Linac based SBRT for prostate cancer in 5 fractions with VMAT and flattening filter free beams: preliminary report of a ... View Full Text


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Article Info

DATE

2013-12

AUTHORS

Filippo Alongi, Luca Cozzi, Stefano Arcangeli, Cristina Iftode, Tiziana Comito, Elisa Villa, Francesca Lobefalo, Pierina Navarria, Giacomo Reggiori, Pietro Mancosu, Elena Clerici, Antonella Fogliata, Stefano Tomatis, Gianluigi Taverna, Pierpaolo Graziotti, Marta Scorsetti

ABSTRACT

BACKGROUND: To evaluate the feasibility and early side effects of a short course hypo-fractionated SBRT programme with Volumetric Modulated Arc Therapy (VMAT) and Flattening Filter Free (FFF) beams. METHODS: A prospective phase I-II study, started on February 2012. Inclusion criteria were: age ≤ 80 years, WHO-PS ≤ 2, PSA ≤ 20 ng/ml, histologically proven prostate adenocarcinoma, T1-T2 stage, no distant metastases, no previous surgery other than TURP, no malignant tumours in the previous 5 years, IPSS 0-7. The schedule was 35 Gy in 5 alternative days. SBRT was delivered with RapidArc VMAT, with 10MV FFF photons. Toxicity assessment was performed according to CTCAE v4.0 scale. EPIC questionnaires assessed Quality-of-Life. Neo-adjuvant/concomitant hormonal-therapy was prescribed according to risk classification. SpaceOAR™ gel was optionally implanted to increase the separation space between the prostate and the rectal wall. RESULTS: Median follow-up was 11 months (range: 5-16); 40 patients were recruited in the protocol and treated. According to NCCN criteria, 26/40 patients were low-risk and 14/40 were intermediate risk. Median age was 70 years (56-80), median initial PSA was 6.25 ng/ml (0.50-13.43 ng/ml). Median Gleason score was 6 (6-7). All patients completed the treatment as programmed (median 11.8 days (9-22). Acute Toxicities were as follow: Rectum G0: 30/40 cases (75%); G1: 6/40 (15%); G2: 4/40 (10%). Genito-urinary: G0: 16/40 (40%); G1: 8/40 (20%); G2: 16/34 (40%). In two G2 urinary retention cases, intermittent catheter was needed. No acute G3 or greater toxicity was found. Median treatment time was 126 sec (120-136). SpaceOAR™ was implanted in 8 patients. PSA reduction from the pre-treatment value of the marker was documented in all patients. CONCLUSIONS: Early findings suggest that SBRT with RapidArc and FFF beams for prostate cancer in 5 fractions is feasible and tolerated in acute setting. Longer follow-up is needed for assessment of late toxicity and outcome. More... »

PAGES

171

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1748-717x-8-171

DOI

http://dx.doi.org/10.1186/1748-717x-8-171

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032792993

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23835141


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1748-717x-8-171'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1748-717x-8-171'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1748-717x-8-171'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1748-717x-8-171'


 

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288 schema:name Humanitas Cancer Center, Istituto Clinico Humanitas, Via Manzoni 56, 20089, Rozzano, Milano, Italy
289 Radiotherapy and Radiosurgery, Istituto Clinico Humanitas Cancer Center, Rozzano, Milan, Italy
290 Urology, Istituto Clinico Humanitas Cancer Center, Rozzano, Milan, Italy
291 rdf:type schema:Organization
292 https://www.grid.ac/institutes/grid.419922.5 schema:alternateName Institute of Oncology Research
293 schema:name Medical Physics, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
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