MutL homologs in restriction-modification systems and the origin of eukaryotic MORC ATPases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-12

AUTHORS

Lakshminarayan M Iyer, Saraswathi Abhiman, L Aravind

ABSTRACT

The provenance and biochemical roles of eukaryotic MORC proteins have remained poorly understood since the discovery of their prototype MORC1, which is required for meiotic nuclear division in animals. The MORC family contains a combination of a gyrase, histidine kinase, and MutL (GHKL) and S5 domains that together constitute a catalytically active ATPase module. We identify the prokaryotic MORCs and establish that the MORC family belongs to a larger radiation of several families of GHKL proteins (paraMORCs) in prokaryotes. Using contextual information from conserved gene neighborhoods we show that these proteins primarily function in restriction-modification systems, in conjunction with diverse superfamily II DNA helicases and endonucleases. The common ancestor of these GHKL proteins, MutL and topoisomerase ATPase modules appears to have catalyzed structural reorganization of protein complexes and concomitant DNA-superstructure manipulations along with fused or standalone nuclease domains. Furthermore, contextual associations of the prokaryotic MORCs and their relatives suggest that their eukaryotic counterparts are likely to carry out chromatin remodeling by DNA superstructure manipulation in response to epigenetic signals such as histone and DNA methylation. More... »

PAGES

8

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1745-6150-3-8

DOI

http://dx.doi.org/10.1186/1745-6150-3-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006845773

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18346280


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine Triphosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacterial Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Restriction-Modification Enzymes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Escherichia coli Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Eukaryotic Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evolution, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MutL Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Center for Biotechnology Information", 
          "id": "https://www.grid.ac/institutes/grid.419234.9", 
          "name": [
            "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iyer", 
        "givenName": "Lakshminarayan M", 
        "id": "sg:person.012162224357.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162224357.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center for Biotechnology Information", 
          "id": "https://www.grid.ac/institutes/grid.419234.9", 
          "name": [
            "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abhiman", 
        "givenName": "Saraswathi", 
        "id": "sg:person.0614440470.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614440470.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center for Biotechnology Information", 
          "id": "https://www.grid.ac/institutes/grid.419234.9", 
          "name": [
            "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aravind", 
        "givenName": "L", 
        "id": "sg:person.01106662166.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106662166.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/hmg/8.7.1201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000701704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkl450", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008630897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/17.12.1244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011480981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr0404794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018749551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr0404794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018749551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.5.1526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019840658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.05.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022853308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2006.06.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026543483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pro.5560050513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033754482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pro.5560050513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033754482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/26.18.4205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034175495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.24.14361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034274726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/29.18.3728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038007865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/28.18.3417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040509484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35040600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041485991", 
          "https://doi.org/10.1038/35040600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35040600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041485991", 
          "https://doi.org/10.1038/35040600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)00097-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044268158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2003.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044843814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2003.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044843814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1105/tpc.104.026112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045229487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2004.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046861416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/25.17.3389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047265454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpara.2007.07.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048177202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.11.5831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052836458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.5.7.2629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298867"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-12", 
    "datePublishedReg": "2008-12-01", 
    "description": "The provenance and biochemical roles of eukaryotic MORC proteins have remained poorly understood since the discovery of their prototype MORC1, which is required for meiotic nuclear division in animals. The MORC family contains a combination of a gyrase, histidine kinase, and MutL (GHKL) and S5 domains that together constitute a catalytically active ATPase module. We identify the prokaryotic MORCs and establish that the MORC family belongs to a larger radiation of several families of GHKL proteins (paraMORCs) in prokaryotes. Using contextual information from conserved gene neighborhoods we show that these proteins primarily function in restriction-modification systems, in conjunction with diverse superfamily II DNA helicases and endonucleases. The common ancestor of these GHKL proteins, MutL and topoisomerase ATPase modules appears to have catalyzed structural reorganization of protein complexes and concomitant DNA-superstructure manipulations along with fused or standalone nuclease domains. Furthermore, contextual associations of the prokaryotic MORCs and their relatives suggest that their eukaryotic counterparts are likely to carry out chromatin remodeling by DNA superstructure manipulation in response to epigenetic signals such as histone and DNA methylation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1745-6150-3-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1036001", 
        "issn": [
          "1745-6150"
        ], 
        "name": "Biology Direct", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "name": "MutL homologs in restriction-modification systems and the origin of eukaryotic MORC ATPases", 
    "pagination": "8", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "209be29fbbda97a0c5b6a77ff7063ccaa7a5992389cd4eecd5999911fced0f54"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18346280"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101258412"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1745-6150-3-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006845773"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1745-6150-3-8", 
      "https://app.dimensions.ai/details/publication/pub.1006845773"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1745-6150-3-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1745-6150-3-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1745-6150-3-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1745-6150-3-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1745-6150-3-8'


 

This table displays all metadata directly associated to this object as RDF triples.

190 TRIPLES      21 PREDICATES      61 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1745-6150-3-8 schema:about N14b3cbdbddd14402858e347e6a730120
2 N1c18cb20de3a4f9ca370c213bdd291dd
3 N2e4b3f0e78a8420ca1cca6c816fc7521
4 N49fec7f8360741a89b52ec2a3b2a24a7
5 N5ea7eef2cdd6493a849b45926ccb8114
6 N84a618ab69754a3c83c1cdf7eaad4313
7 N944c46f1a81949f7a30b85b037e141ea
8 N9f7bcca63fab44d3a40c2f7e9175a4da
9 Na662613100eb4ea9bdfa40860390a33b
10 Nf7b98981c53f4125b2412f042caa285b
11 Nfa5671e22cb04d178eac6090c48a7279
12 anzsrc-for:06
13 anzsrc-for:0604
14 schema:author Na9c1619808b549e8bdc3f57d76f68043
15 schema:citation sg:pub.10.1038/35040600
16 https://doi.org/10.1002/pro.5560050513
17 https://doi.org/10.1016/j.cell.2006.05.039
18 https://doi.org/10.1016/j.dnarep.2004.02.008
19 https://doi.org/10.1016/j.ijpara.2007.07.018
20 https://doi.org/10.1016/j.jmb.2006.06.049
21 https://doi.org/10.1016/j.tibs.2003.09.007
22 https://doi.org/10.1016/s1097-2765(00)00097-6
23 https://doi.org/10.1021/cr0404794
24 https://doi.org/10.1073/pnas.94.11.5831
25 https://doi.org/10.1073/pnas.95.24.14361
26 https://doi.org/10.1093/bioinformatics/17.12.1244
27 https://doi.org/10.1093/emboj/17.5.1526
28 https://doi.org/10.1093/hmg/8.7.1201
29 https://doi.org/10.1093/nar/25.17.3389
30 https://doi.org/10.1093/nar/26.18.4205
31 https://doi.org/10.1093/nar/28.18.3417
32 https://doi.org/10.1093/nar/29.18.3728
33 https://doi.org/10.1093/nar/gkl450
34 https://doi.org/10.1105/tpc.104.026112
35 https://doi.org/10.4161/cc.5.7.2629
36 schema:datePublished 2008-12
37 schema:datePublishedReg 2008-12-01
38 schema:description The provenance and biochemical roles of eukaryotic MORC proteins have remained poorly understood since the discovery of their prototype MORC1, which is required for meiotic nuclear division in animals. The MORC family contains a combination of a gyrase, histidine kinase, and MutL (GHKL) and S5 domains that together constitute a catalytically active ATPase module. We identify the prokaryotic MORCs and establish that the MORC family belongs to a larger radiation of several families of GHKL proteins (paraMORCs) in prokaryotes. Using contextual information from conserved gene neighborhoods we show that these proteins primarily function in restriction-modification systems, in conjunction with diverse superfamily II DNA helicases and endonucleases. The common ancestor of these GHKL proteins, MutL and topoisomerase ATPase modules appears to have catalyzed structural reorganization of protein complexes and concomitant DNA-superstructure manipulations along with fused or standalone nuclease domains. Furthermore, contextual associations of the prokaryotic MORCs and their relatives suggest that their eukaryotic counterparts are likely to carry out chromatin remodeling by DNA superstructure manipulation in response to epigenetic signals such as histone and DNA methylation.
39 schema:genre research_article
40 schema:inLanguage en
41 schema:isAccessibleForFree true
42 schema:isPartOf N5175fe514561442fa696020966817ca6
43 N6f2cdf80fb5f43cda0223785f7729db2
44 sg:journal.1036001
45 schema:name MutL homologs in restriction-modification systems and the origin of eukaryotic MORC ATPases
46 schema:pagination 8
47 schema:productId N2e43d6305aa64ca08a222c62b2c21c75
48 N503cc66a13a24458abbac285ff3d291e
49 N85da8953aefe484f8fe64a056a3a25f3
50 Naf854d80aa164ed9a1b543b067aa8a14
51 Ncffcc4eb47584d0ebab323288e455aca
52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006845773
53 https://doi.org/10.1186/1745-6150-3-8
54 schema:sdDatePublished 2019-04-10T14:09
55 schema:sdLicense https://scigraph.springernature.com/explorer/license/
56 schema:sdPublisher Nc6e255c146ec464f92ea2ea5052d9a72
57 schema:url http://link.springer.com/10.1186%2F1745-6150-3-8
58 sgo:license sg:explorer/license/
59 sgo:sdDataset articles
60 rdf:type schema:ScholarlyArticle
61 N14b3cbdbddd14402858e347e6a730120 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Eukaryotic Cells
63 rdf:type schema:DefinedTerm
64 N1c18cb20de3a4f9ca370c213bdd291dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Evolution, Molecular
66 rdf:type schema:DefinedTerm
67 N2e43d6305aa64ca08a222c62b2c21c75 schema:name readcube_id
68 schema:value 209be29fbbda97a0c5b6a77ff7063ccaa7a5992389cd4eecd5999911fced0f54
69 rdf:type schema:PropertyValue
70 N2e4b3f0e78a8420ca1cca6c816fc7521 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Humans
72 rdf:type schema:DefinedTerm
73 N49fec7f8360741a89b52ec2a3b2a24a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Escherichia coli Proteins
75 rdf:type schema:DefinedTerm
76 N503cc66a13a24458abbac285ff3d291e schema:name pubmed_id
77 schema:value 18346280
78 rdf:type schema:PropertyValue
79 N5175fe514561442fa696020966817ca6 schema:volumeNumber 3
80 rdf:type schema:PublicationVolume
81 N5ea7eef2cdd6493a849b45926ccb8114 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Amino Acid Sequence
83 rdf:type schema:DefinedTerm
84 N6f2cdf80fb5f43cda0223785f7729db2 schema:issueNumber 1
85 rdf:type schema:PublicationIssue
86 N84a618ab69754a3c83c1cdf7eaad4313 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name DNA Restriction-Modification Enzymes
88 rdf:type schema:DefinedTerm
89 N85da8953aefe484f8fe64a056a3a25f3 schema:name nlm_unique_id
90 schema:value 101258412
91 rdf:type schema:PropertyValue
92 N944c46f1a81949f7a30b85b037e141ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Adenosine Triphosphatases
94 rdf:type schema:DefinedTerm
95 N9f7bcca63fab44d3a40c2f7e9175a4da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Bacterial Proteins
97 rdf:type schema:DefinedTerm
98 Na662613100eb4ea9bdfa40860390a33b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Nuclear Proteins
100 rdf:type schema:DefinedTerm
101 Na9c1619808b549e8bdc3f57d76f68043 rdf:first sg:person.012162224357.20
102 rdf:rest Nbed35c76b8ab43daa6340a10d6b5647e
103 Naf854d80aa164ed9a1b543b067aa8a14 schema:name doi
104 schema:value 10.1186/1745-6150-3-8
105 rdf:type schema:PropertyValue
106 Nbc56475da8db4e918d7e6f9a42c4cec7 rdf:first sg:person.01106662166.38
107 rdf:rest rdf:nil
108 Nbed35c76b8ab43daa6340a10d6b5647e rdf:first sg:person.0614440470.83
109 rdf:rest Nbc56475da8db4e918d7e6f9a42c4cec7
110 Nc6e255c146ec464f92ea2ea5052d9a72 schema:name Springer Nature - SN SciGraph project
111 rdf:type schema:Organization
112 Ncffcc4eb47584d0ebab323288e455aca schema:name dimensions_id
113 schema:value pub.1006845773
114 rdf:type schema:PropertyValue
115 Nf7b98981c53f4125b2412f042caa285b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name MutL Proteins
117 rdf:type schema:DefinedTerm
118 Nfa5671e22cb04d178eac6090c48a7279 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Molecular Sequence Data
120 rdf:type schema:DefinedTerm
121 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
122 schema:name Biological Sciences
123 rdf:type schema:DefinedTerm
124 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
125 schema:name Genetics
126 rdf:type schema:DefinedTerm
127 sg:journal.1036001 schema:issn 1745-6150
128 schema:name Biology Direct
129 rdf:type schema:Periodical
130 sg:person.01106662166.38 schema:affiliation https://www.grid.ac/institutes/grid.419234.9
131 schema:familyName Aravind
132 schema:givenName L
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106662166.38
134 rdf:type schema:Person
135 sg:person.012162224357.20 schema:affiliation https://www.grid.ac/institutes/grid.419234.9
136 schema:familyName Iyer
137 schema:givenName Lakshminarayan M
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162224357.20
139 rdf:type schema:Person
140 sg:person.0614440470.83 schema:affiliation https://www.grid.ac/institutes/grid.419234.9
141 schema:familyName Abhiman
142 schema:givenName Saraswathi
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614440470.83
144 rdf:type schema:Person
145 sg:pub.10.1038/35040600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041485991
146 https://doi.org/10.1038/35040600
147 rdf:type schema:CreativeWork
148 https://doi.org/10.1002/pro.5560050513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033754482
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1016/j.cell.2006.05.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022853308
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1016/j.dnarep.2004.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046861416
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1016/j.ijpara.2007.07.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048177202
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1016/j.jmb.2006.06.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026543483
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/j.tibs.2003.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044843814
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/s1097-2765(00)00097-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044268158
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1021/cr0404794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018749551
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1073/pnas.94.11.5831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052836458
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1073/pnas.95.24.14361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034274726
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1093/bioinformatics/17.12.1244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011480981
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1093/emboj/17.5.1526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019840658
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1093/hmg/8.7.1201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000701704
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1093/nar/25.17.3389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047265454
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1093/nar/26.18.4205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034175495
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1093/nar/28.18.3417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040509484
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1093/nar/29.18.3728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038007865
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1093/nar/gkl450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008630897
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1105/tpc.104.026112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045229487
185 rdf:type schema:CreativeWork
186 https://doi.org/10.4161/cc.5.7.2629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298867
187 rdf:type schema:CreativeWork
188 https://www.grid.ac/institutes/grid.419234.9 schema:alternateName National Center for Biotechnology Information
189 schema:name National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA
190 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...