Problems and challenges in the development and validation of human cell-based assays to determine nanoparticle-induced immunomodulatory effects View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Gertie J Oostingh, Eudald Casals, Paola Italiani, Renato Colognato, René Stritzinger, Jessica Ponti, Tobias Pfaller, Yvonne Kohl, Daniëlla Ooms, Flavia Favilli, Hilde Leppens, Davide Lucchesi, François Rossi, Inge Nelissen, Hagen Thielecke, Victor F Puntes, Albert Duschl, Diana Boraschi

ABSTRACT

BACKGROUND: With the increasing use of nanomaterials, the need for methods and assays to examine their immunosafety is becoming urgent, in particular for nanomaterials that are deliberately administered to human subjects (as in the case of nanomedicines). To obtain reliable results, standardised in vitro immunotoxicological tests should be used to determine the effects of engineered nanoparticles on human immune responses. However, before assays can be standardised, it is important that suitable methods are established and validated. RESULTS: In a collaborative work between European laboratories, existing immunological and toxicological in vitro assays were tested and compared for their suitability to test effects of nanoparticles on immune responses. The prototypical nanoparticles used were metal (oxide) particles, either custom-generated by wet synthesis or commercially available as powders. Several problems and challenges were encountered during assay validation, ranging from particle agglomeration in biological media and optical interference with assay systems, to chemical immunotoxicity of solvents and contamination with endotoxin. CONCLUSION: The problems that were encountered in the immunological assay systems used in this study, such as chemical or endotoxin contamination and optical interference caused by the dense material, significantly affected the data obtained. These problems have to be solved to enable the development of reliable assays for the assessment of nano-immunosafety. More... »

PAGES

8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1743-8977-8-8

DOI

http://dx.doi.org/10.1186/1743-8977-8-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023324345

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21306632


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