Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Dapeng Zhang, Robson F de Souza, Vivek Anantharaman, Lakshminarayan M Iyer, L Aravind

ABSTRACT

BACKGROUND: Proteinaceous toxins are observed across all levels of inter-organismal and intra-genomic conflicts. These include recently discovered prokaryotic polymorphic toxin systems implicated in intra-specific conflicts. They are characterized by a remarkable diversity of C-terminal toxin domains generated by recombination with standalone toxin-coding cassettes. Prior analysis revealed a striking diversity of nuclease and deaminase domains among the toxin modules. We systematically investigated polymorphic toxin systems using comparative genomics, sequence and structure analysis. RESULTS: Polymorphic toxin systems are distributed across all major bacterial lineages and are delivered by at least eight distinct secretory systems. In addition to type-II, these include type-V, VI, VII (ESX), and the poorly characterized "Photorhabdus virulence cassettes (PVC)", PrsW-dependent and MuF phage-capsid-like systems. We present evidence that trafficking of these toxins is often accompanied by autoproteolytic processing catalyzed by HINT, ZU5, PrsW, caspase-like, papain-like, and a novel metallopeptidase associated with the PVC system. We identified over 150 distinct toxin domains in these systems. These span an extraordinary catalytic spectrum to include 23 distinct clades of peptidases, numerous previously unrecognized versions of nucleases and deaminases, ADP-ribosyltransferases, ADP ribosyl cyclases, RelA/SpoT-like nucleotidyltransferases, glycosyltranferases and other enzymes predicted to modify lipids and carbohydrates, and a pore-forming toxin domain. Several of these toxin domains are shared with host-directed effectors of pathogenic bacteria. Over 90 families of immunity proteins might neutralize anywhere between a single to at least 27 distinct types of toxin domains. In some organisms multiple tandem immunity genes or immunity protein domains are organized into polyimmunity loci or polyimmunity proteins. Gene-neighborhood-analysis of polymorphic toxin systems predicts the presence of novel trafficking-related components, and also the organizational logic that allows toxin diversification through recombination. Domain architecture and protein-length analysis revealed that these toxins might be deployed as secreted factors, through directed injection, or via inter-cellular contact facilitated by filamentous structures formed by RHS/YD, filamentous hemagglutinin and other repeats. Phyletic pattern and life-style analysis indicate that polymorphic toxins and polyimmunity loci participate in cooperative behavior and facultative 'cheating' in several ecosystems such as the human oral cavity and soil. Multiple domains from these systems have also been repeatedly transferred to eukaryotes and their viruses, such as the nucleo-cytoplasmic large DNA viruses. CONCLUSIONS: Along with a comprehensive inventory of toxins and immunity proteins, we present several testable predictions regarding active sites and catalytic mechanisms of toxins, their processing and trafficking and their role in intra-specific and inter-specific interactions between bacteria. These systems provide insights regarding the emergence of key systems at different points in eukaryotic evolution, such as ADP ribosylation, interaction of myosin VI with cargo proteins, mediation of apoptosis, hyphal heteroincompatibility, hedgehog signaling, arthropod toxins, cell-cell interaction molecules like teneurins and different signaling messengers. More... »

PAGES

18

References to SciGraph publications

  • 2010-01. An overview on nucleases (DNase, RNase, and phosphodiesterase) in snake venoms in BIOCHEMISTRY (MOSCOW)
  • 2009-12. Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement in BMC GENOMICS
  • 2010-01. Twenty years hunting for sulfur in DNA in PROTEIN & CELL
  • 2003-12. New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system in GENOME BIOLOGY
  • 2003-02. Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes in GENOME BIOLOGY
  • 2001-10. Genotype versus phenotype: conflicting results in mapping a lung tumor susceptibility locus to the G7c recombination interval in the mouse MHC class III region in IMMUNOGENETICS
  • 2009-07. Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2009-12. Horizontal gene transfer between Wolbachia and the mosquito Aedes aegypti in BMC GENOMICS
  • 2008-10. The AID/APOBEC family of nucleic acid mutators in GENOME BIOLOGY
  • 2001-02. G7c in the lung tumor susceptibility (Lts) region of the Mhc class III region encodes a von Willebrand factor type A domain protein in IMMUNOGENETICS
  • 2008-12. Insights beyond <i>Wolbachia</i>–<i>Drosophila</i> interactions: Never completely trust a model: insights from cytoplasmic incompatibility beyond <i>Wolbachia</i>–<i>Drosophila</i> interactions in HEREDITY
  • 2011-07. Type VI secretion delivers bacteriolytic effectors to target cells in NATURE
  • 2010-11. An Rhs-like genetic element is involved in bacteriocin production by Pseudomonas savastanoi pv. savastanoi in ANTONIE VAN LEEUWENHOEK
  • 2004-08. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling in NATURE
  • 2012-03. Type VI secretion requires a dynamic contractile phage tail-like structure in NATURE
  • 1989-03. High-resolution (1.5 Å) crystal structure of phospholipase C from Bacillus cereus in NATURE
  • 2006-11. The type III secretion injectisome in NATURE REVIEWS MICROBIOLOGY
  • 2006-03. The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like β-grasp domains in GENOME BIOLOGY
  • 2005-12. In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs) in BMC GENOMICS
  • 2012-01. The PIDDosome, DNA-damage-induced apoptosis and beyond in CELL DEATH & DIFFERENTIATION
  • 2002-05. Pore-forming toxins in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2008-12. MutL homologs in restriction-modification systems and the origin of eukaryotic MORC ATPases in BIOLOGY DIRECT
  • 2004-12. MUSCLE: a multiple sequence alignment method with reduced time and space complexity in BMC BIOINFORMATICS
  • 2011. The Lysine-Specific Gingipain of Porphyromonas gingivalis in CYSTEINE PROTEASES OF PATHOGENIC ORGANISMS
  • 2010-11. A widespread family of polymorphic contact-dependent toxin delivery systems in bacteria in NATURE
  • 2010-10. Structural basis for 16S ribosomal RNA cleavage by the cytotoxic domain of colicin E3 in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1997. Sequence and Structural Links between Distant ADP-Ribosyltransferase Families in ADP-RIBOSYLATION IN ANIMAL TISSUES
  • 2008-02. Bacterial pore-forming toxins: The (w)hole story? in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2012-05. A Xanthomonas uridine 5′-monophosphate transferase inhibits plant immune kinases in NATURE
  • 2012-01. Bacterial outer membrane evolution via sporulation? in NATURE CHEMICAL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1745-6150-7-18

    DOI

    http://dx.doi.org/10.1186/1745-6150-7-18

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040385591

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22731697


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