Pleomorphic carcinoma of the breast associated with cyst formation: a unique surgical case focusing on cytological and immunohistochemical findings. Cystic ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-05-07

AUTHORS

Sohsuke Yamada, Atsunori Nabeshima, Yoshika Nagata, Takashi Tasaki, Hirotsugu Noguchi, Shohei Kitada, Satoshi Kimura, Ke-Yong Wang, Shohei Shimajiri, Yasuyuki Sasaguri

ABSTRACT

A mammary nodular lesion was recognized one month before the surgery in the right upper breast of a 55-year-old female. The fine needle aspiration cytology specimens contained many individual bizarre, multi-nucleated, and/or giant cells having hyperchromatic pleomorphic nuclei, prominent nucleoli, and relatively abundant cytoplasm, admixed with numerous mitotic figures in a hemorrhagic or inflammatory background. A small amount of sheet-like or three-dimensional clusters of malignant cells coexisted. We first interpreted it as high-grade malignancy, such as invasive carcinoma, not otherwise specified. A right breast-conserving surgery was performed, and gross examination revealed a cystic cavity-formed and solid tumor lesion, measuring 35 × 35 × 25 mm and looking gray-yellowish to -whitish. On microscopic examination, the tumor was composed of a diffuse proliferation of highly atypical cells devoid of adhesive characteristics, including many multi-nucleated giant bizarre cells, in a haphazard fashion with stromal invasion, alternating with sarcomatoid features of spindle tumor cells. The cystic cavity was surrounded by hemorrhagic and inflammatory granulation tissue and lined by mostly denuded but atypical tumor cells or bland-looking flattened epithelial cells. Immunohistochemically, these tumor cells are specifically positive for all epithelial markers. Therefore, we made a conclusive diagnosis of pleomorphic carcinoma of the breast with cyst formation. We should be aware that, owing to its characteristic findings, cytopathologists can diagnose correctly, based on careful cytological examination of adequate samplings. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9290689448998782. More... »

PAGES

75-75

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1746-1596-8-75

DOI

http://dx.doi.org/10.1186/1746-1596-8-75

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23651662


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25 schema:description A mammary nodular lesion was recognized one month before the surgery in the right upper breast of a 55-year-old female. The fine needle aspiration cytology specimens contained many individual bizarre, multi-nucleated, and/or giant cells having hyperchromatic pleomorphic nuclei, prominent nucleoli, and relatively abundant cytoplasm, admixed with numerous mitotic figures in a hemorrhagic or inflammatory background. A small amount of sheet-like or three-dimensional clusters of malignant cells coexisted. We first interpreted it as high-grade malignancy, such as invasive carcinoma, not otherwise specified. A right breast-conserving surgery was performed, and gross examination revealed a cystic cavity-formed and solid tumor lesion, measuring 35 × 35 × 25 mm and looking gray-yellowish to -whitish. On microscopic examination, the tumor was composed of a diffuse proliferation of highly atypical cells devoid of adhesive characteristics, including many multi-nucleated giant bizarre cells, in a haphazard fashion with stromal invasion, alternating with sarcomatoid features of spindle tumor cells. The cystic cavity was surrounded by hemorrhagic and inflammatory granulation tissue and lined by mostly denuded but atypical tumor cells or bland-looking flattened epithelial cells. Immunohistochemically, these tumor cells are specifically positive for all epithelial markers. Therefore, we made a conclusive diagnosis of pleomorphic carcinoma of the breast with cyst formation. We should be aware that, owing to its characteristic findings, cytopathologists can diagnose correctly, based on careful cytological examination of adequate samplings. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9290689448998782.
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32 schema:keywords Cystic breast PC
33 PC
34 abundant cytoplasm
35 adequate sampling
36 adhesive characteristics
37 amount
38 article
39 aspiration cytology specimens
40 atypical cells
41 atypical tumor cells
42 background
43 bizarre cells
44 breast
45 breast PC
46 breast-conserving surgery
47 carcinoma
48 careful cytological examination
49 cases
50 cavity
51 cells
52 characteristic findings
53 characteristics
54 clusters
55 conclusive diagnosis
56 cyst formation
57 cystic cavity
58 cytological examination
59 cytology specimens
60 cytopathologists
61 cytoplasm
62 diagnosis
63 diffuse proliferation
64 epithelial cells
65 epithelial markers
66 examination
67 fashion
68 features
69 females
70 figures
71 findings
72 fine needle aspiration cytology specimens
73 formation
74 giant bizarre cells
75 giant cells
76 granulation tissue
77 gross examination
78 haphazard fashion
79 high-grade malignancy
80 hyperchromatic pleomorphic nuclei
81 immunohistochemical findings
82 inflammatory background
83 inflammatory granulation tissue
84 invasion
85 invasive carcinoma
86 lesions
87 malignancy
88 malignant cells
89 mammary nodular lesion
90 markers
91 microscopic examination
92 mitotic figures
93 months
94 multi-nucleated giant bizarre cells
95 needle aspiration cytology specimens
96 nodular lesions
97 nucleoli
98 nucleus
99 numerous mitotic figures
100 pleomorphic carcinoma
101 pleomorphic nuclei
102 proliferation
103 prominent nucleoli
104 right breast-conserving surgery
105 right upper breast
106 sampling
107 sarcomatoid features
108 small amount
109 solid tumor lesions
110 specimens
111 spindle tumor cells
112 stromal invasion
113 surgery
114 surgical cases
115 three-dimensional clusters
116 tissue
117 tumor cells
118 tumor lesions
119 tumors
120 unique surgical case
121 upper breast
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