Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-12

AUTHORS

Tsung-Chieh Chen, Ying-Ying Cheng, Wei-Zen Sun, Bai-Chuang Shyu

ABSTRACT

BACKGROUND: Mice lacking the preproenkephalin (ppENK) gene are hyperalgesic and show more anxiety and aggression than wild-type (WT) mice. The marked behavioral changes in ppENK knock-out (KO) mice appeared to occur in supraspinal response to painful stimuli. However the functional role of enkephalins in the supraspinal nociceptive processing and their underlying mechanism is not clear. The aim of present study was to compare supraspinal nociceptive and morphine antinociceptive responses between WT and ppENK KO mice. RESULTS: The genotypes of bred KO mice were confirmed by PCR. Met-enkephalin immunoreactive neurons were labeled in the caudate-putamen, intermediated part of lateral septum, lateral globus pallidus, intermediated part of lateral septum, hypothalamus, and amygdala of WT mice. Met-enkephalin immunoreactive neurons were not found in the same brain areas in KO mice. Tail withdrawal and von Frey test results did not differ between WT and KO mice. KO mice had shorter latency to start paw licking than WT mice in the hot plate test. The maximal percent effect of morphine treatments (5 mg/kg and 10 mg/kg, i.p.) differed between WT and KO mice in hot plate test. The current source density (CSD) profiles evoked by peripheral noxious stimuli in the primary somatosenstory cortex (S1) and anterior cingulate cortex (ACC) were similar in WT and KO mice. After morphine injection, the amplitude of the laser-evoked sink currents was decreased in S1 while the amplitude of electrical-evoked sink currents was increased in the ACC. These differential morphine effects in S1 and ACC were enhanced in KO mice. Facilitation of synaptic currents in the ACC is mediated by GABA inhibitory interneurons in the local circuitry. Percent increases in opioid receptor binding in S1 and ACC were 5.1% and 5.8%, respectively. CONCLUSION: The present results indicate that the endogenous enkephalin system is not involved in acute nociceptive transmission in the spinal cord, S1, and ACC. However, morphine preferentially suppressed supraspinal related nociceptive behavior in KO mice. This effect was reflected in the potentiated differential effects of morphine in the S1 and ACC in KO mice. This potentiation may be due to an up-regulation of opioid receptors. Thus these findings strongly suggest an antagonistic interaction between the endogenous enkephalinergic system and exogenous opioid analgesic actions in the supraspinal brain structures. More... »

PAGES

41

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1744-8069-4-41

DOI

http://dx.doi.org/10.1186/1744-8069-4-41

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002709829

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18826595


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analgesics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enkephalins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Morphine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pain Threshold", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prosencephalon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Precursors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Opioid, mu", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "gamma-Aminobutyric Acid", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Academia Sinica", 
          "id": "https://www.grid.ac/institutes/grid.28665.3f", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, 11529, Taipei, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Tsung-Chieh", 
        "id": "sg:person.01117337433.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117337433.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academia Sinica", 
          "id": "https://www.grid.ac/institutes/grid.28665.3f", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, 11529, Taipei, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "Ying-Ying", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "Department of Anaesthesiology, National Taiwan University Hospital, 10002, Taipei, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Wei-Zen", 
        "id": "sg:person.01010602037.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010602037.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academia Sinica", 
          "id": "https://www.grid.ac/institutes/grid.28665.3f", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, 11529, Taipei, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shyu", 
        "givenName": "Bai-Chuang", 
        "id": "sg:person.0755551072.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755551072.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1152/jn.01150.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000054548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0079-6123(08)62141-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001356859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0470869127.ch13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002630856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(91)90455-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003516138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(91)90455-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003516138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(88)90339-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004230169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(88)90339-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004230169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00623.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004709026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.3758/cabn.4.2.270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005402923", 
          "https://doi.org/10.3758/cabn.4.2.270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2005.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006136808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2005.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006136808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.490190416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007531370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(96)00561-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007723762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(96)00561-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007723762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(82)90337-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009770595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(82)90337-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009770595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2003.10.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010697797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.20249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011362141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0163-1047(82)90725-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013304322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/383535a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013458501", 
          "https://doi.org/10.1038/383535a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3959(89)90046-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014098472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3959(89)90046-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014098472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3959(89)90046-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014098472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.901710204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015591962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1254/jjp.75.337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016323683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe.0.1070147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017379288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-0082(97)00070-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017638274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(86)91371-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019926849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(86)91371-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019926849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(95)12266-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020302612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(91)90151-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020493651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(91)90151-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020493651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.903110310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021062215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0024-3205(97)00542-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021756089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7793.1999.0551p.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022547473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.98.4.1958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024606662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinph.2006.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025142394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-0102(02)00232-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025189389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-0102(02)00232-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025189389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/bhl113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025353163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(90)91697-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025402924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(90)91697-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025402924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3008-04.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028195811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.890120206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028218196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.102.033159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028709304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1986.tb14619.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029007539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0091-3057(03)00166-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029857294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0091-3057(03)00166-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029857294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0470869127.ch12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031918249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3959(85)90145-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032697273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3959(85)90145-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032697273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0707277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034133190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2005.04302.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035302240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2005.04302.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035302240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(80)90047-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035780891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(80)90047-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035780891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0196-9781(97)00264-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037295460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4684-8721-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039039706", 
          "https://doi.org/10.1007/978-1-4684-8721-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4684-8721-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039039706", 
          "https://doi.org/10.1007/978-1-4684-8721-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2006.03.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041730959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(99)01185-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042740157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2003.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042933100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2003.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042933100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4886(85)90102-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043221564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-004-1904-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044661754", 
          "https://doi.org/10.1007/s00213-004-1904-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-004-1904-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044661754", 
          "https://doi.org/10.1007/s00213-004-1904-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0091-3057(00)00374-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044969936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00294.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045869805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00294.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045869805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0196-9781(93)90195-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046244090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3959(97)00125-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047250962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3959(97)00125-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047250962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pain.2004.05.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047336197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pain.2004.05.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047336197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-0102(00)00177-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048446807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.21008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048787545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(03)03218-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050185087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(03)03218-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050185087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3959(98)00115-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050692109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3959(98)00115-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050692109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(01)02686-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051369772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/2.6.477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059458275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7352263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062645897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.22-24-10906.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075204827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1975.38.2.369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077200290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.1985.65.1.37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080011685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1983.50.6.1479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081889005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.14-02-00751.1994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082559379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082754298", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.16-23-07742.1996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082999413"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-12", 
    "datePublishedReg": "2008-12-01", 
    "description": "BACKGROUND: Mice lacking the preproenkephalin (ppENK) gene are hyperalgesic and show more anxiety and aggression than wild-type (WT) mice. The marked behavioral changes in ppENK knock-out (KO) mice appeared to occur in supraspinal response to painful stimuli. However the functional role of enkephalins in the supraspinal nociceptive processing and their underlying mechanism is not clear. The aim of present study was to compare supraspinal nociceptive and morphine antinociceptive responses between WT and ppENK KO mice.\nRESULTS: The genotypes of bred KO mice were confirmed by PCR. Met-enkephalin immunoreactive neurons were labeled in the caudate-putamen, intermediated part of lateral septum, lateral globus pallidus, intermediated part of lateral septum, hypothalamus, and amygdala of WT mice. Met-enkephalin immunoreactive neurons were not found in the same brain areas in KO mice. Tail withdrawal and von Frey test results did not differ between WT and KO mice. KO mice had shorter latency to start paw licking than WT mice in the hot plate test. The maximal percent effect of morphine treatments (5 mg/kg and 10 mg/kg, i.p.) differed between WT and KO mice in hot plate test. The current source density (CSD) profiles evoked by peripheral noxious stimuli in the primary somatosenstory cortex (S1) and anterior cingulate cortex (ACC) were similar in WT and KO mice. After morphine injection, the amplitude of the laser-evoked sink currents was decreased in S1 while the amplitude of electrical-evoked sink currents was increased in the ACC. These differential morphine effects in S1 and ACC were enhanced in KO mice. Facilitation of synaptic currents in the ACC is mediated by GABA inhibitory interneurons in the local circuitry. Percent increases in opioid receptor binding in S1 and ACC were 5.1% and 5.8%, respectively.\nCONCLUSION: The present results indicate that the endogenous enkephalin system is not involved in acute nociceptive transmission in the spinal cord, S1, and ACC. However, morphine preferentially suppressed supraspinal related nociceptive behavior in KO mice. This effect was reflected in the potentiated differential effects of morphine in the S1 and ACC in KO mice. This potentiation may be due to an up-regulation of opioid receptors. Thus these findings strongly suggest an antagonistic interaction between the endogenous enkephalinergic system and exogenous opioid analgesic actions in the supraspinal brain structures.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1744-8069-4-41", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1035131", 
        "issn": [
          "1744-8069"
        ], 
        "name": "Molecular Pain", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice", 
    "pagination": "41", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0ce6e7ed22cd020b175f1957a927d4b798881be28d062e89605234a946d2d76d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18826595"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101242662"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1744-8069-4-41"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002709829"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1744-8069-4-41", 
      "https://app.dimensions.ai/details/publication/pub.1002709829"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000509.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1744-8069-4-41"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1744-8069-4-41'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1744-8069-4-41'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1744-8069-4-41'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1744-8069-4-41'


 

This table displays all metadata directly associated to this object as RDF triples.

347 TRIPLES      21 PREDICATES      109 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1744-8069-4-41 schema:about N0b8b29a92760464ca90983b71d76c486
2 N1d9956da4a5842ffb35c770502787358
3 N3d5c101168c544f4a63fe1fb5f3df03f
4 N642f48272c95434eb5941fc6e43b3718
5 N8f2890b2da4b436fabf132b277cc63df
6 Nb001119483fd48ba80d3f96081a52eaa
7 Nbc751a7298144464af1325030f9b6042
8 Nc65cc0f0c6344128b5a11809af31887d
9 Ncefd084f916f4bf2a4c6691c27f61a0a
10 Ndbdfb347ec8a43e88d26ab5a08345b63
11 Ne9b10bcc5cab4217be6755f6b0146809
12 Nee83a2aaf6cf4f498e9d27c5e39df314
13 Nfb01f2bcaa7e41cb99e22b971be02ba4
14 anzsrc-for:11
15 anzsrc-for:1109
16 schema:author N3e84e93c13f544dab572db783cd3db85
17 schema:citation sg:pub.10.1007/978-1-4684-8721-3
18 sg:pub.10.1007/s00213-004-1904-9
19 sg:pub.10.1038/383535a0
20 sg:pub.10.3758/cabn.4.2.270
21 https://app.dimensions.ai/details/publication/pub.1082754298
22 https://doi.org/10.1002/0470869127.ch12
23 https://doi.org/10.1002/0470869127.ch13
24 https://doi.org/10.1002/art.21008
25 https://doi.org/10.1002/cne.20249
26 https://doi.org/10.1002/cne.901710204
27 https://doi.org/10.1002/cne.903110310
28 https://doi.org/10.1002/jnr.490190416
29 https://doi.org/10.1002/syn.890120206
30 https://doi.org/10.1016/0006-2952(82)90337-9
31 https://doi.org/10.1016/0006-8993(80)90047-5
32 https://doi.org/10.1016/0006-8993(86)91371-5
33 https://doi.org/10.1016/0006-8993(90)91697-f
34 https://doi.org/10.1016/0006-8993(91)90455-5
35 https://doi.org/10.1016/0006-8993(96)00561-6
36 https://doi.org/10.1016/0014-4886(85)90102-5
37 https://doi.org/10.1016/0196-9781(93)90195-m
38 https://doi.org/10.1016/0304-3940(95)12266-4
39 https://doi.org/10.1016/0304-3959(85)90145-9
40 https://doi.org/10.1016/0304-3959(89)90046-8
41 https://doi.org/10.1016/0306-4522(88)90339-9
42 https://doi.org/10.1016/0306-4522(91)90151-d
43 https://doi.org/10.1016/j.brainres.2003.10.006
44 https://doi.org/10.1016/j.clinph.2006.04.013
45 https://doi.org/10.1016/j.neuropharm.2005.06.009
46 https://doi.org/10.1016/j.neuroscience.2003.07.011
47 https://doi.org/10.1016/j.neuroscience.2006.03.018
48 https://doi.org/10.1016/j.pain.2004.05.016
49 https://doi.org/10.1016/s0006-8993(01)02686-5
50 https://doi.org/10.1016/s0006-8993(03)03218-9
51 https://doi.org/10.1016/s0006-8993(99)01185-3
52 https://doi.org/10.1016/s0024-3205(97)00542-0
53 https://doi.org/10.1016/s0079-6123(08)62141-x
54 https://doi.org/10.1016/s0091-3057(00)00374-9
55 https://doi.org/10.1016/s0091-3057(03)00166-7
56 https://doi.org/10.1016/s0163-1047(82)90725-7
57 https://doi.org/10.1016/s0168-0102(00)00177-2
58 https://doi.org/10.1016/s0168-0102(02)00232-8
59 https://doi.org/10.1016/s0196-9781(97)00264-7
60 https://doi.org/10.1016/s0301-0082(97)00070-1
61 https://doi.org/10.1016/s0304-3959(97)00125-5
62 https://doi.org/10.1016/s0304-3959(98)00115-8
63 https://doi.org/10.1038/sj.bjp.0707277
64 https://doi.org/10.1073/pnas.98.4.1958
65 https://doi.org/10.1093/cercor/2.6.477
66 https://doi.org/10.1093/cercor/bhl113
67 https://doi.org/10.1111/j.1460-9568.2005.04302.x
68 https://doi.org/10.1111/j.1469-7793.1999.0551p.x
69 https://doi.org/10.1111/j.1749-6632.1986.tb14619.x
70 https://doi.org/10.1124/jpet.102.033159
71 https://doi.org/10.1126/science.7352263
72 https://doi.org/10.1152/jn.00294.2005
73 https://doi.org/10.1152/jn.00623.2006
74 https://doi.org/10.1152/jn.01150.2002
75 https://doi.org/10.1152/jn.1975.38.2.369
76 https://doi.org/10.1152/jn.1983.50.6.1479
77 https://doi.org/10.1152/physrev.1985.65.1.37
78 https://doi.org/10.1254/jjp.75.337
79 https://doi.org/10.1523/jneurosci.14-02-00751.1994
80 https://doi.org/10.1523/jneurosci.16-23-07742.1996
81 https://doi.org/10.1523/jneurosci.22-24-10906.2002
82 https://doi.org/10.1523/jneurosci.3008-04.2005
83 https://doi.org/10.1677/joe.0.1070147
84 schema:datePublished 2008-12
85 schema:datePublishedReg 2008-12-01
86 schema:description BACKGROUND: Mice lacking the preproenkephalin (ppENK) gene are hyperalgesic and show more anxiety and aggression than wild-type (WT) mice. The marked behavioral changes in ppENK knock-out (KO) mice appeared to occur in supraspinal response to painful stimuli. However the functional role of enkephalins in the supraspinal nociceptive processing and their underlying mechanism is not clear. The aim of present study was to compare supraspinal nociceptive and morphine antinociceptive responses between WT and ppENK KO mice. RESULTS: The genotypes of bred KO mice were confirmed by PCR. Met-enkephalin immunoreactive neurons were labeled in the caudate-putamen, intermediated part of lateral septum, lateral globus pallidus, intermediated part of lateral septum, hypothalamus, and amygdala of WT mice. Met-enkephalin immunoreactive neurons were not found in the same brain areas in KO mice. Tail withdrawal and von Frey test results did not differ between WT and KO mice. KO mice had shorter latency to start paw licking than WT mice in the hot plate test. The maximal percent effect of morphine treatments (5 mg/kg and 10 mg/kg, i.p.) differed between WT and KO mice in hot plate test. The current source density (CSD) profiles evoked by peripheral noxious stimuli in the primary somatosenstory cortex (S1) and anterior cingulate cortex (ACC) were similar in WT and KO mice. After morphine injection, the amplitude of the laser-evoked sink currents was decreased in S1 while the amplitude of electrical-evoked sink currents was increased in the ACC. These differential morphine effects in S1 and ACC were enhanced in KO mice. Facilitation of synaptic currents in the ACC is mediated by GABA inhibitory interneurons in the local circuitry. Percent increases in opioid receptor binding in S1 and ACC were 5.1% and 5.8%, respectively. CONCLUSION: The present results indicate that the endogenous enkephalin system is not involved in acute nociceptive transmission in the spinal cord, S1, and ACC. However, morphine preferentially suppressed supraspinal related nociceptive behavior in KO mice. This effect was reflected in the potentiated differential effects of morphine in the S1 and ACC in KO mice. This potentiation may be due to an up-regulation of opioid receptors. Thus these findings strongly suggest an antagonistic interaction between the endogenous enkephalinergic system and exogenous opioid analgesic actions in the supraspinal brain structures.
87 schema:genre research_article
88 schema:inLanguage en
89 schema:isAccessibleForFree true
90 schema:isPartOf N2fe8f87304fb4364a1c55865e3188790
91 Nd3dd614599784d94b754d176c3dda4aa
92 sg:journal.1035131
93 schema:name Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice
94 schema:pagination 41
95 schema:productId N2b96541f593c4691a314f6404f8a728c
96 N37425aa51d9a403b914bfdcd9b18b663
97 N426e7485a2d64286afd4c18e22143e60
98 N94b6385456124b04ab92bf515d096ddb
99 Na5e95121003e4805acf2cf4a69a67ea4
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002709829
101 https://doi.org/10.1186/1744-8069-4-41
102 schema:sdDatePublished 2019-04-10T23:23
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher Nf6d9b25369fa45099bf4d41480a5da2c
105 schema:url http://link.springer.com/10.1186%2F1744-8069-4-41
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N045c9ff373df49d28e1d1c03e835d712 rdf:first sg:person.01010602037.06
110 rdf:rest Neafd31fbd162429e996984aaa33b8183
111 N0b8b29a92760464ca90983b71d76c486 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Pain
113 rdf:type schema:DefinedTerm
114 N1d9956da4a5842ffb35c770502787358 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Analgesics
116 rdf:type schema:DefinedTerm
117 N2b96541f593c4691a314f6404f8a728c schema:name dimensions_id
118 schema:value pub.1002709829
119 rdf:type schema:PropertyValue
120 N2deda831c8424116bc6fdc2a32cd10eb rdf:first Nfe24acb05ff74ea1bc81ef059ee4df29
121 rdf:rest N045c9ff373df49d28e1d1c03e835d712
122 N2fe8f87304fb4364a1c55865e3188790 schema:issueNumber 1
123 rdf:type schema:PublicationIssue
124 N37425aa51d9a403b914bfdcd9b18b663 schema:name pubmed_id
125 schema:value 18826595
126 rdf:type schema:PropertyValue
127 N3d5c101168c544f4a63fe1fb5f3df03f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Mice, Knockout
129 rdf:type schema:DefinedTerm
130 N3e84e93c13f544dab572db783cd3db85 rdf:first sg:person.01117337433.98
131 rdf:rest N2deda831c8424116bc6fdc2a32cd10eb
132 N426e7485a2d64286afd4c18e22143e60 schema:name doi
133 schema:value 10.1186/1744-8069-4-41
134 rdf:type schema:PropertyValue
135 N642f48272c95434eb5941fc6e43b3718 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Enkephalins
137 rdf:type schema:DefinedTerm
138 N8f2890b2da4b436fabf132b277cc63df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Pain Threshold
140 rdf:type schema:DefinedTerm
141 N94b6385456124b04ab92bf515d096ddb schema:name nlm_unique_id
142 schema:value 101242662
143 rdf:type schema:PropertyValue
144 Na5e95121003e4805acf2cf4a69a67ea4 schema:name readcube_id
145 schema:value 0ce6e7ed22cd020b175f1957a927d4b798881be28d062e89605234a946d2d76d
146 rdf:type schema:PropertyValue
147 Nb001119483fd48ba80d3f96081a52eaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Prosencephalon
149 rdf:type schema:DefinedTerm
150 Nbc751a7298144464af1325030f9b6042 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Morphine
152 rdf:type schema:DefinedTerm
153 Nc65cc0f0c6344128b5a11809af31887d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Protein Precursors
155 rdf:type schema:DefinedTerm
156 Ncefd084f916f4bf2a4c6691c27f61a0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Animals
158 rdf:type schema:DefinedTerm
159 Nd3dd614599784d94b754d176c3dda4aa schema:volumeNumber 4
160 rdf:type schema:PublicationVolume
161 Ndbdfb347ec8a43e88d26ab5a08345b63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Mice
163 rdf:type schema:DefinedTerm
164 Ne9b10bcc5cab4217be6755f6b0146809 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Receptors, Opioid, mu
166 rdf:type schema:DefinedTerm
167 Neafd31fbd162429e996984aaa33b8183 rdf:first sg:person.0755551072.09
168 rdf:rest rdf:nil
169 Nee83a2aaf6cf4f498e9d27c5e39df314 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name gamma-Aminobutyric Acid
171 rdf:type schema:DefinedTerm
172 Nf6d9b25369fa45099bf4d41480a5da2c schema:name Springer Nature - SN SciGraph project
173 rdf:type schema:Organization
174 Nfb01f2bcaa7e41cb99e22b971be02ba4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Gene Expression Regulation
176 rdf:type schema:DefinedTerm
177 Nfe24acb05ff74ea1bc81ef059ee4df29 schema:affiliation https://www.grid.ac/institutes/grid.28665.3f
178 schema:familyName Cheng
179 schema:givenName Ying-Ying
180 rdf:type schema:Person
181 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
182 schema:name Medical and Health Sciences
183 rdf:type schema:DefinedTerm
184 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
185 schema:name Neurosciences
186 rdf:type schema:DefinedTerm
187 sg:journal.1035131 schema:issn 1744-8069
188 schema:name Molecular Pain
189 rdf:type schema:Periodical
190 sg:person.01010602037.06 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
191 schema:familyName Sun
192 schema:givenName Wei-Zen
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010602037.06
194 rdf:type schema:Person
195 sg:person.01117337433.98 schema:affiliation https://www.grid.ac/institutes/grid.28665.3f
196 schema:familyName Chen
197 schema:givenName Tsung-Chieh
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117337433.98
199 rdf:type schema:Person
200 sg:person.0755551072.09 schema:affiliation https://www.grid.ac/institutes/grid.28665.3f
201 schema:familyName Shyu
202 schema:givenName Bai-Chuang
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755551072.09
204 rdf:type schema:Person
205 sg:pub.10.1007/978-1-4684-8721-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039039706
206 https://doi.org/10.1007/978-1-4684-8721-3
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/s00213-004-1904-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044661754
209 https://doi.org/10.1007/s00213-004-1904-9
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/383535a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013458501
212 https://doi.org/10.1038/383535a0
213 rdf:type schema:CreativeWork
214 sg:pub.10.3758/cabn.4.2.270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005402923
215 https://doi.org/10.3758/cabn.4.2.270
216 rdf:type schema:CreativeWork
217 https://app.dimensions.ai/details/publication/pub.1082754298 schema:CreativeWork
218 https://doi.org/10.1002/0470869127.ch12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031918249
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/0470869127.ch13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002630856
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/art.21008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048787545
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/cne.20249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011362141
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1002/cne.901710204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015591962
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1002/cne.903110310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021062215
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1002/jnr.490190416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007531370
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1002/syn.890120206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028218196
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/0006-2952(82)90337-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009770595
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/0006-8993(80)90047-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035780891
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/0006-8993(86)91371-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019926849
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/0006-8993(90)91697-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1025402924
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/0006-8993(91)90455-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003516138
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/0006-8993(96)00561-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007723762
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/0014-4886(85)90102-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043221564
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/0196-9781(93)90195-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1046244090
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/0304-3940(95)12266-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020302612
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/0304-3959(85)90145-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032697273
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/0304-3959(89)90046-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014098472
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/0306-4522(88)90339-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004230169
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/0306-4522(91)90151-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1020493651
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.brainres.2003.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010697797
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.clinph.2006.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025142394
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.neuropharm.2005.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006136808
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.neuroscience.2003.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042933100
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.neuroscience.2006.03.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041730959
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.pain.2004.05.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047336197
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s0006-8993(01)02686-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051369772
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s0006-8993(03)03218-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050185087
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s0006-8993(99)01185-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042740157
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/s0024-3205(97)00542-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021756089
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/s0079-6123(08)62141-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001356859
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/s0091-3057(00)00374-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044969936
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s0091-3057(03)00166-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029857294
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/s0163-1047(82)90725-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013304322
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/s0168-0102(00)00177-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048446807
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/s0168-0102(02)00232-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025189389
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/s0196-9781(97)00264-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037295460
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/s0301-0082(97)00070-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017638274
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/s0304-3959(97)00125-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047250962
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/s0304-3959(98)00115-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050692109
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1038/sj.bjp.0707277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034133190
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1073/pnas.98.4.1958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024606662
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1093/cercor/2.6.477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059458275
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1093/cercor/bhl113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025353163
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1111/j.1460-9568.2005.04302.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035302240
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1111/j.1469-7793.1999.0551p.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022547473
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1111/j.1749-6632.1986.tb14619.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029007539
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1124/jpet.102.033159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028709304
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1126/science.7352263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062645897
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1152/jn.00294.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045869805
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1152/jn.00623.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004709026
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1152/jn.01150.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000054548
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1152/jn.1975.38.2.369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077200290
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1152/jn.1983.50.6.1479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081889005
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1152/physrev.1985.65.1.37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080011685
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1254/jjp.75.337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016323683
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1523/jneurosci.14-02-00751.1994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082559379
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1523/jneurosci.16-23-07742.1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082999413
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1523/jneurosci.22-24-10906.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075204827
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1523/jneurosci.3008-04.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028195811
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1677/joe.0.1070147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017379288
341 rdf:type schema:CreativeWork
342 https://www.grid.ac/institutes/grid.28665.3f schema:alternateName Academia Sinica
343 schema:name Institute of Biomedical Sciences, Academia Sinica, 11529, Taipei, Taiwan, ROC
344 rdf:type schema:Organization
345 https://www.grid.ac/institutes/grid.412094.a schema:alternateName National Taiwan University Hospital
346 schema:name Department of Anaesthesiology, National Taiwan University Hospital, 10002, Taipei, Taiwan, ROC
347 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...