Protocol for the Osteoporosis Choice trial. A pilot randomized trial of a decision aid in primary care practice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-12

AUTHORS

Laurie J Pencille, Megan E Campbell, Holly K Van Houten, Nilay D Shah, Rebecca J Mullan, Brian A Swiglo, Maggie Breslin, Rebecca L Kesman, Sidna M Tulledge-Scheitel, Thomas M Jaeger, Ruth E Johnson, Gregory A Bartel, Robert A Wermers, L Joseph Melton, Victor M Montori

ABSTRACT

BACKGROUND: Bisphosphonates can reduce fracture risk in patients with osteoporosis, but many at-risk patients do not start or adhere to these medications. The aims of this study are to: (1) preliminarily evaluate the effect of an individualized 10-year osteoporotic fracture risk calculator and decision aid (OSTEOPOROSIS CHOICE) for postmenopausal women at risk for osteoporotic fractures; and (2) assess the feasibility and validity (i.e., absence of contamination) of patient-level randomization (vs. cluster randomization) in pilot trials of decision aid efficacy. METHODS/DESIGN: This is a protocol for a parallel, 2-arm, randomized trial to compare an intervention group receiving OSTEOPOROSIS CHOICE to a control group receiving usual primary care. Postmenopausal women with bone mineral density T-scores of <-1.0, not receiving bisphosphonate therapy, and receiving care at participating primary care practices in and around Rochester, Minnesota, USA will be eligible to participate in the trial. We will measure the effect of OSTEOPOROSIS CHOICE on five outcomes: (a) patient knowledge regarding osteoporosis risk factors and treatment; (b) quality of the decision-making process for both the patient and clinician; (c) patient and clinician acceptability and satisfaction with the decision aid; (d) rate of bisphosphonate use and adherence, and (e) trial processes (e.g., ability to recruit participants, collect patient outcomes). To capture these outcomes, we will use patient and clinician surveys following each visit and video recordings of the clinical encounters. These video recordings will also allow us to determine the extent to which clinicians previously exposed to the decision aid were able to recreate elements of the decision aid with control patients (i.e., contamination). Pharmacy prescription profiles and follow-up phone interviews will assess medication start and adherence at 6 months. DISCUSSION: This pilot trial will provide evidence of feasibility, validity of patient randomization, and preliminary efficacy of a novel approach--decision aids--to improving medication adherence for postmenopausal women at risk of osteoporotic fractures. The results will inform the design of a larger trial that could provide more precise estimates of the efficacy of the decision aid. TRIAL REGISTRATION: Clinical Trials.gov Identifier: NCT00578981. More... »

PAGES

113

References to SciGraph publications

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  • 2009-12. Development of a theory of implementation and integration: Normalization Process Theory in IMPLEMENTATION SCIENCE
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1745-6215-10-113

    DOI

    http://dx.doi.org/10.1186/1745-6215-10-113

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051078892

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20003299


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