who were treated with 3-fraction SBRT and were analyzed. This cohort comprised 74 Child-Turcotte-Pugh (CTP) class A patients and 8 CTP class B7 patients. The median LD was 3.0 cm (range, 1.0-7.0 cm), and the median dose was 51 Gy (range, 33-60 Gy). RESULTS: LC and OS rates at 2 years after SBRT were 87% and 63%, respectively, with a median follow-up duration of 30 months for all patients. The 2-year LC/OS rates for patients treated with doses of > 54, 45-54, and < 45 Gy were 100/71, 78/64, and 64%/30%, respectively (p = .009/p < .001). Multivariate analysis revealed that the SBRT dose (p = .005) and Barcelona Clinic Liver Cancer stage (p = .015) were significant prognostic factors for OS. Correlation analysis revealed a positive linear relationship between the SBRT dose and LC (p = .006, R = .899)/OS (p = .002, R = .940) at 2 years. Based on the tumor-control probability model, a dose of 54.8 Gy provides 2-year LC with a 90% probability. Five patients experienced grade 3 or higher gastrointestinal toxicity, and 6 had deteriorating of CTP score by greater than or equal to 2 within 3 months of SBRT. CONCLUSIONS: This study demonstrated a dose response relationship for LC and OS with SBRT for HCC. Higher LC rates resulting from an increased dose may translate into survival benefits for patients with HCC.
65 schema:genre research_article
66 schema:inLanguage en
67 schema:isAccessibleForFree true
68 schema:isPartOf N2134f3ddda3b4911b7baa4b414b2c26f
69 N59f680a2493a4bcf905681220ba1969d
70 sg:journal.1036451
71 schema:name High-dose stereotactic body radiotherapy correlates increased local control and overall survival in patients with inoperable hepatocellular carcinoma
72 schema:pagination 250
73 schema:productId N54ee372056844366842134cff27b0642
74 N878b9b8148a6443eb26fd048fa54a8c4
75 N897e02188693433099124b562f7454eb
76 Na6c1143d14ef455c95a4db1db2c02cf5
77 Naaf8fefbd5164fe38af221872e9de567
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039364339
79 https://doi.org/10.1186/1748-717x-8-250
80 schema:sdDatePublished 2019-04-10T18:25
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N7a121ac2cb3241efa50882261b375002
83 schema:url http://link.springer.com/10.1186%2F1748-717X-8-250
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N016fa2f4a5044f92818cc84f324a90cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Tomography, X-Ray Computed
89 rdf:type schema:DefinedTerm
90 N0472caeba398487e9a42f2c7d98f3cce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Liver Neoplasms
92 rdf:type schema:DefinedTerm
93 N05d283d7e2a7444693cef0fd65af540e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Aged
95 rdf:type schema:DefinedTerm
96 N0652d57fb93549338baa9e4802224ff2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Radiosurgery
98 rdf:type schema:DefinedTerm
99 N0677653d150743debdb11e1c84ffbca6 rdf:first sg:person.0671120155.56
100 rdf:rest Nd0e75320bae6433384ce379236d98a8c
101 N0a2713a380d64357a95300da85a36809 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Models, Statistical
103 rdf:type schema:DefinedTerm
104 N1072d29ee62e466d8de0ad6217efb6d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Treatment Outcome
106 rdf:type schema:DefinedTerm
107 N1258dda2ddc341198bbeae7f7e627029 rdf:first sg:person.01323455574.30
108 rdf:rest N236fbc2998234963a81fd6f86cd636f2
109 N18fefe86b79144d184d66e0a92e3dd29 rdf:first sg:person.01304163056.09
110 rdf:rest N5799c0473077405a8d3088049b7b923f
111 N200b2b394de546cfa9e6b74cd2e54113 rdf:first sg:person.0623004755.80
112 rdf:rest N18fefe86b79144d184d66e0a92e3dd29
113 N2134f3ddda3b4911b7baa4b414b2c26f schema:volumeNumber 8
114 rdf:type schema:PublicationVolume
115 N236fbc2998234963a81fd6f86cd636f2 rdf:first sg:person.01160354500.37
116 rdf:rest Nd28e5ae1b593434686733ef8900450b2
117 N2e0eea3eb8ab411293283c05a096f379 rdf:first sg:person.016440253400.40
118 rdf:rest N7927ae0dada6410382120d4b5ab0b88a
119 N35c5767046bb41f7939d84a94a1a2d84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Probability
121 rdf:type schema:DefinedTerm
122 N4ba79427a1a443588d6219da5f0b0a33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Survival Rate
124 rdf:type schema:DefinedTerm
125 N520c1a33cfe5480bbe3f9748e14d2e7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Adult
127 rdf:type schema:DefinedTerm
128 N54ee372056844366842134cff27b0642 schema:name pubmed_id
129 schema:value 24160944
130 rdf:type schema:PropertyValue
131 N5799c0473077405a8d3088049b7b923f rdf:first sg:person.0653764505.15
132 rdf:rest N0677653d150743debdb11e1c84ffbca6
133 N58aee3308b634b7aa23dcf19e28b49b3 rdf:first sg:person.01335707537.42
134 rdf:rest Nbc20d0ac5b6d4b8b9d69a66b298e18fe
135 N59f680a2493a4bcf905681220ba1969d schema:issueNumber 1
136 rdf:type schema:PublicationIssue
137 N65e9eecacb5749e6a54a401044bbff3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Carcinoma, Hepatocellular
139 rdf:type schema:DefinedTerm
140 N6faf1c7564e04f6a8729d169257f5d13 schema:name Department of Radiation Oncology, Kyung Hee University Gangdong Hospital, Seoul, Republic of Korea
141 rdf:type schema:Organization
142 N7927ae0dada6410382120d4b5ab0b88a rdf:first sg:person.01213325326.66
143 rdf:rest N1258dda2ddc341198bbeae7f7e627029
144 N7a121ac2cb3241efa50882261b375002 schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 N8025de36853d4447af64b37dcf1b7a94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Middle Aged
148 rdf:type schema:DefinedTerm
149 N878b9b8148a6443eb26fd048fa54a8c4 schema:name dimensions_id
150 schema:value pub.1039364339
151 rdf:type schema:PropertyValue
152 N8923d41a5bd14d7f89460f32e6f2cb89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Female
154 rdf:type schema:DefinedTerm
155 N897e02188693433099124b562f7454eb schema:name doi
156 schema:value 10.1186/1748-717x-8-250
157 rdf:type schema:PropertyValue
158 N9ccc197f001c4d7e8a995c1cf0f4f4d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Follow-Up Studies
160 rdf:type schema:DefinedTerm
161 Na6c1143d14ef455c95a4db1db2c02cf5 schema:name nlm_unique_id
162 schema:value 101265111
163 rdf:type schema:PropertyValue
164 Naaf8fefbd5164fe38af221872e9de567 schema:name readcube_id
165 schema:value bb82fa9432afdb2e31fdd36b4fd7ee5a1dc4786c80b4d12a3d61125182b400a4
166 rdf:type schema:PropertyValue
167 Nab4ce3066e484a1189ab8c6be0ec9c82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Multivariate Analysis
169 rdf:type schema:DefinedTerm
170 Nb3b389c4f567434191dda47e3f5aede9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Humans
172 rdf:type schema:DefinedTerm
173 Nbc20d0ac5b6d4b8b9d69a66b298e18fe rdf:first sg:person.0660416637.71
174 rdf:rest N2e0eea3eb8ab411293283c05a096f379
175 Nc2d2c86512ed47bfa5bc200565589951 rdf:first sg:person.016544247014.42
176 rdf:rest N58aee3308b634b7aa23dcf19e28b49b3
177 Nc9d3f3dff2244de68b2b1b0af436a451 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Retrospective Studies
179 rdf:type schema:DefinedTerm
180 Nd0e75320bae6433384ce379236d98a8c rdf:first sg:person.01014561065.11
181 rdf:rest Nd1044aab76f348e9bc89a95f236ec64b
182 Nd1044aab76f348e9bc89a95f236ec64b rdf:first sg:person.01042760437.25
183 rdf:rest rdf:nil
184 Nd28e5ae1b593434686733ef8900450b2 rdf:first sg:person.01225322237.32
185 rdf:rest N200b2b394de546cfa9e6b74cd2e54113
186 Nd6084cd75565417f82cf369ae1a50421 rdf:first sg:person.01306764130.88
187 rdf:rest Nc2d2c86512ed47bfa5bc200565589951
188 Ne1ff614e10a7427eb10be25ad2471ec0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Cohort Studies
190 rdf:type schema:DefinedTerm
191 Ne8af07aa0709417585abc28783ee1c19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Dose-Response Relationship, Radiation
193 rdf:type schema:DefinedTerm
194 Nefe6e1ffcfe8462b800e15a91cb446ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Chemoembolization, Therapeutic
196 rdf:type schema:DefinedTerm
197 Nfc7d9f20b3a6454797544ff107b05770 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Male
199 rdf:type schema:DefinedTerm
200 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
201 schema:name Medical and Health Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
204 schema:name Oncology and Carcinogenesis
205 rdf:type schema:DefinedTerm
206 sg:journal.1036451 schema:issn 1748-717X
207 schema:name Radiation Oncology
208 rdf:type schema:Periodical
209 sg:person.01014561065.11 schema:affiliation https://www.grid.ac/institutes/grid.415464.6
210 schema:familyName Cho
211 schema:givenName Eung-Ho
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014561065.11
213 rdf:type schema:Person
214 sg:person.01042760437.25 schema:affiliation https://www.grid.ac/institutes/grid.415464.6
215 schema:familyName Kim
216 schema:givenName Young Han
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042760437.25
218 rdf:type schema:Person
219 sg:person.01160354500.37 schema:affiliation https://www.grid.ac/institutes/grid.415464.6
220 schema:familyName Kim
221 schema:givenName So Young
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160354500.37
223 rdf:type schema:Person
224 sg:person.01213325326.66 schema:affiliation https://www.grid.ac/institutes/grid.415464.6
225 schema:familyName Seo
226 schema:givenName Young Seok
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213325326.66
228 rdf:type schema:Person
229 sg:person.01225322237.32 schema:affiliation https://www.grid.ac/institutes/grid.415464.6
230 schema:familyName Lee
231 schema:givenName Dong Han
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225322237.32
233 rdf:type schema:Person
234 sg:person.01304163056.09 schema:affiliation https://www.grid.ac/institutes/grid.415464.6
235 schema:familyName Kim
236 schema:givenName Jin
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304163056.09
238 rdf:type schema:Person
239 sg:person.01306764130.88 schema:affiliation https://www.grid.ac/institutes/grid.415464.6
240 schema:familyName Jang
241 schema:givenName Won Il
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306764130.88
243 rdf:type schema:Person
244 sg:person.01323455574.30 schema:affiliation https://www.grid.ac/institutes/grid.415464.6
245 schema:familyName Kang
246 schema:givenName Jin-Kyu
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323455574.30
248 rdf:type schema:Person
249 sg:person.01335707537.42 schema:affiliation N6faf1c7564e04f6a8729d169257f5d13
250 schema:familyName Bae
251 schema:givenName Sun Hyun
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335707537.42
253 rdf:type schema:Person
254 sg:person.016440253400.40 schema:affiliation https://www.grid.ac/institutes/grid.415464.6
255 schema:familyName Yoo
256 schema:givenName Hyung Jun
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016440253400.40
258 rdf:type schema:Person
259 sg:person.016544247014.42 schema:affiliation https://www.grid.ac/institutes/grid.415464.6
260 schema:familyName Kim
261 schema:givenName Mi-Sook
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016544247014.42
263 rdf:type schema:Person
264 sg:person.0623004755.80 schema:affiliation https://www.grid.ac/institutes/grid.415464.6
265 schema:familyName Han
266 schema:givenName Chul Ju
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623004755.80
268 rdf:type schema:Person
269 sg:person.0653764505.15 schema:affiliation https://www.grid.ac/institutes/grid.415464.6
270 schema:familyName Park
271 schema:givenName Su Cheol
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653764505.15
273 rdf:type schema:Person
274 sg:person.0660416637.71 schema:affiliation https://www.grid.ac/institutes/grid.415464.6
275 schema:familyName Cho
276 schema:givenName Chul Koo
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660416637.71
278 rdf:type schema:Person
279 sg:person.0671120155.56 schema:affiliation https://www.grid.ac/institutes/grid.415464.6
280 schema:familyName Kim
281 schema:givenName Sang Bum
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671120155.56
283 rdf:type schema:Person
284 sg:pub.10.1007/s00384-013-1717-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010012627
285 https://doi.org/10.1007/s00384-013-1717-6
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/ajg.2011.425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046919308
288 https://doi.org/10.1038/ajg.2011.425
289 rdf:type schema:CreativeWork
290 sg:pub.10.1186/1471-230x-9-31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002692483
291 https://doi.org/10.1186/1471-230x-9-31
292 rdf:type schema:CreativeWork
293 https://app.dimensions.ai/details/publication/pub.1076364874 schema:CreativeWork
294 https://doi.org/10.1001/jama.2010.261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003265331
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1002/cncr.27533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018094042
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1002/jso.21593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010503228
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/0360-3016(85)90341-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025409329
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/0360-3016(94)00418-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1033032320
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/0360-3016(94)00471-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012681231
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.amjsurg.2007.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014113215
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.ijrobp.2004.08.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050410884
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.ijrobp.2009.06.092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015294133
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.ijrobp.2009.09.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039743176
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.ijrobp.2011.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050600815
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.ijrobp.2011.11.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053309927
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.ijrobp.2012.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036521547
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.jhep.2012.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003169563
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/s0360-3016(02)02846-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052821361
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/s0360-3016(02)02864-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041823191
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/s0360-3016(02)03929-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002997071
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/s1470-2045(08)70284-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002260226
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1053/j.gastro.2005.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003211599
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1053/jhep.2000.20456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038888047
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1053/jhep.2003.50047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030703205
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1055/s-0030-1247132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031319462
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/jjco/27.4.251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011833416
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1111/j.1440-1746.2009.06125.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036799048
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1118/1.2968096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031120022
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1148/radiol.2371032102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027343849
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1177/153303461000900506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049376611
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1200/jco.2000.18.11.2210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074645669
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1200/jco.2007.14.3529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015883962
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1200/jco.2008.19.6329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017605315
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1200/jco.2012.44.1659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012458621
355 rdf:type schema:CreativeWork
356 https://doi.org/10.3109/02841869509127197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023036250
357 rdf:type schema:CreativeWork
358 https://doi.org/10.3322/caac.20107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009055747
359 rdf:type schema:CreativeWork
360 https://doi.org/10.3857/roj.2012.30.4.189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014397694
361 rdf:type schema:CreativeWork
362 https://www.grid.ac/institutes/grid.415464.6 schema:alternateName Korea Institute of Radiological and Medical Sciences
363 schema:name Cyberknife Center, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea
364 Department of Internal Medicine, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea
365 Department of Radiation Oncology, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea
366 Department of Radiology, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea
367 Department of Surgery, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea
368 Division of Heavy Ion Clinical Research, Korea Institute of Radiological & Medical Science, Seoul, Republic of Korea
369 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...