Developing core outcome sets for clinical trials: issues to consider View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-08-06

AUTHORS

Paula R Williamson, Douglas G Altman, Jane M Blazeby, Mike Clarke, Declan Devane, Elizabeth Gargon, Peter Tugwell

ABSTRACT

The selection of appropriate outcomes or domains is crucial when designing clinical trials in order to compare directly the effects of different interventions in ways that minimize bias. If the findings are to influence policy and practice then the chosen outcomes need to be relevant and important to key stakeholders including patients and the public, health care professionals and others making decisions about health care. There is a growing recognition that insufficient attention has been paid to the outcomes measured in clinical trials. These issues could be addressed through the development and use of an agreed standardized collection of outcomes, known as a core outcome set, which should be measured and reported, as a minimum, in all trials for a specific clinical area. Accumulating work in this area has identified the need for general guidance on the development of core outcome sets. Key issues to consider in the development of a core outcome set include its scope, the stakeholder groups to involve, choice of consensus method and the achievement of a consensus. More... »

PAGES

132

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1745-6215-13-132

DOI

http://dx.doi.org/10.1186/1745-6215-13-132

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024507815

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22867278


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