The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Hideaki Kobayashi, Hiroshi Ujike, Nakao Iwata, Toshiya Inada, Mitsuhiko Yamada, Yoshimoto Sekine, Naohisa Uchimura, Masaomi Iyo, Norio Ozaki, Masanari Itokawa, Ichiro Sora

ABSTRACT

BACKGROUND: Several lines of evidence suggest that the dopaminergic nervous system contributes to methamphetamine (METH) dependence, and there is increasing evidence of antagonistic interactions between dopamine and adenosine receptors. We therefore hypothesized that variations in the A2A adenosine receptor (ADORA2A) gene modify genetic susceptibility to METH dependence/psychosis. METHODS: We first analyzed variations in the exons and exon-intron boundaries of the ADORA2A gene in METH dependent/psychotic patients. Then an association analysis between these single nucleotide polymorphisms and METH dependence/psychosis was performed using a total of 171 METH dependent/psychotic patients and 229 controls. RESULTS: We found 6 variations, of which one single nucleotide polymorphism (SNP) was novel. Significant associations were observed between the allelic and genotypic frequencies of the Exon2+751 (rs5751876) SNP and METH dependence/psychosis. These associations were observed especially in females. In the clinical feature analyses, significant associations were observed between the SNP and the patient subgroup using METH alone (i.e., without concomitant use of other substances of abuse). CONCLUSIONS: These results suggest that the ADORA2A gene could be a vulnerability factor for METH dependence/psychosis, especially in females and/or in patients using only METH. More... »

PAGES

50

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1744-9081-6-50

DOI

http://dx.doi.org/10.1186/1744-9081-6-50

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005513994

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20799992


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    "description": "BACKGROUND: Several lines of evidence suggest that the dopaminergic nervous system contributes to methamphetamine (METH) dependence, and there is increasing evidence of antagonistic interactions between dopamine and adenosine receptors. We therefore hypothesized that variations in the A2A adenosine receptor (ADORA2A) gene modify genetic susceptibility to METH dependence/psychosis.\nMETHODS: We first analyzed variations in the exons and exon-intron boundaries of the ADORA2A gene in METH dependent/psychotic patients. Then an association analysis between these single nucleotide polymorphisms and METH dependence/psychosis was performed using a total of 171 METH dependent/psychotic patients and 229 controls.\nRESULTS: We found 6 variations, of which one single nucleotide polymorphism (SNP) was novel. Significant associations were observed between the allelic and genotypic frequencies of the Exon2+751 (rs5751876) SNP and METH dependence/psychosis. These associations were observed especially in females. In the clinical feature analyses, significant associations were observed between the SNP and the patient subgroup using METH alone (i.e., without concomitant use of other substances of abuse).\nCONCLUSIONS: These results suggest that the ADORA2A gene could be a vulnerability factor for METH dependence/psychosis, especially in females and/or in patients using only METH.", 
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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1744-9081-6-50'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1744-9081-6-50'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1744-9081-6-50'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1744-9081-6-50'


 

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308 schema:name Department of Neuropsychiatry, Kurume University School of Medicine, 830-0011, Kurume, Japan
309 Japanese Genetics Initiative for Drug Abuse (JGIDA), Japan
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312 schema:name Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology and Psychiatry, 187-8553, Tokyo, Japan
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315 https://www.grid.ac/institutes/grid.417113.1 schema:alternateName Tokyo Institute of Psychiatry
316 schema:name Schizophrenia Research Project, Tokyo Institute of Psychiatry, 156-8585, Tokyo, Japan
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318 https://www.grid.ac/institutes/grid.452711.4 schema:alternateName Seiwa Hospital
319 schema:name Department of Psychiatry, Seiwa Hospital, Institute of Neuropsychiatry, 162-0851, Tokyo, Japan
320 Japanese Genetics Initiative for Drug Abuse (JGIDA), Japan
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322 https://www.grid.ac/institutes/grid.69566.3a schema:alternateName Tohoku University
323 schema:name Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, 980-8574, Sendai, Japan
324 Japanese Genetics Initiative for Drug Abuse (JGIDA), Japan
325 rdf:type schema:Organization
 




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