A two-year survey of the oseltamivir-resistant influenza A(H1N1) virus in Yamagata, Japan and the clinical effectiveness of oseltamivir and zanamivir View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-03-05

AUTHORS

Yoko Matsuzaki, Katsumi Mizuta, Yoko Aoki, Asuka Suto, Chieko Abiko, Kanako Sanjoh, Kanetsu Sugawara, Emi Takashita, Tsutomu Itagaki, Yuriko Katsushima, Makoto Ujike, Masatsugu Obuchi, Takato Odagiri, Masato Tashiro

ABSTRACT

BACKGROUND: Oseltamivir is the preferred antiviral drug for influenza, but oseltamivir-resistant A(H1N1) viruses have circulated worldwide since the 2007-2008 influenza season. We aimed to determine the rate of oseltamivir resistance among A(H1N1) isolates from Yamagata, Japan, to compare the virological characteristics between isolates from the 2007-2008 and 2008-2009 seasons, and to evaluate the clinical effectiveness of oseltamivir. RESULTS: Oseltamivir resistance, determined by detecting the H275Y mutation in the neuraminidase (NA) gene, was observed in 2.5% (2 of 79) and 100% (77 of 77) of isolates from the 2007-2008 and 2008-2009 seasons, respectively. Antigenic analysis suggested that antigenically different variants of A(H1N1) viruses circulated in the 2008-2009 season. Growth testing demonstrated that the ability of the 2008-2009 isolates to replicate in MDCK cells was similar to those of the oseltamivir-susceptible isolates from the 2007-2008 season. A phylogenetic analysis revealed that two oseltamivir-resistant viruses isolated in the 2007-2008 season were closely related to other oseltamivir-susceptible viruses in Yamagata but were different from oseltamivir-resistant viruses isolated in Europe and North America in the 2007-2008 season. The oseltamivir-resistant viruses isolated in Japan in the 2008-2009 season were phylogenetically similar to oseltamivir-resistant isolates from Europe and North America during the 2007-2008 season. Furthermore, the median duration of fever after the start of oseltamivir treatment was significantly longer in oseltamivir-resistant cases (2 days; range 1-6 days) than in oseltamivir-susceptible cases (1.5 days: range 1-2 days) (P = 0.0356). CONCLUSION: Oseltamivir-resistant A(H1N1) isolates from Yamagata in the 2007-2008 season might have acquired resistance through the use of oseltamivir, and the 2008-2009 oseltamivir-resistant isolates might have been introduced into Japan and circulated throughout the country. Influenza surveillance to monitor oseltamivir-resistance would aid clinicians in determining an effective antiviral treatment strategy. More... »

PAGES

53-53

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1743-422x-7-53

DOI

http://dx.doi.org/10.1186/1743-422x-7-53

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048949592

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20202225


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31 schema:description BACKGROUND: Oseltamivir is the preferred antiviral drug for influenza, but oseltamivir-resistant A(H1N1) viruses have circulated worldwide since the 2007-2008 influenza season. We aimed to determine the rate of oseltamivir resistance among A(H1N1) isolates from Yamagata, Japan, to compare the virological characteristics between isolates from the 2007-2008 and 2008-2009 seasons, and to evaluate the clinical effectiveness of oseltamivir. RESULTS: Oseltamivir resistance, determined by detecting the H275Y mutation in the neuraminidase (NA) gene, was observed in 2.5% (2 of 79) and 100% (77 of 77) of isolates from the 2007-2008 and 2008-2009 seasons, respectively. Antigenic analysis suggested that antigenically different variants of A(H1N1) viruses circulated in the 2008-2009 season. Growth testing demonstrated that the ability of the 2008-2009 isolates to replicate in MDCK cells was similar to those of the oseltamivir-susceptible isolates from the 2007-2008 season. A phylogenetic analysis revealed that two oseltamivir-resistant viruses isolated in the 2007-2008 season were closely related to other oseltamivir-susceptible viruses in Yamagata but were different from oseltamivir-resistant viruses isolated in Europe and North America in the 2007-2008 season. The oseltamivir-resistant viruses isolated in Japan in the 2008-2009 season were phylogenetically similar to oseltamivir-resistant isolates from Europe and North America during the 2007-2008 season. Furthermore, the median duration of fever after the start of oseltamivir treatment was significantly longer in oseltamivir-resistant cases (2 days; range 1-6 days) than in oseltamivir-susceptible cases (1.5 days: range 1-2 days) (P = 0.0356). CONCLUSION: Oseltamivir-resistant A(H1N1) isolates from Yamagata in the 2007-2008 season might have acquired resistance through the use of oseltamivir, and the 2008-2009 oseltamivir-resistant isolates might have been introduced into Japan and circulated throughout the country. Influenza surveillance to monitor oseltamivir-resistance would aid clinicians in determining an effective antiviral treatment strategy.
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39 Europe
40 H275Y mutation
41 Japan
42 MDCK cells
43 North America
44 Yamagata
45 ability
46 analysis
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48 antiviral drugs
49 antiviral treatment strategies
50 cases
51 cells
52 characteristics
53 clinical effectiveness
54 clinicians
55 countries
56 different variants
57 drugs
58 duration
59 effective antiviral treatment strategy
60 effectiveness
61 fever
62 genes
63 growth testing
64 influenza
65 influenza season
66 influenza surveillance
67 isolates
68 median duration
69 mutations
70 neuraminidase gene
71 oseltamivir
72 oseltamivir resistance
73 oseltamivir treatment
74 oseltamivir-resistant cases
75 oseltamivir-resistant isolates
76 oseltamivir-resistant viruses
77 oseltamivir-susceptible cases
78 oseltamivir-susceptible viruses
79 phylogenetic analysis
80 preferred antiviral drug
81 rate
82 resistance
83 resistant influenza
84 resistant isolates
85 resistant viruses
86 season
87 start
88 strategies
89 surveillance
90 survey
91 susceptible isolates
92 testing
93 treatment
94 treatment strategies
95 two-year survey
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98 variants
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