Two novel PIWI families: roles in inter-genomic conflicts in bacteria and Mediator-dependent modulation of transcription in eukaryotes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

A Maxwell Burroughs, Lakshminarayan M Iyer, L Aravind

ABSTRACT

BACKGROUND: The PIWI module, found in the PIWI/AGO superfamily of proteins, is a critical component of several cellular pathways including germline maintenance, chromatin organization, regulation of splicing, RNA interference, and virus suppression. It binds a guide strand which helps it target complementary nucleic strands. RESULTS: Here we report the discovery of two divergent, novel families of PIWI modules, the first such to be described since the initial discovery of the PIWI/AGO superfamily over a decade ago. Both families display conservation patterns consistent with the binding of oligonucleotide guide strands. The first family is bacterial in distribution and is typically encoded by a distinctive three-gene operon alongside genes for a restriction endonuclease fold enzyme and a helicase of the DinG family. The second family is found only in eukaryotes. It is the core conserved module of the Med13 protein, a subunit of the CDK8 subcomplex of the transcription regulatory Mediator complex. CONCLUSIONS: Based on the presence of the DinG family helicase, which specifically acts on R-loops, we infer that the first family of PIWI modules is part of a novel RNA-dependent restriction system which could target invasive DNA from phages, plasmids or conjugative transposons. It is predicted to facilitate restriction of actively transcribed invading DNA by utilizing RNA guides. The PIWI family found in the eukaryotic Med13 proteins throws new light on the regulatory switch through which the CDK8 subcomplex modulates transcription at Mediator-bound promoters of highly transcribed genes. We propose that this involves recognition of small RNAs by the PIWI module in Med13 resulting in a conformational switch that propagates through the Mediator complex. REVIEWERS: This article was reviewed by Sandor Pongor, Frank Eisenhaber and Balaji Santhanam. More... »

PAGES

13

References to SciGraph publications

  • 2010-08. Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-09. Biogenic mechanisms and utilization of small RNAs derived from human protein-coding genes in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2005-03. Structural insights into mRNA recognition from a PIWI domain–siRNA guide complex in NATURE
  • 2012-02. The N domain of Argonaute drives duplex unwinding during RISC assembly in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-12. Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems in BIOLOGY DIRECT
  • 2009-05. Tiny RNAs associated with transcription start sites in animals in NATURE GENETICS
  • 2011-12. Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila in NATURE
  • 2009-10-08. Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes in NATURE
  • 2013-02. Activating RNAs associate with Mediator to enhance chromatin architecture and transcription in NATURE
  • 2009-12. Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements in BIOLOGY DIRECT
  • 2012-02. HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment in NATURE METHODS
  • 2010-12. Initiation of bacteriophage T4 DNA replication and replication fork dynamics: a review in the Virology Journal series on bacteriophage T4 and its relatives in VIROLOGY JOURNAL
  • 2008-11. Structure of the guide-strand-containing argonaute silencing complex in NATURE
  • 2010-06. Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2 in NATURE
  • 2010-12. Hidden Markov model speed heuristic and iterative HMM search procedure in BMC BIOINFORMATICS
  • 2012-10. Argonaute proteins couple chromatin silencing to alternative splicing in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-05-24. Transcription and RNA interference in the formation of heterochromatin in NATURE
  • 2005-03. Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein in NATURE
  • 2000-09. TFIIH is negatively regulated by cdk8-containing mediator complexes in NATURE
  • 2008-12-18. Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1745-6150-8-13

    DOI

    http://dx.doi.org/10.1186/1745-6150-8-13

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035765560

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23758928


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Argonaute Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bacteria", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Eukaryota", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "National Center for Biotechnology Information", 
              "id": "https://www.grid.ac/institutes/grid.419234.9", 
              "name": [
                "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Burroughs", 
            "givenName": "A Maxwell", 
            "id": "sg:person.010440663102.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010440663102.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Center for Biotechnology Information", 
              "id": "https://www.grid.ac/institutes/grid.419234.9", 
              "name": [
                "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iyer", 
            "givenName": "Lakshminarayan M", 
            "id": "sg:person.012162224357.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162224357.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Center for Biotechnology Information", 
              "id": "https://www.grid.ac/institutes/grid.419234.9", 
              "name": [
                "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aravind", 
            "givenName": "L", 
            "id": "sg:person.01106662166.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106662166.38"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ng.312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000428682", 
              "https://doi.org/10.1038/ng.312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001784688", 
              "https://doi.org/10.1038/nature10492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.20921", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002979620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.23.3715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003429037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m707064200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004774577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.embor.7400637", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005274342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.77.5.2450", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005332821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2008.00722.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006138261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2005.03.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006385068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkn349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008077599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkn238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008081924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2011.01.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008138518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008333766", 
              "https://doi.org/10.1038/nsmb.2091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1103946108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008398844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.01.043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008754622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.9.4006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011635363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.05.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012171803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.10.8.1172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012322753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81644-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014004558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2005.07.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015155076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1030497100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015367558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1745-6150-4-29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015797830", 
              "https://doi.org/10.1186/1745-6150-4-29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkp985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016317136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1818", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017098509", 
              "https://doi.org/10.1038/nmeth.1818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m807943200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017435578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.19.10233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018759414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1743-422x-7-358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019471756", 
              "https://doi.org/10.1186/1743-422x-7-358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019751093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2006.03.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019814880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.10.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019990374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07315", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020271916", 
              "https://doi.org/10.1038/nature07315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bse0480089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021121938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m700376200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021228189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021262460", 
              "https://doi.org/10.1038/nature05914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021329082", 
              "https://doi.org/10.1038/nature03514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021329082", 
              "https://doi.org/10.1038/nature03514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022404163", 
              "https://doi.org/10.1038/nature09039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022404163", 
              "https://doi.org/10.1038/nature09039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(00)80112-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022492922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2232", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023344327", 
              "https://doi.org/10.1038/nsmb.2232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20111903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023959142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20111903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023959142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.10.8.1204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024524090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.043174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024590731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkh340", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025846396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0709749105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026417492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mmbr.64.2.412-434.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026540541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2006.03.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027014310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.12.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027273832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0300-9084(02)00020-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027647851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0300-9084(02)00020-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027647851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/wsbm.53", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029127854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07666", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029382170", 
              "https://doi.org/10.1038/nature07666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biochem.76.052305.115300", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029673044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2012.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029962892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-genet-110410-132432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031807521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.sbi.2010.03.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031903918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1841", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032317971", 
              "https://doi.org/10.1038/nsmb.1841"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fcimb.2012.00089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032935679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/26.18.4205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034175495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.08.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034393359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2009.308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034609507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2009.308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034609507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0607483103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035051191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkn468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035130838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035319022", 
              "https://doi.org/10.1038/nature11884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035787061", 
              "https://doi.org/10.1038/nsmb.2373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1745-6150-6-38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036092892", 
              "https://doi.org/10.1186/1745-6150-6-38"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036230339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35024111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036793227", 
              "https://doi.org/10.1038/35024111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35024111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036793227", 
              "https://doi.org/10.1038/35024111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1370605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037794461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1767009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038210211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039130147", 
              "https://doi.org/10.1038/nature03462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039130147", 
              "https://doi.org/10.1038/nature03462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042379011", 
              "https://doi.org/10.1038/nature08434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042379011", 
              "https://doi.org/10.1038/nature08434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceb.2004.04.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042538008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.01.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043214540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01625-09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046986891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/25.17.3389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047265454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.10.8.1074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047615307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2006.07.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048328308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2005.03.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050878795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.fmrre.2004.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051848957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkn1006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052453917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1191138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052719154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-11-431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053037263", 
              "https://doi.org/10.1186/1471-2105-11-431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0968-0004(00)01641-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053160884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/embor.2010.81", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053710475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.femsre.2004.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054735314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1102514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062450977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1140494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062455882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2741/3975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070916136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.8.15.9154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072300168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.8.16.9305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072300198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.9.22.13958", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072301231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/rna.8.1.14300", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072310641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082762984", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083102713", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-12", 
        "datePublishedReg": "2013-12-01", 
        "description": "BACKGROUND: The PIWI module, found in the PIWI/AGO superfamily of proteins, is a critical component of several cellular pathways including germline maintenance, chromatin organization, regulation of splicing, RNA interference, and virus suppression. It binds a guide strand which helps it target complementary nucleic strands.\nRESULTS: Here we report the discovery of two divergent, novel families of PIWI modules, the first such to be described since the initial discovery of the PIWI/AGO superfamily over a decade ago. Both families display conservation patterns consistent with the binding of oligonucleotide guide strands. The first family is bacterial in distribution and is typically encoded by a distinctive three-gene operon alongside genes for a restriction endonuclease fold enzyme and a helicase of the DinG family. The second family is found only in eukaryotes. It is the core conserved module of the Med13 protein, a subunit of the CDK8 subcomplex of the transcription regulatory Mediator complex.\nCONCLUSIONS: Based on the presence of the DinG family helicase, which specifically acts on R-loops, we infer that the first family of PIWI modules is part of a novel RNA-dependent restriction system which could target invasive DNA from phages, plasmids or conjugative transposons. It is predicted to facilitate restriction of actively transcribed invading DNA by utilizing RNA guides. The PIWI family found in the eukaryotic Med13 proteins throws new light on the regulatory switch through which the CDK8 subcomplex modulates transcription at Mediator-bound promoters of highly transcribed genes. We propose that this involves recognition of small RNAs by the PIWI module in Med13 resulting in a conformational switch that propagates through the Mediator complex.\nREVIEWERS: This article was reviewed by Sandor Pongor, Frank Eisenhaber and Balaji Santhanam.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1745-6150-8-13", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2726065", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1036001", 
            "issn": [
              "1745-6150"
            ], 
            "name": "Biology Direct", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "Two novel PIWI families: roles in inter-genomic conflicts in bacteria and Mediator-dependent modulation of transcription in eukaryotes", 
        "pagination": "13", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "aa5fcba05859ab71e3dc1369bc8f83c96dcd01afd7f7a14d6f69a1df8046bea9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23758928"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101258412"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1745-6150-8-13"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1035765560"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1745-6150-8-13", 
          "https://app.dimensions.ai/details/publication/pub.1035765560"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T01:07", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000514.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F1745-6150-8-13"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1745-6150-8-13'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1745-6150-8-13'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1745-6150-8-13'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1745-6150-8-13'


     

    This table displays all metadata directly associated to this object as RDF triples.

    394 TRIPLES      21 PREDICATES      125 URIs      25 LITERALS      13 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1745-6150-8-13 schema:about N494a8fed1d2b4b19af64097d3ff18a16
    2 N6c397cdde7834d25b522f14573c4b438
    3 N9c9c57a0934642d0889e0b12a4271364
    4 Ndece1071001f4338a52b380bb0b61ec0
    5 anzsrc-for:06
    6 anzsrc-for:0601
    7 schema:author Nb7567b06295541f4ac4f28e2b0b14c8c
    8 schema:citation sg:pub.10.1038/35024111
    9 sg:pub.10.1038/nature03462
    10 sg:pub.10.1038/nature03514
    11 sg:pub.10.1038/nature05914
    12 sg:pub.10.1038/nature07315
    13 sg:pub.10.1038/nature07666
    14 sg:pub.10.1038/nature08434
    15 sg:pub.10.1038/nature09039
    16 sg:pub.10.1038/nature10492
    17 sg:pub.10.1038/nature11884
    18 sg:pub.10.1038/ng.312
    19 sg:pub.10.1038/nmeth.1818
    20 sg:pub.10.1038/nsmb.1841
    21 sg:pub.10.1038/nsmb.2091
    22 sg:pub.10.1038/nsmb.2232
    23 sg:pub.10.1038/nsmb.2373
    24 sg:pub.10.1186/1471-2105-11-431
    25 sg:pub.10.1186/1743-422x-7-358
    26 sg:pub.10.1186/1745-6150-4-29
    27 sg:pub.10.1186/1745-6150-6-38
    28 https://app.dimensions.ai/details/publication/pub.1082762984
    29 https://app.dimensions.ai/details/publication/pub.1083102713
    30 https://doi.org/10.1002/prot.20921
    31 https://doi.org/10.1002/wsbm.53
    32 https://doi.org/10.1016/j.ceb.2004.04.003
    33 https://doi.org/10.1016/j.cell.2005.08.044
    34 https://doi.org/10.1016/j.cell.2005.10.020
    35 https://doi.org/10.1016/j.cell.2007.01.043
    36 https://doi.org/10.1016/j.cell.2010.01.019
    37 https://doi.org/10.1016/j.femsre.2004.12.008
    38 https://doi.org/10.1016/j.fmrre.2004.12.008
    39 https://doi.org/10.1016/j.gde.2011.01.013
    40 https://doi.org/10.1016/j.molcel.2005.07.011
    41 https://doi.org/10.1016/j.molcel.2006.03.023
    42 https://doi.org/10.1016/j.molcel.2006.03.032
    43 https://doi.org/10.1016/j.molcel.2006.07.019
    44 https://doi.org/10.1016/j.molcel.2008.05.023
    45 https://doi.org/10.1016/j.molcel.2008.12.012
    46 https://doi.org/10.1016/j.molcel.2012.04.009
    47 https://doi.org/10.1016/j.sbi.2010.03.011
    48 https://doi.org/10.1016/j.tibs.2005.03.002
    49 https://doi.org/10.1016/j.tibs.2005.03.009
    50 https://doi.org/10.1016/s0092-8674(00)81644-x
    51 https://doi.org/10.1016/s0300-9084(02)00020-2
    52 https://doi.org/10.1016/s0968-0004(00)01641-8
    53 https://doi.org/10.1016/s1097-2765(00)80112-4
    54 https://doi.org/10.1038/emboj.2009.308
    55 https://doi.org/10.1038/embor.2010.81
    56 https://doi.org/10.1038/sj.emboj.7600488
    57 https://doi.org/10.1038/sj.embor.7400637
    58 https://doi.org/10.1042/bj20111903
    59 https://doi.org/10.1042/bse0480089
    60 https://doi.org/10.1073/pnas.0607483103
    61 https://doi.org/10.1073/pnas.0709749105
    62 https://doi.org/10.1073/pnas.1030497100
    63 https://doi.org/10.1073/pnas.1103946108
    64 https://doi.org/10.1073/pnas.77.5.2450
    65 https://doi.org/10.1073/pnas.92.9.4006
    66 https://doi.org/10.1073/pnas.94.19.10233
    67 https://doi.org/10.1074/jbc.m700376200
    68 https://doi.org/10.1074/jbc.m707064200
    69 https://doi.org/10.1074/jbc.m807943200
    70 https://doi.org/10.1093/nar/25.17.3389
    71 https://doi.org/10.1093/nar/26.18.4205
    72 https://doi.org/10.1093/nar/gkh340
    73 https://doi.org/10.1093/nar/gkn1006
    74 https://doi.org/10.1093/nar/gkn238
    75 https://doi.org/10.1093/nar/gkn349
    76 https://doi.org/10.1093/nar/gkn468
    77 https://doi.org/10.1093/nar/gkp985
    78 https://doi.org/10.1093/nar/gkq366
    79 https://doi.org/10.1101/gad.12.23.3715
    80 https://doi.org/10.1101/gad.1370605
    81 https://doi.org/10.1101/gad.1767009
    82 https://doi.org/10.1101/gr.10.8.1074
    83 https://doi.org/10.1101/gr.10.8.1172
    84 https://doi.org/10.1101/gr.10.8.1204
    85 https://doi.org/10.1111/j.1600-065x.2008.00722.x
    86 https://doi.org/10.1126/science.1102514
    87 https://doi.org/10.1126/science.1140494
    88 https://doi.org/10.1126/science.1191138
    89 https://doi.org/10.1128/mcb.01625-09
    90 https://doi.org/10.1128/mmbr.64.2.412-434.2000
    91 https://doi.org/10.1146/annurev-genet-110410-132432
    92 https://doi.org/10.1146/annurev.biochem.76.052305.115300
    93 https://doi.org/10.1242/dev.043174
    94 https://doi.org/10.2741/3975
    95 https://doi.org/10.3389/fcimb.2012.00089
    96 https://doi.org/10.4161/cc.8.15.9154
    97 https://doi.org/10.4161/cc.8.16.9305
    98 https://doi.org/10.4161/cc.9.22.13958
    99 https://doi.org/10.4161/rna.8.1.14300
    100 schema:datePublished 2013-12
    101 schema:datePublishedReg 2013-12-01
    102 schema:description BACKGROUND: The PIWI module, found in the PIWI/AGO superfamily of proteins, is a critical component of several cellular pathways including germline maintenance, chromatin organization, regulation of splicing, RNA interference, and virus suppression. It binds a guide strand which helps it target complementary nucleic strands. RESULTS: Here we report the discovery of two divergent, novel families of PIWI modules, the first such to be described since the initial discovery of the PIWI/AGO superfamily over a decade ago. Both families display conservation patterns consistent with the binding of oligonucleotide guide strands. The first family is bacterial in distribution and is typically encoded by a distinctive three-gene operon alongside genes for a restriction endonuclease fold enzyme and a helicase of the DinG family. The second family is found only in eukaryotes. It is the core conserved module of the Med13 protein, a subunit of the CDK8 subcomplex of the transcription regulatory Mediator complex. CONCLUSIONS: Based on the presence of the DinG family helicase, which specifically acts on R-loops, we infer that the first family of PIWI modules is part of a novel RNA-dependent restriction system which could target invasive DNA from phages, plasmids or conjugative transposons. It is predicted to facilitate restriction of actively transcribed invading DNA by utilizing RNA guides. The PIWI family found in the eukaryotic Med13 proteins throws new light on the regulatory switch through which the CDK8 subcomplex modulates transcription at Mediator-bound promoters of highly transcribed genes. We propose that this involves recognition of small RNAs by the PIWI module in Med13 resulting in a conformational switch that propagates through the Mediator complex. REVIEWERS: This article was reviewed by Sandor Pongor, Frank Eisenhaber and Balaji Santhanam.
    103 schema:genre research_article
    104 schema:inLanguage en
    105 schema:isAccessibleForFree true
    106 schema:isPartOf Na8c1c4d5a8ea44408eb36acc4e44c725
    107 Nfd9ff33f7d7b4119acc757312614c793
    108 sg:journal.1036001
    109 schema:name Two novel PIWI families: roles in inter-genomic conflicts in bacteria and Mediator-dependent modulation of transcription in eukaryotes
    110 schema:pagination 13
    111 schema:productId N3615aad2ec774e2597387b4a1ee07eea
    112 N6cacc95352794f81a26f3f41c8de021e
    113 N7a028d94f7d54240bea1d79468ba84fb
    114 N9d0a8445c4dd4422a2e069090c637b48
    115 Na129dd584c264f2abd2aa470bf8ff019
    116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035765560
    117 https://doi.org/10.1186/1745-6150-8-13
    118 schema:sdDatePublished 2019-04-11T01:07
    119 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    120 schema:sdPublisher N7f5f799c70a2423092a481e392950601
    121 schema:url http://link.springer.com/10.1186%2F1745-6150-8-13
    122 sgo:license sg:explorer/license/
    123 sgo:sdDataset articles
    124 rdf:type schema:ScholarlyArticle
    125 N3615aad2ec774e2597387b4a1ee07eea schema:name dimensions_id
    126 schema:value pub.1035765560
    127 rdf:type schema:PropertyValue
    128 N494a8fed1d2b4b19af64097d3ff18a16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Argonaute Proteins
    130 rdf:type schema:DefinedTerm
    131 N6c397cdde7834d25b522f14573c4b438 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Bacteria
    133 rdf:type schema:DefinedTerm
    134 N6cacc95352794f81a26f3f41c8de021e schema:name readcube_id
    135 schema:value aa5fcba05859ab71e3dc1369bc8f83c96dcd01afd7f7a14d6f69a1df8046bea9
    136 rdf:type schema:PropertyValue
    137 N7a028d94f7d54240bea1d79468ba84fb schema:name pubmed_id
    138 schema:value 23758928
    139 rdf:type schema:PropertyValue
    140 N7f5f799c70a2423092a481e392950601 schema:name Springer Nature - SN SciGraph project
    141 rdf:type schema:Organization
    142 N9c9c57a0934642d0889e0b12a4271364 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name RNA
    144 rdf:type schema:DefinedTerm
    145 N9d0a8445c4dd4422a2e069090c637b48 schema:name nlm_unique_id
    146 schema:value 101258412
    147 rdf:type schema:PropertyValue
    148 Na129dd584c264f2abd2aa470bf8ff019 schema:name doi
    149 schema:value 10.1186/1745-6150-8-13
    150 rdf:type schema:PropertyValue
    151 Na17eedb56979407d8fb03d940c8f8f51 rdf:first sg:person.012162224357.20
    152 rdf:rest Nbdb26e82f4894a4e885fa877bbb3ad34
    153 Na8c1c4d5a8ea44408eb36acc4e44c725 schema:volumeNumber 8
    154 rdf:type schema:PublicationVolume
    155 Nb7567b06295541f4ac4f28e2b0b14c8c rdf:first sg:person.010440663102.58
    156 rdf:rest Na17eedb56979407d8fb03d940c8f8f51
    157 Nbdb26e82f4894a4e885fa877bbb3ad34 rdf:first sg:person.01106662166.38
    158 rdf:rest rdf:nil
    159 Ndece1071001f4338a52b380bb0b61ec0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Eukaryota
    161 rdf:type schema:DefinedTerm
    162 Nfd9ff33f7d7b4119acc757312614c793 schema:issueNumber 1
    163 rdf:type schema:PublicationIssue
    164 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    165 schema:name Biological Sciences
    166 rdf:type schema:DefinedTerm
    167 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    168 schema:name Biochemistry and Cell Biology
    169 rdf:type schema:DefinedTerm
    170 sg:grant.2726065 http://pending.schema.org/fundedItem sg:pub.10.1186/1745-6150-8-13
    171 rdf:type schema:MonetaryGrant
    172 sg:journal.1036001 schema:issn 1745-6150
    173 schema:name Biology Direct
    174 rdf:type schema:Periodical
    175 sg:person.010440663102.58 schema:affiliation https://www.grid.ac/institutes/grid.419234.9
    176 schema:familyName Burroughs
    177 schema:givenName A Maxwell
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010440663102.58
    179 rdf:type schema:Person
    180 sg:person.01106662166.38 schema:affiliation https://www.grid.ac/institutes/grid.419234.9
    181 schema:familyName Aravind
    182 schema:givenName L
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106662166.38
    184 rdf:type schema:Person
    185 sg:person.012162224357.20 schema:affiliation https://www.grid.ac/institutes/grid.419234.9
    186 schema:familyName Iyer
    187 schema:givenName Lakshminarayan M
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162224357.20
    189 rdf:type schema:Person
    190 sg:pub.10.1038/35024111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036793227
    191 https://doi.org/10.1038/35024111
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/nature03462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039130147
    194 https://doi.org/10.1038/nature03462
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/nature03514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021329082
    197 https://doi.org/10.1038/nature03514
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/nature05914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021262460
    200 https://doi.org/10.1038/nature05914
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/nature07315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020271916
    203 https://doi.org/10.1038/nature07315
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/nature07666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029382170
    206 https://doi.org/10.1038/nature07666
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/nature08434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042379011
    209 https://doi.org/10.1038/nature08434
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/nature09039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022404163
    212 https://doi.org/10.1038/nature09039
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/nature10492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001784688
    215 https://doi.org/10.1038/nature10492
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/nature11884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035319022
    218 https://doi.org/10.1038/nature11884
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/ng.312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000428682
    221 https://doi.org/10.1038/ng.312
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/nmeth.1818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017098509
    224 https://doi.org/10.1038/nmeth.1818
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/nsmb.1841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032317971
    227 https://doi.org/10.1038/nsmb.1841
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/nsmb.2091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008333766
    230 https://doi.org/10.1038/nsmb.2091
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/nsmb.2232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023344327
    233 https://doi.org/10.1038/nsmb.2232
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/nsmb.2373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035787061
    236 https://doi.org/10.1038/nsmb.2373
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1186/1471-2105-11-431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053037263
    239 https://doi.org/10.1186/1471-2105-11-431
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1186/1743-422x-7-358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019471756
    242 https://doi.org/10.1186/1743-422x-7-358
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1186/1745-6150-4-29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015797830
    245 https://doi.org/10.1186/1745-6150-4-29
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1186/1745-6150-6-38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036092892
    248 https://doi.org/10.1186/1745-6150-6-38
    249 rdf:type schema:CreativeWork
    250 https://app.dimensions.ai/details/publication/pub.1082762984 schema:CreativeWork
    251 https://app.dimensions.ai/details/publication/pub.1083102713 schema:CreativeWork
    252 https://doi.org/10.1002/prot.20921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002979620
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1002/wsbm.53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029127854
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/j.ceb.2004.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042538008
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/j.cell.2005.08.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034393359
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/j.cell.2005.10.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019990374
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1016/j.cell.2007.01.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008754622
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/j.cell.2010.01.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043214540
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/j.femsre.2004.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054735314
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/j.fmrre.2004.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051848957
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/j.gde.2011.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008138518
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.molcel.2005.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015155076
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.molcel.2006.03.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027014310
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.molcel.2006.03.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019814880
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.molcel.2006.07.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048328308
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.molcel.2008.05.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012171803
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.molcel.2008.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027273832
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.molcel.2012.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029962892
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.sbi.2010.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031903918
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.tibs.2005.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006385068
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.tibs.2005.03.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050878795
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/s0092-8674(00)81644-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014004558
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/s0300-9084(02)00020-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027647851
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/s0968-0004(00)01641-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053160884
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/s1097-2765(00)80112-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022492922
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1038/emboj.2009.308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034609507
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1038/embor.2010.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053710475
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1038/sj.emboj.7600488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036230339
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1038/sj.embor.7400637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005274342
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1042/bj20111903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023959142
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1042/bse0480089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021121938
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1073/pnas.0607483103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035051191
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1073/pnas.0709749105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026417492
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1073/pnas.1030497100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015367558
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1073/pnas.1103946108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008398844
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1073/pnas.77.5.2450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005332821
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1073/pnas.92.9.4006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011635363
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1073/pnas.94.19.10233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018759414
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1074/jbc.m700376200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021228189
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1074/jbc.m707064200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004774577
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1074/jbc.m807943200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017435578
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1093/nar/25.17.3389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047265454
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1093/nar/26.18.4205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034175495
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1093/nar/gkh340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025846396
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1093/nar/gkn1006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052453917
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1093/nar/gkn238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008081924
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1093/nar/gkn349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008077599
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1093/nar/gkn468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035130838
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1093/nar/gkp985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016317136
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1093/nar/gkq366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019751093
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1101/gad.12.23.3715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003429037
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1101/gad.1370605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037794461
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1101/gad.1767009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038210211
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1101/gr.10.8.1074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047615307
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1101/gr.10.8.1172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012322753
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1101/gr.10.8.1204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024524090
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1111/j.1600-065x.2008.00722.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006138261
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1126/science.1102514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062450977
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1126/science.1140494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062455882
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1126/science.1191138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052719154
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1128/mcb.01625-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046986891
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1128/mmbr.64.2.412-434.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026540541
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1146/annurev-genet-110410-132432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031807521
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1146/annurev.biochem.76.052305.115300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029673044
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1242/dev.043174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024590731
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.2741/3975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070916136
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.3389/fcimb.2012.00089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032935679
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.4161/cc.8.15.9154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300168
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.4161/cc.8.16.9305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300198
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.4161/cc.9.22.13958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072301231
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.4161/rna.8.1.14300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072310641
    391 rdf:type schema:CreativeWork
    392 https://www.grid.ac/institutes/grid.419234.9 schema:alternateName National Center for Biotechnology Information
    393 schema:name National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA
    394 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...