Glycated albumin suppresses glucose-induced insulin secretion by impairing glucose metabolism in rat pancreatic β-cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04-06

AUTHORS

Takayuki Shiraki, Yoshikazu Miura, Tokihiko Sawada, Toshie Okada, Yuhki Sakuraoka, Takashi Muto, Keiichi Kubota

ABSTRACT

BackgroundGlycated albumin (GA) is an Amadori product used as a marker of hyperglycemia. In this study, we investigated the effect of GA on insulin secretion from pancreatic β cells.MethodsIslets were collected from male Wistar rats by collagenase digestion. Insulin secretion in the presence of non-glycated human albumin (HA) and GA was measured under three different glucose concentrations, 3 mM (G3), 7 mM (G7), and 15 mM (G15), with various stimulators. Insulin secretion was measured with antagonists of inducible nitric oxide synthetase (iNOS), and the expression of iNOS-mRNA was investigated by real-time PCR.ResultsInsulin secretion in the presence of HA and GA was 20.9 ± 3.9 and 21.6 ± 5.5 μU/3 islets/h for G3 (P = 0.920), and 154 ± 9.3 and 126.1 ± 7.3 μU/3 islets/h (P = 0.046), for G15, respectively. High extracellular potassium and 10 mM tolbutamide abrogated the inhibition of insulin secretion by GA. Glyceraldehyde, dihydroxyacetone, methylpyruvate, GLP-1, and forskolin, an activator of adenylate cyclase, did not abrogate the inhibition. Real-time PCR showed that GA did not induce iNOS-mRNA expression. Furthermore, an inhibitor of nitric oxide synthetase, aminoguanidine, and NG-nitro-L-arginine methyl ester did not abrogate the inhibition of insulin secretion.ConclusionGA suppresses glucose-induced insulin secretion from rat pancreatic β-cells through impairment of intracellular glucose metabolism. More... »

PAGES

20

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URI

http://scigraph.springernature.com/pub.10.1186/1743-7075-8-20

DOI

http://dx.doi.org/10.1186/1743-7075-8-20

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https://app.dimensions.ai/details/publication/pub.1030395534

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21470398


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180 Second Department of Surgery, Dokkyo Medical University, School of Medicine, Kitakobayashi 880, 321-0293, Mibu, Shimotsuga, Tochigi, Japan
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