LOCAT (low-dose computed tomography for appendicitis trial) comparing clinical outcomes following low- vs standard-dose computed tomography as the first-line imaging ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-01-17

AUTHORS

Soyeon Ahn

ABSTRACT

BACKGROUND: Computed tomography is widely used to diagnose acute appendicitis. Many adolescents and young adults are exposed to the associated radiation. A recent single-institution trial has reported promising results for low-dose computed tomography; however, this technique has not yet been widely adopted. LOCAT (low-dose computed tomography for appendicitis trial), a multi-institution randomized controlled non-inferiority trial, aims to compare low-dose computed tomography and standard-dose computed tomography as the first-line imaging tests for adolescents and young adults, and therefore to test the generalizability of the previous single-institution trial results. METHODS/DESIGN: Participants with suspected appendicitis are randomly assigned to either the low-dose group (with a typical effective dose of 2 mSv) or the standard-dose group (as used in normal practice at each participating site, typically 8 mSv). The primary end point is the negative appendectomy rate (the percentage of the number of uninflamed appendices that were removed among all non-incidental appendectomies), which is a consequence of false-positive diagnoses, with a non-inferiority margin of 4.5 percentage points. The key secondary end point is the appendiceal perforation rate, which is a consequence of delayed (or false-negative) diagnoses. Participant recruitment will be continued until the number of non-incidental appendectomies for each group exceeds 444. The total number of expected participants approximates 3,000, including those not undergoing appendectomy. DISCUSSION: In addition to the study protocol, we elaborate on several challenging or potentially debatable components of the study design, including the broad eligibility criteria, choice of the primary end point, potential effect of using advanced imaging techniques on study results, determining and adjusting the radiation doses, ambiguities in reference standards, rationale for the non-inferiority margin, use of the intention-to-treat approach and difficulties in defining adverse events. TRIAL REGISTRATION: ClinicalTrials.gov NCT01925014. More... »

PAGES

28-28

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1745-6215-15-28

DOI

http://dx.doi.org/10.1186/1745-6215-15-28

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040694798

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24438500


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Appendectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Appendicitis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intention to Treat Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiation Dosage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Republic of Korea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Research Design", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Single-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, X-Ray Computed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Unnecessary Procedures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Medical Research Collaborating Center, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Medical Research Collaborating Center, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahn", 
        "givenName": "Soyeon", 
        "id": "sg:person.0612662613.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612662613.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00330-013-2769-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020329249", 
          "https://doi.org/10.1007/s00330-013-2769-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10278-007-9067-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050734428", 
          "https://doi.org/10.1007/s10278-007-9067-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00330-003-1883-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019416871", 
          "https://doi.org/10.1007/s00330-003-1883-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10278-005-5163-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005450663", 
          "https://doi.org/10.1007/s10278-005-5163-z"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-01-17", 
    "datePublishedReg": "2014-01-17", 
    "description": "BACKGROUND: Computed tomography is widely used to diagnose acute appendicitis. Many adolescents and young adults are exposed to the associated radiation. A recent single-institution trial has reported promising results for low-dose computed tomography; however, this technique has not yet been widely adopted. LOCAT (low-dose computed tomography for appendicitis trial), a multi-institution randomized controlled non-inferiority trial, aims to compare low-dose computed tomography and standard-dose computed tomography as the first-line imaging tests for adolescents and young adults, and therefore to test the generalizability of the previous single-institution trial results.\nMETHODS/DESIGN: Participants with suspected appendicitis are randomly assigned to either the low-dose group (with a typical effective dose of 2\u00a0mSv) or the standard-dose group (as used in normal practice at each participating site, typically 8\u00a0mSv). The primary end point is the negative appendectomy rate (the percentage of the number of uninflamed appendices that were removed among all non-incidental appendectomies), which is a consequence of false-positive diagnoses, with a non-inferiority margin of 4.5 percentage points. The key secondary end point is the appendiceal perforation rate, which is a consequence of delayed (or false-negative) diagnoses. Participant recruitment will be continued until the number of non-incidental appendectomies for each group exceeds 444. The total number of expected participants approximates 3,000, including those not undergoing appendectomy.\nDISCUSSION: In addition to the study protocol, we elaborate on several challenging or potentially debatable components of the study design, including the broad eligibility criteria, choice of the primary end point, potential effect of using advanced imaging techniques on study results, determining and adjusting the radiation doses, ambiguities in reference standards, rationale for the non-inferiority margin, use of the intention-to-treat approach and difficulties in defining adverse events.\nTRIAL REGISTRATION: ClinicalTrials.gov NCT01925014.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1745-6215-15-28", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1297400", 
        "issn": [
          "1468-6708", 
          "1745-6215"
        ], 
        "name": "Trials", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "keywords": [
      "primary end point", 
      "non-inferiority margin", 
      "acute appendicitis", 
      "end point", 
      "study protocol", 
      "young adults", 
      "key secondary end point", 
      "single-institution trial", 
      "low-dose computed tomography", 
      "standard-dose group", 
      "Secondary end points", 
      "low-dose group", 
      "negative appendectomy rate", 
      "non-inferiority trial", 
      "appendiceal perforation rate", 
      "broad eligibility criteria", 
      "false-positive diagnoses", 
      "advanced imaging techniques", 
      "adverse events", 
      "clinical outcomes", 
      "appendectomy rate", 
      "treat approach", 
      "perforation rate", 
      "eligibility criteria", 
      "computed tomography", 
      "appendicitis", 
      "study design", 
      "trial results", 
      "participant recruitment", 
      "tomography", 
      "trials", 
      "appendectomy", 
      "radiation doses", 
      "adults", 
      "reference standard", 
      "diagnosis", 
      "adolescents", 
      "imaging techniques", 
      "group", 
      "total number", 
      "potential effects", 
      "participants", 
      "study results", 
      "doses", 
      "promising results", 
      "outcomes", 
      "percentage points", 
      "protocol", 
      "rate", 
      "test", 
      "associated radiation", 
      "recruitment", 
      "rationale", 
      "LOCAT", 
      "consequences", 
      "margin", 
      "criteria", 
      "number", 
      "generalizability", 
      "results", 
      "events", 
      "effect", 
      "use", 
      "point", 
      "addition", 
      "challenging", 
      "difficulties", 
      "standards", 
      "technique", 
      "intention", 
      "choice", 
      "radiation", 
      "components", 
      "approach", 
      "design", 
      "ambiguity", 
      "recent single-institution trial", 
      "previous single-institution trial results", 
      "single-institution trial results", 
      "non-incidental appendectomies", 
      "debatable components", 
      "NCT01925014"
    ], 
    "name": "LOCAT (low-dose computed tomography for appendicitis trial) comparing clinical outcomes following low- vs standard-dose computed tomography as the first-line imaging test in adolescents and young adults with suspected acute appendicitis: study protocol for a randomized controlled trial", 
    "pagination": "28-28", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040694798"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1745-6215-15-28"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24438500"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1745-6215-15-28", 
      "https://app.dimensions.ai/details/publication/pub.1040694798"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_648.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1745-6215-15-28"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1745-6215-15-28'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1745-6215-15-28'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1745-6215-15-28'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1745-6215-15-28'


 

This table displays all metadata directly associated to this object as RDF triples.

224 TRIPLES      22 PREDICATES      128 URIs      116 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1745-6215-15-28 schema:about N1a154edee8644e029b9a06ade865cf1a
2 N32a54f2832ab497d805b7bc485b4c311
3 N3d48a65a42de480a9358ac5cd89037ee
4 N6abc2eb2cf3c43e492ba6e41922ce66e
5 N6b4bca94026c4cc59187b38a6ea923df
6 N7748754211cd45fd84d2359616f88c13
7 N7a3384697f324e0196e18872bcd234a5
8 N8c97a222295e462ea925bf4f69c232ad
9 N91849060266b42f1b4437b9b67059979
10 N980199c26867457e98f469bdf83f731d
11 N983765c2de49413b85844276ac98eb05
12 N9cb481b8ba2a4474abc1d1e15a1392a8
13 Na849de22f5f441ec81ba55bc7d9bce81
14 Nd24a1694f05e4470a1264d31bc2d4c2e
15 Nd6a542896cef4ba0a9114550af5e0e05
16 Nf7997b695f814aac8d5cecdd62dc7ec1
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author Ne6d12189207e409f83e4dc921041ab1a
20 schema:citation sg:pub.10.1007/s00330-003-1883-y
21 sg:pub.10.1007/s00330-013-2769-2
22 sg:pub.10.1007/s10278-005-5163-z
23 sg:pub.10.1007/s10278-007-9067-y
24 schema:datePublished 2014-01-17
25 schema:datePublishedReg 2014-01-17
26 schema:description BACKGROUND: Computed tomography is widely used to diagnose acute appendicitis. Many adolescents and young adults are exposed to the associated radiation. A recent single-institution trial has reported promising results for low-dose computed tomography; however, this technique has not yet been widely adopted. LOCAT (low-dose computed tomography for appendicitis trial), a multi-institution randomized controlled non-inferiority trial, aims to compare low-dose computed tomography and standard-dose computed tomography as the first-line imaging tests for adolescents and young adults, and therefore to test the generalizability of the previous single-institution trial results. METHODS/DESIGN: Participants with suspected appendicitis are randomly assigned to either the low-dose group (with a typical effective dose of 2 mSv) or the standard-dose group (as used in normal practice at each participating site, typically 8 mSv). The primary end point is the negative appendectomy rate (the percentage of the number of uninflamed appendices that were removed among all non-incidental appendectomies), which is a consequence of false-positive diagnoses, with a non-inferiority margin of 4.5 percentage points. The key secondary end point is the appendiceal perforation rate, which is a consequence of delayed (or false-negative) diagnoses. Participant recruitment will be continued until the number of non-incidental appendectomies for each group exceeds 444. The total number of expected participants approximates 3,000, including those not undergoing appendectomy. DISCUSSION: In addition to the study protocol, we elaborate on several challenging or potentially debatable components of the study design, including the broad eligibility criteria, choice of the primary end point, potential effect of using advanced imaging techniques on study results, determining and adjusting the radiation doses, ambiguities in reference standards, rationale for the non-inferiority margin, use of the intention-to-treat approach and difficulties in defining adverse events. TRIAL REGISTRATION: ClinicalTrials.gov NCT01925014.
27 schema:genre article
28 schema:inLanguage en
29 schema:isAccessibleForFree true
30 schema:isPartOf N0ead627bc31048d6b4809a829f9abfdc
31 N61683305206646babbf37113497b5db9
32 sg:journal.1297400
33 schema:keywords LOCAT
34 NCT01925014
35 Secondary end points
36 acute appendicitis
37 addition
38 adolescents
39 adults
40 advanced imaging techniques
41 adverse events
42 ambiguity
43 appendectomy
44 appendectomy rate
45 appendiceal perforation rate
46 appendicitis
47 approach
48 associated radiation
49 broad eligibility criteria
50 challenging
51 choice
52 clinical outcomes
53 components
54 computed tomography
55 consequences
56 criteria
57 debatable components
58 design
59 diagnosis
60 difficulties
61 doses
62 effect
63 eligibility criteria
64 end point
65 events
66 false-positive diagnoses
67 generalizability
68 group
69 imaging techniques
70 intention
71 key secondary end point
72 low-dose computed tomography
73 low-dose group
74 margin
75 negative appendectomy rate
76 non-incidental appendectomies
77 non-inferiority margin
78 non-inferiority trial
79 number
80 outcomes
81 participant recruitment
82 participants
83 percentage points
84 perforation rate
85 point
86 potential effects
87 previous single-institution trial results
88 primary end point
89 promising results
90 protocol
91 radiation
92 radiation doses
93 rate
94 rationale
95 recent single-institution trial
96 recruitment
97 reference standard
98 results
99 single-institution trial
100 single-institution trial results
101 standard-dose group
102 standards
103 study design
104 study protocol
105 study results
106 technique
107 test
108 tomography
109 total number
110 treat approach
111 trial results
112 trials
113 use
114 young adults
115 schema:name LOCAT (low-dose computed tomography for appendicitis trial) comparing clinical outcomes following low- vs standard-dose computed tomography as the first-line imaging test in adolescents and young adults with suspected acute appendicitis: study protocol for a randomized controlled trial
116 schema:pagination 28-28
117 schema:productId N27135f3effe04e7ca641e6a11e9c0ab2
118 N95fa91d4201c4ecb9240bfae273a8f21
119 Nad2c9190bd18471492692e04f5c4d70d
120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040694798
121 https://doi.org/10.1186/1745-6215-15-28
122 schema:sdDatePublished 2022-01-01T18:35
123 schema:sdLicense https://scigraph.springernature.com/explorer/license/
124 schema:sdPublisher N575402e59df8431d92c2b24d5eec9d90
125 schema:url https://doi.org/10.1186/1745-6215-15-28
126 sgo:license sg:explorer/license/
127 sgo:sdDataset articles
128 rdf:type schema:ScholarlyArticle
129 N0ead627bc31048d6b4809a829f9abfdc schema:volumeNumber 15
130 rdf:type schema:PublicationVolume
131 N1a154edee8644e029b9a06ade865cf1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Adolescent
133 rdf:type schema:DefinedTerm
134 N27135f3effe04e7ca641e6a11e9c0ab2 schema:name doi
135 schema:value 10.1186/1745-6215-15-28
136 rdf:type schema:PropertyValue
137 N32a54f2832ab497d805b7bc485b4c311 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Radiation Dosage
139 rdf:type schema:DefinedTerm
140 N3d48a65a42de480a9358ac5cd89037ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Clinical Protocols
142 rdf:type schema:DefinedTerm
143 N575402e59df8431d92c2b24d5eec9d90 schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 N61683305206646babbf37113497b5db9 schema:issueNumber 1
146 rdf:type schema:PublicationIssue
147 N6abc2eb2cf3c43e492ba6e41922ce66e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Appendectomy
149 rdf:type schema:DefinedTerm
150 N6b4bca94026c4cc59187b38a6ea923df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Age Factors
152 rdf:type schema:DefinedTerm
153 N7748754211cd45fd84d2359616f88c13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Research Design
155 rdf:type schema:DefinedTerm
156 N7a3384697f324e0196e18872bcd234a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Intention to Treat Analysis
158 rdf:type schema:DefinedTerm
159 N8c97a222295e462ea925bf4f69c232ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Unnecessary Procedures
161 rdf:type schema:DefinedTerm
162 N91849060266b42f1b4437b9b67059979 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Adult
164 rdf:type schema:DefinedTerm
165 N95fa91d4201c4ecb9240bfae273a8f21 schema:name dimensions_id
166 schema:value pub.1040694798
167 rdf:type schema:PropertyValue
168 N980199c26867457e98f469bdf83f731d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Republic of Korea
170 rdf:type schema:DefinedTerm
171 N983765c2de49413b85844276ac98eb05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Humans
173 rdf:type schema:DefinedTerm
174 N9cb481b8ba2a4474abc1d1e15a1392a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Young Adult
176 rdf:type schema:DefinedTerm
177 Na849de22f5f441ec81ba55bc7d9bce81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Tomography, X-Ray Computed
179 rdf:type schema:DefinedTerm
180 Nad2c9190bd18471492692e04f5c4d70d schema:name pubmed_id
181 schema:value 24438500
182 rdf:type schema:PropertyValue
183 Nd24a1694f05e4470a1264d31bc2d4c2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Single-Blind Method
185 rdf:type schema:DefinedTerm
186 Nd6a542896cef4ba0a9114550af5e0e05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Predictive Value of Tests
188 rdf:type schema:DefinedTerm
189 Ne6d12189207e409f83e4dc921041ab1a rdf:first sg:person.0612662613.04
190 rdf:rest rdf:nil
191 Nf7997b695f814aac8d5cecdd62dc7ec1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Appendicitis
193 rdf:type schema:DefinedTerm
194 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
195 schema:name Medical and Health Sciences
196 rdf:type schema:DefinedTerm
197 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
198 schema:name Clinical Sciences
199 rdf:type schema:DefinedTerm
200 sg:journal.1297400 schema:issn 1468-6708
201 1745-6215
202 schema:name Trials
203 schema:publisher Springer Nature
204 rdf:type schema:Periodical
205 sg:person.0612662613.04 schema:affiliation grid-institutes:grid.412480.b
206 schema:familyName Ahn
207 schema:givenName Soyeon
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612662613.04
209 rdf:type schema:Person
210 sg:pub.10.1007/s00330-003-1883-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1019416871
211 https://doi.org/10.1007/s00330-003-1883-y
212 rdf:type schema:CreativeWork
213 sg:pub.10.1007/s00330-013-2769-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020329249
214 https://doi.org/10.1007/s00330-013-2769-2
215 rdf:type schema:CreativeWork
216 sg:pub.10.1007/s10278-005-5163-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1005450663
217 https://doi.org/10.1007/s10278-005-5163-z
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/s10278-007-9067-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1050734428
220 https://doi.org/10.1007/s10278-007-9067-y
221 rdf:type schema:CreativeWork
222 grid-institutes:grid.412480.b schema:alternateName Medical Research Collaborating Center, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Republic of Korea
223 schema:name Medical Research Collaborating Center, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Republic of Korea
224 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...