Orthogonal inactivation of influenza and the creation of detergent resistant viral aggregates: towards a novel vaccine strategy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Julie M Belanger, Yossef Raviv, Mathias Viard, Ulrich Baxa, Robert Blumenthal

ABSTRACT

BACKGROUND: It has been previously shown that enveloped viruses can be inactivated using aryl azides, such as 1-iodo-5-azidonaphthalene (INA), plus UVA irradiation with preservation of surface epitopes in the inactivated virus preparations. Prolonged UVA irradiation in the presence of INA results in ROS-species formation, which in turn results in detergent resistant viral protein fractions. RESULTS: Herein, we characterize the applicability of this technique to inactivate influenza. It is shown that influenza virus + INA (100 micromolar) + UVA irradiation for 30 minutes results in a significant (p < 0.05) increase in pelletablehemagglutinin after Triton X-100 treatment followed by ultracentrifugation. Additionally, characterization of the virus suspension by immunogold labeling in cryo-EM, and viral pellet characterization via immunoprecipitation with a neutralizing antibody, shows preservation of neutralization epitopes after this treatment. CONCLUSION: These orthogonally inactivated viral preparations with detergent resistant fractions are being explored as a novel route for safe, effective inactivated vaccines generated from a variety of enveloped viruses. More... »

PAGES

72

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1743-422x-9-72

DOI

http://dx.doi.org/10.1186/1743-422x-9-72

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023021965

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22449007


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiviral Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Detergents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Influenza Vaccines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Orthomyxoviridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultraviolet Rays", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virus Inactivation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "King's College", 
          "id": "https://www.grid.ac/institutes/grid.419785.6", 
          "name": [
            "Center for Cancer Research Nanobiology Program, National Cancer Institute Frederick, Frederick, USA", 
            "Department of Chemistry and Physics, King's College, Wilkes-Barre, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Belanger", 
        "givenName": "Julie M", 
        "id": "sg:person.01142331501.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142331501.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leidos (United States)", 
          "id": "https://www.grid.ac/institutes/grid.419407.f", 
          "name": [
            "Basic Research Program, SAIC-Frederick, Inc., NCI-Frederick, 21702, Frederick, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raviv", 
        "givenName": "Yossef", 
        "id": "sg:person.01251671127.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251671127.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leidos (United States)", 
          "id": "https://www.grid.ac/institutes/grid.419407.f", 
          "name": [
            "Basic Research Program, SAIC-Frederick, Inc., NCI-Frederick, 21702, Frederick, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Viard", 
        "givenName": "Mathias", 
        "id": "sg:person.01047331332.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047331332.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leidos (United States)", 
          "id": "https://www.grid.ac/institutes/grid.419407.f", 
          "name": [
            "Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, 21702, Frederick, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baxa", 
        "givenName": "Ulrich", 
        "id": "sg:person.01116315441.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116315441.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Frederick National Laboratory for Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.418021.e", 
          "name": [
            "Center for Cancer Research Nanobiology Program, National Cancer Institute Frederick, Frederick, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blumenthal", 
        "givenName": "Robert", 
        "id": "sg:person.0622515432.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622515432.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.virol.2011.06.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000876185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-422x-3-63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000911842", 
          "https://doi.org/10.1186/1743-422x-3-63"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0264-410x(90)90133-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001306219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0264-410x(90)90133-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001306219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jss.400010308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001378662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jss.400010308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001378662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jviromet.2005.01.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003264997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.02045-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003930238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2004.00237.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006755141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1751-1097.2010.00780.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012053892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1751-1097.2010.00780.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012053892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.79.19.12394-12400.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014547247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471729256.mc15g01s3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021702937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(74)90254-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024671459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(74)90254-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024671459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-2659.2008.00038.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026345459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1201/9780203911594.ch11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030399594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro1819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031201834", 
          "https://doi.org/10.1038/nrmicro1819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02233-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034612310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2007.04.115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048069924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/520605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053714396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00601a020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055182261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/0022-1317-66-6-1327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060355769"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "BACKGROUND: It has been previously shown that enveloped viruses can be inactivated using aryl azides, such as 1-iodo-5-azidonaphthalene (INA), plus UVA irradiation with preservation of surface epitopes in the inactivated virus preparations. Prolonged UVA irradiation in the presence of INA results in ROS-species formation, which in turn results in detergent resistant viral protein fractions.\nRESULTS: Herein, we characterize the applicability of this technique to inactivate influenza. It is shown that influenza virus + INA (100 micromolar) + UVA irradiation for 30 minutes results in a significant (p < 0.05) increase in pelletablehemagglutinin after Triton X-100 treatment followed by ultracentrifugation. Additionally, characterization of the virus suspension by immunogold labeling in cryo-EM, and viral pellet characterization via immunoprecipitation with a neutralizing antibody, shows preservation of neutralization epitopes after this treatment.\nCONCLUSION: These orthogonally inactivated viral preparations with detergent resistant fractions are being explored as a novel route for safe, effective inactivated vaccines generated from a variety of enveloped viruses.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1743-422x-9-72", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2343593", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2723574", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1034449", 
        "issn": [
          "1743-422X"
        ], 
        "name": "Virology Journal", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Orthogonal inactivation of influenza and the creation of detergent resistant viral aggregates: towards a novel vaccine strategy", 
    "pagination": "72", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6daea17b0cbb91865425a73b2f58e47120cdcc8526927ea9601703ff1d502097"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22449007"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101231645"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1743-422x-9-72"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1023021965"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1743-422x-9-72", 
      "https://app.dimensions.ai/details/publication/pub.1023021965"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1743-422X-9-72"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1743-422x-9-72'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1743-422x-9-72'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1743-422x-9-72'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1743-422x-9-72'


 

This table displays all metadata directly associated to this object as RDF triples.

195 TRIPLES      21 PREDICATES      55 URIs      28 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1743-422x-9-72 schema:about N0af6749f99ce4f06901124a4af2d5ba9
2 N13068df0ce16420fbed648d9fa71f0ea
3 N2daf7771eac242dd91f63a2a4cdcfe40
4 N83fc6ac9bb5f45088813119a69add125
5 N889ac0cd931e46c6b9167c64162cf076
6 N98703becc7d94f4096f451edd3b70213
7 Nccf75bcd31d34446af0bf6d0e02fb928
8 anzsrc-for:11
9 anzsrc-for:1108
10 schema:author N0c2b083d9de646a2926d6526df7da8b1
11 schema:citation sg:pub.10.1038/nrmicro1819
12 sg:pub.10.1186/1743-422x-3-63
13 https://doi.org/10.1002/0471729256.mc15g01s3
14 https://doi.org/10.1002/jss.400010308
15 https://doi.org/10.1016/0005-2736(74)90254-5
16 https://doi.org/10.1016/0264-410x(90)90133-7
17 https://doi.org/10.1016/j.bbrc.2007.04.115
18 https://doi.org/10.1016/j.jviromet.2005.01.016
19 https://doi.org/10.1016/j.virol.2011.06.007
20 https://doi.org/10.1021/bi00601a020
21 https://doi.org/10.1086/520605
22 https://doi.org/10.1099/0022-1317-66-6-1327
23 https://doi.org/10.1111/j.1600-0854.2004.00237.x
24 https://doi.org/10.1111/j.1750-2659.2008.00038.x
25 https://doi.org/10.1111/j.1751-1097.2010.00780.x
26 https://doi.org/10.1128/jcm.02045-09
27 https://doi.org/10.1128/jvi.02233-07
28 https://doi.org/10.1128/jvi.79.19.12394-12400.2005
29 https://doi.org/10.1201/9780203911594.ch11
30 schema:datePublished 2012-12
31 schema:datePublishedReg 2012-12-01
32 schema:description BACKGROUND: It has been previously shown that enveloped viruses can be inactivated using aryl azides, such as 1-iodo-5-azidonaphthalene (INA), plus UVA irradiation with preservation of surface epitopes in the inactivated virus preparations. Prolonged UVA irradiation in the presence of INA results in ROS-species formation, which in turn results in detergent resistant viral protein fractions. RESULTS: Herein, we characterize the applicability of this technique to inactivate influenza. It is shown that influenza virus + INA (100 micromolar) + UVA irradiation for 30 minutes results in a significant (p < 0.05) increase in pelletablehemagglutinin after Triton X-100 treatment followed by ultracentrifugation. Additionally, characterization of the virus suspension by immunogold labeling in cryo-EM, and viral pellet characterization via immunoprecipitation with a neutralizing antibody, shows preservation of neutralization epitopes after this treatment. CONCLUSION: These orthogonally inactivated viral preparations with detergent resistant fractions are being explored as a novel route for safe, effective inactivated vaccines generated from a variety of enveloped viruses.
33 schema:genre research_article
34 schema:inLanguage en
35 schema:isAccessibleForFree true
36 schema:isPartOf N255ee25f5b354f5eb721ec833cd51615
37 N8ee0dd7b7d714e85aac4468968a36ca4
38 sg:journal.1034449
39 schema:name Orthogonal inactivation of influenza and the creation of detergent resistant viral aggregates: towards a novel vaccine strategy
40 schema:pagination 72
41 schema:productId N049876b278264c8dab0a076fa0513ef4
42 N46d95d0cbec2456393773b749f9694ce
43 N9ac7c193e94641baa40b554479002e36
44 Nc674abbf9cc24bf18a484c6ee8e6c733
45 Ne68bbccec0364f56860d7fa9cade0137
46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023021965
47 https://doi.org/10.1186/1743-422x-9-72
48 schema:sdDatePublished 2019-04-10T15:51
49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
50 schema:sdPublisher Nc2e9300503944d6fafaf67fe5f7e9a59
51 schema:url http://link.springer.com/10.1186%2F1743-422X-9-72
52 sgo:license sg:explorer/license/
53 sgo:sdDataset articles
54 rdf:type schema:ScholarlyArticle
55 N049876b278264c8dab0a076fa0513ef4 schema:name pubmed_id
56 schema:value 22449007
57 rdf:type schema:PropertyValue
58 N0af6749f99ce4f06901124a4af2d5ba9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Detergents
60 rdf:type schema:DefinedTerm
61 N0c2b083d9de646a2926d6526df7da8b1 rdf:first sg:person.01142331501.69
62 rdf:rest N8cfe722c27764930a069ef364f554b0f
63 N13068df0ce16420fbed648d9fa71f0ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name Humans
65 rdf:type schema:DefinedTerm
66 N255ee25f5b354f5eb721ec833cd51615 schema:issueNumber 1
67 rdf:type schema:PublicationIssue
68 N2daf7771eac242dd91f63a2a4cdcfe40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Antiviral Agents
70 rdf:type schema:DefinedTerm
71 N3ad254c574044012b3751c2403f69362 rdf:first sg:person.0622515432.21
72 rdf:rest rdf:nil
73 N3ce643bdc7734df0b5b2be20bcf2ee94 rdf:first sg:person.01047331332.06
74 rdf:rest N6a9535c929694630a6e99ff7790eefc7
75 N46d95d0cbec2456393773b749f9694ce schema:name nlm_unique_id
76 schema:value 101231645
77 rdf:type schema:PropertyValue
78 N6a9535c929694630a6e99ff7790eefc7 rdf:first sg:person.01116315441.38
79 rdf:rest N3ad254c574044012b3751c2403f69362
80 N83fc6ac9bb5f45088813119a69add125 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Ultraviolet Rays
82 rdf:type schema:DefinedTerm
83 N889ac0cd931e46c6b9167c64162cf076 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Orthomyxoviridae
85 rdf:type schema:DefinedTerm
86 N8cfe722c27764930a069ef364f554b0f rdf:first sg:person.01251671127.06
87 rdf:rest N3ce643bdc7734df0b5b2be20bcf2ee94
88 N8ee0dd7b7d714e85aac4468968a36ca4 schema:volumeNumber 9
89 rdf:type schema:PublicationVolume
90 N98703becc7d94f4096f451edd3b70213 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Virus Inactivation
92 rdf:type schema:DefinedTerm
93 N9ac7c193e94641baa40b554479002e36 schema:name doi
94 schema:value 10.1186/1743-422x-9-72
95 rdf:type schema:PropertyValue
96 Nc2e9300503944d6fafaf67fe5f7e9a59 schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 Nc674abbf9cc24bf18a484c6ee8e6c733 schema:name readcube_id
99 schema:value 6daea17b0cbb91865425a73b2f58e47120cdcc8526927ea9601703ff1d502097
100 rdf:type schema:PropertyValue
101 Nccf75bcd31d34446af0bf6d0e02fb928 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Influenza Vaccines
103 rdf:type schema:DefinedTerm
104 Ne68bbccec0364f56860d7fa9cade0137 schema:name dimensions_id
105 schema:value pub.1023021965
106 rdf:type schema:PropertyValue
107 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
108 schema:name Medical and Health Sciences
109 rdf:type schema:DefinedTerm
110 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
111 schema:name Medical Microbiology
112 rdf:type schema:DefinedTerm
113 sg:grant.2343593 http://pending.schema.org/fundedItem sg:pub.10.1186/1743-422x-9-72
114 rdf:type schema:MonetaryGrant
115 sg:grant.2723574 http://pending.schema.org/fundedItem sg:pub.10.1186/1743-422x-9-72
116 rdf:type schema:MonetaryGrant
117 sg:journal.1034449 schema:issn 1743-422X
118 schema:name Virology Journal
119 rdf:type schema:Periodical
120 sg:person.01047331332.06 schema:affiliation https://www.grid.ac/institutes/grid.419407.f
121 schema:familyName Viard
122 schema:givenName Mathias
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047331332.06
124 rdf:type schema:Person
125 sg:person.01116315441.38 schema:affiliation https://www.grid.ac/institutes/grid.419407.f
126 schema:familyName Baxa
127 schema:givenName Ulrich
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116315441.38
129 rdf:type schema:Person
130 sg:person.01142331501.69 schema:affiliation https://www.grid.ac/institutes/grid.419785.6
131 schema:familyName Belanger
132 schema:givenName Julie M
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142331501.69
134 rdf:type schema:Person
135 sg:person.01251671127.06 schema:affiliation https://www.grid.ac/institutes/grid.419407.f
136 schema:familyName Raviv
137 schema:givenName Yossef
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251671127.06
139 rdf:type schema:Person
140 sg:person.0622515432.21 schema:affiliation https://www.grid.ac/institutes/grid.418021.e
141 schema:familyName Blumenthal
142 schema:givenName Robert
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622515432.21
144 rdf:type schema:Person
145 sg:pub.10.1038/nrmicro1819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031201834
146 https://doi.org/10.1038/nrmicro1819
147 rdf:type schema:CreativeWork
148 sg:pub.10.1186/1743-422x-3-63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000911842
149 https://doi.org/10.1186/1743-422x-3-63
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1002/0471729256.mc15g01s3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021702937
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1002/jss.400010308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001378662
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/0005-2736(74)90254-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024671459
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/0264-410x(90)90133-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001306219
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/j.bbrc.2007.04.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048069924
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1016/j.jviromet.2005.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003264997
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1016/j.virol.2011.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000876185
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1021/bi00601a020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055182261
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1086/520605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053714396
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1099/0022-1317-66-6-1327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060355769
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1111/j.1600-0854.2004.00237.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006755141
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1111/j.1750-2659.2008.00038.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026345459
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1111/j.1751-1097.2010.00780.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012053892
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1128/jcm.02045-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003930238
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1128/jvi.02233-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034612310
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1128/jvi.79.19.12394-12400.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014547247
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1201/9780203911594.ch11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030399594
184 rdf:type schema:CreativeWork
185 https://www.grid.ac/institutes/grid.418021.e schema:alternateName Frederick National Laboratory for Cancer Research
186 schema:name Center for Cancer Research Nanobiology Program, National Cancer Institute Frederick, Frederick, USA
187 rdf:type schema:Organization
188 https://www.grid.ac/institutes/grid.419407.f schema:alternateName Leidos (United States)
189 schema:name Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, 21702, Frederick, Maryland, USA
190 Basic Research Program, SAIC-Frederick, Inc., NCI-Frederick, 21702, Frederick, Maryland, USA
191 rdf:type schema:Organization
192 https://www.grid.ac/institutes/grid.419785.6 schema:alternateName King's College
193 schema:name Center for Cancer Research Nanobiology Program, National Cancer Institute Frederick, Frederick, USA
194 Department of Chemistry and Physics, King's College, Wilkes-Barre, PA, USA
195 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...