Prostate carcinoma metastatic to the skin as an extrammamary Paget’s disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Eugen Bogdan Petcu, Aldo Gonzalez-Serva, Robert G Wright, Mark Slevin, Klara Brinzaniuc

ABSTRACT

AIM: The current paper describes a case of prostatic adenocarcinoma metastatic to the skin presenting as an extrammamary Paget's disease, a very rare and poorly characterised morphological entity. We report a case of prostatic carcinoma metastatic to skin showing a pattern of extramammary Paget's disease which has not been clearly illustrated in the literature Case presentation: A 63 year-old man with prostatic adenocarcinoma developed cutaneous metastases after 16 years. The inguinal metastases were sessile and 'keratotic.' The tumour displayed solid, glandular areas as well as a polypoid region suggestive of extramammary Paget's disease were identified. DISCUSSION AND CONCLUSIONS: We review the diagnostic criteria that have led to the correct histopathological diagnosis in this case. A differential diagnosis of the pagetoid spread in the skin and various forms of cutaneous metastases determined by a prostatic adenocarcinoma as well as the role of immunohistochemistry in establishing the prostatic origin are presented in the context of this case. Although, morphologically the cells presented in the skin deposits were not characteristic for adenocarcinoma of prostate, immunohistochemistry for PSA and PSAP suggested a prostatic origin. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1395450057455276. More... »

PAGES

106

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1746-1596-7-106

DOI

http://dx.doi.org/10.1186/1746-1596-7-106

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038760111

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22901743


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