Inhibition of HCV by the serpin antithrombin III View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Mohammed Asmal, Michael Seaman, Wenyu Lin, Raymond T Chung, Norman L Letvin, Ralf Geiben-Lynn

ABSTRACT

BACKGROUND: Although there have been dramatic strides made recently in the treatment of chronic hepatitis C virus infection, interferon-α based therapy remains challenging for certain populations, including those with unfavorable IL28B genotypes, psychiatric co-morbidity, HIV co-infection, and decompensated liver disease. We have recently shown that ATIII, a serine protease inhibitor (serpin), has broad antiviral properties. RESULTS: We now show that ATIII is capable of inhibiting HCV in the OR6 replicon model at micromolar concentrations. At a mechanistic level using gene-expression arrays, we found that ATIII treatment down-regulated multiple host cell signal transduction factors involved in the pathogenesis of cirrhosis and hepatocellular carcinoma, including Jun, Myc and BMP2. Using a protein interactive network analysis we found that changes in gene-expression caused by ATIII were dependent on three nodes previously implicated in HCV disease progression or HCV replication: NFκB, P38 MAPK, and ERK1/2. CONCLUSIONS: Our findings suggest that ATIII stimulates a novel innate antiviral host cell defense different from current treatment options. More... »

PAGES

226

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1743-422x-9-226

DOI

http://dx.doi.org/10.1186/1743-422x-9-226

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004434556

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23031791


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antithrombin III", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiviral Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepacivirus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Host-Pathogen Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virus Replication", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Division of Viral Pathogenesis, BIDMC, 02215, Boston, MA, USA", 
            "Harvard Medical School, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Asmal", 
        "givenName": "Mohammed", 
        "id": "sg:person.01214371701.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214371701.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Division of Viral Pathogenesis, BIDMC, 02215, Boston, MA, USA", 
            "Harvard Medical School, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seaman", 
        "givenName": "Michael", 
        "id": "sg:person.01317002041.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317002041.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Harvard Medical School, 02215, Boston, MA, USA", 
            "Gastrointestinal Unit, Massachusetts General Hospital, 02114, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Wenyu", 
        "id": "sg:person.01133554125.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133554125.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Harvard Medical School, 02215, Boston, MA, USA", 
            "Gastrointestinal Unit, Massachusetts General Hospital, 02114, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Raymond T", 
        "id": "sg:person.014222240037.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014222240037.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Division of Viral Pathogenesis, BIDMC, 02215, Boston, MA, USA", 
            "Harvard Medical School, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Letvin", 
        "givenName": "Norman L", 
        "id": "sg:person.01106522134.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106522134.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Division of Viral Pathogenesis, BIDMC, 02215, Boston, MA, USA", 
            "Harvard Medical School, 02215, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Geiben-Lynn", 
        "givenName": "Ralf", 
        "id": "sg:person.01306673235.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306673235.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/hep.22849", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001243975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.00-0311com", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001522409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200411190-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004693064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200411190-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004693064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.22.12766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005469440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.283.1.74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006230981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.20371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006563550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.23697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007780327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2006.02.190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008867315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.22070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009231999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00705-002-0925-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010384670", 
          "https://doi.org/10.1007/s00705-002-0925-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc1854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012031897", 
          "https://doi.org/10.1186/cc1854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013075955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa020047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013273688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2005.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014508585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.02.138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014746351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/380130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015124100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00033.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015591554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200409030-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018363417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200409030-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018363417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa011232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018682386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m207079200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018757014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.04-3455fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019436138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virusres.2006.12.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019689769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.qai.0000174930.64145.a9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020229547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.qai.0000174930.64145.a9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020229547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.qai.0000174930.64145.a9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020229547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.qai.0000174930.64145.a9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020229547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa032653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021542593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200310010-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022180531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200310010-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022180531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.qai.0000174649.51084.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023431829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.qai.0000174649.51084.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023431829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.qai.0000174649.51084.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023431829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.76.16.8189-8199.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024763183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2893.2000.00221.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026521893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200308150-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028443519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200308150-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028443519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200108150-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028898314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200108150-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028898314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1601-0825.1997.tb00379.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029632717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0025-7753(01)72194-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030459128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.10.5533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030879684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.aids.0000226956.02719.fd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031019507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.aids.0000226956.02719.fd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031019507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2007.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031943468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2006.01.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032588295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cmr.00010-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032701399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/379255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032784994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034751597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.992302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034948896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m808773200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035043448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(01)06102-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037049358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.510300409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038488364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1746.2006.04380.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040330850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040616127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2893.2005.00651.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042492533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2893.2005.00651.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042492533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/367643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042666609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043648066", 
          "https://doi.org/10.1038/ng1777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043648066", 
          "https://doi.org/10.1038/ng1777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2005.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043713287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0018589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043731904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/318501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044905859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(06)69155-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044914997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2009.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046697414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.17.6547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047626694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2012.02.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049138262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(89)80524-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049862415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199908193410802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050689155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/382595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058674089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/1079990041535647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059207183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci20945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v11.i20.3027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071363144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v12.i13.2065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071364352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v13.i17.2446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071365734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v18.i16.1884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071368225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.16.2.191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071506082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5580/301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072998764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074867339", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076980100", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mcg.0000148398.73197.65", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076980100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mcg.0000148398.73197.65", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076980100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083124346", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083345378", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "BACKGROUND: Although there have been dramatic strides made recently in the treatment of chronic hepatitis C virus infection, interferon-\u03b1 based therapy remains challenging for certain populations, including those with unfavorable IL28B genotypes, psychiatric co-morbidity, HIV co-infection, and decompensated liver disease. We have recently shown that ATIII, a serine protease inhibitor (serpin), has broad antiviral properties.\nRESULTS: We now show that ATIII is capable of inhibiting HCV in the OR6 replicon model at micromolar concentrations. At a mechanistic level using gene-expression arrays, we found that ATIII treatment down-regulated multiple host cell signal transduction factors involved in the pathogenesis of cirrhosis and hepatocellular carcinoma, including Jun, Myc and BMP2. Using a protein interactive network analysis we found that changes in gene-expression caused by ATIII were dependent on three nodes previously implicated in HCV disease progression or HCV replication: NF\u03baB, P38 MAPK, and ERK1/2.\nCONCLUSIONS: Our findings suggest that ATIII stimulates a novel innate antiviral host cell defense different from current treatment options.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1743-422x-9-226", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438712", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2633896", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2687785", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2452034", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5246406", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2695801", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1034449", 
        "issn": [
          "1743-422X"
        ], 
        "name": "Virology Journal", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Inhibition of HCV by the serpin antithrombin III", 
    "pagination": "226", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1521615ed895c84453b352470e5fab957db5f71b743d97f5227b31151ab5cd5e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23031791"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101231645"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1743-422x-9-226"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004434556"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1743-422x-9-226", 
      "https://app.dimensions.ai/details/publication/pub.1004434556"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1743-422X-9-226"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1743-422x-9-226'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1743-422x-9-226'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1743-422x-9-226'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1743-422x-9-226'


 

This table displays all metadata directly associated to this object as RDF triples.

372 TRIPLES      21 PREDICATES      110 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1743-422x-9-226 schema:about N41642443a9654a45afc869fdad890e29
2 N57ccd47416db4cffbd5f1fe47d47e071
3 N5a0d75c177624215bbc086493c15d6a2
4 N7639c836394a406d80a2741d589f313a
5 N7f225fbd87034742903cd0ebd437f209
6 Nbc0c3b826ef2468b90bb4ce9638dcb83
7 Nde4f0027a03c40cb900c523c060e93a6
8 Ne4eacc803f3e4df3ae215ce905102ac2
9 Ne88b1794c275440fb4b37a95fd71856d
10 Nef2ca486d1cb4c9fb6db7681604f54e7
11 anzsrc-for:11
12 anzsrc-for:1108
13 schema:author Ndc80ac32da3e451793fae8cd7a89cd26
14 schema:citation sg:pub.10.1007/s00705-002-0925-0
15 sg:pub.10.1038/ng1777
16 sg:pub.10.1186/cc1854
17 https://app.dimensions.ai/details/publication/pub.1074867339
18 https://app.dimensions.ai/details/publication/pub.1076980100
19 https://app.dimensions.ai/details/publication/pub.1083124346
20 https://app.dimensions.ai/details/publication/pub.1083345378
21 https://doi.org/10.1001/jama.283.1.74
22 https://doi.org/10.1002/hep.20371
23 https://doi.org/10.1002/hep.21232
24 https://doi.org/10.1002/hep.21672
25 https://doi.org/10.1002/hep.22070
26 https://doi.org/10.1002/hep.22849
27 https://doi.org/10.1002/hep.23697
28 https://doi.org/10.1002/hep.510300409
29 https://doi.org/10.1016/0002-9343(89)80524-8
30 https://doi.org/10.1016/j.bbrc.2005.02.138
31 https://doi.org/10.1016/j.bbrc.2006.02.190
32 https://doi.org/10.1016/j.chom.2009.02.001
33 https://doi.org/10.1016/j.jhep.2005.11.007
34 https://doi.org/10.1016/j.jhep.2007.08.018
35 https://doi.org/10.1016/j.virol.2005.01.008
36 https://doi.org/10.1016/j.virusres.2006.12.018
37 https://doi.org/10.1016/s0025-7753(01)72194-x
38 https://doi.org/10.1016/s0140-6736(01)06102-5
39 https://doi.org/10.1016/s0140-6736(06)69155-1
40 https://doi.org/10.1046/j.1365-2893.2000.00221.x
41 https://doi.org/10.1053/j.gastro.2006.01.034
42 https://doi.org/10.1053/j.gastro.2012.02.012
43 https://doi.org/10.1056/nejm199908193410802
44 https://doi.org/10.1056/nejmoa011232
45 https://doi.org/10.1056/nejmoa020047
46 https://doi.org/10.1056/nejmoa032653
47 https://doi.org/10.1073/pnas.87.17.6547
48 https://doi.org/10.1073/pnas.96.10.5533
49 https://doi.org/10.1073/pnas.96.22.12766
50 https://doi.org/10.1074/jbc.m207079200
51 https://doi.org/10.1074/jbc.m808773200
52 https://doi.org/10.1086/318501
53 https://doi.org/10.1086/367643
54 https://doi.org/10.1086/379255
55 https://doi.org/10.1086/380130
56 https://doi.org/10.1086/382595
57 https://doi.org/10.1089/1079990041535647
58 https://doi.org/10.1096/fj.00-0311com
59 https://doi.org/10.1096/fj.04-3455fje
60 https://doi.org/10.1097/00002030-200308150-00009
61 https://doi.org/10.1097/00002030-200409030-00002
62 https://doi.org/10.1097/00002030-200411190-00008
63 https://doi.org/10.1097/00126334-200108150-00002
64 https://doi.org/10.1097/00126334-200310010-00006
65 https://doi.org/10.1097/01.aids.0000226956.02719.fd
66 https://doi.org/10.1097/01.mcg.0000148398.73197.65
67 https://doi.org/10.1097/01.qai.0000174649.51084.46
68 https://doi.org/10.1097/01.qai.0000174930.64145.a9
69 https://doi.org/10.1101/gad.992302
70 https://doi.org/10.1111/j.1365-2893.2005.00651.x
71 https://doi.org/10.1111/j.1440-1746.2006.04380.x
72 https://doi.org/10.1111/j.1601-0825.1997.tb00379.x
73 https://doi.org/10.1128/cmr.00010-06
74 https://doi.org/10.1128/jvi.76.16.8189-8199.2002
75 https://doi.org/10.1152/physrev.00033.2007
76 https://doi.org/10.1172/jci118056
77 https://doi.org/10.1172/jci20945
78 https://doi.org/10.1371/journal.pone.0018589
79 https://doi.org/10.3748/wjg.v11.i20.3027
80 https://doi.org/10.3748/wjg.v12.i13.2065
81 https://doi.org/10.3748/wjg.v13.i17.2446
82 https://doi.org/10.3748/wjg.v18.i16.1884
83 https://doi.org/10.3892/ijmm.16.2.191
84 https://doi.org/10.5580/301
85 schema:datePublished 2012-12
86 schema:datePublishedReg 2012-12-01
87 schema:description BACKGROUND: Although there have been dramatic strides made recently in the treatment of chronic hepatitis C virus infection, interferon-α based therapy remains challenging for certain populations, including those with unfavorable IL28B genotypes, psychiatric co-morbidity, HIV co-infection, and decompensated liver disease. We have recently shown that ATIII, a serine protease inhibitor (serpin), has broad antiviral properties. RESULTS: We now show that ATIII is capable of inhibiting HCV in the OR6 replicon model at micromolar concentrations. At a mechanistic level using gene-expression arrays, we found that ATIII treatment down-regulated multiple host cell signal transduction factors involved in the pathogenesis of cirrhosis and hepatocellular carcinoma, including Jun, Myc and BMP2. Using a protein interactive network analysis we found that changes in gene-expression caused by ATIII were dependent on three nodes previously implicated in HCV disease progression or HCV replication: NFκB, P38 MAPK, and ERK1/2. CONCLUSIONS: Our findings suggest that ATIII stimulates a novel innate antiviral host cell defense different from current treatment options.
88 schema:genre research_article
89 schema:inLanguage en
90 schema:isAccessibleForFree true
91 schema:isPartOf N7a88446a1e6d49878be5dc9e23f62a77
92 Nf683ef2eb78d44c0a487cb955232d1a4
93 sg:journal.1034449
94 schema:name Inhibition of HCV by the serpin antithrombin III
95 schema:pagination 226
96 schema:productId N3a90dec971884fa298cd1310e06142ce
97 N5741013081864f5a845ec99efd7d6752
98 N9632e8a05f5844e88b3e5bfbdbeef8bb
99 Nd8c15c941aa140e3835d7a253a2537c7
100 Nf2b6adf2f3414b5b9dae6c5cd09edd19
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004434556
102 https://doi.org/10.1186/1743-422x-9-226
103 schema:sdDatePublished 2019-04-10T15:00
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher N1e4ab002f3ff4680b2772c6c2e6314d0
106 schema:url http://link.springer.com/10.1186%2F1743-422X-9-226
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N05e454f23c8b423691be8d2a12ebbf3f rdf:first sg:person.014222240037.63
111 rdf:rest Nd9d05a44408b42839c09f3f27435d6e9
112 N1e4ab002f3ff4680b2772c6c2e6314d0 schema:name Springer Nature - SN SciGraph project
113 rdf:type schema:Organization
114 N2a1882c20ffd43e2a6cbb898e4aae6b7 rdf:first sg:person.01133554125.91
115 rdf:rest N05e454f23c8b423691be8d2a12ebbf3f
116 N3a90dec971884fa298cd1310e06142ce schema:name pubmed_id
117 schema:value 23031791
118 rdf:type schema:PropertyValue
119 N40fc2068894e48539b59e3b2218e613a rdf:first sg:person.01306673235.29
120 rdf:rest rdf:nil
121 N41642443a9654a45afc869fdad890e29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Antiviral Agents
123 rdf:type schema:DefinedTerm
124 N5741013081864f5a845ec99efd7d6752 schema:name nlm_unique_id
125 schema:value 101231645
126 rdf:type schema:PropertyValue
127 N57ccd47416db4cffbd5f1fe47d47e071 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Virus Replication
129 rdf:type schema:DefinedTerm
130 N5a0d75c177624215bbc086493c15d6a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Gene Expression Profiling
132 rdf:type schema:DefinedTerm
133 N7639c836394a406d80a2741d589f313a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cell Line
135 rdf:type schema:DefinedTerm
136 N7a88446a1e6d49878be5dc9e23f62a77 schema:issueNumber 1
137 rdf:type schema:PublicationIssue
138 N7f225fbd87034742903cd0ebd437f209 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Signal Transduction
140 rdf:type schema:DefinedTerm
141 N9632e8a05f5844e88b3e5bfbdbeef8bb schema:name doi
142 schema:value 10.1186/1743-422x-9-226
143 rdf:type schema:PropertyValue
144 Nbc0c3b826ef2468b90bb4ce9638dcb83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Antithrombin III
146 rdf:type schema:DefinedTerm
147 Nd63793236ece4fb795c318357496c625 rdf:first sg:person.01317002041.59
148 rdf:rest N2a1882c20ffd43e2a6cbb898e4aae6b7
149 Nd8c15c941aa140e3835d7a253a2537c7 schema:name dimensions_id
150 schema:value pub.1004434556
151 rdf:type schema:PropertyValue
152 Nd9d05a44408b42839c09f3f27435d6e9 rdf:first sg:person.01106522134.30
153 rdf:rest N40fc2068894e48539b59e3b2218e613a
154 Ndc80ac32da3e451793fae8cd7a89cd26 rdf:first sg:person.01214371701.76
155 rdf:rest Nd63793236ece4fb795c318357496c625
156 Nde4f0027a03c40cb900c523c060e93a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Gene Expression Regulation
158 rdf:type schema:DefinedTerm
159 Ne4eacc803f3e4df3ae215ce905102ac2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Hepacivirus
161 rdf:type schema:DefinedTerm
162 Ne88b1794c275440fb4b37a95fd71856d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Host-Pathogen Interactions
164 rdf:type schema:DefinedTerm
165 Nef2ca486d1cb4c9fb6db7681604f54e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Humans
167 rdf:type schema:DefinedTerm
168 Nf2b6adf2f3414b5b9dae6c5cd09edd19 schema:name readcube_id
169 schema:value 1521615ed895c84453b352470e5fab957db5f71b743d97f5227b31151ab5cd5e
170 rdf:type schema:PropertyValue
171 Nf683ef2eb78d44c0a487cb955232d1a4 schema:volumeNumber 9
172 rdf:type schema:PublicationVolume
173 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
174 schema:name Medical and Health Sciences
175 rdf:type schema:DefinedTerm
176 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical Microbiology
178 rdf:type schema:DefinedTerm
179 sg:grant.2438712 http://pending.schema.org/fundedItem sg:pub.10.1186/1743-422x-9-226
180 rdf:type schema:MonetaryGrant
181 sg:grant.2452034 http://pending.schema.org/fundedItem sg:pub.10.1186/1743-422x-9-226
182 rdf:type schema:MonetaryGrant
183 sg:grant.2633896 http://pending.schema.org/fundedItem sg:pub.10.1186/1743-422x-9-226
184 rdf:type schema:MonetaryGrant
185 sg:grant.2687785 http://pending.schema.org/fundedItem sg:pub.10.1186/1743-422x-9-226
186 rdf:type schema:MonetaryGrant
187 sg:grant.2695801 http://pending.schema.org/fundedItem sg:pub.10.1186/1743-422x-9-226
188 rdf:type schema:MonetaryGrant
189 sg:grant.5246406 http://pending.schema.org/fundedItem sg:pub.10.1186/1743-422x-9-226
190 rdf:type schema:MonetaryGrant
191 sg:journal.1034449 schema:issn 1743-422X
192 schema:name Virology Journal
193 rdf:type schema:Periodical
194 sg:person.01106522134.30 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
195 schema:familyName Letvin
196 schema:givenName Norman L
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106522134.30
198 rdf:type schema:Person
199 sg:person.01133554125.91 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
200 schema:familyName Lin
201 schema:givenName Wenyu
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133554125.91
203 rdf:type schema:Person
204 sg:person.01214371701.76 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
205 schema:familyName Asmal
206 schema:givenName Mohammed
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214371701.76
208 rdf:type schema:Person
209 sg:person.01306673235.29 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
210 schema:familyName Geiben-Lynn
211 schema:givenName Ralf
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306673235.29
213 rdf:type schema:Person
214 sg:person.01317002041.59 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
215 schema:familyName Seaman
216 schema:givenName Michael
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317002041.59
218 rdf:type schema:Person
219 sg:person.014222240037.63 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
220 schema:familyName Chung
221 schema:givenName Raymond T
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014222240037.63
223 rdf:type schema:Person
224 sg:pub.10.1007/s00705-002-0925-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010384670
225 https://doi.org/10.1007/s00705-002-0925-0
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/ng1777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043648066
228 https://doi.org/10.1038/ng1777
229 rdf:type schema:CreativeWork
230 sg:pub.10.1186/cc1854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012031897
231 https://doi.org/10.1186/cc1854
232 rdf:type schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1074867339 schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1076980100 schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1083124346 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1083345378 schema:CreativeWork
237 https://doi.org/10.1001/jama.283.1.74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006230981
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/hep.20371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006563550
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/hep.21232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034751597
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/hep.21672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040616127
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/hep.22070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009231999
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/hep.22849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001243975
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/hep.23697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007780327
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/hep.510300409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038488364
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/0002-9343(89)80524-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049862415
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.bbrc.2005.02.138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014746351
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.bbrc.2006.02.190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008867315
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.chom.2009.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046697414
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.jhep.2005.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014508585
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.jhep.2007.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031943468
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.virol.2005.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043713287
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.virusres.2006.12.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019689769
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/s0025-7753(01)72194-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030459128
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0140-6736(01)06102-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037049358
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0140-6736(06)69155-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044914997
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1046/j.1365-2893.2000.00221.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026521893
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1053/j.gastro.2006.01.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032588295
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1053/j.gastro.2012.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049138262
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1056/nejm199908193410802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050689155
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1056/nejmoa011232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018682386
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1056/nejmoa020047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013273688
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1056/nejmoa032653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021542593
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1073/pnas.87.17.6547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047626694
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1073/pnas.96.10.5533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030879684
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1073/pnas.96.22.12766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005469440
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1074/jbc.m207079200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018757014
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1074/jbc.m808773200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035043448
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1086/318501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044905859
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1086/367643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042666609
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1086/379255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032784994
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1086/380130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015124100
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1086/382595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058674089
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1089/1079990041535647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059207183
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1096/fj.00-0311com schema:sameAs https://app.dimensions.ai/details/publication/pub.1001522409
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1096/fj.04-3455fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1019436138
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1097/00002030-200308150-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028443519
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1097/00002030-200409030-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018363417
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1097/00002030-200411190-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004693064
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1097/00126334-200108150-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028898314
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1097/00126334-200310010-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022180531
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1097/01.aids.0000226956.02719.fd schema:sameAs https://app.dimensions.ai/details/publication/pub.1031019507
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1097/01.mcg.0000148398.73197.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076980100
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1097/01.qai.0000174649.51084.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023431829
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1097/01.qai.0000174930.64145.a9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020229547
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1101/gad.992302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034948896
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1111/j.1365-2893.2005.00651.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042492533
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1111/j.1440-1746.2006.04380.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040330850
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1111/j.1601-0825.1997.tb00379.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029632717
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1128/cmr.00010-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032701399
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1128/jvi.76.16.8189-8199.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024763183
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1152/physrev.00033.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015591554
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1172/jci118056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013075955
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1172/jci20945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416576
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1371/journal.pone.0018589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043731904
352 rdf:type schema:CreativeWork
353 https://doi.org/10.3748/wjg.v11.i20.3027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071363144
354 rdf:type schema:CreativeWork
355 https://doi.org/10.3748/wjg.v12.i13.2065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071364352
356 rdf:type schema:CreativeWork
357 https://doi.org/10.3748/wjg.v13.i17.2446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071365734
358 rdf:type schema:CreativeWork
359 https://doi.org/10.3748/wjg.v18.i16.1884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071368225
360 rdf:type schema:CreativeWork
361 https://doi.org/10.3892/ijmm.16.2.191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071506082
362 rdf:type schema:CreativeWork
363 https://doi.org/10.5580/301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072998764
364 rdf:type schema:CreativeWork
365 https://www.grid.ac/institutes/grid.32224.35 schema:alternateName Massachusetts General Hospital
366 schema:name Gastrointestinal Unit, Massachusetts General Hospital, 02114, Boston, MA, USA
367 Harvard Medical School, 02215, Boston, MA, USA
368 rdf:type schema:Organization
369 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
370 schema:name Division of Viral Pathogenesis, BIDMC, 02215, Boston, MA, USA
371 Harvard Medical School, 02215, Boston, MA, USA
372 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...