A new family of polymerases related to superfamily A DNA polymerases and T7-like DNA-dependent RNA polymerases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-10-04

AUTHORS

Lakshminarayan M Iyer, Saraswathi Abhiman, L Aravind

ABSTRACT

Using sequence profile methods and structural comparisons we characterize a previously unknown family of nucleic acid polymerases in a group of mobile elements from genomes of diverse bacteria, an algal plastid and certain DNA viruses, including the recently reported Sputnik virus. Using contextual information from domain architectures and gene-neighborhoods we present evidence that they are likely to possess both primase and DNA polymerase activity, comparable to the previously reported prim-pol proteins. These newly identified polymerases help in defining the minimal functional core of superfamily A DNA polymerases and related RNA polymerases. Thus, they provide a framework to understand the emergence of both DNA and RNA polymerization activity in this class of enzymes. They also provide evidence that enigmatic DNA viruses, such as Sputnik, might have emerged from mobile elements coding these polymerases. More... »

PAGES

39-39

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1745-6150-3-39

DOI

http://dx.doi.org/10.1186/1745-6150-3-39

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013331012

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18834537


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