Mycobacteriophage-drived diversification of Mycobacterium abscessus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Mohamed Sassi, Philippe Gouret, Olivier Chabrol, Pierre Pontarotti, Michel Drancourt

ABSTRACT

BACKGROUND: Mycobacterium abscessus is an emerging opportunistic pathogen which diversity was acknowledged by the recent description of two subspecies accommodating M. abscessus, Mycobacterium bolletii and Mycobacterium massiliense isolates. RESULTS: Here, genome analysis found 1-8 prophage regions in 47/48 M. abscessus genomes ranging from small prophage-like elements to complete prophages. A total of 20,304 viral and phage proteins clustered into 853 orthologous groups. Phylogenomic and phylogenetic analyses based on prophage region homology found three main clusters corresponding to M. abscessus, M. bolletii and M. massiliense. Analysing 135 annotated Tape Measure Proteins found thirteen clusters and four singletons, suggesting that at least 17 mycobacteriophages had infected M. abscessus during its evolution. The evolutionary history of phages differed from that of their mycobacterial hosts. In particular, 33 phage-related proteins have been horizontally transferred within M. abscessus genomes. They comprise of an integrase, specific mycobacteriophage proteins, hypothetical proteins and DNA replication and metabolism proteins. Gene exchanges, loss and gains which occurred in M. abscessus genomes have been driven by several mycobacteriophages. CONCLUSIONS: This analysis of phage-mycobacterium co-evolution suggests that mycobacteriophages are playing a key-role in the on-going diversification of M. abscessus. REVIEWERS: This article was reviewed by Eric Bapteste, Patrick Forterre and Eugene Koonin. More... »

PAGES

19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1745-6150-9-19

DOI

http://dx.doi.org/10.1186/1745-6150-9-19

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040950864

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25224692


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Download the RDF metadata as:  json-ld nt turtle xml License info

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RDF/XML is a standard XML format for linked data.

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