Pleomorphic carcinoma of the breast associated with cyst formation: a unique surgical case focusing on cytological and immunohistochemical findings. Cystic ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-05-07

AUTHORS

Sohsuke Yamada, Atsunori Nabeshima, Yoshika Nagata, Takashi Tasaki, Hirotsugu Noguchi, Shohei Kitada, Satoshi Kimura, Ke-Yong Wang, Shohei Shimajiri, Yasuyuki Sasaguri

ABSTRACT

A mammary nodular lesion was recognized one month before the surgery in the right upper breast of a 55-year-old female. The fine needle aspiration cytology specimens contained many individual bizarre, multi-nucleated, and/or giant cells having hyperchromatic pleomorphic nuclei, prominent nucleoli, and relatively abundant cytoplasm, admixed with numerous mitotic figures in a hemorrhagic or inflammatory background. A small amount of sheet-like or three-dimensional clusters of malignant cells coexisted. We first interpreted it as high-grade malignancy, such as invasive carcinoma, not otherwise specified. A right breast-conserving surgery was performed, and gross examination revealed a cystic cavity-formed and solid tumor lesion, measuring 35 × 35 × 25 mm and looking gray-yellowish to -whitish. On microscopic examination, the tumor was composed of a diffuse proliferation of highly atypical cells devoid of adhesive characteristics, including many multi-nucleated giant bizarre cells, in a haphazard fashion with stromal invasion, alternating with sarcomatoid features of spindle tumor cells. The cystic cavity was surrounded by hemorrhagic and inflammatory granulation tissue and lined by mostly denuded but atypical tumor cells or bland-looking flattened epithelial cells. Immunohistochemically, these tumor cells are specifically positive for all epithelial markers. Therefore, we made a conclusive diagnosis of pleomorphic carcinoma of the breast with cyst formation. We should be aware that, owing to its characteristic findings, cytopathologists can diagnose correctly, based on careful cytological examination of adequate samplings.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9290689448998782 More... »

PAGES

75

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1746-1596-8-75

DOI

http://dx.doi.org/10.1186/1746-1596-8-75

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029622937

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23651662


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biopsy, Fine-Needle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cysts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mastectomy, Segmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamada", 
        "givenName": "Sohsuke", 
        "id": "sg:person.01103750361.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103750361.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nabeshima", 
        "givenName": "Atsunori", 
        "id": "sg:person.01112550751.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112550751.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Surgery II, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Departments of Surgery II, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagata", 
        "givenName": "Yoshika", 
        "id": "sg:person.01152747571.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152747571.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tasaki", 
        "givenName": "Takashi", 
        "id": "sg:person.01005232765.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005232765.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noguchi", 
        "givenName": "Hirotsugu", 
        "id": "sg:person.01340765141.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340765141.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kitada", 
        "givenName": "Shohei", 
        "id": "sg:person.01053346165.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053346165.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kimura", 
        "givenName": "Satoshi", 
        "id": "sg:person.0776322351.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776322351.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Bio-information Research Center, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan", 
            "Departments of Bio-information Research Center, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Ke-Yong", 
        "id": "sg:person.0616131554.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616131554.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimajiri", 
        "givenName": "Shohei", 
        "id": "sg:person.01043741566.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043741566.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sasaguri", 
        "givenName": "Yasuyuki", 
        "id": "sg:person.01304023165.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304023165.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1746-1596-7-61", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034784951", 
          "https://doi.org/10.1186/1746-1596-7-61"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2013.331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014800721", 
          "https://doi.org/10.1038/bjc.2013.331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-009-0862-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011136418", 
          "https://doi.org/10.1007/s00428-009-0862-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1746-1596-7-104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016564025", 
          "https://doi.org/10.1186/1746-1596-7-104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00795-008-0428-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042807357", 
          "https://doi.org/10.1007/s00795-008-0428-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00795-009-0468-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049291197", 
          "https://doi.org/10.1007/s00795-009-0468-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1746-1596-7-175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052170316", 
          "https://doi.org/10.1186/1746-1596-7-175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1746-1596-8-38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038562644", 
          "https://doi.org/10.1186/1746-1596-8-38"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-05-07", 
    "datePublishedReg": "2013-05-07", 
    "description": "AbstractA mammary nodular lesion was recognized one month before the surgery in the right upper breast of a 55-year-old female. The fine needle aspiration cytology specimens contained many individual bizarre, multi-nucleated, and/or giant cells having hyperchromatic pleomorphic nuclei, prominent nucleoli, and relatively abundant cytoplasm, admixed with numerous mitotic figures in a hemorrhagic or inflammatory background. A small amount of sheet-like or three-dimensional clusters of malignant cells coexisted. We first interpreted it as high-grade malignancy, such as invasive carcinoma, not otherwise specified. A right breast-conserving surgery was performed, and gross examination revealed a cystic cavity-formed and solid tumor lesion, measuring 35 \u00d7 35 \u00d7 25 mm and looking gray-yellowish to -whitish. On microscopic examination, the tumor was composed of a diffuse proliferation of highly atypical cells devoid of adhesive characteristics, including many multi-nucleated giant bizarre cells, in a haphazard fashion with stromal invasion, alternating with sarcomatoid features of spindle tumor cells. The cystic cavity was surrounded by hemorrhagic and inflammatory granulation tissue and lined by mostly denuded but atypical tumor cells or bland-looking flattened epithelial cells. Immunohistochemically, these tumor cells are specifically positive for all epithelial markers. Therefore, we made a conclusive diagnosis of pleomorphic carcinoma of the breast with cyst formation. We should be aware that, owing to its characteristic findings, cytopathologists can diagnose correctly, based on careful cytological examination of adequate samplings.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9290689448998782", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1746-1596-8-75", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1327435", 
        "issn": [
          "2364-4893"
        ], 
        "name": "Diagnostic Pathology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "keywords": [
      "pleomorphic carcinoma", 
      "tumor cells", 
      "right breast-conserving surgery", 
      "fine needle aspiration cytology specimens", 
      "cyst formation", 
      "right upper breast", 
      "careful cytological examination", 
      "unique surgical case", 
      "breast-conserving surgery", 
      "atypical tumor cells", 
      "aspiration cytology specimens", 
      "high-grade malignancy", 
      "spindle tumor cells", 
      "solid tumor lesions", 
      "inflammatory granulation tissue", 
      "giant bizarre cells", 
      "numerous mitotic figures", 
      "inflammatory background", 
      "sarcomatoid features", 
      "stromal invasion", 
      "characteristic findings", 
      "immunohistochemical findings", 
      "atypical cells", 
      "nodular lesions", 
      "hyperchromatic pleomorphic nuclei", 
      "invasive carcinoma", 
      "cystic cavity", 
      "diffuse proliferation", 
      "conclusive diagnosis", 
      "tumor lesions", 
      "bizarre cells", 
      "surgical cases", 
      "pleomorphic nuclei", 
      "gross examination", 
      "cytology specimens", 
      "granulation tissue", 
      "epithelial markers", 
      "cytological examination", 
      "prominent nucleoli", 
      "malignant cells", 
      "giant cells", 
      "abundant cytoplasm", 
      "carcinoma", 
      "mitotic figures", 
      "epithelial cells", 
      "breast", 
      "microscopic examination", 
      "upper breast", 
      "surgery", 
      "lesions", 
      "examination", 
      "cells", 
      "adequate sampling", 
      "malignancy", 
      "tumors", 
      "findings", 
      "diagnosis", 
      "months", 
      "cytopathologists", 
      "haphazard fashion", 
      "invasion", 
      "proliferation", 
      "tissue", 
      "markers", 
      "females", 
      "cytoplasm", 
      "cases", 
      "nucleoli", 
      "specimens", 
      "nucleus", 
      "background", 
      "cavity", 
      "fashion", 
      "small amount", 
      "sampling", 
      "three-dimensional clusters", 
      "features", 
      "formation", 
      "characteristics", 
      "adhesive characteristics", 
      "amount", 
      "article", 
      "figures", 
      "PC", 
      "clusters"
    ], 
    "name": "Pleomorphic carcinoma of the breast associated with cyst formation: a unique surgical case focusing on cytological and immunohistochemical findings. Cystic breast PC", 
    "pagination": "75", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029622937"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1746-1596-8-75"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23651662"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1746-1596-8-75", 
      "https://app.dimensions.ai/details/publication/pub.1029622937"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_598.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1746-1596-8-75"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1746-1596-8-75'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1746-1596-8-75'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1746-1596-8-75'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1746-1596-8-75'


 

This table displays all metadata directly associated to this object as RDF triples.

289 TRIPLES      22 PREDICATES      129 URIs      113 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1746-1596-8-75 schema:about N05f917a1232e40a0a61af49e5515dbed
2 N0810990e1b714d349bb55229c58d6601
3 N270b8d0cff2c469cbeba368713fdd5cf
4 N72dc2bbf77944c3fbbfbf3a47669ccaa
5 N78fa8d79337242e6ab883dbde0dd7b77
6 N7b736df7c2414d949609d73377f27674
7 N8b2c4226fef548e7ac8a7a698d5e114e
8 N8bd207e6c79544c1aaea0ed25c382c12
9 N931f208967e0459c8db73a164b6e9625
10 Nb28e8599bd034fc78231dff3122d897a
11 Nf621f8298fb14e428ef260ed123128a0
12 anzsrc-for:11
13 anzsrc-for:1112
14 schema:author N8cac05a7b25f4b0a8a6244b915811c5b
15 schema:citation sg:pub.10.1007/s00428-009-0862-3
16 sg:pub.10.1007/s00795-008-0428-5
17 sg:pub.10.1007/s00795-009-0468-5
18 sg:pub.10.1038/bjc.2013.331
19 sg:pub.10.1186/1746-1596-7-104
20 sg:pub.10.1186/1746-1596-7-175
21 sg:pub.10.1186/1746-1596-7-61
22 sg:pub.10.1186/1746-1596-8-38
23 schema:datePublished 2013-05-07
24 schema:datePublishedReg 2013-05-07
25 schema:description AbstractA mammary nodular lesion was recognized one month before the surgery in the right upper breast of a 55-year-old female. The fine needle aspiration cytology specimens contained many individual bizarre, multi-nucleated, and/or giant cells having hyperchromatic pleomorphic nuclei, prominent nucleoli, and relatively abundant cytoplasm, admixed with numerous mitotic figures in a hemorrhagic or inflammatory background. A small amount of sheet-like or three-dimensional clusters of malignant cells coexisted. We first interpreted it as high-grade malignancy, such as invasive carcinoma, not otherwise specified. A right breast-conserving surgery was performed, and gross examination revealed a cystic cavity-formed and solid tumor lesion, measuring 35 × 35 × 25 mm and looking gray-yellowish to -whitish. On microscopic examination, the tumor was composed of a diffuse proliferation of highly atypical cells devoid of adhesive characteristics, including many multi-nucleated giant bizarre cells, in a haphazard fashion with stromal invasion, alternating with sarcomatoid features of spindle tumor cells. The cystic cavity was surrounded by hemorrhagic and inflammatory granulation tissue and lined by mostly denuded but atypical tumor cells or bland-looking flattened epithelial cells. Immunohistochemically, these tumor cells are specifically positive for all epithelial markers. Therefore, we made a conclusive diagnosis of pleomorphic carcinoma of the breast with cyst formation. We should be aware that, owing to its characteristic findings, cytopathologists can diagnose correctly, based on careful cytological examination of adequate samplings.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9290689448998782
26 schema:genre article
27 schema:inLanguage en
28 schema:isAccessibleForFree true
29 schema:isPartOf N5bdb5223a28f44a2ba5ce15f422f5642
30 N969ef36335bd45cab7b038568db552b4
31 sg:journal.1327435
32 schema:keywords PC
33 abundant cytoplasm
34 adequate sampling
35 adhesive characteristics
36 amount
37 article
38 aspiration cytology specimens
39 atypical cells
40 atypical tumor cells
41 background
42 bizarre cells
43 breast
44 breast-conserving surgery
45 carcinoma
46 careful cytological examination
47 cases
48 cavity
49 cells
50 characteristic findings
51 characteristics
52 clusters
53 conclusive diagnosis
54 cyst formation
55 cystic cavity
56 cytological examination
57 cytology specimens
58 cytopathologists
59 cytoplasm
60 diagnosis
61 diffuse proliferation
62 epithelial cells
63 epithelial markers
64 examination
65 fashion
66 features
67 females
68 figures
69 findings
70 fine needle aspiration cytology specimens
71 formation
72 giant bizarre cells
73 giant cells
74 granulation tissue
75 gross examination
76 haphazard fashion
77 high-grade malignancy
78 hyperchromatic pleomorphic nuclei
79 immunohistochemical findings
80 inflammatory background
81 inflammatory granulation tissue
82 invasion
83 invasive carcinoma
84 lesions
85 malignancy
86 malignant cells
87 markers
88 microscopic examination
89 mitotic figures
90 months
91 nodular lesions
92 nucleoli
93 nucleus
94 numerous mitotic figures
95 pleomorphic carcinoma
96 pleomorphic nuclei
97 proliferation
98 prominent nucleoli
99 right breast-conserving surgery
100 right upper breast
101 sampling
102 sarcomatoid features
103 small amount
104 solid tumor lesions
105 specimens
106 spindle tumor cells
107 stromal invasion
108 surgery
109 surgical cases
110 three-dimensional clusters
111 tissue
112 tumor cells
113 tumor lesions
114 tumors
115 unique surgical case
116 upper breast
117 schema:name Pleomorphic carcinoma of the breast associated with cyst formation: a unique surgical case focusing on cytological and immunohistochemical findings. Cystic breast PC
118 schema:pagination 75
119 schema:productId N5539e276977242a48cab5d7eb56613de
120 N76238ee4b0154656a99fa9ad302a9337
121 Na51a2083265748d8b0b9311042e11448
122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029622937
123 https://doi.org/10.1186/1746-1596-8-75
124 schema:sdDatePublished 2022-05-20T07:28
125 schema:sdLicense https://scigraph.springernature.com/explorer/license/
126 schema:sdPublisher Nd2db5ffca1e549c48b74d26b5132a65d
127 schema:url https://doi.org/10.1186/1746-1596-8-75
128 sgo:license sg:explorer/license/
129 sgo:sdDataset articles
130 rdf:type schema:ScholarlyArticle
131 N001bbb9c871d4bf291b5a6cc6f5a25dd rdf:first sg:person.01112550751.29
132 rdf:rest Nef1245c90ff5486eaeb9b85d1cea1671
133 N05f917a1232e40a0a61af49e5515dbed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Breast Neoplasms
135 rdf:type schema:DefinedTerm
136 N0810990e1b714d349bb55229c58d6601 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Biomarkers, Tumor
138 rdf:type schema:DefinedTerm
139 N164ac3ac5d8f43bbb5fa4cc41c2cc0a3 rdf:first sg:person.0776322351.15
140 rdf:rest Nd225227a4e964e7f9822c98b3e0ed0ba
141 N1b972c7e547841b897a0c77821496355 rdf:first sg:person.01043741566.35
142 rdf:rest N6d7e64a195754aca92ccf0343eb9f342
143 N270b8d0cff2c469cbeba368713fdd5cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Cysts
145 rdf:type schema:DefinedTerm
146 N5362ab9667944a22b06ecb6f34863b78 rdf:first sg:person.01053346165.54
147 rdf:rest N164ac3ac5d8f43bbb5fa4cc41c2cc0a3
148 N5539e276977242a48cab5d7eb56613de schema:name pubmed_id
149 schema:value 23651662
150 rdf:type schema:PropertyValue
151 N56c6e0641f3d41abbab29056d7bc80d0 rdf:first sg:person.01340765141.30
152 rdf:rest N5362ab9667944a22b06ecb6f34863b78
153 N5bdb5223a28f44a2ba5ce15f422f5642 schema:volumeNumber 8
154 rdf:type schema:PublicationVolume
155 N6d7e64a195754aca92ccf0343eb9f342 rdf:first sg:person.01304023165.50
156 rdf:rest rdf:nil
157 N72dc2bbf77944c3fbbfbf3a47669ccaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Humans
159 rdf:type schema:DefinedTerm
160 N76238ee4b0154656a99fa9ad302a9337 schema:name doi
161 schema:value 10.1186/1746-1596-8-75
162 rdf:type schema:PropertyValue
163 N78fa8d79337242e6ab883dbde0dd7b77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Breast
165 rdf:type schema:DefinedTerm
166 N7b736df7c2414d949609d73377f27674 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Female
168 rdf:type schema:DefinedTerm
169 N8b2c4226fef548e7ac8a7a698d5e114e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Middle Aged
171 rdf:type schema:DefinedTerm
172 N8bd207e6c79544c1aaea0ed25c382c12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Biopsy, Fine-Needle
174 rdf:type schema:DefinedTerm
175 N8cac05a7b25f4b0a8a6244b915811c5b rdf:first sg:person.01103750361.46
176 rdf:rest N001bbb9c871d4bf291b5a6cc6f5a25dd
177 N931f208967e0459c8db73a164b6e9625 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Mastectomy, Segmental
179 rdf:type schema:DefinedTerm
180 N969ef36335bd45cab7b038568db552b4 schema:issueNumber 1
181 rdf:type schema:PublicationIssue
182 Na51a2083265748d8b0b9311042e11448 schema:name dimensions_id
183 schema:value pub.1029622937
184 rdf:type schema:PropertyValue
185 Nb28e8599bd034fc78231dff3122d897a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Immunohistochemistry
187 rdf:type schema:DefinedTerm
188 Nd225227a4e964e7f9822c98b3e0ed0ba rdf:first sg:person.0616131554.41
189 rdf:rest N1b972c7e547841b897a0c77821496355
190 Nd2db5ffca1e549c48b74d26b5132a65d schema:name Springer Nature - SN SciGraph project
191 rdf:type schema:Organization
192 Nef1245c90ff5486eaeb9b85d1cea1671 rdf:first sg:person.01152747571.34
193 rdf:rest Nfd3f9c7fc2eb4cb29cbf351d0539fdba
194 Nf621f8298fb14e428ef260ed123128a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Epithelial Cells
196 rdf:type schema:DefinedTerm
197 Nfd3f9c7fc2eb4cb29cbf351d0539fdba rdf:first sg:person.01005232765.12
198 rdf:rest N56c6e0641f3d41abbab29056d7bc80d0
199 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
200 schema:name Medical and Health Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
203 schema:name Oncology and Carcinogenesis
204 rdf:type schema:DefinedTerm
205 sg:journal.1327435 schema:issn 2364-4893
206 schema:name Diagnostic Pathology
207 schema:publisher Springer Nature
208 rdf:type schema:Periodical
209 sg:person.01005232765.12 schema:affiliation grid-institutes:grid.271052.3
210 schema:familyName Tasaki
211 schema:givenName Takashi
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005232765.12
213 rdf:type schema:Person
214 sg:person.01043741566.35 schema:affiliation grid-institutes:grid.271052.3
215 schema:familyName Shimajiri
216 schema:givenName Shohei
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043741566.35
218 rdf:type schema:Person
219 sg:person.01053346165.54 schema:affiliation grid-institutes:grid.271052.3
220 schema:familyName Kitada
221 schema:givenName Shohei
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053346165.54
223 rdf:type schema:Person
224 sg:person.01103750361.46 schema:affiliation grid-institutes:grid.271052.3
225 schema:familyName Yamada
226 schema:givenName Sohsuke
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103750361.46
228 rdf:type schema:Person
229 sg:person.01112550751.29 schema:affiliation grid-institutes:grid.271052.3
230 schema:familyName Nabeshima
231 schema:givenName Atsunori
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112550751.29
233 rdf:type schema:Person
234 sg:person.01152747571.34 schema:affiliation grid-institutes:grid.271052.3
235 schema:familyName Nagata
236 schema:givenName Yoshika
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152747571.34
238 rdf:type schema:Person
239 sg:person.01304023165.50 schema:affiliation grid-institutes:grid.271052.3
240 schema:familyName Sasaguri
241 schema:givenName Yasuyuki
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304023165.50
243 rdf:type schema:Person
244 sg:person.01340765141.30 schema:affiliation grid-institutes:grid.271052.3
245 schema:familyName Noguchi
246 schema:givenName Hirotsugu
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340765141.30
248 rdf:type schema:Person
249 sg:person.0616131554.41 schema:affiliation grid-institutes:grid.271052.3
250 schema:familyName Wang
251 schema:givenName Ke-Yong
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616131554.41
253 rdf:type schema:Person
254 sg:person.0776322351.15 schema:affiliation grid-institutes:grid.271052.3
255 schema:familyName Kimura
256 schema:givenName Satoshi
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776322351.15
258 rdf:type schema:Person
259 sg:pub.10.1007/s00428-009-0862-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011136418
260 https://doi.org/10.1007/s00428-009-0862-3
261 rdf:type schema:CreativeWork
262 sg:pub.10.1007/s00795-008-0428-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042807357
263 https://doi.org/10.1007/s00795-008-0428-5
264 rdf:type schema:CreativeWork
265 sg:pub.10.1007/s00795-009-0468-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049291197
266 https://doi.org/10.1007/s00795-009-0468-5
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/bjc.2013.331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014800721
269 https://doi.org/10.1038/bjc.2013.331
270 rdf:type schema:CreativeWork
271 sg:pub.10.1186/1746-1596-7-104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016564025
272 https://doi.org/10.1186/1746-1596-7-104
273 rdf:type schema:CreativeWork
274 sg:pub.10.1186/1746-1596-7-175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052170316
275 https://doi.org/10.1186/1746-1596-7-175
276 rdf:type schema:CreativeWork
277 sg:pub.10.1186/1746-1596-7-61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034784951
278 https://doi.org/10.1186/1746-1596-7-61
279 rdf:type schema:CreativeWork
280 sg:pub.10.1186/1746-1596-8-38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038562644
281 https://doi.org/10.1186/1746-1596-8-38
282 rdf:type schema:CreativeWork
283 grid-institutes:grid.271052.3 schema:alternateName Departments of Bio-information Research Center, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan
284 Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan
285 Departments of Surgery II, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan
286 schema:name Departments of Bio-information Research Center, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan
287 Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan
288 Departments of Surgery II, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan
289 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...