Herbal adaptogens combined with protein fractions from bovine colostrum and hen egg yolk reduce liver TNF-α expression and protein carbonylation ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-04-23

AUTHORS

C Brooks Mobley, Ryan G Toedebusch, Christopher M Lockwood, Alexander J Heese, Conan Zhu, Anna E Krieger, Clayton L Cruthirds, John C Hofheins, Joseph M Company, Charles E Wiedmeyer, Dae Y Kim, Frank W Booth, Michael D Roberts

ABSTRACT

BACKGROUND: We examined if a purported anti-inflammatory supplement (AF) abrogated Western-diet (WD)-induced liver pathology in rats. AF contained: 1) protein concentrates from bovine colostrum and avian egg yolk; 2) herbal adaptogens and antioxidants; and 3) acetyl-L-carnitine. METHODS: Nine month-old male Brown Norway rats were allowed ad libitum access to WD for 41-43 days and randomly assigned to WD + AF feeding twice daily for the last 31-33 days (n = 8), or WD and water-placebo feeding twice daily for the last 31-33 days (n = 8). Rats fed a low-fat/low-sucrose diet (CTL, n = 6) for 41-43 days and administered a water-placebo twice daily for the last 31-33 days were also studied. Twenty-four hours following the last gavage-feed, liver samples were analyzed for: a) select mRNAs (via RT-PCR) as well as genome-wide mRNA expression patterns (via RNA-seq); b) lipid deposition; and, c) protein carbonyl and total antioxidant capacity (TAC). Serum was also examined for TAC, 8-isoprostane and clinical chemistry markers. RESULTS: WD + AF rats experienced a reduction in liver Tnf-α mRNA (-2.8-fold, p < 0.01). Serum and liver TAC was lower in WD + AF versus WD and CTL rats (p < 0.05), likely due to exogenous antioxidant ingredients provided through AF as evidenced by a tendency for mitochondrial SOD2 mRNA to increase in WD + AF versus CTL rats (p = 0.07). Liver fat deposition nor liver protein carbonyl content differed between WD + AF versus WD rats, although liver protein carbonyls tended to be lower in WD + AF versus CTL rats (p = 0.08). RNA-seq revealed that 19 liver mRNAs differed between WD + AF versus WD when both groups were compared with CTL rats (+/- 1.5-fold, p < 0.01). Bioinformatics suggest that AF prevented WD-induced alterations in select genes related to the transport and metabolism of carbohydrates in favor of select genes related to lipid transport and metabolism. Finally, serum clinical safety markers and liver pathology (via lesion counting) suggests that chronic consumption of AF was well tolerated. CONCLUSIONS: AF supplementation elicits select metabolic, anti-inflammatory, and anti-oxidant properties which was in spite of WD feeding and persisted up to 24 hours after receiving a final dose. More... »

PAGES

19-19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1743-7075-11-19

DOI

http://dx.doi.org/10.1186/1743-7075-11-19

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024806880

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24822076


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55 colostrum
56 consumption
57 content
58 days
59 deposition
60 diet
61 diet feeding
62 dose
63 egg yolk
64 elicits
65 exogenous antioxidant ingredients
66 expression
67 expression patterns
68 fat deposition
69 favor
70 feeding
71 final dose
72 fraction
73 genes
74 genome-wide mRNA expression patterns
75 group
76 hen egg yolk
77 herbal adaptogens
78 hours
79 ingredients
80 libitum access
81 lipid deposition
82 lipid transport
83 liver TNF
84 liver fat deposition
85 liver mRNA
86 liver pathology
87 liver protein carbonyl content
88 liver protein carbonyls
89 liver samples
90 liver total antioxidant capacity
91 low-sucrose diet
92 mRNA
93 mRNA expression patterns
94 male Brown Norway rats
95 markers
96 metabolism
97 metabolism of carbohydrates
98 mitochondrial SOD2 mRNA
99 month-old male Brown Norway rats
100 pathology
101 patterns
102 properties
103 protein
104 protein carbonyl content
105 protein carbonylation
106 protein carbonyls
107 protein fractions
108 purported anti-inflammatory supplement
109 rats
110 reduction
111 safety markers
112 samples
113 select genes
114 select mRNAs
115 serum
116 serum clinical safety markers
117 spite
118 supplementation elicits
119 supplements
120 tendency
121 total antioxidant capacity
122 transport
123 water-placebo feeding
124 yolk
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